Potassium-depletion metabolic alkalosis

Acid-Base Disorders and Their Treatment

Volumn , Issue , 2005, Pages 553-584

  Soleimani, Manoocher ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

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EID: 84881565280     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (174)

1. Seldin DW, Jacobson H. On the generation, maintenance and correction of metabolic alkalosis. Am J Physiol 1983; 245:F425-F432.
2. Relman AS, Schwartz WB. The effect of DOCA on electrolyte balance in normal man and its relation to sodium chloride intake. Yale J Biol Med 1952; 24:540-558.
3. Seldin DW, Welt LG, Cort JH. The role of sodium salts and adrenal steroids in the production of hypokalemic alkalosis. Yale J Biol Med 1956; 29:229-247.
4. Seldin DW, Rector FC Jr. The generation and maintenance of metabolic alkalosis. Kidney Int 1972; 1:306-321.
5. Kassirer JP, London AM, Goldman DM, Schwartz WB. On the pathogenesis of metabolic alkalosis in hyperaldosteronism. Am J Med 1970; 49:306-315.
6. Mohamed SD, Chapman RS, Crooks J. Hypokalaemia, flaccid quadraparesis and myoglobinuria with carbenoxolone (Biogastrone). Brit Med J 1966; 5503:1581-1582.
7. Taylor GJ. Apnoea due to apparent potassium imbalance. Anaesthesia 1963; 18:9-15.
8. Rastegar A, DeFronzo RA. Disorders of potassium and acid-base metabolism in association with renal disease. In: RW Schrier, CW Gottschalk, eds. Diseases of the Kidney 6th ed. Boston: Little, Brown and Co., 1997:2452-2477.
9. Surawicz B, Barum H, Crim WB et al. Quantitative analysis of the electrocar-diographic pattern of hypopotassemia. Circulation 1957; 16:750-763.
10. Helfant RH. Hypokalemia and arrhythmias. Am J Med 1986; 80 (suppl 4A):13-22.
11. Packer M, Gottlieb SS, Blum MA. Immediate and long-term pathophysiologic mechanisms underlying the genesis of sudden cardiac death in patients with congestive heart failure. Am J Med 1987; 82 (suppl 3A):4-10.
12. Bank N, Aynedjian HS. A micropuncture study of the renal concentrating defect of potassium depletion. Am J Physiol 1964; 206:1347-1354.
13. Relman AS, Schwartz WB. The kidney in potassium depletion. Am J Med 1958; 24:764-773.
14. Welt LG, Hollander W Jr, Blythe WB. The consequences of potassium depletion. J Chron Dis 1960; 11:213-254.
15. Amlal H, Krane CM, Chen QK, Soleimani M. Early polyuria and urinary concentrating defect in potassium deprivation. Am J Physiol 2000; 279:F655-F663.
16. Adrogue HJ, Madias NE. Changes in plasma potassium concentration during acute acid-base disturbances. Am J Med 1981; 71:456-462.
17. Luke RG, Levitin H. Impaired renal conservation of chloride and the acid-base changes associated with potassium depletion in the rat. Clin Sci 1967; 23:511-526.
18. Struyvenberg A, DeGraeff J, Lameijer, LDF. The role of chloride in hypokalemic alkalosis in the rat. J Clin Invest 1965; 44:326-331.
19. Adams WR, Koretsky AP, Weiner MW. 31P-NMR in vivo measurement of renal intracellular pH: effect of acidosis and K+ depletion in rats. Am J Physiol 1986; 20:F904-F910.
20. Jones JW, Sebastian A, Hulter HN, Schambelan M, Sutton JM, Biglieri EG. Systemic and renal acid-base effects of chronic potassium restriction in humans. Kidney Int 1982; 21:402-410.
