메뉴 건너뛰기




Volumn 46, Issue 7, 2013, Pages 634-642

A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay

Author keywords

Drug testing; Pancreatic cancer; Spheroid; Three dimensional culture

Indexed keywords

ACID PHOSPHATASE; FLUOROURACIL; GEMCITABINE;

EID: 84881604704     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20132647     Document Type: Article
Times cited : (69)

References (39)
  • 1
    • 80053254048 scopus 로고    scopus 로고
    • Adjuvant treatment of pancreatic cancer
    • doi: 10.1016/ S0959-8049(11)70210-6
    • Neoptolemos JP. Adjuvant treatment of pancreatic cancer. Eur J Cancer 2011; 47 (Suppl 3): S378-S380. doi: 10.1016/ S0959-8049(11)70210-6.
    • (2011) Eur J Cancer , vol.47 , Issue.SUPPL. 3
    • Neoptolemos, J.P.1
  • 2
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • doi: 10.1038/nrm1858
    • Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006; 7: 211-224. doi: 10.1038/nrm1858.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 4
    • 77952932509 scopus 로고    scopus 로고
    • Engineering tumors: A tissue engineering perspective in cancer biology
    • doi: 10.1089/ ten.teb.2009.0676
    • Burdett E, Kasper FK, Mikos AG, Ludwig JA. Engineering tumors: a tissue engineering perspective in cancer biology. Tissue Eng Part B Rev 2010; 16: 351-359. doi: 10.1089/ ten.teb.2009.0676.
    • (2010) Tissue Eng Part B Rev , vol.16 , pp. 351-359
    • Burdett, E.1    Kasper, F.K.2    Mikos, A.G.3    Ludwig, J.A.4
  • 5
    • 0016875214 scopus 로고
    • Radiation response of multicell spheroids -an in vitro tumour model
    • Sutherland RM, Durand RE. Radiation response of multicell spheroids -an in vitro tumour model. Curr Top Radiat Res Q 1976; 11: 87-139.
    • (1976) Curr Top Radiat Res Q , vol.11 , pp. 87-139
    • Sutherland, R.M.1    Durand, R.E.2
  • 6
    • 0025428326 scopus 로고
    • Multicell spheroids as a model for cell kinetic studies
    • Durand RE. Multicell spheroids as a model for cell kinetic studies. Cell Tissue Kinet 1990; 23: 141-159.
    • (1990) Cell Tissue Kinet , vol.23 , pp. 141-159
    • Durand, R.E.1
  • 7
    • 0026559474 scopus 로고
    • Evaluation of bioreductive drugs in multicell spheroids
    • doi: 10.1016/0360-3016(92)90504-B
    • Durand RE, Olive PL. Evaluation of bioreductive drugs in multicell spheroids. Int J Radiat Oncol Biol Phys 1992; 22: 689-692. doi: 10.1016/0360-3016(92)90504-B.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 689-692
    • Durand, R.E.1    Olive, P.L.2
  • 8
    • 0028610142 scopus 로고
    • Glucose diffusion coefficients determined from concentration profiles in EMT6 tumor spheroids incubated in radioactively labeled Lglucose
    • doi: 10.1007/978-1-4615-1875-4_114
    • Groebe K, Erz S, Mueller-Klieser W. Glucose diffusion coefficients determined from concentration profiles in EMT6 tumor spheroids incubated in radioactively labeled Lglucose. Adv Exp Med Biol 1994; 361: 619-625. doi: 10.1007/978-1-4615-1875-4_114.
    • (1994) Adv Exp Med Biol , vol.361 , pp. 619-625
    • Groebe, K.1    Erz, S.2    Mueller-Klieser, W.3
  • 9
    • 84859728428 scopus 로고    scopus 로고
    • Multicellular tumor spheroid formation in duplex microcapsules for analysis of chemosensitivity
    • doi: 10.1111/j.1349-7006.2011.02187.x
    • Sakai S, Inamoto K, Liu Y, Tanaka S, Arii S, Taya M. Multicellular tumor spheroid formation in duplex microcapsules for analysis of chemosensitivity. Cancer Sci 2012; 103: 549-554. doi: 10.1111/j.1349-7006.2011.02187.x.
