Easing the global burden of diarrhoeal disease: Can synthetic biology help?

Systems and Synthetic Biology

Volumn 7, Issue 3, 2013, Pages 73-78

  Vohra, Prerna ^a   Blakely, Garry W ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Diarrhoeal disease; Global health; Synthetic biology; Vaccines

Indexed keywords

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SALMONELLA; SHIGELLA;

EID: 84881552008     PISSN: 18725325     EISSN: 18725333     Source Type: Journal    
DOI: 10.1007/s11693-013-9114-6     Document Type: Article

References (30)

1. Annan KA (2000) http://www. un. org/millennium/sg/report/full. htm.
2. Bailey C, Metcalf H, Crook B (2012) Synthetic biology: A review of the technology, and current and future needs from the regulatory framework in Great Britain. Health and Safety Executive, Research Report RR944. http://www. hse. gov. uk/research/rrpdf/rr944. pdf.
3. Balmer A, Martin P (2008) Synthetic biology: social and ethical challenges institute for science and society, University of Nottingham. http://www. bbsrc. ac. uk/organisation/policies/reviews/scientific-areas/0806-synthetic-biology. aspx.
4. Blakely GW, Murray NE (2009) DNA restriction and modification, in the encyclopedia of microbiology, 3rd Edition, edited by Moselio Schaechter, Elsevier.
5. Bradbrook S (2007) HSE horizon scanning intelligence group short report synthetic biology. SR010. http://www. hse. gov. uk/horizons/.
6. Burbelo PD, Ching KH, Han BL, Klimavicz CM, Iadarola MJ (2010) Synthetic biology for translational research. Am J Trans Res 2: 381-389.
7. Church G (2005) Let us go forth and safely multiply. Nature 438: 423. doi: 10. 1038/438423a.
8. Directive 2009/41/EC of the European Parliament and of the Council of 6 May 2009 on the contained use of genetically modified micro-organisms. Off J Eur Union. L 125/75. http://www. bmwf. gv. at/fileadmin/user_upload/forschung/gentechnik/2009-41-EC. pdf.
9. European Commission (2010) Synthetic Biology: From Science to Governance. A workshop organised by the European Commission's Directorate-General for Health and Consumers, Brussels. http://ec. europa. eu/health/.../docs/synbio_workshop_report_en. pdf.
10. Fouchier R, Osterhaus A, Steinbruner J et al (2012) Preventing pandemics: the fight over flu. Nature 481: 257-259. doi: 10. 1038/481257a.
11. French CE, de Mora K, Joshi N, Elfick A, Haseloff J, Ajioka J (2011) Synthetic biology And the art of biosensor design. In: Institute of Medicine (US) Forum on Microbial Threats. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington (DC): National Academies Press (US). A5. http://www. ncbi. nlm. nih. gov/books/NBK84465/.
12. Garfinkel MS, Endy D, Epstein GL, Friedman RM (2007) Synthetic genomics: options for governance available here. http://www. jcvi. org/cms/fileadmin/site/research/projects/synthetic-genomics-report/synthetic-genomics-report. pdf.
13. Hoshino K et al (1999) Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
14. ISBN: 978-92-4-159841-5 (NLM classification: WS 312) (WHO). http://whqlibdoc. who. int/publications/2009/9789241598415_eng. pdf.
15. Kelle A (2007) Synthetic biology and biosecurity: awareness in Europe. Bradford Science and Technology Report No. 9. http://www. synbiosafe. eu/uploads///pdf/Synbiosafe-Biosecurity_awareness_in_Europe_Kelle. pdf.
16. Martin DK, Greenwood HL, Nisker J (2010) Public perceptions of ethical issues regarding adult predictive genetic testing. Health Care Anal 18: 103-112.
17. Maurer SM, Lucas KV, Terrell S (2006) From understanding to action: community-based options for improving safety and security in synthetic biology. Goldman School of Public Policy, University of California at Berkeley. http://gspp. berkeley. edu/iths/UC%20White%20Paper. pdf.
18. Murray K, Bruce SA, Hinnen A, Wingfield P, van Erd PM, de Reus A, Schellekens H (1984) Hepatitis B virus antigens made in microbial cells immunise against viral infection. EMBO J 3: 645-650.
19. Pasotti L, Zucca S, Lupotto M, Cusella De Angelis MG, Magni P (2011) Characterization of a synthetic bacterial self-destruction device for programmed cell death and for recombinant proteins release. J Biol Eng 5.
20. Presidential Commission for the Study of Bioethical Issues (2010). New directions: the ethics of synthetic biology and emerging technologies. http://bioethics. gov/cms/sites/default/files/PCSBI-Synthetic-Biology-Report-12. 16. 10_0. pdf.
21. WHO report (2011) The world health report-Health systems financing: the path to universal coverage. http://www. who. int/whr/2010/en/index. html.
22. Ro D, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MCY, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440: 940-943.
23. Ruder WC, Lu T, Collins JJ (2011) Synthetic biology moving into the clinic. Science 333: 1248-1252.
24. Schmidt M, Ganguli-Mitra A, Torgersen H, Kelle A, Deplanes A, Biller-Andorno N (2009) A priority paper for the societal and ethical aspects of synthetic biology. Syst Synth Biol 3: 3-7.
25. Technology Strategy Board on behalf of UK Synthetic Biology Roadmap Coordination Group (2012). A synthetic biology roadmap for the UK. http://www. rcuk. ac. uk/Publications/reports/Pages/syntheticbiologyroadmap. aspx.
26. van Est R, de Vriend H, Walhout B (2007) Constructing Life: The World of Synthetic Biology, Rathenau Institute-Technology Assessment. http://www. synbiosafe. eu/uploads///pdf/BAP_Synthetic_biology_nov2007[1]. pdf.
27. Veenstra DL, Roth JA, Garrison LP Jr, Ramsey SD, Burke W (2010) A formal risk-benefit framework for genomic tests: facilitating the appropriate translation of genomics into clinical practice. Genetics in Medicine 12: 686-693. doi: 10. 1097/GIM. 0b013e3181eff533.
28. Weber W, Schoenmakers R, Keller B, Gitzinger M, Grau T, Daoud-El Baba M, Sander P, Fussenegger M (2008) A synthetic mammalian gene circuit reveals antituberculosis compounds. PNAS 105: 9994-9998.
29. WHO (2009) Diarrhoea: Why children are still dying and what can be done.
30. Windbichler N, Menichelli M, Papathanos PA, Thyme SB, Li H, Ulge UY, Hovde BT, Baker D, Monnat RJ Jr, Burt A, Crisanti A (2011) A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature 473: 212-217.