Escalation of drug self-administration as a hallmark of persistent addiction liability

Behavioural Pharmacology

Volumn 24, Issue 5-6, 2013, Pages 356-362

  Edwards, Scott ^a   Koob, George F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

addiction; alcohol; cocaine; escalation; heroin; self administration

Indexed keywords

ALCOHOL; COCAINE; CORTICOTROPIN RELEASING FACTOR; DIAMORPHINE; DOPAMINE; DYNORPHIN; GLUTAMIC ACID; HISTONE DEACETYLASE; IONOTROPIC RECEPTOR; METHAMPHETAMINE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINE; NORADRENALIN; VASOPRESSIN V1B RECEPTOR;

ALCOHOLISM; BEHAVIOR CHANGE; CENTRAL NUCLEUS (AMYGDALA); COCAINE DEPENDENCE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG DEPENDENCE; DRUG EXPOSURE; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; DRUG USE; EMOTIONALITY; EPIGENETICS; HUMAN; INTRAVENOUS DRUG ABUSE; LATENT PERIOD; METHAMPHETAMINE DEPENDENCE; MORPHINE ADDICTION; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; PROTEIN PHOSPHORYLATION; REINFORCEMENT; REVIEW; REWARD; SIGNAL TRANSDUCTION; TOBACCO DEPENDENCE; WITHDRAWAL SYNDROME;

ANIMALS; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; DRUG-SEEKING BEHAVIOR; HUMANS; MOTIVATION; SELF ADMINISTRATION; SUBSTANCE-RELATED DISORDERS;

EID: 84881545157     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0b013e3283644d15     Document Type: Review

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