21. Tannen RL, McGill J. Influence of potassium on renal ammonia production. Am J Physiol 1976; 231:F1178-F1184.
22. Sastrasinh S, Tannen RL. Effect of potassium on renal NH3 production. Am J Physiol 1983; 244:F383-F391.
23. Tannen RL. Relationship of renal ammonia production and potassium homeostasis. Kidney Int 1977; 11:453-465.
24. Hamm LL, Simon EE. Ammonia transport in the proximal tubule in vivo. Am J Kidney Dis 1989; 14:253-257.
25. Tizianello A, Garibotto G, Robaudo C, Saffioti S, Pontremoli R, Bruzzone M, Deferrari G. Renal ammoniagenesis in humans with chronic potassium depletion. Kidney Int 1991; 40:772-778.
26. Sleeper RS, Belanger P, Lemieux G, Preuss HG. Effects of in vitro potassium on ammoniagenesis in rat and canine kidney tissue. Kidney Int 1982; 21:345-353.
27. Nakamura S, Amlal H, Galla JH, Soleimani M. Colonic H+-K+ATPase mediates NH+ secretion in inner medullary collecting duct in potassium depletion. Kidney Int 1999; 56:2160-2167.
28. Hernandez RE, Schambelan M, Cogan MG, Colman J, Morris RC Jr, Sebastian A. Dietary NaCl determines severity of potassium depletion-induced metabolic alkalosis. Kidney Int 1987; 31:1356-1367.
29. Kaufman AM, Kahn T. Potassium-depletion alkalosis in the rat. Am J Physiol 1988; 255:F763-F770.
30. Black DAK, Milne MD. Experimental potassium depletion in man. Clin Sci 1952; 11:397-415.
31. Cannon PJ, Ames RP, Laragh JH. Relation between potassium balance and aldosterone secretion in normal subjects and in patients with hypertensive and renal tubular disease. J Clin Invest 1966; 45:865-879.
32. Kornandakieti C, Tannen RL. Hydrogen ion secretion by the distal nephron in the rat: effect of potassium. J Lab Clin Med 1984; 104:293-303.
33. Harrington JT, Hulter HN, Cohen JJ, Madias NE. Mineralocorticoid-stimulated renal acidification: the critical role of dietary sodium. Kidney Int 1986; 30:43-48.
34. Kornandakieti C, Tannen RL. H+ transport by the aldosterone-deficient rat distal nephron. Kidney Int 1984; 25:629-635.
35. Hulter HN, Sebastian A, Sigala JF, Licht JH, Glynn RD, Schambelan M, Biglieri EG. Pathogenesis of renal hyperchloremic acidosis resulting from dietary potassium restriction in the dog: role of aldosterone. Am J Physiol 1980; 28:F79-F91.
36. McKinney TD, Davidson KK. Effect of potassium depletion and protein intake in vivo on renal bicarbonate transport in vitro. Am J Physiol 1987; 252:F509-F516.
37. Kessaris N, Shotliff K, Nussey SS. Hypokalaemic alkalosis. Postgrad Med J 1998; 74:305-306.
38. Tannen RL. Effect of potassium on renal acidification and acid-base homeostasis. Semin Nephrol 1987; 7:263-273.
39. Hamm LL, Alpern RJ. Cellular mechanisms of renal tubular acidification. In: DW Seldin, G, Giebisch, eds. The Kidney: Physiology and Pathophysiology. 2nd ed. New York: Raven Press, 1992:2581-2717.
40. Conn JW. Presidential address. II. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med 1955; 45:3-17.
41. Conn JW, Cohen EL, Lucas CP, McDonald WJ, Mayor GH, Blough WM, Eveland WC, Bookstein JJ, Lapides J. Primary reninism. Hypertension, hyperreninemia and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors. Arch Intern Med 1972; 130:682-696.
42. Hulter HN, Sigala JF, Sebastian A. K+ deprivation potentiates the renal alka-losis-producing effect of mineralocorticoid. Am J Physiol 1978; 235:F298-F309.
43. Grunder S, Rossier BC. A reappraisal of aldosterone effects on the kidney: new insights provided by epithelial sodium channel cloning. Curr Opin Nephrol Hypertens 1997; 6:35-39.
44. Cely CM, Contreras G. Approach to the patient with hypertension, unexplained hypokalemia, and metabolic alkalosis. Am J Kidney Dis 2001; 37:E24.
45. Stone DK, Seldin DW, Kokko JP, Jacobson HR. Mineralocorticoid modulation of rabbit medullary collecting duct acidification. J Clin Invest 1983; 72:77-83.
