Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line

Toxicology Letters

Volumn 202, Issue 1, 2011, Pages 30-35

  Ptak, Anna ^a   Wróbel, Anna ^a   Gregoraszczuk, Ewa L ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Apoptosis; BPA; Cell cycle; OVCAR 3

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; CASPASE 3; CASPASE 7; ENDONUCLEASE G; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DNA REPAIR; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION;

APOPTOSIS; CARCINOGENICITY TESTS; CARCINOGENS, ENVIRONMENTAL; CASPASE 3; CASPASE 7; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS, NON-STEROIDAL; FEMALE; GENE EXPRESSION; HUMANS; OVARIAN NEOPLASMS; PHENOLS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79952041609     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.01.015     Document Type: Article

References (35)

1. Auersperg N., Wong A.S., Choi K.C., Kang S.K., Leung P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 2001, 22:255-288.
2. Bali A., O'Brien P.M., Edwards L.S., Sutherland R.L., Hacker N.F., Henshall S.M. Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer. Clin. Cancer Res. 2004, 10:5167-5177.
3. Bargou R.C., Wagener C., Bommert K., Mapara M.Y., Daniel P.T., Arnold W., Dietel M., Guski H., Feller A., Royer H.D., Dorken B. Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J. Clin. Invest. 1996, 97:2569-2651.
4. Betabcourt A.M., Mobley J.A., Russo J., Lamartiniere C.A. Proteomic analysis in mammary glands of rat offspring exposed in utero to bisphenol A. J. Proteomics 2010, 73:1241-1253.
5. Bolli A., Galluzzo P., Ascenzi P., Del Pozzo G., Manco I., Vietri M.T., Mita L., Altucci L., Mita D.G., Marino M. Laccase treatment impairs bisphenol A-induced cancer cell proliferation affecting estrogen receptor alpha-dependent rapid signals. IUBMB Life. 2008, 60:843-852.
6. Bouskine A., Nebout M., Brucker-Davis F., Benahmed M., Fenichel P. Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environ Health Perspect. 2009, 117:1053-1058.
7. Bredhult C., Backlin B.M., Olovsson M. Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro. Reprod. Toxicol. 2007, 23:550-559.
8. Broker L.E., Kruyt F.A., Giaccone G. Cell death independent of caspases: a review. Clin. Cancer Res. 2005, 11:3155-3162.
9. Calafat A.M., Kuklenyik Z., Reidy J.A., Caudill S.P., Ekong J., Needham L.L. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health Perspect. 2005, 113:391-395.
10. Dairkee S.H., Seok J., Champion S., Sayeed A., Mindrinos M., Xiao W., Davis R.W., Goodson W.H. Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Res. 2008, 68:2076-2080.
11. Decker P., Muller S. Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr. Pharm. Biotechnol. 2002, 3:275-283.
12. Diel P., Olff S., Schmidt S., Michna H. Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J. Steroid. Biochem. Mol. Biol. 2002, 80:61-70.
13. Donovan M., Cotter T.G. Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim. Biophys. Acta 2004, 1644:133-147.
14. Durando M., Kass L., Piva J., Sonnenschein C., Soto A.M., Luque E.H., Muñoz-de-Toro M. Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environ. Health Perspect. 2007, 115:80-86.
15. Jin Z., El-Deiry W.S. Overview of cell death signaling pathways. Cancer Biol. Therapy 2005, 4:139-163.
16. Keri R.A., Ho S.M., Hunt P.A., Knudsen K.E., Soto A.M., Prins G.S. An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod. Toxicol. 2007, 24:240-252.
17. Koh D.W., Dawson T.M., Dawson V.L. Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacol. Res. 2005, 52:5-14.
18. LaPensee E.W., Tuttle T.R., Fox S.R., Ben-Jonathan N. Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. Environ. Health Perspect. 2009, 117:175-180.
19. LaPensee E.W., LaPensee C.R., Fox S., Schwemberger S., Afton S., Ben-Jonathan N. Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. Cancer Lett. 2010, 290:167-173.
20. Li L.Y., Luo X., Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 2001, 412:95-99.
21. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995, 6:37-43.
22. Olsen C.M., Meussen-Elholm E.T., Samuelsen M., Holme J.A, Hongslo J.K. Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4'-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7. Pharmacol. Toxicol. 2003, 92:180-188.
23. Park S.H., Kim K.Y., An B.S., Choi J.H., Jeung E.B., Leung P.C., Choi K.C. Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38. J. Reprod. Dev. 2009, 55:23-29.
24. Ricupito A., Del Pozzo G., Diano N., Grano V., Portaccio M., Marino M., Bolli A., Gzlluzzo P., Bontempo P., Mita L., Altucci L., Mita D.G. Effect of bisphenol A with or without enzyme treatment on the proliferation and viability of MCF-7 cells. Environ. Int. 2009, 35:21-26.
25. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999, 13:1501-1512.
26. Singleton D.W., Feng Y., Yang J., Puga A., Lee A.V., Khan S.A. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ. Res. 2006, 100:86-92.
27. Sun Y., Irie M., Kishikawa N., Wada M., Kuroda N., Nakashima K. Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection. Biomed. Chromatogr. 2004, 18:501-507.
28. Tellmann G. The E-Method: a highly accurate technique for gene-expression analysis. Nat. Methods 2006, 3. 10.1038/nmeth894.
29. Wang Z., Goulet R., Stanton K.J., Sadaria M., Nakshatri H. Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxel. Anticancer Res. 2005, 25:2367-2379.
30. Watanabe J., Kamata Y., Seo N., Okayasu I., Kyramoto H. Stimulatory effect of estrogen on the growth of endometrial cancer cells is regulated by cell-cycle regulators. J. Steroid Biochem. Mol. Biol. 2007, 107:163-171.
31. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 1995, 81:323-330.
32. Welshons W.V., Nagel S.C., vom Saal F.S. Large effects from small exposures III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006, 147:S56-S69.
33. Vandenberg L.N., Hauser R., Marcus M., Olea N., Welshons W.V. Human exposure to bisphenol A (BPA). Reprod. Toxicol. 2007, 24:139-177.
34. Xu J., Osuga Y., Yano T., Morita Y., Tang X., Fujiwara T., Takai Y., Matsumi H., Koga K., Taketani Y., Tsutsumi O. Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells. Biochem. Biophys. Res. Commun. 2002, 292:456-462.
35. Zhu H., Xiao X., Zheng J., Zheng S., Dong K., Yu Y. Growth-promoting effect of bisphenol A on neuroblastoma in vitro and in vivo. J. Pediatr. Surg. 2009, 44:672-680.