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Volumn 98, Issue 8, 2013, Pages 3149-3164

Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: An update

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AMINOGLUTETHIMIDE; AXITINIB; CABOZANTINIB; CALCITONIN; CORTICOTROPIN; CYTARABINE; ETOMIDATE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; IMATINIB; KETOCONAZOLE; METYRAPONE; MIFEPRISTONE; MITOTANE; MOTESANIB; PLACEBO; SORAFENIB; SUNITINIB; TIPIFARNIB; VANDETANIB;

EID: 84881507082     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-1204     Document Type: Article
Times cited : (254)

References (163)
  • 1
    • 85047682409 scopus 로고    scopus 로고
    • Guidelines for diagnosis and therapy ofMENtype 1 and type 2
    • Brandi ML, Gagel RF, Angeli A, et al. Guidelines for diagnosis and therapy ofMENtype 1 and type 2. J Clin Endocrinol Metab. 2001; 86:5658-5671.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 5658-5671
    • Brandi, M.L.1    Gagel, R.F.2    Angeli, A.3
  • 2
    • 0141940150 scopus 로고    scopus 로고
    • Early malignant progression of hereditary medullary thyroid cancer
    • Machens A, Niccoli-Sire P, Hoegel J, et al. Early malignant progression of hereditary medullary thyroid cancer. N Engl J Med. 2003;349:1517-1525.
    • (2003) N Engl J Med. , vol.349 , pp. 1517-1525
    • Machens, A.1    Niccoli-Sire, P.2    Hoegel, J.3
  • 3
    • 36849029085 scopus 로고    scopus 로고
    • The occurrence and the type of germline mutations in the RET gene in patients with medullary thyroid carcinoma and their unaffected kindred's from Central Poland
    • Paszko Z, Sromek M, Czetwertynska M, et al. The occurrence and the type of germline mutations in the RET gene in patients with medullary thyroid carcinoma and their unaffected kindred's from Central Poland. Cancer Invest. 2007;25:742-749.
    • (2007) Cancer Invest. , vol.25 , pp. 742-749
    • Paszko, Z.1    Sromek, M.2    Czetwertynska, M.3
  • 4
    • 78650484357 scopus 로고    scopus 로고
    • Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10
    • Frank-Raue K, Rybicki LA, Erlic Z, et al. Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10.HumMutat. 2011; 32:51-58.
    • (2011) HumMutat. , vol.32 , pp. 51-58
    • Frank-Raue, K.1    Rybicki, L.A.2    Erlic, Z.3
  • 5
    • 67749130797 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Management guidelines of the American Thyroid Association
    • American Thyroid Association Guidelines Task Force
    • Kloos RT, Eng C, Evans DB, et al; American Thyroid Association Guidelines Task Force. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid. 2009; 19:565-612.
    • (2009) Thyroid. , vol.19 , pp. 565-612
    • Kloos, R.T.1    Eng, C.2    Evans, D.B.3
  • 7
    • 77955214443 scopus 로고    scopus 로고
    • The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer
    • Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas. 2010;39:775-783.
    • (2010) Pancreas. , vol.39 , pp. 775-783
    • Chen, H.1    Sippel, R.S.2    O'Dorisio, M.S.3    Vinik, A.I.4    Lloyd, R.V.5    Pacak, K.6
  • 8
    • 0027303248 scopus 로고
    • Mutations in the RET protooncogene are associated with MEN 2A and FMTC
    • Donis-Keller H, Dou S, Chi D, et al. Mutations in the RET protooncogene are associated with MEN 2A and FMTC. Hum Mol Genet. 1993;2:851-856.
    • (1993) Hum Mol Genet. , vol.2 , pp. 851-856
    • Donis-Keller, H.1    Dou, S.2    Chi, D.3
  • 9
    • 0027231568 scopus 로고
    • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    • Mulligan LM, Kwok JB, Healey CS, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature. 1993;363:458-460.
    • (1993) Nature. , vol.363 , pp. 458-460
    • Mulligan, L.M.1    Kwok, J.B.2    Healey, C.S.3
  • 10
    • 0027977002 scopus 로고
    • Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B
    • Carlson KM, Dou S, Chi D, et al. Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. Proc Natl Acad Sci U S A. 1994;91:1579-1583.
    • (1994) Proc Natl Acad Sci U S A. , vol.91 , pp. 1579-1583
    • Carlson, K.M.1    Dou, S.2    Chi, D.3
  • 11
    • 0028174024 scopus 로고
    • A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
    • Hofstra RM, Landsvater RM, Ceccherini I, et al. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature. 1994; 367:375-376.