46. Whinnery MA, Kunau RT. Effect of potassium deficiency on papillary plasma flow in the rat. Am J Physiol 1979; 237:F226-F231.
47. Linas SL, Dickmann D. Mechanism of the decreased renal blood flow in the potassium-depleted conscious rat. Kidney Int 1982; 21:757-764.
48. Rector FC Jr, Bloomer HA, Seldin DW. Effect of potassium deficiency on the reabsorption of bicarbonate in the proximal tubule of the rat kidney. J Clin Invest 1964; 43:1976-1982.
49. Kunau RT Jr, Frick A, Rector FC Jr, Seldin DW. Micropuncture study of the proximal tubular factors responsible for the maintenance of alkalosis during potassium deficiency in the rat. Clin Sci (Lond) 1968; 34:223-231.
50. Soleimani M, Singh G. Physiologic and molecular aspects of the Na+/H+ exchangers in health and disease processes. J Invest Med 1995; 43:419-430.
51. Soleimani M, Burnham CE. Physiologic and molecular aspects of the cotransporter in health and disease processes. Kidney Int 2000; 57:371-384.
52. Soleimani M, Bergman JA, Hosford MA, McKinney TD. Potassium depletion increases cotransport in rat renal cortex. J Clin Invest 1990; 86:1076-1083.
53. Alpern RJ. Mechanism of basolateral membrane transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process. J Gen Physiol 1985; 86:613-636.
54. Cemerikic D, Wilcox CS, Giebisch G. Intracellular potential and K+ activity in rat kidney proximal tubular cells in acidosis and K+ deprivation. J Membr Biol 1982; 69:159-165.
55. Wang Z, Baird N, Shumaker H, Soleimani M. Potassium depletion and acid-base transporters in rat kidney: differential effect of hypophysectomy. Am J Physiol 1997; 272:F736-F743.
56. Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M. Cloning and functional expression of a human kidney cotransporter. J Biol Chem 1997; 272:19111-19114.
57. Burnham CE, Flagella M, Wang Z, Amlal H, Shull GE, Soleimani M. Cloning, renal distribution, and regulation of the rat cotransporter. Am J Physiol 1998; 274:F1119-F1126.
58. Amlal H, Habo K, Soleimani M. Potassium depletion upregulates the expression of the renal basolateral cotransporter (NBC-1). Am J Physiol 2000; 279:F532-F543.
59. Bastani B, Haragsim L. Immunocytochemistry of renal H-ATPase. Miner Electrolyte Metab 1996; 22:382-395.
60. Bank N, Aynedjian HS, Mutz BF. Proximal tubule bicarbonate reabsorption independent of Na+-H+ exchange: Effect of bicarbonate load. Am J Physiol 1989; 256:F577-F582.
61. Aronson PS. The renal proximal tubule: a model for diversity of anion exchangers and stilbene-sensitive anion transporters. Annu Rev Physiol 1989; 51:419-441.
62. Aronson PS, Giebisch G. Mechanisms of chloride transport in the proximal tubule. Am J Physiol 1997; 273:F179-F192.
63. Wang T, Egbert AL Jr, Aronson PS, Giebisch G. Effect of metabolic acidosis on NaCl transport in the proximal tubule. Am J Physiol 1998; 274: F1015-F1019.
64. Luke RG, Wright FS, Fowler N, Kashgarian M, Giebisch G. Effect of potassium depletion on renal tubular chloride transport in the rat. Kidney Int 1978; 14:414-427.
65. Wang T, Malnic G, Giebisch G, Chan YL. Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule. J Clin Invest 1993; 91:2776-2784.
66. Silver R, Soleimani M. H+-K+-ATPases: regulation and role in pathophysiologic states. Am J Physiol 1999; 276:F799-F811.
67. Biemesderfer D, Pizzonia J, Abu-Alfa A, Markus E, Reilly RF, Igarashi P, Aronson PS. NHE3: a Na+/H+ exchanger isoform of renal brush border. Am J Physiol 1993; 265:F736-F742.