    • (2012) Cancer Sci , vol.103 , pp. 549-554
    • Sakai, S.1    Inamoto, K.2    Liu, Y.3    Tanaka, S.4    Arii, S.5    Taya, M.6
  • 10
    • 80054885209 scopus 로고    scopus 로고
    • Stress clamp experiments on multicellular tumor spheroids
    • doi: 10.1103/ PhysRevLett.107.188102
    • Montel F, Delarue M, Elgeti J, Malaquin L, Basan M, Risler T, et al. Stress clamp experiments on multicellular tumor spheroids. Phys Rev Lett 2011; 107: 188102. doi: 10.1103/ PhysRevLett.107.188102.
    • (2011) Phys Rev Lett , vol.107 , pp. 188102
    • Montel, F.1    Delarue, M.2    Elgeti, J.3    Malaquin, L.4    Basan, M.5    Risler, T.6
  • 11
    • 78449290991 scopus 로고    scopus 로고
    • Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs
    • doi: 10.1111/j.1349-7006.2010.01723.x
    • Ho WJ, Pham EA, Kim JW, Ng CW, Kim JH, Kamei DT, et al. Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs. Cancer Sci 2010; 101: 2637-2643. doi: 10.1111/j.1349-7006.2010.01723.x.
    • (2010) Cancer Sci , vol.101 , pp. 2637-2643
    • Ho, W.J.1    Pham, E.A.2    Kim, J.W.3    Ng, C.W.4    Kim, J.H.5    Kamei, D.T.6
  • 12
    • 78149256887 scopus 로고    scopus 로고
    • Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: Monitoring by magnetic resonance imaging and optical imaging
    • doi: 10.1007/ s11307-009-0289-x
    • Kruttwig K, Brueggemann C, Kaijzel E, Vorhagen S, Hilger T, Lowik C, et al. Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: monitoring by magnetic resonance imaging and optical imaging. Mol Imaging Biol 2010; 12: 367-376. doi: 10.1007/ s11307-009-0289-x.
    • (2010) Mol Imaging Biol , vol.12 , pp. 367-376
    • Kruttwig, K.1    Brueggemann, C.2    Kaijzel, E.3    Vorhagen, S.4    Hilger, T.5    Lowik, C.6
  • 13
    • 16544380146 scopus 로고    scopus 로고
    • The use of 3-D cultures for high-throughput screening: The multicellular spheroid model
    • doi: 10.1177/1087057104265040
    • Kunz-Schughart LA, Freyer JP, Hofstaedter F, Ebner R. The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen 2004; 9: 273-285. doi: 10.1177/1087057104265040.
    • (2004) J Biomol Screen , vol.9 , pp. 273-285
    • Kunz-Schughart, L.A.1    Freyer, J.P.2    Hofstaedter, F.3    Ebner, R.4
  • 14
    • 36849009670 scopus 로고    scopus 로고
    • Experimental anti-tumor therapy in 3-D: Spheroids -old hat or new challenge?
    • doi: 10.1080/09553000701727531
    • Friedrich J, Ebner R, Kunz-Schughart LA. Experimental anti-tumor therapy in 3-D: spheroids -old hat or new challenge? Int J Radiat Biol 2007; 83: 849-871. doi: 10.1080/09553000701727531.
    • (2007) Int J Radiat Biol , vol.83 , pp. 849-871
    • Friedrich, J.1    Ebner, R.2    Kunz-Schughart, L.A.3
  • 15
    • 0030934594 scopus 로고    scopus 로고
    • Multicellular tumor spheroids grown from pancreatic carcinoma cell lines: Use as an orthotopic xenograft in athymic nude mice
    • doi: 10.1097/00006676-199704000-00004
    • McLeod EJ, Beischer AD, Hill JS, Kaye AH. Multicellular tumor spheroids grown from pancreatic carcinoma cell lines: use as an orthotopic xenograft in athymic nude mice. Pancreas 1997; 14: 237-248. doi: 10.1097/00006676-199704000-00004.
