메뉴 건너뛰기




Volumn 52, Issue 9, 2013, Pages 715-725

Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis

Author keywords

Cell proliferation; CXCL12; CXCR4; Endocrine disrupting chemicals (EDCs); Estrogen receptor; Ovarian cancer

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; CHEMOKINE RECEPTOR CXCR4; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; GENISTEIN; MESSENGER RNA; SMALL INTERFERING RNA;

EID: 84881613679     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.21913     Document Type: Article
Times cited : (50)

References (49)
  • 1
    • 77955479427 scopus 로고    scopus 로고
    • The multiple roles of estrogens and the enzyme aromatase
    • Boon WC, Chow JD, Simpson ER. The multiple roles of estrogens and the enzyme aromatase. Prog Brain Res 2010; 181: 209-232.
    • (2010) Prog Brain Res , vol.181 , pp. 209-232
    • Boon, W.C.1    Chow, J.D.2    Simpson, E.R.3
  • 2
    • 52949111533 scopus 로고    scopus 로고
    • Minireview: Nuclear receptors and breast cancer
    • Conzen SD. Minireview: Nuclear receptors and breast cancer. Mol Endocrinol 2008; 22: 2215-2228.
    • (2008) Mol Endocrinol , vol.22 , pp. 2215-2228
    • Conzen, S.D.1
  • 3
    • 77956944344 scopus 로고    scopus 로고
    • Influence of sex hormones on cancer progression
    • Folkerd EJ, Dowsett M. Influence of sex hormones on cancer progression. J Clin Oncol 2010; 28: 4038-4044.
    • (2010) J Clin Oncol , vol.28 , pp. 4038-4044
    • Folkerd, E.J.1    Dowsett, M.2
  • 4
    • 0035813112 scopus 로고    scopus 로고
    • The multifaceted mechanisms of estradiol and estrogen receptor signaling
    • Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 2001; 276: 36869-36872.
    • (2001) J Biol Chem , vol.276 , pp. 36869-36872
    • Hall, J.M.1    Couse, J.F.2    Korach, K.S.3
  • 5
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: The second decade. Cell 1995; 83: 835-839.
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3
  • 6
    • 57749178899 scopus 로고    scopus 로고
    • Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways
    • Safe S, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. J Mol Endocrinol 2008; 41: 263-275.
    • (2008) J Mol Endocrinol , vol.41 , pp. 263-275
    • Safe, S.1    Kim, K.2
  • 7
    • 77955629953 scopus 로고    scopus 로고
    • Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
    • Stender JD, Kim K, Charn TH, et al. Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol 2010; 30: 3943-3955.
    • (2010) Mol Cell Biol , vol.30 , pp. 3943-3955
    • Stender, J.D.1    Kim, K.2    Charn, T.H.3
  • 8
    • 70450197247 scopus 로고    scopus 로고
    • Membrane oestrogen receptor alpha signalling to cell functions
    • Levin ER. Membrane oestrogen receptor alpha signalling to cell functions . J Physiol 2009; 587: 5019-5023.
    • (2009) J Physiol , vol.587 , pp. 5019-5023
    • Levin, E.R.1
  • 9
    • 75149186664 scopus 로고    scopus 로고
    • The unfolding stories of GPR30, a new membrane-bound estrogen receptor
    • Maggiolini M, Picard D. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 2010; 204: 105-114.
    • (2010) J Endocrinol , vol.204 , pp. 105-114
    • Maggiolini, M.1    Picard, D.2
  • 10
    • 77956283422 scopus 로고    scopus 로고
    • Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling
    • Henley DV, Korach KS. Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones 2010; 9: 191-205.
    • (2010) Hormones , vol.9 , pp. 191-205
    • Henley, D.V.1    Korach, K.S.2
  • 11
    • 67449132400 scopus 로고    scopus 로고
    • Endocrine-disrupting chemicals: An Endocrine Society scientific statement
    • Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endocrine-disrupting chemicals: An Endocrine Society scientific statement. Endocr Rev 2009; 30: 293-342.
    • (2009) Endocr Rev , vol.30 , pp. 293-342
    • Diamanti-Kandarakis, E.1    Bourguignon, J.P.2    Giudice, L.C.3
  • 12
    • 18044380279 scopus 로고    scopus 로고
    • Clinical correlates of environmental endocrine disruptors
    • Safe S. Clinical correlates of environmental endocrine disruptors. Trends Endocrinol Metab 2005; 16: 139-144.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 139-144
    • Safe, S.1
  • 13
    • 77954035810 scopus 로고    scopus 로고
    • Environmental causes of cancer: Endocrine disruptors as carcinogens