68. Capasso G, Jaeger P, Giebisch G, Guckian V, Malnic G. Renal bicarbonate reabsorption in the rat. II. Distal tubule load dependence and effect of hypo-kalemia. J Clin Invest 1987; 80:409-414.
69. Bailey M, Capasso G, Agulian S, Giebisch G, Unwin R. The relationship between distal tubular proton secretion and dietary potassium depletion: evidence for up-regulation of H+-ATPase. Nephrol Dial Transplant 1999; 14:1435-1440.
70. Bailey MA, Fletcher RM, Woodrow DF, Unwin RJ, Walter SJ. Upregulation of H+-ATPase in the distal nephron during potassium depletion: structural and functional evidence. Am J Physiol 1998; 275:F878-F884.
71. Wingo CS, Smolka AJ. Function and structure of H-K-ATPase in the kidney. Am J Physiol 1995; 269:F1-F16.
72. Kone BC. Renal H, K-ATPase: structure, function, and regulation. Miner Elect Metab 1996; 22:349-365.
73. Zhou X, Wingo CS. Mechanisms of rubidium permeation by rabbit cortical collecting duct during potassium restriction. Am J Physiol 1992; 263: F1134-F1141.
74. Silver RB, Breton S, Brown D. Potassium depletion increases proton pump (H+-ATPase) activity in intercalated cells of cortical collecting duct. Am J Physiol 2000; 279:F195-F202.
75. Wingo CS. Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. J Clin Invest 1989; 84:361-365.
76. Wingo CS, Armitage F. Rubidium absorption and proton secretion by rabbit outer medullary collecting duct via H+,K+-ATPase. Am J Physiol 1993; 263:F849-F857.
77. Gifford JD, Rome L, Galla JH. H+-K+-ATPase activity in rat collecting duct segments. Am J Physiol 1992; 262:F692-F695.
78. Kuwahara M, Fu WJ, Marumo F. Functional activity of H-K ATPase in individual cells of OMCD: localization and effect of K+ depletion. Am J Physiol 1996; 270:F116-F122.
79. DuBose TD, Codina J, Burges A, Pressley TA. Regulation of H+-K+-ATPase expression in kidney. Am J Physiol 1995; 269:F500-F507.
80. Kraut JA, Hiura J, Besancon M, Smolka A, Sachs G, Scott D. Effect of hypokalemia on the abundance of HKa1 and HKa2 protein in the rat kidney. Am J Physiol 1997; 272:F744-F750.
81. Nakamura S, Wang Z, Galla JH, Soleimani M. Potassium depletion increases reabsorption in outer medullary collecting duct by activation of colonic H-K-ATPase. Am J Physiol 1998; 274:F687-F692.
82. Kone BC, Higham SC. A novel N-terminal splice variant of the rat H+-K+ -ATPase a2 subunit. J Biol Chem 1998; 273:2543-2552.
83. Nakamura S, Amlal H, Galla J, Soleimani M. Colonic H+-K+-ATPase is induced and mediates reabsorption in IMCDt in potassium depletion. Kidney Int 1998; 54:1233-1239.
84. Amlal H, Goel A, Soleimani M. Activation of H+-ATPase by hypotonicity: a novel regulatory mechanism for H+ secretion in IMCD cells. Am J Physiol 1998; 275:F487-F501.
85. Alexander EA, Shih T, Schwartz JH. H+ secretion is inhibited by clostridial toxins in an inner medullary collecting duct cell line. Am J Physiol 1997; 273:F1054-F1057.
86. Alexander EA, Brown D, Shih T, McKee M, Schwartz JH. Effect of acidification on the location of H+-ATPase in cultured inner medullary collecting duct cells. Am J Physiol 1999; 276:758-763.
87. Buffin-Meyer B, Younes-Ibrahim M, Barlet-Bas C, Chevel L, Marsy S, Doucet A. K depletion modifies properties of SCH-28080-sensitive K-ATPase in rat collecting duct. Am J Physiol 1997; 272:F124-F131.
88. Amlal H, Wang Z, Soleimani M. Potassium depletion downregulates chloride-absorbing transporters in rat kidney. J Clin Invest 1998; 101: 1045-1054.
