Antidepressant activity: Contribution of brain microdialysis in knock-out mice to the understanding of BDNF/5-HT transporter/5-HT autoreceptor interactions

Frontiers in Pharmacology

Volumn 4 AUG, Issue , 2013, Pages

  Gardier, Alain M ^a  

^a University of Paris XI   (France)

Author keywords

Antidepressants; Autoreceptors; BDNF; Knock out mice; Microdialysis; Serotonin

Indexed keywords

AUTORECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; DOPAMINE; ESCITALOPRAM; FLUOXETINE; MONOAMINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NORADRENALIN; PAROXETINE; PINDOLOL; SEROTONIN; SEROTONIN AUTORECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VENLAFAXINE;

ANALYTIC METHOD; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN MICRODIALYSIS; CONSCIOUSNESS; DEPRESSION; DRUG MEGADOSE; DRUG POTENTIATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MICRODIALYSIS; MONOAMINERGIC SYSTEM; NERVE CELL NETWORK; NERVE ENDING; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; POSTSYNAPTIC POTENTIAL; QUANTITATIVE ANALYSIS; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SINGLE DRUG DOSE; STATISTICAL ANALYSIS; ZERO NET FLUX METHOD;

EID: 84881619154     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2013.00098     Document Type: Article

References (80)

