Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia

Nephrology Dialysis Transplantation

Volumn 24, Issue 8, 2009, Pages 2338-2349

  Olesen, Emma T B ^a,b   De Seigneux, Sophie ^a,c   Wang, Guixian ^a,b   Lütken, Sophie C ^a,b   Frøkiær, Jørgen ^a,b   Kwon, Tae Hwan ^a,d   Nielsen, Søren ^a,b  

^a Water and Salt Research Centre   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Service of Nephrology   (Switzerland)

^d Kyungpook National University School of Medicine   (South Korea)

Author keywords

Acute renal failure; Aquaporin; INOS; LPS; Urine concentration

Indexed keywords

AQUAPORIN 2; EPITHELIAL SODIUM CHANNEL; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N6 (1 IMINOETHYL)LYSINE; SERINE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTOXEMIA; ENZYME INHIBITION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NATRIURESIS; NONHUMAN; POLYURIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SODIUM EXCRETION; SODIUM URINE LEVEL; URINE FLOW RATE; URINE VOLUME;

ANESTHESIA; ANIMALS; AQUAPORIN 2; BLOTTING, WESTERN; DOWN-REGULATION; ENDOTOXEMIA; ENZYME INHIBITORS; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; KIDNEY; LIPOPOLYSACCHARIDES; LYSINE; MACROPHAGES; MALE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; RATS; RATS, WISTAR; SODIUM; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 67651115764     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp011     Document Type: Article

References (56)