89. Streeten DH, Tomycz N, Anderson GH Jr. Reliability of screening methods for diagnosis of primary aldosteronism. Am J Med 1979; 67:403-413.
90. Katz FH. Primary aldosteronism with suppressed plasma renin activity due to bilateral nodular adrenocortical hyperplasia. Ann Int Med 1967; 67: 1035-1042.
91. Ganguly A. Primary aldosteronism. N Engl J Med 1998; 339:1828-1834.
92. Kono T, Ikeda F, Oseko F, Imura H, Tanimura H. Normotensive primary hyperaldosteronism: report of a case. J Clin Endocrinol Metab 1981; 52: 1009-1013.
93. Sutherland DJA, Ruse JL, Laidlaw JC. Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J 1966; 95:1109-1119.
94. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S, Ulick S, Lalouel JM. A chimaeric 11ß-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992; 355: 262-265.
95. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S, Ulick S, Lalouel JM. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet 1992; 2:66-74.
96. Auchus RJ. The genetics, pathophysiology, and management of human deficiencies of P450c17. Endocrinol Metab Clin North Am 2001; 30:101-119.
97. Peter M, Sippell WG, Wernze H. Diagnosis and treatment of 17-hydroxylase deficiency. J Steroid Biochem Mol Biol 1993; 45:107-116.
98. Laragh JH, Ulick S, Januszewicz V, Deming QB, Kelly WG, Lieberman S. Aldosterone secretion and primary and malignant hypertension. J Clin Invest 1960; 39:1091-1106.
99. White PC. 11 ß-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess. Am J Med Sci 2001; 322:308-315.
100. Stewart PM, Murry BA, Mason JI. Human kidney 11 ß-hydroxysteroid dehy-drogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform. J Clin Endocrinol Metab 1994; 79:480-484.
101. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS. Cloning and tissue distribution of the human 11 ß-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 1994; 105:R11-R17.
102. Mantero F, Palermo M, Petrelli MD, Tedde R, Stewart PM, Shackleton CH. Apparent mineralocorticoid excess: type I and type II. Steroids 1996; 61: 193-196.
103. de Klerk GJ, Nieuwenhuis MG, Beutler JJ. Hypokalaemia and hypertension associated with use of liquorice-flavoured chewing gum. BMJ 1997; 314: 731-732.
104. Blachley JD, Knochel JP. Tobacco chewer's hypokalemia: licorice revisited. N Engl J Med 1980; 320:784-785.
105. Davies GJ, Rhodes J, Calcraft BJ. Complications of carbenoxolone therapy. Br Med J 1974; 3:400-402.
106. Farese RV Jr, Biglieri EG, Shackleton CH, Irony I, Gomez-Fontes R. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991; 325: 1223-1227.
107. Mantero F, Armanini D, Opocher G, Fallo F, Sampieri L, Cuspidi B, Ambrosi C, Faglia G. Mineralocorticoid hypertension due to a nasal spray containing 9 alpha-fluoroprednisolone. Am J Med 1981; 71:352-357.
108. Liddle GW, Bledsoe T, Coppage WS Jr. A familial renal disorder stimulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Physicians 1963; 76:199-213.
109. Botero-Velez M, Curtis JJ, Warnock DG. Brief report: Liddle's syndrome revisited. N Engl J Med 1994; 330:178-181.
110. Gadallah MF, Abreo K, Work J. Liddle's syndrome: an under-recognized entity: a report of four cases including the first report in black individuals. Am J Kidney Dis 1995; 25:924-927.
111. Rodriquez JA, Biglieri EG, Schambelan M. Pseudohypoaldosteronism with renal tubular resistance to mineralocorticoid hormones. Trans Assoc Am Physicians 1981; 94:172-182.
112. Yamashita Y, Koga M, Takeda Y, Enomoto N, Uchida S, Hashimoto K, Yamano S, Dohi K, Marumo F, Sasaki S. Two sporadic cases of Liddle's syndrome caused by de novo ENaC mutations. Am J Kidney Dis 2001; 37: 499-504.