    • Soto AM, Sonnenschein C. Environmental causes of cancer: Endocrine disruptors as carcinogens. Nat Rev Endocrinol 2010; 6: 363-370.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 363-370
    • Soto, A.M.1    Sonnenschein, C.2
  • 14
    • 77249116901 scopus 로고    scopus 로고
    • Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation
    • Yang X, Yang S, McKimmey C, et al. Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation. Carcinogenesis 2010; 31: 695-702.
    • (2010) Carcinogenesis , vol.31 , pp. 695-702
    • Yang, X.1    Yang, S.2    McKimmey, C.3
  • 15
    • 0344141177 scopus 로고    scopus 로고
    • Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients
    • Fanti P, Sawaya BP, Custer LJ, Franke AA. Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients. J Am Soc Nephrol 1999; 10: 864-871.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 864-871
    • Fanti, P.1    Sawaya, B.P.2    Custer, L.J.3    Franke, A.A.4
  • 16
    • 0029805716 scopus 로고    scopus 로고
    • Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells
    • Peterson G, Barnes S. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ 1996; 7: 1345-1351.
    • (1996) Cell Growth Differ , vol.7 , pp. 1345-1351
    • Peterson, G.1    Barnes, S.2
  • 17
    • 33646815750 scopus 로고    scopus 로고
    • Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    • Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006; 147: S56-S69.
    • (2006) Endocrinology , vol.147
    • Welshons, W.V.1    Nagel, S.C.2    Vom Saal, F.S.3
  • 18
    • 34247134018 scopus 로고    scopus 로고
    • Developmental estrogen exposures predispose to prostate carcinogenesis with aging
    • Prins GS, Birch L, Tang WY, Ho SM. Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reprod Toxicol 2007; 23: 374-382.
    • (2007) Reprod Toxicol , vol.23 , pp. 374-382
    • Prins, G.S.1    Birch, L.2    Tang, W.Y.3    Ho, S.M.4
  • 20
    • 77952296027 scopus 로고    scopus 로고
    • Estrogen and xenoestrogens in breast cancer
    • Fernandez SV, Russo J. Estrogen and xenoestrogens in breast cancer. Toxicol Pathol 2010; 38: 110-122.
    • (2010) Toxicol Pathol , vol.38 , pp. 110-122
    • Fernandez, S.V.1    Russo, J.2
  • 21
    • 0034457890 scopus 로고    scopus 로고
    • Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: Requirement of estrogen receptor-alpha
    • Klotz DM, Hewitt SC, Korach KS, Diaugustine RP. Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: Requirement of estrogen receptor-alpha. Endocrinology 2000; 141: 3430-3439.
    • (2000) Endocrinology , vol.141 , pp. 3430-3439
    • Klotz, D.M.1    Hewitt, S.C.2    Korach, K.S.3    Diaugustine, R.P.4
  • 22
    • 78751492254 scopus 로고    scopus 로고
    • Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles
    • Hewitt SC, Korach KS. Estrogenic activity of bisphenol A and 2, 2-bis(p-hydroxyphenyl)-1, 1, 1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect 2010; 119: 63-70.
    • (2010) Environ Health Perspect , vol.119 , pp. 63-70
    • Hewitt, S.C.1    Korach, K.S.2
  • 23
    • 79551682463 scopus 로고    scopus 로고
    • Nongenomic signaling pathways of estrogen toxicity
    • Watson CS, Jeng YJ, Kochukov MY. Nongenomic signaling pathways of estrogen toxicity. Toxicol Sci 2010; 115: 1-11.
    • (2010) Toxicol Sci , vol.115 , pp. 1-11
    • Watson, C.S.1    Jeng, Y.J.2    Kochukov, M.Y.3
  • 24
    • 33750442923 scopus 로고    scopus 로고
    • Genome-wide analysis of estrogen receptor binding sites
    • Carroll JS, Meyer CA, Song J, et al. Genome-wide analysis of estrogen receptor binding sites. Nat Genet 2006; 38: 1289-1297.
    • (2006) Nat Genet , vol.38 , pp. 1289-1297
    • Carroll, J.S.1    Meyer, C.A.2    Song, J.3
  • 25
    • 0141785350 scopus 로고    scopus 로고
    • Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
    • Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 2003; 144: 4562-4574.
    • (2003) Endocrinology , vol.144 , pp. 4562-4574
    • Frasor, J.1    Danes, J.M.2    Komm, B.3    Chang, K.C.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 26
    • 23844485897 scopus 로고
    • From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response
    • Laganiere J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguere V. From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A 1005; 102: 11651-11656.
