Human Hemorrhagic Pulmonary Leptospirosis: Pathological Findings and Pathophysiological Correlations

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  De Brito, Thales ^a   De Aiello, Veramarchi ^a   da Silva, Luis Fernando Ferraz ^a   Gonçalves da Silva, Ana Maria ^a   Ferreira da Silva, Wellington Luiz ^a   Castelli, Jussara Bianchi ^a   Seguro, Antonio Carlos ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 1; AQUAPORIN 5; CD34 ANTIGEN; CONNEXIN 43; PARASITE ANTIGEN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEPTOSPIROSIS; LUNG ALVEOLUS CELL; LUNG EDEMA; LUNG FLUID; LUNG HEMORRHAGE; LUNG INJURY; MALE; MICROCIRCULATION; PATHOGENESIS; PROTEIN EXPRESSION; SEPTICEMIA;

ADULT; AGED; AGED, 80 AND OVER; BLOOD VESSELS; CASE-CONTROL STUDIES; CONNEXIN 43; EPITHELIAL SODIUM CHANNELS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG DISEASES; MALE; MICROCIRCULATION; MICROSCOPY, CONFOCAL; MIDDLE AGED; PNEUMOCYTES; WEIL DISEASE; YOUNG ADULT;

EID: 84881531935     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071743     Document Type: Article

References (35)