113. Warnock DG. Liddle syndrome: genetics and mechanisms of Na+ channel defects. Am J Med Sci 2001; 322:302-307.
114. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW. Liddle's syndrome: heritable human hypertension caused by mutations in the B subunit of the epithelial sodium channel. Cell 1994; 79:407-414.
115. Hansson JH, Nelson-Williams C, Suzuki H, Schlid L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP. Hypertension caused by a truncated epithelial sodium channel g subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 1995; 11:76-82.
116. Canessa CM, Horisberger J, Rossier BC. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 1993; 361:467-470.
117. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. The amiloride-sensitive epithelial sodium channel is made of three homologous subunits. Nature 1994; 367:463-467.
118. Staub O, Dho S, Henry PC, Correa J, Ishikawa T, McGlade J, Rotin D. WW domains off Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J 1996; 15:2371-2380.
119. Palmer BF, Alpern RJ. Liddle's syndrome. Am J Med 1998; 104:301-309.
120. Orth DN. Cushing's syndrome. N Engl J Med 1995; 332:791-803.
121. Guthrie GP Jr, Kotchen TA. Hypertension and aldosterone overproduction without renin suppression in Cushing's syndrome from an adrenal adenoma. Am J Med 1979; 67:524-528.
122. Krakoff L, Nicolis G, Amsel B. Pathogenesis of hypertension in Cushing's syndrome. Am J Med 1975; 58:216-220.
123. Ritchie CM, Sheridan B, Fraser R, Hadden DR, Kennedy AL, Riddell J, Atkinson AB. Studies on the pathogenesis of hypertension in Cushing's disease and acromegaly. Q J Med 1990; 76:855-867.
124. Mantero F, Armanini D, Boscaro M. Plasma renin activity and urinary aldosterone in Cushing's syndrome. Horm Metab Res 1978; 10:65-71.
125. Biglieri EG, Hane S, Slaton PE, Forsham PH. In vivo and in vitro studies of adrenal secretions in Cushing's syndrome and primary aldosteronism. J Clin Invest 1963; 42:516-524.
126. Rickman T, Garmany R, Doherty T, Benson D, Okusa MD. Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. Am J Kidney Dis 2001; 37: 838-846.
127. Torpy DJ, Mullne N, Ilias I, Nieman LK. Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases. Ann NY Acad Sci 2002; 970:134-144.
128. Ulick S, Wang JZ, Blumenfeld JD, Pickering TG. Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab 1992; 74:963-967.
129. Walker BR, Campbell JC, Fraser R, Stewart PM, Edwards CR. Mineralocor-ticoid excess and inhibition of 11 ß-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol 1992; 37:483-492.
130. Ali R, Amlal H, Burnham CE, Soleimani M. Glucocorticoids enhance the expression of the basolateral cotransporter in renal proximal tubules. Kidney Int 2000; 57:1063-1071.
131. Bartter FC, Provone P, Gill JR, MacCardle RC. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. Am J Med 1962; 33:811-828.
132. Simon DB, Lifton RP. Ion transporter mutations in Gitelman's and Bartter's syndromes. Curr Opin Nephrol Hypertens 1998; 7:43-47.
133. Fanconi A, Schachenmann G, Nussli R, Prader A. Chronic hypokalemia with growth retardation, normotensive hyperrenin-hyperaldosteronism (Bartter's syndrome) and hypercalciuria. Helv Paediatr Acta 1971; 26:144-163.
134. Proesmans W. Bartter syndrome and its neonatal variant. Eur J Pediatr 1997; 156:669-679.
135. Simon DB, Karet FE, Hamdan JM, Di Pietro A, Sanjad SA, Lifton RP. Bartter's syndrome, hypokalemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl co-transporter NKCC2. Nat Genet 1996; 13: 183-188.
136. Vargas-Poussou R, Feldmann D, Vollmer M, Konrad M, Kelly L, van den Heuvel LPWJ, Tebourbi L, Brandis M, Karolyi L, Hebert SC, Lemmink HH, Deschenes G, Hildebrandt F, Seyberth HW, Guay-Woodford L, Knoers NVAM, Antignac C. Novel molecular variants of the Na-K-2Cl cotransporter gene are responsible for antenatal Bartter syndrome. Am J Hum Genet 1998; 62:1332-1340.