    • (1997) Pancreas , vol.14 , pp. 237-248
    • McLeod, E.J.1    Beischer, A.D.2    Hill, J.S.3    Kaye, A.H.4
  • 16
    • 84990604710 scopus 로고
    • Dynamics of cell kinetic parameters during 9L spheroid growth
    • Sweigert SE, Alpen EL. Dynamics of cell kinetic parameters during 9L spheroid growth. Cell Tissue Kinet 1986; 19: 567-576.
    • (1986) Cell Tissue Kinet , vol.19 , pp. 567-576
    • Sweigert, S.E.1    Alpen, E.L.2
  • 17
    • 0014984766 scopus 로고
    • Growth of multicell spheroids in tissue culture as a model of nodular carcinomas
    • Sutherland RM, McCredie JA, Inch WR. Growth of multicell spheroids in tissue culture as a model of nodular carcinomas. J Natl Cancer Inst 1971; 46: 113-120.
    • (1971) J Natl Cancer Inst , vol.46 , pp. 113-120
    • Sutherland, R.M.1    McCredie, J.A.2    Inch, W.R.3
  • 18
    • 35148838586 scopus 로고    scopus 로고
    • A reliable tool to determine cell viability in complex 3-D culture: The acid phosphatase assay
    • doi: 10.1177/1087057107306839
    • Friedrich J, Eder W, Castaneda J, Doss M, Huber E, Ebner R, et al. A reliable tool to determine cell viability in complex 3-D culture: the acid phosphatase assay. J Biomol Screen 2007; 12: 925-937. doi: 10.1177/1087057107306839.
    • (2007) J Biomol Screen , vol.12 , pp. 925-937
    • Friedrich, J.1    Eder, W.2    Castaneda, J.3    Doss, M.4    Huber, E.5    Ebner, R.6
  • 19
    • 0030011119 scopus 로고    scopus 로고
    • Threedimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation
    • doi: 10.1002/(SICI)1097-0215(19960516)66:4,578::AID-IJC25.3.0.CO;2-2
    • Kunz-Schughart LA, Groebe K, Mueller-Klieser W. Threedimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation. Int J Cancer 1996; 66: 578-586. doi: 10.1002/(SICI)1097-0215(19960516)66:4,578::AID-IJC25.3.0.CO;2-2.
    • (1996) Int J Cancer , vol.66 , pp. 578-586
    • Kunz-Schughart, L.A.1    Groebe, K.2    Mueller-Klieser, W.3
  • 20
    • 83455236148 scopus 로고    scopus 로고
    • Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues
    • doi: 10.1002/biot.201100290
    • Drewitz M, Helbling M, Fried N, Bieri M, Moritz W, Lichtenberg J, et al. Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues. Biotechnol J 2011; 6: 1488-1496. doi: 10.1002/biot.201100290.
    • (2011) Biotechnol J , vol.6 , pp. 1488-1496
    • Drewitz, M.1    Helbling, M.2    Fried, N.3    Bieri, M.4    Moritz, W.5    Lichtenberg, J.6
  • 21
    • 84859142802 scopus 로고    scopus 로고
    • Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy
    • doi: 10.1039/c1ib00090j
    • Cichon MA, Gainullin VG, Zhang Y, Radisky DC. Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy. Integr Biol 2012; 4: 440-448. doi: 10.1039/c1ib00090j.
    • (2012) Integr Biol , vol.4 , pp. 440-448
    • Cichon, M.A.1    Gainullin, V.G.2    Zhang, Y.3    Radisky, D.C.4
  • 22
    • 45149094559 scopus 로고    scopus 로고
    • Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
    • doi: 10.1074/jbc.M709698200
    • Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus VC. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J Biol Chem 2008; 283: 13021-13030. doi: 10.1074/jbc.M709698200.
    • (2008) J Biol Chem , vol.283 , pp. 13021-13030
    • Barbone, D.1    Yang, T.M.2    Morgan, J.R.3    Gaudino, G.4    Broaddus, V.C.5
  • 24
    • 0033800091 scopus 로고    scopus 로고
    • Multicellular resistance: A paradigm for clinical resistance?
