Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: Pooled analysis of the mechanical embolus removal in cerebral ischemia (merci) and multi merci trials

Stroke

Volumn 40, Issue 12, 2009, Pages 3777-3783

  Nogueira, Raul G ^a   Liebeskind, David S ^b   Sung, Gene ^c   Duckwiler, Gary ^d   Smith, Wade S ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute stroke; Endovascular treatment; Thrombectomy

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; GLUCOSE;

ADULT; AGE DISTRIBUTION; AGED; ANGIOGRAPHY; ARTERY EMBOLISM; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; EMBOLECTOMY; FEMALE; GLUCOSE BLOOD LEVEL; HEART ATRIUM FIBRILLATION; HEART MUSCLE ISCHEMIA; HUMAN; HYPERTENSION; INTERNAL CAROTID ARTERY OCCLUSION; MAJOR CLINICAL STUDY; MALE; MECHANICAL THROMBECTOMY; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; MULTIVARIATE ANALYSIS; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OCCLUSIVE CEREBROVASCULAR DISEASE; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; RANKIN SCALE; RECANALIZATION; REVASCULARIZATION; RISK ASSESSMENT; SCORING SYSTEM; SYSTOLIC BLOOD PRESSURE; THROMBECTOMY; TREATMENT OUTCOME; UNIVARIATE ANALYSIS;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CAROTID ARTERY DISEASES; CAROTID ARTERY, INTERNAL; CEREBRAL REVASCULARIZATION; FEMALE; HUMANS; HYPERTENSION; INTRACRANIAL EMBOLISM; MALE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; PREDICTIVE VALUE OF TESTS; THROMBECTOMY; TREATMENT OUTCOME;

EID: 73449111232     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.561431     Document Type: Article

References (25)

1. Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. 2005;36: 1432-1438.
2. Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S, Gobin YP, Frei D, Grobelny T, Hellinger F, Huddle D, Kidwell C, Koroshetz W, Marks M, Nesbit G, Silverman IE. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke. 2008;39: 1205-1212
3. Generalized efficacy of t-PA for acute stroke. Subgroup analysis of the NINDS t-PA Stroke Trial. Stroke. 1997;28:2119-2125.
4. Tsivgoulis G, Saqqur M, Sharma VK, Lao AY, Hill MD, Alexandrov AV. Association of pretreatment blood pressure with tissue plasminogen activator-induced arterial recanalization in acute ischemic stroke. Stroke. 2007;38:961-966.
5. Kent DM, Selker HP, Ruthazer R, Bluhmki E, Hacke W. The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke. Stroke. 2006;37: 2957-2962.
6. Ueda T, Sakaki S, Kumon Y, Ohta S. Multivariable analysis of predictive factors related to outcome at 6 months after intra-arterial thrombolysis for acute ischemic stroke. Stroke. 1999;30:2360-2365.
7. Arnold M, Schroth G, Nedeltchev K, Loher T, Remonda L, Stepper F, Sturzenegger M, Mattle HP. Intra-arterial thrombolysis in 100 patients with acute stroke due to middle cerebral artery occlusion. Stroke. 2002; 33:1828-1833.
8. Brekenfeld C, Remonda L, Nedeltchev K, v Bredow F, Ozdoba C, Wiest R, Arnold M, Mattle HP, Schroth G. Endovascular neuroradiological treatment of acute ischemic stroke: techniques and results in 350 patients. Neurol Res. 2005;27(suppl 1):S29-S35.
9. Wechsler LR, Roberts R, Furlan AJ, Higashida RT, Dillon W, Roberts H, Rowley HA, Pettigrew LC, Callahan AS 3rd, Bruno A, Fayad P, Smith WS, Firszt CM, Schulz GA. Factors influencing outcome and treatment effect in PROACT II. Stroke. 2003;34:1224-1229.
10. Alvarez-Sabin J, Molina CA, Montaner J, Arenillas JF, Huertas R, Ribo M, Codina A, Quintana M. Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator-treated patients. Stroke. 2003;34:1235-1241.
11. Elkind MS, Prabhakaran S, Pittman J, Koroshetz W, Jacoby M, Johnston KC. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology. 2007;68:842-848.
12. Kent DM, Buchan AM, Hill MD. The gender effect in stroke thrombolysis. Of CASES, controls, and treatment-effect modification. Neurology. 2008;71:1080-1083.
13. Tomsick T, Broderick J, Carrozella J, Khatri P, Hill M, Palesch Y, Khoury J. Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol. 2008;29:582-587.
14. McDougall C, Clark W, Mayer T, Doerfler A, Grunwald I, Berkefeld J, Lopes D, Shownkken H, Madison M, Budzik R, Heck D, Frei D, Zaidat O, Branca V, Ahktar N, Rai A, Chaloupka J, Hellinger F, Rasmussen P, Rudolph S, Spiegel G. The Penumbra Stroke Trial: Safety and Effectiveness of a New Generation of Mechanical Devices for Clot Removal in Acute Ischemic Stroke. International Stroke Conference; New Orleans, La; 2008.
15. Tsivgoulis G, Saqqur M, Sharma VK, Lao AY, Hoover SL, Alexandrov AV. Association of pretreatment ASPECTS scores with tPA-induced arterial recanalization in acute middle cerebral artery occlusion. J Neuroimaging. 2008;18:56-61.
16. Zangerle A, Kiechl S, Spiegel M, Furtner M, Knoflach M, Werner P, Mair A, Wille G, Schmidauer C, Gautsch K, Gotwald T, Felber S, Poewe W, Willeit J. Recanalization after thrombolysis in stroke patients: predictors and prognostic implications. Neurology. 2007;68:39-44.
17. Ribo M, Molina C, Montaner J, Rubiera M, Delgado-Mederos R, Are-nillas JF, Quintana M, Alvarez-Sabin J. Acute hyperglycemia state is associated with lower tPA-induced recanalization rates in stroke patients. Stroke. 2005;36:1705-1709.
18. Jovin TG, Gupta R, Horowitz MB, Grahovac SZ, Jungreis CA, Wechsler L, Gebel JM, Yonas H. Pretreatment ipsilateral regional cortical blood flow influences vessel recanalization in intra-arterial thrombolysis for MCA occlusion. AJNR Am J Neuroradiol. 2007;28:164-167.
19. Gupta R, Vora NA, Horowitz MB, Tayal AH, Hammer MD, Uchino K, Levy EI, Wechsler LR, Jovin TG. Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalization. Stroke. 2006;37:986-990.
20. Jo KJ, Saver JL, Starkman S, Kim D, Ali LK, Ovbiagele B, Bang OY, Yun S, Towfighi A, Shah SH, Vespa PM, Miller C, Tateshima S, Jahan R, Vinuela F, Duckwiler GR, Liebeskind DS. Predictors of recanalization with mechanical thrombectomy for acute ischemic stroke. Stroke. 2008; 39:599.
21. Christoforidis GA, Mohammad Y, Avutu B, Tejada A, Slivka AP. Arte-riographic demonstration of slow antegrade opacification distal to a cerebrovascular thromboembolic occlusion site as a favorable indicator for intra-arterial thrombolysis. AJNR Am J Neuroradiol. 2006;27: 1528-1531.
22. Pillai JJ, Lanzieri CF, Trinidad SB, Tarr RW, Sunshine JL, Lewin JS. Initial angiographic appearance of intracranial vascular occlusions in acute stroke as a predictor of outcome of thrombolysis: initial experience. Radiology. 2001;218:733-738.
23. Wityk RJ. Blood pressure augmentation in acute ischemic stroke. J Neurol Sci. 2007;261:63-73.
24. Mattle HP, Kappeler L, Arnold M, Fischer U, Nedeltchev K, Remonda L, Jakob SM, Schroth G. Blood pressure and vessel recanalization in the first hours after ischemic stroke. Stroke. 2005;36:264-268.
25. Liebeskind DS, Starkman S, Jo KJ, Ohanian AG, Sayre JW, Yun S, Kim D, Ali LK, Ovbiagele B, Towfighi A, Shah SH, Jahan R, Duckwiler GR, Vinuela F, Saver JL. Blood pressure in acute stroke is inversely related to the extent of collaterals. Stroke. 2008;39:538.