137. Kurtz CL, Karolyi L, Seyberth HW, Koch MC, Vargas R, Feldmann D, Vollmer M, Knoers NVAM, Madrigal G, Guay-Woodford LM. A common NKCC2 mutation in Costa Rican Bartter's syndrome patients: evidence for a founder effect. J Am Soc Nephrol 1997; 8:1706-1711.
138. Simon DB, Karet FE, Rodriguez-Soriano J, Hamdan JH, DiPietro A, Trachtman H, Sanjad SA, Lifton RP. Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K channel, ROMK. Nat Genet 1996; 14:152-156.
139. Vollmer M, Koehrer M, Topaloglu R, Strahm B, Omran H. Two novel mutations of the gene for Kir 1.1 (ROMK) in neonatal Bartter syndrome. Pediatr Nephrol 1998; 12:69-71.
140. Thakker RV. Molecular pathology of renal chloride channels in Dent's disease and Bartter's syndrome. Exp Nephrol 2000; 8:351-360.
141. Shaer AJ. Inherited primary renal tubular hypokalemic alkalosis: a review of Gitelman and Bartter syndromes. Am J Med Sci 2001; 322:316-332.
142. Simon DB, Bindra RS, Mansfield TA, Nelson-Williams C, Mendonca E, Stone R, Schurmann S, Nayir A, Alpay H, Bakkaloglu A, Rodrigeuz-Soriano J, Morales JM, Saniad SA, Taylor CM, Pilz D, Brem A, Trachtman H, Griswold W, Richard GA, John E, Lifton RP. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet 1997; 17:171-178.
143. Konrad M, Vollmer M, Lemmink HH, van den Huevel LPWJ, Jeck N, Vargas-Possou R, Lakings A, Ruf R, Deschenes G, Antignac C, Guay-Wood-ford L, Knoers NVAM, Seyberth HW, Feldmann D, Hildebrant F. Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome. J Am Soc Nephrol 2000; 11:1449-1459.
144. Schwalbe RA, Bianchi L, Accili EA, Brown AM. Functional consequences of ROMK mutants linked to antenatal Bartter's syndrome and implications for treatment. Hum Mol Genet 1998; 7:975-980.
145. Lu M, Wang T, Yan Q, Yang X, Dong K, Knepper MA, Wang W, Giebisch G, Shull GE, Hebert SC. Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice. J Biol Chem 2002; 277:37881-37887.
146. Cho JT, Guay-Woodford LM. Heterozygous mutations of the gene for Kir 1.1 (ROMK) in antenatal Bartter syndrome presenting with transient hyperkalemia, evolving to a benign course. J Korean Med Sci 2003; 18:65-68.
147. Simon DB, Nelson-Williams C, Bia MJ, Ellsion D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen, M, Gainza FJ, Gitelman HJ, Lifton RP. Gitelman's variant of Bartter's syndrome, inherited hypokalemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl co-transporter. Nat Genet 1996; 12:24-30.
148. Zelikovic I, Szargel R, Hawash A, Labay V, Hatib I, Cohen N, Nakhoul F. A novel mutation in the chloride channel gene, CLCNKB, as a cause of Gitelman and Bartter syndromes. Kidney Int 2003; 63:24-32.
149. Bettinelli A, Bianchetti MG, Girardin E, Caringella A, Cecconi M, Appiani AC, Pavanello L, Gastaldi R, Isimbaldi C, Lama G, Marchesoni C, Matteucci C, Patriarca P, DiNatale B, Setzu C, Vitucci P. Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitlelman syndromes. J Pediatr 1992; 20:38-43.
150. Cruz DN, Simon DB, Nelson-Williams C, Farhi A, Finberg K, Burleson L, Gill JR, Lifton RP. Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension 2001; 37:1458-1464.
151. Cruz DN, Shaer AJ, Bia MJ, Lifton RP, Simon DB. Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life. Kidney Int 2001; 59:710-717.