    • doi: 10.1016/S1040-8428(00)00086-X
    • Desoize B, Jardillier J. Multicellular resistance: a paradigm for clinical resistance? Crit Rev Oncol Hematol 2000; 36: 193-207. doi: 10.1016/S1040-8428(00)00086-X.
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 193-207
    • Desoize, B.1    Jardillier, J.2
  • 26
    • 78650062139 scopus 로고    scopus 로고
    • A review of three-dimensional in vitro tissue models for drug discovery and transport studies
    • doi: 10.1002/jps.22257
    • Elliott NT, Yuan F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies. J Pharm Sci 2011; 100: 59-74. doi: 10.1002/jps.22257.
    • (2011) J Pharm Sci , vol.100 , pp. 59-74
    • Elliott, N.T.1    Yuan, F.2
  • 27
    • 78649567005 scopus 로고    scopus 로고
    • Assessment of pancreatic carcinoma cell chemosensitivity using a threedimensional culture system
    • Liao Q, Hu Y, Zhao YP, Zhou T, Zhang Q. Assessment of pancreatic carcinoma cell chemosensitivity using a threedimensional culture system. Chin Med J 2010; 123: 1871-1877.
    • (2010) Chin Med J , vol.123 , pp. 1871-1877
    • Liao, Q.1    Hu, Y.2    Zhao, Y.P.3    Zhou, T.4    Zhang, Q.5
  • 28
    • 79961226547 scopus 로고    scopus 로고
    • A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFb in pancreatic cancer cells
    • doi: 10.4161/cbt.12.3.15979
    • Sempere LF, Gunn JR, Korc M. A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFb in pancreatic cancer cells. Cancer Biol Ther 2011; 12: 198-207. doi: 10.4161/cbt.12.3.15979.
    • (2011) Cancer Biol Ther , vol.12 , pp. 198-207
    • Sempere, L.F.1    Gunn, J.R.2    Korc, M.3
  • 29
    • 0346995281 scopus 로고    scopus 로고
    • Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids
    • Enmon R, Yang WH, Ballangrud AM, Solit DB, Heller G, Rosen N, et al. Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids. Cancer Res 2003; 63: 8393-8399.
    • (2003) Cancer Res , vol.63 , pp. 8393-8399
    • Enmon, R.1    Yang, W.H.2    Ballangrud, A.M.3    Solit, D.B.4    Heller, G.5    Rosen, N.6
  • 30
    • 27644577735 scopus 로고    scopus 로고
    • Effects of irradiation and cisplatin on human glioma spheroids: Inhibition of cell proliferation and cell migration
    • doi: 10.1007/s00432-005-0014-3
    • Fehlauer F, Muench M, Rades D, Stalpers LJ, Leenstra S, van der Valk P, et al. Effects of irradiation and cisplatin on human glioma spheroids: inhibition of cell proliferation and cell migration. J Cancer Res Clin Oncol 2005; 131: 723-732. doi: 10.1007/s00432-005-0014-3.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 723-732
    • Fehlauer, F.1    Muench, M.2    Rades, D.3    Stalpers, L.J.4    Leenstra, S.5    van der Valk, P.6
  • 31
    • 2042435766 scopus 로고    scopus 로고
    • Screening for supra-additive effects of cytotoxic drugs and gamma irradiation in an in vitro model for hepatocellular carcinoma
    • doi: 10.1139/y04-008
    • Lambert B, de Ridder L, Slegers G, De Gelder V, Dierckx RA, Thierens H. Screening for supra-additive effects of cytotoxic drugs and gamma irradiation in an in vitro model for hepatocellular carcinoma. Can J Physiol Pharmacol 2004; 82: 146-152. doi: 10.1139/y04-008.