    • (1005) Proc Natl Acad Sci U S A , vol.102 , pp. 11651-11656
    • Laganiere, J.1    Deblois, G.2    Lefebvre, C.3    Bataille, A.R.4    Robert, F.5    Giguere, V.6
  • 27
    • 0038636392 scopus 로고    scopus 로고
    • Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells
    • Hall JM, Korach KS. Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol 2003; 17: 792-803.
    • (2003) Mol Endocrinol , vol.17 , pp. 792-803
    • Hall, J.M.1    Korach, K.S.2
  • 29
    • 78349245224 scopus 로고    scopus 로고
    • Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk
    • Rhodes LV, Antoon JW, Muir SE, et al. Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk. Mol Cancer 2010; 9: 295.
    • (2010) Mol Cancer , vol.9 , pp. 295
    • Rhodes, L.V.1    Antoon, J.W.2    Muir, S.E.3
  • 30
    • 78751560129 scopus 로고    scopus 로고
    • Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer
    • Rhodes LV, Short SP, Neel N, et al. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res 2011; 71: 603-613.
    • (2011) Cancer Res , vol.71 , pp. 603-613
    • Rhodes, L.V.1    Short, S.P.2    Neel, N.3
  • 31
    • 67651005771 scopus 로고    scopus 로고
    • Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway
    • Sauve K, Lepage J, Sanchez M, Heveker N, Tremblay A. Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway. Cancer Res 2009; 69: 5793-5800.
    • (2009) Cancer Res , vol.69 , pp. 5793-5800
    • Sauve, K.1    Lepage, J.2    Sanchez, M.3    Heveker, N.4    Tremblay, A.5
  • 32
    • 0037108923 scopus 로고    scopus 로고
    • Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer
    • Scotton CJ, Wilson JL, Scott K, et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002; 62: 5930-5938.
    • (2002) Cancer Res , vol.62 , pp. 5930-5938
    • Scotton, C.J.1    Wilson, J.L.2    Scott, K.3
  • 33
    • 0024489926 scopus 로고
    • Characterization of a human ovarian carcinoma cell line with estrogen and progesterone receptors
    • Geisinger KR, Kute TE, Pettenati MJ, et al. Characterization of a human ovarian carcinoma cell line with estrogen and progesterone receptors. Cancer 1989; 63: 280-288.
    • (1989) Cancer , vol.63 , pp. 280-288
    • Geisinger, K.R.1    Kute, T.E.2    Pettenati, M.J.3
  • 34
    • 0034826708 scopus 로고    scopus 로고
    • Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues
    • Schmitt E, Dekant W, Stopper H. Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues. Toxicol In Vitro 2001; 15: 433-439.
    • (2001) Toxicol In Vitro , vol.15 , pp. 433-439
    • Schmitt, E.1    Dekant, W.2    Stopper, H.3
  • 35
    • 77952532124 scopus 로고    scopus 로고
    • Association of urinary bisphenol a concentration with heart disease: Evidence from NHANES 2003/06
    • Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS. Association of urinary bisphenol a concentration with heart disease: Evidence from NHANES 2003/06. PLoS One 2010; 5: e8673.
    • (2010) PLoS One , vol.5
    • Melzer, D.1    Rice, N.E.2    Lewis, C.3    Henley, W.E.4    Galloway, T.S.5
  • 36
    • 77949890714 scopus 로고    scopus 로고
    • Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain
    • Hinton CV, Avraham S, Avraham HK. Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis 2010; 27: 97-105.
    • (2010) Clin Exp Metastasis , vol.27 , pp. 97-105
    • Hinton, C.V.1    Avraham, S.2    Avraham, H.K.3
  • 37
    • 0034989592 scopus 로고    scopus 로고
    • Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals
    • McLachlan JA. Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 2001; 22: 319-341.
    • (2001) Endocr Rev , vol.22 , pp. 319-341
    • McLachlan, J.A.1
  • 38
    • 65349088088 scopus 로고    scopus 로고
    • Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38
    • Park SH, Kim KY, An BS, et al. Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38. J Reprod Dev 2009; 55: 23-29.
    • (2009) J Reprod Dev , vol.55 , pp. 23-29
    • Park, S.H.1    Kim, K.Y.2    An, B.S.3
  • 39
    • 79952041609 scopus 로고    scopus 로고
    • Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line
    • Ptak A, Wróbel A, Gregoraszczuk EL. Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line. Toxicol Lett 2011; 202: 30-35.
