High levels of FOXP3+ regulatory T cells in gastric MALT Lymphoma predict responsiveness to helicobacter pylori eradication

Helicobacter

Volumn 18, Issue 5, 2013, Pages 356-362

  Iwaya, Yugo ^a,b   Kobayashi, Motohiro ^a   Momose, Masanobu ^c   Hiraoka, Nobuyoshi ^d   Sakai, Yasuhiro ^a   Akamatsu, Taiji ^b   Tanaka, Eiji ^b   Ohtani, Haruo ^e   Fukuda, Minoru ^f   Nakayama, Jun ^a  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHINSHU UNIVERSITY HOSPITAL   (Japan)

^d NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^e NATIONAL HOSPITAL ORGANIZATION MITO MEDICAL CENTER   (Japan)

^f BURNHAM INSTITUTE   (United States)

Author keywords

Eradication responsiveness; FOXP3; Gastric MALT lymphoma; Helicobacter pylori; Regulatory T cell

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; LANSOPRAZOLE; METRONIDAZOLE; OMEPRAZOLE; RABEPRAZOLE; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CHRONIC GASTRITIS; ERADICATION THERAPY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MARGINAL ZONE LYMPHOMA; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SENSITIVITY AND SPECIFICITY; STOMACH LYMPHOMA; STOMACH MUCOSA; TREATMENT OUTCOME; TREATMENT RESPONSE; YOUDEN INDEX;

ERADICATION RESPONSIVENESS; FOXP3; GASTRIC MALT LYMPHOMA; HELICOBACTER PYLORI; REGULATORY T CELL;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; ANTIGENS, CD4; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HELICOBACTER INFECTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, B-CELL, MARGINAL ZONE; MALE; MIDDLE AGED; PROGNOSIS; SENSITIVITY AND SPECIFICITY; STOMACH; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84881590039     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/hel.12051     Document Type: Article

References (36)

1. Sagaert X, Van Cutsem E, De Hertogh G, et al. Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development. Nat Rev Gastroenterol Hepatol 2010;7:336-46.
2. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer 1983;52:1410-6.
3. Isaacson PG, Du MQ. MALT lymphoma: from morphology to molecules. Nat Rev Cancer 2004;4:644-53.
4. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175-6.
5. Kobayashi M, Mitoma J, Nakamura N, et al. Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori. Proc Natl Acad Sci U S A 2004;101:17807-12.
6. Hussell T, Isaacson PG, Crabtree JE, et al. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 1993;342:571-4.
7. Hussell T, Isaacson PG, Crabtree JE, et al. Helicobacter pylori-specific tumour-infiltrating T cells provide contact dependent help for the growth of malignant B cells in low-grade gastric lymphoma of mucosa-associated lymphoid tissue. J Pathol 1996;178:122-7.
8. Craig VJ, Cogliatti SB, Arnold I, et al. B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis. Leukemia 2010;24:1186-96.
9. Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993;342:575-7.
10. Bayerdörffer E, Neubauer A, Rudolph B, et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group. Lancet 1995;345:1591-4.
11. Thieblemont C, Berger F, Dumontet C, et al. Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one-third of 158 patients analyzed. Blood 2000;95:802-6.
12. Inagaki H, Nakamura T, Li C, et al. Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter pylori eradication and detection of API2-MALT1 fusion. Am J Surg Pathol 2004;28:1560-7.
13. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
14. Weaver CT, Harrington LE, Mangan PR, et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006;24:677-88.
15. + regulatory T cells. Nat Immunol 2003;4:330-6.
16. Raghavan S, Quiding-Järbrink M. Immune modulation by regulatory T cells in Helicobacter pylori-associated diseases. Endocr Metab Immune Disord Durg Targets 2012;12:71-85.
17. van Driel IR, Ang DK. Role of regulatory T cells in gastrointestinal inflammatory disease. J Gastroenterol Hepatol 2008;23:171-7.
18. high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun 2005;73:523-31.
19. Enarsson K, Lundgren A, Kindlund B, et al. Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin Immunol 2006;121:358-68.
20. Cheng HH, Tseng GY, Yang HB, et al. Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma. World J Gastroenterol 2012;18:34-43.
21. + regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. Clin Exp Immunol 2003;132:393-400.
22. + T lymphocytes. Infect Immun 2010;78:845-53.
23. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
24. Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005;22:329-41.
25. + regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006;12:5423-34.
26. Dixon MF, Genta RM, Yardley JH, et al. Classification and grading of gastritis. The updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-81.
27. Copie-Bergman C, Gaulard P, Lavergne-Slove A, et al. Proposal for a new histological grading system for post-treatment evaluation of gastric MALT lymphoma. Gut 2003;52:1656.
28. Kobayashi M, Nakayama J. Immunohistochemical analysis of carbohydrate antigens in chronic inflammatory gastrointestinal diseases. Methods Enzymol 2010;479:271-89.
29. Youden WJ. Index for rating diagnostic tests. Cancer 1950;3:32-5.
30. García M, Bellosillo B, Sánchez-González B, et al. Study of regulatory T-cells in patients with gastric malt lymphoma: influence on treatment response and outcome. PLoS One 2012;7:e51681.
31. + cytoplasmic granules in actively inflammatory lesions of human chronic gastritis. Lab Invest 2004;84:368-75.
32. Dogan A, Du M, Koulis A, et al. Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissue. Am J Pathol 1997;151:1361-9.
33. Kobayashi M, Mitoma J, Hoshino H, et al. Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma. J Pathol 2011;224:67-77.
34. + regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol 2007;178:291-300.
35. Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 2007;109:194-202.
36. + regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 2007;13:902-11.