    • (2004) Can J Physiol Pharmacol , vol.82 , pp. 146-152
    • Lambert, B.1    de Ridder, L.2    Slegers, G.3    de Gelder, V.4    Dierckx, R.A.5    Thierens, H.6
  • 32
    • 62749197305 scopus 로고    scopus 로고
    • Multicellular spheroids in ovarian cancer metastases: Biology and pathology
    • doi: 10.1016/j.ygyno.2008.11.032
    • Shield K, Ackland ML, Ahmed N, Rice GE. Multicellular spheroids in ovarian cancer metastases: Biology and pathology. Gynecol Oncol 2009; 113: 143-148. doi: 10.1016/j.ygyno.2008.11.032.
    • (2009) Gynecol Oncol , vol.113 , pp. 143-148
    • Shield, K.1    Ackland, M.L.2    Ahmed, N.3    Rice, G.E.4
  • 33
    • 60549103259 scopus 로고    scopus 로고
    • Spheroid-based drug screen: Considerations and practical approach
    • doi: 10.1038/ nprot.2008.226
    • Friedrich J, Seidel C, Ebner R, Kunz-Schughart LA. Spheroid-based drug screen: considerations and practical approach. Nat Protoc 2009; 4: 309-324. doi: 10.1038/ nprot.2008.226.
    • (2009) Nat Protoc , vol.4 , pp. 309-324
    • Friedrich, J.1    Seidel, C.2    Ebner, R.3    Kunz-Schughart, L.A.4
  • 34
    • 33645378251 scopus 로고    scopus 로고
    • Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy
    • doi: 10.1186/1479-5876-4-12
    • Khaitan D, Chandna S, Arya MB, Dwarakanath BS. Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy. J Transl Med 2006; 4: 12. doi: 10.1186/1479-5876-4-12.
    • (2006) J Transl Med , vol.4 , pp. 12
    • Khaitan, D.1    Chandna, S.2    Arya, M.B.3    Dwarakanath, B.S.4
  • 35
    • 67650999217 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    • doi: 10.1158/0008-5472.CAN-08-2819
    • Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, Abbruzzese JL, et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res 2009; 69: 5820-5828. doi: 10.1158/0008-5472.CAN-08-2819.
    • (2009) Cancer Res , vol.69 , pp. 5820-5828
    • Arumugam, T.1    Ramachandran, V.2    Fournier, K.F.3    Wang, H.4    Marquis, L.5    Abbruzzese, J.L.6
  • 36
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabineresistant pancreatic tumor cells
    • doi: 10.1245/s10434-007-9583-5
    • Shah AN, Summy JM, Zhang J, Park SI, Parikh NU, Gallick GE. Development and characterization of gemcitabineresistant pancreatic tumor cells. Ann Surg Oncol 2007; 14: 3629-3637. doi: 10.1245/s10434-007-9583-5.
    • (2007) Ann Surg Oncol , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 37
    • 17144390205 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer
    • doi: 10.1158/1078-0432.CCR-04-1785
    • Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon P, Lopes R, Sunamura M, et al. Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin Cancer Res 2005; 11: 3094-3101. doi: 10.1158/1078-0432.CCR-04-1785.
    • (2005) Clin Cancer Res , vol.11 , pp. 3094-3101
    • Akada, M.1    Crnogorac-Jurcevic, T.2    Lattimore, S.3    Mahon, P.4    Lopes, R.5    Sunamura, M.6
  • 38
    • 79551715811 scopus 로고    scopus 로고
    • Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells
    • Zhang Q, Zhao YP, Liao Q, Hu Y, Xu Q, Zhou L, et al. Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells. Chin Med J 2011; 124: 262-267.
    • (2011) Chin Med J , vol.124 , pp. 262-267
    • Zhang, Q.1    Zhao, Y.P.2    Liao, Q.3    Hu, Y.4    Xu, Q.5    Zhou, L.6
  • 39
    • 79959992295 scopus 로고    scopus 로고
    • Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil
    • Kurata N, Fujita H, Ohuchida K, Mizumoto K, Mahawithitwong P, Sakai H, et al. Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil. Int J Oncol 2011; 39: 473-482.
    • (2011) Int J Oncol , vol.39 , pp. 473-482
    • Kurata, N.1    Fujita, H.2    Ohuchida, K.3    Mizumoto, K.4    Mahawithitwong, P.5    Sakai, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.