New antidepressant strategy based on acute siRNA silencing of 5-HT 1A autoreceptors

Molecular Psychiatry

Volumn 17, Issue 6, 2012, Pages 567-

  Bortolozzi, A ^a,b,c   Castane A ^a,c   Semakova, J ^d   Santana, N ^a,c   Alvarado, G ^e   Cortes R ^a,f   Ferres Coy A ^a,b   Fernandez G ^e   Carmona, M C ^e   Toth, M ^g   Perales, J C ^d   Montefeltro, A ^e   Artigas, F ^a,c  

^a INST D INVESTIGACIONS B   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e N Life Therapeutics SL   (Spain)

^f CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 1A RECEPTOR; SERTRALINE; SMALL INTERFERING RNA;

ANTIDEPRESSANT ACTIVITY; ARTICLE; DEPRESSION; DORSAL RAPHE NUCLEUS; GENE SILENCING; HIPPOCAMPUS; MESENCEPHALON; MOLECULARLY TARGETED THERAPY; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC NERVE CELL;

ANIMALS; ANTIDEPRESSIVE AGENTS; AUTORECEPTORS; MICE; RECEPTOR, SEROTONIN, 5-HT1A; RNA, MESSENGER; RNA, SMALL INTERFERING; SERTRALINE;

EID: 84861447563     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2012.52     Document Type: Article

References (0)