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Volumn 52, Issue 32, 2013, Pages 8210-8212

Propargyl amides as irreversible inhibitors of cysteine proteases - A lesson on the biological reactivity of alkynes

Author keywords

bioorthogonality; irreversible inhibitors; proteases; protein templated reactions; ubiquitin

Indexed keywords

ACTIVITY-BASED; ALIPHATIC ALKYNES; BIOORTHOGONALITY; CYSTEINE PROTEASE; PROPARGYL; PROTEASES; PROTEIN-TEMPLATED REACTIONS; UBIQUITIN;

AMIDES; AMINO ACIDS; HYDROCARBONS;

PROTEINS;

ALKYNE; AMIDE; CYSTEINE PROTEINASE; DRUG DERIVATIVE; PARGYLINE; PROTEINASE INHIBITOR; UBIQUITIN;

ARTICLE; BIOORTHOGONALITY; CHEMISTRY; HUMAN; IRREVERSIBLE INHIBITORS; METABOLISM; PROTEASES; PROTEIN-TEMPLATED REACTIONS;

BIOORTHOGONALITY; IRREVERSIBLE INHIBITORS; PROTEASES; PROTEIN-TEMPLATED REACTIONS; UBIQUITIN;

ALKYNES; AMIDES; CYSTEINE PROTEASES; HUMANS; PARGYLINE; PROTEASE INHIBITORS;

EID: 84882284309 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201303544 Document Type: Article

Times cited : (20)

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