152. Nishihara G, Higashi H, Matsuo S, Yasunaga C. Acute renal failure due to hypokalemic rhabdomyolysis in Gitelman's syndrome. Clin Nephrol 1998; 50:330-332.
153. Wall BM, Williams HH, Cooke CR. Chloride-resistant metabolic alkalosis in an adult with congenital chloride diarrhea. Am J Med 1988; 85:570-572.
154. Schwartz WB, Relman AS. Metabolic and renal studies in chronic potassium depletion resulting from overuse of laxatives. J Clin Invest 1953; 32:258-271.
155. Fleischer N, Brown H, Graham DY, Delena S. Chronic laxative-induced hyperaldosteronism and hypokalemia simulating Bartter's syndrome. Ann Intern Med 1969; 70:791-798.
156. Cummings JH, Sladen GE, James OFW, Sarner M, Misiewicz JJ. Laxative-induced diarrhoea: a continuing clinical problem. Br Med J 1974; 1:537-541.
157. Wright LF, DuVal JW Jr. Renal injury associated with laxative abuse. South Med J 1987; 80:1304-1306.
158. Severance HW, Holt T, Patrone NA, Chapman L. Profound muscle weakness and hypokalemia due to clay ingestion. South Med J 1988; 81:272-274.
159. Ethier JH, Kamel KS, Magner PO, Lemann J Jr, Halperin ML. The transtubular potassium concentration in patients with hypokalemia and hyperkalemia. Am J Kidney Dis 1990; 15:309-315.
160. Solomon R. The relationship between disorders of K+ and Mg++ homeostasis. Semin Nephrol 1987; 7:253-262.
161. Konrad M, Weber S. Recent advances in molecular genetics of hereditary magnesium-losing disorders. J Am Soc Nephrol 2003; 14:249-260.
162. Darr M, Hamburger S, Ellerbeck E. Acid-base and electrolyte abnormalities due to capreomycin. South Med J 1982; 75:627-628.
163. Clausen T, Everts ME. Regulation of the Na, K-pump in skeletal muscle. Kidney Int 1989; 35:1-13.
164. Krishna GG, Kapoor SC. Potassium supplementation ameliorates mineralo-corticoid-induced sodium retention. Kidney Int 1993; 43:1097-1103.
165. Guay-Woodford LM. Bartter syndrome: unraveling the pathophysiologic enigma. Am J Med 1998; 105:151-161.
166. Verberckmoes R, Van Damme B, Clement J, Amery A, Michielsen P. Bartter's syndrome with hyperplasia of renomedullary cells. Successful treatment with indomethacin. Kidney Int 1976; 9:302-307.
167. Marlow N, Chiswick ML. Neonatal Bartter's syndrome, indomethacin, and necrotizing enterocolitis. Acta Pediatr Scand 1982; 71:1031-1032.
168. Schachter AD, Arbus GS, Alexander RJ, Balfe JW. Non-steroidal anti-inflammatory drug-associated nephrotoxicity in Bartter syndrome. Pediatr Nephrol 1998; 12:775-777.
169. Mayan H, Gurevitz O, Farfel Z. Successful treatment by cylcooxygenase-2 inhibitor of refractory hypokalemia in a patient with Gitelman's syndrome. Clin Nephrol 2002; 58:73-76.
170. Hene RJ, Koomans HA, Dorhout Mees EJ, vd Stolpe A, Verhoef GE, Boer P. Correction of hypokalemia in Bartter's syndrome by enalapril. Am J Kidney Dis 1987; 9:200-205.
171. Melby JC. Primary aldosteronism. Kidney Int 1984; 26:769-778.
172. Winquist EW, Laskey J, Crump M, Khamsi F, Shepherd FA. Ketoconazole in the management of paraneoplastic Cushing's syndrome secondary to ectopic adrenocorticotropin production. J Clin Oncol 1995; 13:157-164.
173. Abraham J, Fojo T, Wood BJ. Radiofrequency ablation of metastatic lesions in adrenocortical cancer. Ann Intern Med 2000; 133:312-313.
174. Sterns RH, Cox M, Feig PU, Singer IM. Internal potassium balance and the control of plasma potassium concentration. Medicine 1981; 60:339-354.