    • (2011) Toxicol Lett , vol.202 , pp. 30-35
    • Ptak, A.1    Wróbel, A.2    Gregoraszczuk, E.L.3
  • 40
    • 74049083327 scopus 로고    scopus 로고
    • Neonatal bisphenol A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons
    • Adewale HB, Jefferson WN, Newbold RR, Patisaul HB. Neonatal bisphenol A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons. Biol Reprod 2009; 81: 690-699.
    • (2009) Biol Reprod , vol.81 , pp. 690-699
    • Adewale, H.B.1    Jefferson, W.N.2    Newbold, R.R.3    Patisaul, H.B.4
  • 41
    • 67349143766 scopus 로고    scopus 로고
    • Prenatal exposure to bisphenol A at environmentally relevant doses adversely affects the murine female reproductive tract later in life
    • Newbold RR, Jefferson WN, Padilla-Banks E. Prenatal exposure to bisphenol A at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environ Health Perspect 2009; 117: 879-885.
    • (2009) Environ Health Perspect , vol.117 , pp. 879-885
    • Newbold, R.R.1    Jefferson, W.N.2    Padilla-Banks, E.3
  • 42
    • 67349105361 scopus 로고    scopus 로고
    • Mechanisms of estrogen signaling and gene expression via GPR30
    • Prossnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 2009; 308: 32-38.
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 32-38
    • Prossnitz, E.R.1    Maggiolini, M.2
  • 43
    • 79957620026 scopus 로고    scopus 로고
    • Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression
    • Lucki NC, Sewer MB. Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J Biol Chem 2011; 286: 19399-19409.
    • (2011) J Biol Chem , vol.286 , pp. 19399-19409
    • Lucki, N.C.1    Sewer, M.B.2
  • 44
    • 84881616827 scopus 로고    scopus 로고
    • editor. Gynecologic oncology [Internet]. California: Gynecologic Oncology Associates [cited 2011 Aug 9]. Available from
    • Rich WM, editor. Gynecologic oncology [Internet]. California: Gynecologic Oncology Associates [cited 2011 Aug 9]. Available from: http://www.gyncancer.com/ovarian-cancer.html
    • Rich, W.M.1
  • 45
    • 0026317212 scopus 로고
    • Dopaminergic and ligand-independent activation of steroid hormone receptors
    • Power RF, Mani SK, Codina J, Conneely OM, O'Malley BW. Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 1991; 254: 1636-1639.
    • (1991) Science , vol.254 , pp. 1636-1639
    • Power, R.F.1    Mani, S.K.2    Codina, J.3    Conneely, O.M.4    O'Malley, B.W.5
  • 46
    • 36749003738 scopus 로고    scopus 로고
    • Involvement of SDF-1α/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma
    • Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F. Involvement of SDF-1α/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. Int J Cancer 2008; 122: 91-99.
    • (2008) Int J Cancer , vol.122 , pp. 91-99
    • Kajiyama, H.1    Shibata, K.2    Terauchi, M.3    Ino, K.4    Nawa, A.5    Kikkawa, F.6
  • 47
    • 33748548126 scopus 로고    scopus 로고
    • Expression of chemokine CXCL12 and its receptor CXCR4 in human epithelial ovarian cancer: An independent prognostic factor for tumor progression
    • Jiang YP, Wu XH, Shi B, Wu WX, Yin GR. Expression of chemokine CXCL12 and its receptor CXCR4 in human epithelial ovarian cancer: An independent prognostic factor for tumor progression. Gynecol Oncol 2006; 103: 226-233.
    • (2006) Gynecol Oncol , vol.103 , pp. 226-233
    • Jiang, Y.P.1    Wu, X.H.2    Shi, B.3    Wu, W.X.4    Yin, G.R.5
  • 48
    • 67651176019 scopus 로고    scopus 로고
    • An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells
    • Kwong H, Kulbe H, Wong D, Chakravarty P, Balkwill F. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther 2009; 8: 1893-1905.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1893-1905
    • Kwong, H.1    Kulbe, H.2    Wong, D.3    Chakravarty, P.4    Balkwill, F.5
  • 49
    • 80051690814 scopus 로고    scopus 로고
    • CXCL12/CXCR4 blockade induces multimodal anti-tumor effects and prolongs survival of immunocompetent mice with ovarian cancer
    • Righi E, Kashiwagi S, Yuan J, et al. CXCL12/CXCR4 blockade induces multimodal anti-tumor effects and prolongs survival of immunocompetent mice with ovarian cancer. Cancer Res 2011; 71: 5522-5534.
    • (2011) Cancer Res , vol.71 , pp. 5522-5534
    • Righi, E.1    Kashiwagi, S.2    Yuan, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.