1. Levy EM, Viscoli CM, Horwitz RI. The effect of acute renal failure on mortality. A cohort analysis. JAMA 1996; 275: 1489-1494
2. Rangel-Frausto MS, Pittet D, Costigan M et al. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 1995; 273: 117-123
3. Kikeri D, Pennell JP, Hwang KH et al. Endotoxemic acute renal failure in awake rats. Am J Physiol 1986; 250: F1098-F1106
4. Nitescu N, Grimberg E, Ricksten SE et al. Endothelin B receptors preserve renal blood flow in a normotensive model of endotoxininduced acute kidney dysfunction. Shock 2008; 29: 402-409
5. Wang W, Jittikanont S, Falk SA et al. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am J Physiol Renal Physiol 2003; 284: F532-F537
6. Boffa JJ, Arendshorst WJ. Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock. J Am Soc Nephrol 2005; 16: 117-124
7. Boffa JJ, Just A, Coffman TM et al. Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice. J Am Soc Nephrol 2004; 15: 2358-2365
8. Thijs A, Thijs LG. Pathogenesis of renal failure in sepsis. Kidney Int Suppl 1998; 66: S34-S37
9. Cupples WA, Braam B. Assessment of renal autoregulation. Am J Physiol Renal Physiol 2007; 292: F1105-F1123
10. Kwon TH, Frokiaer J, Fernandez-Llama P et al. Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha-MSH. Am J Physiol 1999; 277: F413-F427
11. Li C, Wang W, Kwon TH et al. Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction. Am J Physiol Renal Physiol 2003; 285: F889-F901
12. Catania A, Lipton JM. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 1993; 14: 564-576
13. Chiao H, Kohda Y, McLeroy P et al. Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest 1997; 99: 1165-1172
14. Grinevich V, Knepper MA, Verbalis J et al. Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla. Kidney Int 2004; 65: 54-62
15. Fernandez-Llama P, Andrews P, Turner R et al. Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats. J Am Soc Nephrol 1999; 10: 1658-1668
16. Frokiaer J, Marples D, Knepper MA et al. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol 1996; 270: F657-F668
17. Norregaard R, Jensen BL, Li C et al. COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. Am J Physiol Renal Physiol 2005; 289: F322-F333
18. Ecelbarger CA, Nielsen S, Olson BR et al. Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat. J Clin Invest 1997; 99: 1852-1863
19. Schwartz D, Mendonca M, Schwartz I et al. Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J Clin Invest 1997; 100: 439-448
20. Plato CF, Stoos BA, Wang D et al. Endogenous nitric oxide inhibits chloride transport in the thick ascending limb. Am J Physiol 1999; 276: F159-F163
21. Ortiz PA, Hong NJ, Garvin JL. NO decreases thick ascending limb chloride absorption by reducing Na(+)-K(+)-2Cl(-) cotransporter activity. Am J Physiol Renal Physiol 2001; 281: F819-F825
22. Mount PF, Power DA. Nitric oxide in the kidney: functions and regulation of synthesis. Acta Physiol (Oxf) 2006; 187: 433-446
23. Bultinck J, Sips P, Vakaet L et al. Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock. FASEB J 2006; 20: 2363-2365
24. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007; 87: 315-424
25. De SS, Kim SW, Hemmingsen SC et al. Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome. Am J Physiol Renal Physiol 2006; 291: F208-F217
26. Nielsen S, DiGiovanni SR, Christensen EI et al. Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci U S A 1993; 90: 11663-11667
27. Nielsen S, Chou CL, Marples D et al. Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci U S A 1995; 92: 1013-1017
28. Nielsen J, Kwon TH, Praetorius J et al. Aldosterone increases urine production and decreases apicalAQP2 expression in rats with diabetes insipidus. Am J Physiol Renal Physiol 2006; 290: F438-F449
29. Christensen BM, Zelenina M, Aperia A et al. Localization and regulation of PKA-phosphorylated AQP2 in response to V(2)-receptor agonist/antagonist treatment. Am J Physiol Renal Physiol 2000; 278: F29-F42
30. Kwon TH, Frokiaer J, Fernandez-Llama P et al. Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys. Am J Physiol 1999; 277: F257-F270
31. Kim SW, de SS, Sassen MC et al. Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats. Am J Physiol Renal Physiol 2006; 290: F674-F687
32. Kim SW, Schou UK, Peters CD et al. Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2-11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis. J Am Soc Nephrol 2005; 16: 3196-3210
33. Masilamani S, Kim GH, Mitchell C et al. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 1999; 104: R19-R23
34. Kim GH, Ecelbarger CA, Mitchell C et al. Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol 1999; 276: F96-F103
35. Kim GH, Masilamani S, Turner R et al. The thia! zide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 1998; 95: 14552-14557
36. Dimke H, Flyvbjerg A, Bourgeois S et al. Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2. AmJ Physiol Renal Physiol 2007; 292: F723-F735
37. Fenton RA, Brond L, Nielsen S et al. Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney. Am J Physiol Renal Physiol 2007; 293: F748-F760
38. Gimenez I, Forbush B. Short-term stimulation of the renal Na-KCl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J Biol Chem 2003; 278: 26946-26951
39. Holmqvist B, Olsson CF, Svensson ML et al. Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4. J Mol Histol 2005; 36: 499-516
40. Cohen RI, Hassell AM, Marzouk K et al. Renal effects of nitric oxide in endotoxemia. Am J Respir Crit Care Med 2001; 164: 1890-1895
41. Carnio EC, Stabile AM, Batalhao ME et al. Vasopressin release during endotoxaemic shock in mice lacking inducible nitric oxide synthase. Pflugers Arch 2005; 450: 390-394
42. Giusti-Paiva A, De CM, ntunes-Rodrigues J et al. Inducible nitric oxide synthase pathway in the central nervous system and vasopressin release during experimental septic shock. Crit Care Med 2002; 30: 1306-1310
43. Giusti-Paiva A, Elias LL, ntunes-Rodrigues J. Inhibitory effect of gaseous neuromodulators in vasopressin and oxytocin release induced by endotoxin in rats. Neurosci Lett 2005; 381: 320-324
44. Schmidt C, Hocherl K, Schweda F et al. Regulation of renal sodium transporters during severe inflammation. J Am Soc Nephrol 2007; 18: 1072-1083
45. Li C, Wang W, Knepper MA et al. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Am J Physiol Renal Physiol 2003; 284: F1066-F1079
46. Jensen AM, Li C, Praetorius HA et al. Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction. Am J Physiol Renal Physiol 2006; 291: F1021-F1032
47. Purkerson ML, Blaine EH, Stokes TJ et al. Role of atrial peptide in the natriuresis and diuresis that follows relief of obstruction in rat. Am J Physiol 1989; 256: F583-F589
48. Plato CF, Shesely EG, Garvin JL. eNOS mediates L-arginine-induced inhibition of thick ascending limb chloride flux. Hypertension 2000; 35: 319-323
49. Schlatter E, Salomonsson M, Persson AE et al. Macula densa cells sense luminal NaCl concentration via furosemide sensitive Na+2Cl-K+ cotransport. Pflugers Arch 1989; 414: 286-290
50. Wakabayashi S, Shigekawa M, Pouyssegur J. Molecular physiology of vertebrate Na+/H+ exchangers. Physiol Rev 1997; 77: 51-74
51. Russell JM. Sodium-potassium-chloride cotransport. Physiol Rev 2000; 80: 211-276
52. Loffing J, Zecevic M, Feraille E et al. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol 2001; 280: F675 F682
53. Garcia NH, Stoos BA, Carretero OA et al. Mechanism of the nitric oxide-induced blockade of collecting duct water permeability. Hypertension 1996; 27: 679-683
54. Stoos BA, Garcia NH, Garvin JL. Nitric oxide inhibits sodium reabsorption in the isolated perfused cortical collecting duct. J Am Soc Nephrol 1995; 6: 89-94
55. Garcia NH, Pomposiello SI, Garvin JL. Nitric oxide inhibits ADHstimulated osmotic water permeability in cortical collecting ducts. Am J Physiol 1996; 270: F206-F210
56. Bouley R, Breton S, Sun T et al. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest 2000; 106: 1115-1126