    • (1994) Nature. , vol.367 , pp. 375-376
    • Hofstra, R.M.1    Landsvater, R.M.2    Ceccherini, I.3
  • 12
    • 0024351090 scopus 로고
    • Human ret proto-oncogene mapped to chromosome 10q11.2
    • Ishizaka Y, Itoh F, Tahira T, et al. Human ret proto-oncogene mapped to chromosome 10q11.2. Oncogene. 1989;4:1519-1521.
    • (1989) Oncogene. , vol.4 , pp. 1519-1521
    • Ishizaka, Y.1    Itoh, F.2    Tahira, T.3
  • 13
    • 85047677255 scopus 로고    scopus 로고
    • Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons
    • Hahn M, Bishop J. Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons. Proc Natl Acad Sci U S A. 2001;98:1053-1058.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , pp. 1053-1058
    • Hahn, M.1    Bishop, J.2
  • 14
    • 0028227510 scopus 로고
    • Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin
    • Nakamura T, Ishizaka Y, Nagao M, Hara M, Ishikawa T. Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin. J Pathol. 1994;172:255-260.
    • (1994) J Pathol. , vol.172 , pp. 255-260
    • Nakamura, T.1    Ishizaka, Y.2    Nagao, M.3    Hara, M.4    Ishikawa, T.5
  • 15
    • 73149115248 scopus 로고    scopus 로고
    • Targeting the RET pathway in thyroid cancer
    • Wells SA Jr, Santoro M. Targeting the RET pathway in thyroid cancer. Clin Cancer Res. 2009;15:7119-7123.
    • (2009) Clin Cancer Res. , vol.15 , pp. 7119-7123
    • Wells Jr., S.A.1    Santoro, M.2
  • 16
    • 79955669404 scopus 로고    scopus 로고
    • High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas
    • Moura MM, Cavaco BM, Pinto AE, Leite V. High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab. 2011;96:E863-E868.
    • (2011) J Clin Endocrinol Metab. , vol.96
    • Moura, M.M.1    Cavaco, B.M.2    Pinto, A.E.3    Leite, V.4
  • 17
    • 84872058009 scopus 로고    scopus 로고
    • Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series
    • Ciampi R, Mian C, Fugazzola L, et al. Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series. Thyroid. 2013;23:50-57.
    • (2013) Thyroid. , vol.23 , pp. 50-57
    • Ciampi, R.1    Mian, C.2    Fugazzola, L.3
  • 18
    • 84873687468 scopus 로고    scopus 로고
    • Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS
    • Agrawal N, Jiao Y, Sausen M, et al. Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. J Clin Endocrinol Metab. 2013;98:E364-E369.
    • (2013) J Clin Endocrinol Metab. , vol.98
    • Agrawal, N.1    Jiao, Y.2    Sausen, M.3
  • 19
    • 0028120882 scopus 로고
    • Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease
    • Romeo G, Ronchetto P, Luo Y, et al. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature. 1994;367:377-378.
    • (1994) Nature. , vol.367 , pp. 377-378
    • Romeo, G.1    Ronchetto, P.2    Luo, Y.3
  • 20
    • 33845255290 scopus 로고    scopus 로고
    • RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture
    • Santoro M, Melillo RM, Fusco A. RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. Eur J Endocrinol. 2006;155:645-653.
    • (2006) Eur J Endocrinol. , vol.155 , pp. 645-653
    • Santoro, M.1    Melillo, R.M.2    Fusco, A.3
  • 21
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B-RET fusions in lung adenocarcinoma
    • Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012;18:375-377.
    • (2012) Nat Med. , vol.18 , pp. 375-377
    • Kohno, T.1    Ichikawa, H.2    Totoki, Y.3
  • 22
    • 84869088940 scopus 로고    scopus 로고
    • RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation
    • Ballerini P, Struski S, Cresson C, et al. RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation. Leukemia. 2012;26:2384-2389.
    • (2012) Leukemia. , vol.26 , pp. 2384-2389
    • Ballerini, P.1    Struski, S.2    Cresson, C.3
  • 23
    • 0014331669 scopus 로고
    • Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: Multiple endocrine neoplasia, type 2
    • Steiner AL, Goodman AD, Powers SR. Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2. Medicine. 1968;47:371-409.
    • (1968) Medicine. , vol.47 , pp. 371-409
    • Steiner, A.L.1    Goodman, A.D.2    Powers, S.R.3
  • 24
    • 76349083384 scopus 로고    scopus 로고
    • Kindred with prominent corneal nerves associated with a mutation in codon 804 of RET on chromosome 10q11
    • Ong DS, Lakhani V, Oates JA Jr, O'Day DM. Kindred with prominent corneal nerves associated with a mutation in codon 804 of RET on chromosome 10q11. Arch Ophthalmol. 2010;128:247-249.