1. Artigas, F., Adell, A., and Celada, P. (2006). Pindolol augmentation of antidepressant response. Curr. Drug Targets 7, 139-147. doi: 10.2174/138945006775515446
2. Beaulieu, J. M., Marion, S., Rodriguiz, R. M., Medvedev, I. O., Sotnikova, T. D., Ghisi, V., et al. (2008). A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 132, 125-136. doi: 10.1016/j.cell.2007.11.041
3. Bel, N., and Artigas, F. (1996). Reduction of serotonergic function in rat brain by tryptophan depletion: effects in control and fluvoxamine-treated rats. J. Neurochem. 67, 669-676. doi: 10.1046/j.1471-4159.1996.67020669.x
4. Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D., Heils, A., et al. (1998). Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 53, 649-655.
5. Benmansour, S., Deltheil, T., Piotrowski, J., Nicolas, L., Reperant, C., Gardier, A. M., et al. (2008). Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. Eur. J. Pharmacol. 587, 90-98. doi: 10.1016/j.ejphar.2008.03.048
6. Benmansour, S., Owens, W. A., Cecchi, M., Morilak, D. A., and Frazer, A. (2002). Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. J. Neurosci. 22, 6766-6772.
7. Bert, L., Favale, D., Jego, G., Greve, P., Guilloux, J.-P., Guiard, B. P., et al. (2004). Rapid and precise method to locate microdialysis probe implantation in the rodent brain. J. Neurosci. Methods 140, 53-57. doi: 10.1016/j.jneumeth.2004.04.042
8. Blier, P. (2001). Pharmacology of rapid-onset antidepressant treatment strategies. J. Clin. Psychiatry 15, 12-17.
9. Blier, P. (2010). Altered function of the serotonin 1A autoreceptor and the antidepressant response. Neuron 65, 1-2. doi: 10.1016/j.neuron.2009.12.028
10. Blier, P., de Montigny, C., and Azzaro, A. J. (1986). Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: electrophysiological studies in the rat central nervous system. J. Pharmacol. Exp. Ther. 237, 987-994.
11. Blier, P., de Montigny, C., and Chaput, Y. (1987). Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. J. Clin. Psychopharmacol. 7(Suppl.), 24S-35S.
12. Bortolozzi, A., Amargós-Bosch, M., Toth, M., Artigas, F., and Adell, A. (2004). In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice. J. Neurochem. 88, 1373-1379.
13. Bortolozzi, A., Castañé, A., Semakova, J., Santana, N., Alvarado, G., Cortés, R., et al. (2012). New antidepressant strategy based on acute siRNA silencing of 5-HT(1A) autoreceptors. Mol. Psychiatry 17, 567. doi: 10.1038/mp.2012.52
14. Bouwknecht, J. A., Hijzen, T. H., van der Gugten, J., Maes, R. A., Hen, R., and Olivier, B. (2002). 5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses. Brain Res. Bull. 57, 93-102. doi: 10.1016/S0361-9230(01)00640-2
15. Chaput, Y., Blier, P., and de Montigny, C. (1986). In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotoninergic terminals. J. Neurosci. 6, 2796-2801.
16. Chen, Z. Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C. J., et al. (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314, 140-143. doi: 10.1126/science.1129663
17. David, D. J., Bourin, M., Jego, G., Przybylski, C., Jolliet, P., and Gardier, A. M. (2003). Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice. Br. J. Pharmacol. 140, 1128-1136. doi: 10.1038/sj.bjp.0705538
18. David, D. J., Froger, N., Guiard, B., Przybylski, C., Jego, G., Boni, C., et al. (2004). Serotonin transporter in substance P (neurokinin 1) receptor knock-out mice. Eur. J. Pharmacol. 492, 41-48. doi: 10.1016/j.ejphar.2004.03.016
19. David, D. J., Samuels, B. A., Rainer, Q., Wang, J. W., Marsteller, D., Mendez, I., et al. (2009). Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62, 479-493. doi: 10.1016/j.neuron.2009.04.017
20. David, D. J., Wang, J., Samuels, B. A., Rainer, Q., David, I., Gardier, A. M., et al. (2010). Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders. Neuroscientist 16, 578-591. doi: 10.1177/1073858409360281
21. Delgado, J. M., DeFeudis, F. V., Roth, R. H., Ryugo, D. K., and Mitruka, B. M. (1972). Dialytrode for long term intracerebral perfusion in awake monkeys. Arch. Int. Pharmacodyn. Ther. 198, 9-21
22. Deltheil, T., Guiard, B. P., Cerdan, J., David, D. J., Tanaka, K. F., Repérant, C., et al. (2008). Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology 55, 1006-1014. doi: 10.1016/j.neuropharm.200808.001
23. Deltheil, T., Tanaka, K., Reperant, C., Hen, R., David, D. J., and Gardier, A. M. (2009). Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice. Int. J. Neuropsychopharmacol. 12, 905-915. doi: 10.1017/S1461145709000017
24. Denoroy, L., Parrot, S., Renaud, L., Renaud, B., and Zimmer, L. (2008). In-capillary derivatization and capillary electrophoresis separation of amino acid neurotransmitters from brain microdialysis samples. J. Chromatogr. A 1205, 144-149. doi: 10.1016/j.chroma.2008.07.043
25. El Mansari, M., Sánchez, C., Chouvet, G., Renaud, B., and Haddjeri, N. (2005). Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain. Neuropsychopharmacology 30, 1269-1277. doi: 10.1038/sj.npp.1300686
26. Froger, N., Gardier, A. M., Moratalla, R., Alberti, I., Lena, I., Boni, C., et al. (2001). 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. J. Neurosci. 21, 8188-8197.
27. Gainetdinov, R. R., Fumagalli, F., Jones, S. R., and Caron, M. G. (1997). Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J. Neurochem. 69, 1322-1325. doi: 10.1046/j.1471-4159.1997.69031322.x