1. Vinetz JM, (2001) Leptospirosis. Curr Opin Infect Dis 14(5): 527-38.
2. McBride AJ, Athanazio DA, Reis MG, Ko AI, (2005) Leptospirosis. Curr Opin Infect Dis 18(5): 376-86.
3. Dolhnikoff M, Mauad T, Bethlem EP, Carvalho CR, (2007) Pathology and pathophysiology of pulmonary manifestations in leptospirosis. Braz J Infect Dis 11(1): 142-8 DOI:10.1590/S1413-86702007000100029.
4. Trevejo RT, Rigau-Pérez JG, Ashford DA, McClure EM, Jarquín-González C, et al. (1998) Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995. J Infect Dis 178(5): 1457-63 DOI:10.1086/314424.
5. Park SK, Lee SH, Rhee YK, Kang SK, Kim KJ, et al. (1989) Leptospirosis in Chonbuk province of Korea in 1987: a study of 93 patients. Am J Trop. Med. Hyg 41(3): 345-51. Available: http://www.ajtmh.org/content/41/3/345.long. Accessed 2013 February 4.
6. Zaki SR, Shieh WJ, (1996) Leptospirosis associated with outbreak of acute febrile illness and pulmonary haemorrhage, Nicaragua, 1995. The Epidemic Working Group at Ministry of Health in Nicaragua. Lancet 347(9000): 535-6.
7. Marotto PC, Nascimento CM, Eluf-Neto J, Marotto MS, Andrade L, et al. (1999) Acute lung injury in leptospirosis: clinical and laboratory features,outcome,and factors associated wth mortality. Clin Infect Dis. 29(6): 1561-3 DOI:10.1086/313501.
8. Yersin C, Bovet P, Mérien F, Clément J, Laille M, et al. (2000) Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles. Trans R Soc Trop Med Hyg 94(1): 71-6.
9. Andrade L, Rodrigues AC Jr, Sanches TR, Souza RB, Seguro AC (2007) Leptospirosis leads to dysregulation of sodium transporters in the kidney and lung. Am J Physiol Renal Physiol 292, F586-F592. DOI: 10.1152/ajprenal.00102.2006.
10. Matthay MA, Su X, (2007) Pulmonary barriers to pneumonia and sepsis. Nat Med 13(7): 780-1 DOI:-10.1038/nm0707-780.
11. Matthay MA, (2002) Regulation of ion and fluid transport across the distal pulmonary epithelia: new insights. Am J Physiol Lung Cell Mol Physiol 282: L595-L598 DOI:10.1152/ajplung.00473.2001.
12. Olesen ET, de Seigneux S, Wang G, Lütken SC, Frøkiaer J, et al. (2009) Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia. Nephrol Dial Transplant 24(8): 2338-49 DOI:10.1093/ndt/gfp011.
13. Araujo ER, Seguro AC, Spichler A, Magaldi AJ, Volpini RA, et al. (2010) Acute kidney injury in human leptospirosis: an immunohistochemical study with pathophysiological correlation. Virchows Arch 456(4): 367-75 DOI:10.1007/s00428-010-0894-8.
14. Martínez García MA, de Diego Damiá A, Menéndez Villanueva R, López Hontagas JL (2000) Pulmonary involvement in leptospirosis. Eur J Clin Microbiol Infect Dis 19(6): 471-4. Available: http://link.springer.com/article/10.1007/s100960000294. Accessed 2013 February 4.
15. Luks AM, Lakshminarayanan S, Hirschmann JV, (2003) Leptospirosis presenting as diffuse alveolar hemorrhage - case report and literature review. Chest 123(2): 639-43.
16. Marchiori E, Lourenço S, Setúbal S, Zanetti G, Gasparetto TD, et al. (2010) Clinical and imaging manifestations of hemorrhagic pulmonary leptospirosis: a State-of-Art review. Lung 189(1): 1-9 DOI:10.1007/s00408-010-9273-0.
17. De Brito T, Menezes LF, Lima DM, Lourenço S, Silva AM, et al. (2006) Immunohistochemical and in situ hybridization studies of the liver and kidney in human leptospirosis. Virchows Arch 448(5): 576-83 DOI:10.1007/s00428-006-0163-z.
18. Del Carlo Bernardi F, Ctenas B, da Silva LF, Nicodemo AC, Saldiva PH, et al. (2012) Immune receptors and adhesion molecules in human pulmonary leptospirosis. Hum Pathol 43(10): 1601-10 DOI:10.1016/j.humpath.2011.11.017.
19. Nogueira LG, Santos RH, Ianni BM, Fiorelli AI, Mairena EC, et al. (2012) Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10. PLoS Negl Trop Dis 6(10): e1867 DOI:10.1371/journal.pntd.0001867.
20. Szeredi L, Haake DA, (2006) Immunohistochemical identification and pathologic findings in natural cases of equine abortion caused by leptospiral infection. Vet Pathol 43(5): 755-61 DOI:10.1354/vp.43-5-755.
21. Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, et al. (1998) Highly water permeable type I alveolar epithelial cells confer high water permeability between the air space and vasculature in rat lung. Proc Natl Acad Sci U S A 95(6): 2991-6. Available: http://www.pnas.org/content/95/6/2991.full.pdf. Accessed 2013 February 4.
22. Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, et al. (2006) Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport. Proc Natl Acad Sci U S A 103(13): 4964-9 DOI:10.1073/pnas.0600855103.
23. Rannels DE (2001) Gap junction communication in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 280(6): L1083-4. Available: http://ajplung.physiology.org/content/280/6/L1083.full.pdfhtml. Accessed 2013 February 4.
24. Clerici C, (2011) The challenge of modeling human acute respiratory distress syndrome: a new model of lung injury due to sepsis with impaired alveolar edema fluid removal. Am J Physiol Lung Cell Mol Physiol 301(1): L20-2 DOI:10.1152/ajplung.00126.2011.
25. Minami M, Sobue S, Ichihara M, Hasegawa T, (2012) Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes. Pathol Int 62(2): 99-104 DOI:10.1111/j.1440-1827.2011.02756.x.
26. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, et al. (2001) Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 282(4): L599-608 DOI:10.1152/ajplung.00130.2000.
27. Croda J, Neto AN, Brasil RA, Pagliari C, Nicodemo AC, et al. (2010) Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. Clin Microbiol Infect 16(6): 593-9 DOI:10.1111/j.1469-0691.2009.02916.x.
28. Nicodemo AC, Duarte MI, Alves VA, Takakura CF, Santos RT, et al. (1997) Lung lesions in human leptospirosis: microscopic, immunohistochemical and ultrastructural features related to thrombocytopenia. Am J. Trop. Med. Hyg 56(2): 181-7. Available: http://www.ajtmh.org/content/56/2/181.long. Accessed 2013 February 4.
29. Nally JE, Chantranuwat C, Wu XY, Fishbein MC, Pereira MM, et al. (2004) Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis. Am J. Pathol 164(3): 1115-27 DOI:10.1016/S0002-9440(10)63198-7.
30. De Brito T, Böhm GM, Yasuda PH, (1979) Vascular damage in acute experimental leptospirosis of the guinea-pig. J Pathol 128(4): 177-82 DOI:10.1002/path.1711280403.
31. Miller NG, Allen JE, Wilson RB, (1974) The pathogenesis of hemorrhage in the lung of the hamster during acute leptospirosis. Med Microbiol Immunol 160(4): 269-78.
32. Ordóñez NG, (2012) Immunohistochemical endothelial markers: a review. Adv Anat Pathol 19(5): 281-95 DOI:10.1097/PAP.0b013e3182691c2a.
33. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS, (2005) Impairment of angiogenesis and cell migration by targeted aquaporin 1 gene disruption. Nature 434(7034): 786-92 DOI:10.1038/nature03460.
34. Hoque MO, Soria JC, Woo J, Lee T, Lee J, et al. (2006) Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage - independent growth. Am J Pathol 168(4): 1345-53 DOI:10.2353/ajpath.2006.050596.
35. Droemann D, Goldmann T, Branscheid D, Clark R, Dalhoff K,et al. (2003) Toll-lyke receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the lung. Histochem Cell Biol 119(2): 103-8 DOI:10.1007/s00418-003-0497-4.