28. Gardier, A., Malagié, I., Trillat, A.-C., Jacquot, C., and Artigas, F. (1996). Role of 5-HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies. Fundam. Clin. Pharmacol. 10, 16-27.
29. Gardier, A. M. (2009). Mutant mouse models and antidepressant drug research: focus on serotonin and brain-derived neurotrophic factor. Behav. Pharmacol. 20, 18-32. doi: 10.1097/FBP.0b013e3283243fcd
30. Gardier, A. M., David, D. J., Jego, G., Przybylski, C., Jacquot, C., Durier, S., et al. (2003). Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. J. Neurochem. 86, 13-24. doi: 10.1046/j.1471-4159.2003.01827.x
31. Gardier, A. M., Trillat, A. C., Malagié, I., David, D., Hascoët, M., Colombel, M. C., et al. (2001). 5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors. C. R. Acad. Sci. III 324, 433-441.
32. Gorman, J. M., and Coplan, J. D. (1996). Comorbid depression and anxiety spectrum disorders. J. Clin. Psychiatry 57, 34-41.
33. Groenink, L., Pattij, T., De Jongh, R., Van der Gugten, J., Oosting, R. S., Dirks, A., et al. (2003). 5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety. Eur. J. Pharmacol. 463, 185-197. doi: 10.1016/S0014-2999(03)01281-0
34. Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., et al. (2002). Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416, 396-400. doi: 10.1038/416396a
35. Guiard, B. P., David, D. J., Deltheil, T., Chenu, F., Le Maître, E., Renoir, T., et al. (2008). Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. Int. J. Neuropsychopharmacol. 11, 79-92.
36. Guiard, B. P., Guilloux, J. P., Reperant, C., Hunt, S. P., Toth, M., and Gardier, A. M. (2007). Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex. Mol. Pharmacol. 72, 1411-1418. doi: 10.1124/mol.107.040113
37. Guiard, B. P., Przybylski, C., Guilloux, J. P., Seif, I., Froger, N., De Felipe, C., et al. (2004). Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. J. Neurochem. 89, 54-63. doi: 10.1046/j.1471-4159.2003.02304.x
38. Guilloux, J. P., David, D. J., Guiard, B. P., Chenu, F., Repérant, C., Toth, M., et al. (2006). Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology 31, 2162-2172. doi: 10.1038/sj.npp.1301019
39. Guilloux, J. P., David, D. J., Xia, L., Nguyen, H. T., Rainer, Q., Guiard, B. P., et al. (2011). Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments. Neuropharmacology 61, 478-488. doi: 10.1016/j.neuropharm.2011.02.009
40. Heisler, L. K., Chu, H. M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., et al. (1998). Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc. Natl. Acad. Sci. U.S.A. 95, 15049-15054. doi: 10.1073/pnas.95.25.15049
41. Hrdina, P. D., Foy, B., Hepner, A., and Summers, R. J. (1990). Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter. J. Pharmacol. Exp. Ther. 252, 410-418.
42. Invernizzi, R. W. (2007). Role of TPH-2 in brain function: news from behavioral and pharmacologic studies. J. Neurosci. Res. 85, 3030-3035. doi: 10.1002/jnr.21330
43. Kuzelova, H., Ptacek, R., and Macek, M. (2010). The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature. Neuro Endocrinol. Lett. 31, 4-10.
44. Lemonde, S., Turecki, G., Bakish, D., Du, L., Hrdina, P. D., Bown, C. D., et al. (2003). Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J. Neurosci. 23, 8788-8799.
45. Leonardo, E. D., and Hen, R. (2006). Genetics of affective and anxiety disorders. Annu. Rev. Psychol. 57, 117-137. doi: 10.1146/annurev.psych.57.102904.190118
46. Malagié, I., Trillat, A. C., Bourin, M., Jacquot, C., Hen, R., and Gardier, A. M. (2001). 5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex. J. Neurochem. 76, 865-871.
47. Malagié, I., Trillat, A. C., Douvier, E., Anmella, M. C., Dessalles, M. C., Jacquot, C., et al. (1996). Regional differences in the effect of the combined treatment of WAY 100635 and fluoxetine: an in vivo microdialysis study. Naunyn Schmiedebergs Arch. Pharmacol. 354, 785-790.
48. Malagié, I., Trillat, A. C., Jacquot, C., and Gardier, A. M. (1995). Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study. Eur. J. Pharmacol. 286, 213-217. doi: 10.1016/0014-2999(95)00573-4
49. Malberg, J. E., Eisch, A. J., Nestler, E. J., and Duman, R. S. (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104-9110.
50. Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J. P., et al. (2005). Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436, 103-107. doi: 10.1038/nature03694
51. Nakahara, D., Hashiguti, H., Kaneda, N., Sasaoka, T., and Nagatsu, T. (1993). Normalization of tyrosine hydroxylase activity in vivo in the striatum of transgenic mice carrying human tyrosine hydroxylase gene: a microdialysis study. Neurosci. Lett. 158, 44-46. doi: 10.1016/0304-3940(93)90608-N
52. Nguyen, H. T., Guiard, B. P., Bacq, A., David, D. J., David, I., Quesseveur, G., et al. (2013). Blockade of the high-affinity norepinephrine transporter (NET) by the selective serotonin reuptake inhibitor escitalopram: an in vivo microdialysis study in mice. Br. J. Pharmacol. 168, 103-116. doi: 10.1111/j.1476-5381.2012.01850.x
53. Parks, C. L., Robinson, P. S., Sibille, E., Shenk, T., and Toth, M. (1998). Increased anxiety of mice lacking the serotonin1A receptor. Proc. Natl. Acad. Sci. U.S.A. 95, 10734-10739. doi: 10.1073/pnas.95.18.10734
54. Parrot, S., Lambás-Señas, L., Sentenac, S., Denoroy, L., and Renaud, B. (2007). Highly sensitive assay for the measurement of serotonin in microdialysates using capillary high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 850, 303-309.
55. Parsons, L. H., Smith, A. D., and Justice, J. B. Jr. (1991). Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse 9, 60-65. doi: 10.1002/syn.890090109
56. Paxinos, G., and Franklin, K. B. J. (2001). The Mouse Brain in Stereotaxic Coordinates, 2nd Edn. San Diego, CA: Academic Press.
57. Pineyro, G., Blier, P., Dennis, T., and de Montigny, C. (1994). Desensitization of the neuronal 5-HT carrier following its long-term blockade. J. Neurosci. 14, 3036-3047.
58. Pineyro, G., Castanon, N., Hen, R., and Blier, P. (1995). Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice. Neuroreport 7, 353-359.
59. Popa, D., Cerdan, J., Repérant, C., Guiard, B. P., Guilloux, J. P., David, D. J., et al. (2010). A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain. Eur. J. Pharmacol. 628, 83-90. doi: 10.1016/j.ejphar.2009.11.037
60. Porsolt, R. D., Le Pichon, M., and Jalfre, M. (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732. doi: 10.1038/266730a0
61. Portella, M. J., de Diego-Adeliño, J., Ballesteros, J., Puigdemont, D., Oller, S., Santosv, B., et al. (2011). Can we really accelerate and enhance the selective serotonin reuptake inhibitor antidepressant effect? A randomized clinical trial and a meta-analysis of pindolol in nonresistant depression. J. Clin. Psychiatry 72, 962-969. doi: 10.4088/JCP.09m05827blu
62. Ramboz, S., Oosting, R., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M., et al. (1998). Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. U.S.A. 95, 14476-14481. doi: 10.1073/pnas.95.24.14476
63. Reperant, C., Pons, S., Dufour, E., Rollema, H., Gardier, A. M., and Maskos, U. (2010). Effect of the alpha4beta2* nicotinic acetylcholine receptor partial agonist varenicline on dopamine release in beta2 knock-out mice with selective re-expression of the beta2 subunit in the ventral tegmental area. Neuropharmacology 58, 346-350. doi: 10.1016/j.neuropharm.2009.10.007
64. Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., Stephen, A., Metzger, K. L., Kung, H. F., et al. (2010). 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 65, 40-52. doi: 10.1016/j.neuron.2009.12.003
65. Richardson-Jones, J. W., Craige, C. P., Nguyen, T. H., Kung, H. F., Gardier, A. M., Dranovsky, A., et al. (2011). Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety. J. Neurosci. 31, 6008-6018. doi: 10.1523/JNEUROSCI.5836-10.2011
66. Rocher, C., Bert, L., Robert, F., Renaud, B., Jacquot, C., and Gardier, A. M. (1996). Microdialysis monitoring of variations in extracellular levels of serotonin, GABA and excitatory amino acids in the frontal cortex of awake rats in response to a single peripheral or central administration of dexfenfluramine. Brain Res. 737, 221-230. doi: 10.1016/0006-8993(96)00735-4
67. Romero, L., Hervas, I., and Artigas, F. (1996). The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neurosci. Lett. 219, 123-126. doi: 10.1016/S0304-3940(96)13199-2
68. Rutter, J. J., Gundlah, C., and Auerbach, S. B. (1995). Systemic uptake inhibition decreases serotonin release via somatodendritic autoreceptor activation. Synapse 20, 225-233. doi: 10.1002/syn.890200306
69. Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., et al. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809. doi: 10.1126/science.1083328
70. Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., et al. (1994). Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265, 1875-1878. doi: 10.1126/science.8091214
71. Silva, A. J., Paylor, R., Wehner, J. M., and Tonegawa, S. (1992). Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257, 206-211. doi: 10.1126/science.1321493
72. Solich, J., Faron-Gorecka, A., Kusmider, M., Palach, P., Gaska, M., and Dziedzicka-Wasylewska, M. (2011). Norepinephrine transporter (NET) knock-out upregulates dopamine and serotonin transporters in the mouse brain. Neurochem. Int. 59, 185-191. doi: 10.1016/j.neuint.2011.04.012
73. Sotnikova, T. D., and Gainetdinov, R. R. (2007). "Microdialysis in genetically altered animals," in Handbook of Microdialysis: Methods, Applications and Clinical Aspects, Vol. 16, eds B. H. C. Westerink and T. F. H. Cremers (Amsterdam: Academic Press), 399-417.
74. Steru, L., Chermat, R., Thierry, B., and Simon, P. (1985). The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl.) 85, 367-370. doi: 10.1007/BF00428203
75. Szapacs, M. E., Mathews, T. A., Tessarollo, L., Ernest Lyons, W., Mamounas, L. A., and Andrews, A. M. (2004). Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. J. Neurosci. Methods 140, 81-92. doi: 10.1016/j.jneumeth.2004.03.026
76. Trillat, A. C., Malagié, I., Scearce, K., Pons, D., Jacquot, C., Hen, R., et al. (1997). Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. J. Neurochem. 69, 2019-2025.
77. Weisstaub, N. V., Zhou, M., Lira, A., Lambe, E., Gonzalez-Maeso, J., Hornung, J. P., et al. (2006). Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313, 536-540. doi: 10.1126/science.1123432
78. Wolf, W. A., Youdim, M. B., and Kuhn, D. M. (1985). Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity? Eur. J. Pharmacol. 109, 381-387. doi: 10.1016/0014-2999(85)90399-1
79. Zetterström, T., Sharp, T., Marsden, C. A., and Ungerstedt, U. (1983). In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine. J Neurochem. 41, 1769-1773.
80. Zhou, F. C., Lesch, K. P., and Murphy, D. L. (2002). Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res. 942, 109-119. doi: 10.1016/S0006-8993(02)02709-9