    • (2010) Arch Ophthalmol. , vol.128 , pp. 247-249
    • Ong, D.S.1    Lakhani, V.2    Oates Jr., J.A.3    O'Day, D.M.4
  • 25
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature. 1994;367:380-383.
    • (1994) Nature. , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 26
    • 74549165029 scopus 로고    scopus 로고
    • The many faces of RET dysfunction in kidney
    • Jain S. The many faces of RET dysfunction in kidney. Organogenesis. 2009;5:177-190.
    • (2009) Organogenesis. , vol.5 , pp. 177-190
    • Jain, S.1
  • 27
    • 0027346835 scopus 로고
    • The pathology of medullary thyroid carcinoma and its precursors
    • DeLellisRA. The pathology of medullary thyroid carcinoma and its precursors. Monogr Pathol. 1993;35:72-102.
    • (1993) Monogr Pathol. , vol.35 , pp. 72-102
    • De Lellis, R.A.1
  • 29
    • 0031026236 scopus 로고    scopus 로고
    • Sex-related C cell hyperplasia in the normal human thyroid: A quantitative autopsy study
    • Guyétant S, Rousselet MC, Durigon M, et al. Sex-related C cell hyperplasia in the normal human thyroid: a quantitative autopsy study. J Clin Endocrinol Metab. 1997;82:42-47.
    • (1997) J Clin Endocrinol Metab. , vol.82 , pp. 42-47
    • Guyétant, S.1    Rousselet, M.C.2    Durigon, M.3
  • 30
    • 9444241650 scopus 로고    scopus 로고
    • Unraveling the amyloid associated with human medullary thyroid carcinoma
    • Khurana R, Agarwal A, Bajpai VK, et al. Unraveling the amyloid associated with human medullary thyroid carcinoma. Endocrinology. 2004;145:5465-5470.
    • (2004) Endocrinology. , vol.145 , pp. 5465-5470
    • Khurana, R.1    Agarwal, A.2    Bajpai, V.K.3
  • 31
    • 0027238246 scopus 로고
    • Management of pheochromocytomas in patients with multiple endocrine neoplasia type 2 syndromes
    • discussion 601-603
    • Lairmore TC, Ball DW, Baylin SB, Wells SA Jr. Management of pheochromocytomas in patients with multiple endocrine neoplasia type 2 syndromes. Ann Surg. 1993;217:595-601; discussion 601-603.
    • (1993) Ann Surg. , vol.217 , pp. 595-601
    • Lairmore, T.C.1    Ball, D.W.2    Baylin, S.B.3    Wells Jr., S.A.4
  • 32
    • 0028821992 scopus 로고
    • From medical history and biochemical tests to presymptomatic treatment in a largeMEN 2A family
    • Lips CJ, LandsvaterRM, Höppener JW, et al. From medical history and biochemical tests to presymptomatic treatment in a largeMEN 2A family. J Intern Med. 1995;238:347-356.
    • (1995) J Intern Med. , vol.238 , pp. 347-356
    • Lips, C.J.1    Landsvater, R.M.2    Höppener, J.W.3
  • 33
    • 79952223410 scopus 로고    scopus 로고
    • Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma
    • Eisenhofer G, Lenders JW, Timmers H, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011;57:411-420.
    • (2011) Clin Chem. , vol.57 , pp. 411-420
    • Eisenhofer, G.1    Lenders, J.W.2    Timmers, H.3
  • 34
    • 84858705443 scopus 로고    scopus 로고
    • Diagnostic tests and biomarkers for pheochromocytoma and extra-adrenal paraganglioma: From routine laboratory methods to disease stratification
    • Eisenhofer G, Tischler AS, de Krijger RR. Diagnostic tests and biomarkers for pheochromocytoma and extra-adrenal paraganglioma: from routine laboratory methods to disease stratification. Endocr Pathol. 2012;23:4-14.
    • (2012) Endocr Pathol. , vol.23 , pp. 4-14
    • Eisenhofer, G.1    Tischler, A.S.2    De Krijger, R.R.3
  • 35
    • 1442278888 scopus 로고    scopus 로고
    • Current approaches and recommended algorithm for the diagnostic localization of pheochromocytoma
    • Ilias I, Pacak K. Current approaches and recommended algorithm for the diagnostic localization of pheochromocytoma. J Clin Endocrinol Metab. 2004;89:479-491.
    • (2004) J Clin Endocrinol Metab. , vol.89 , pp. 479-491
    • Ilias, I.1    Pacak, K.2
  • 37
    • 0032888718 scopus 로고    scopus 로고
    • Complications after bilateral adrenalectomy for phaeochromocytoma in multiple endocrine neoplasia type 2-A plea to conserve adrenal function
    • de Graaf JS, Dullaart RP, Zwierstra RP. Complications after bilateral adrenalectomy for phaeochromocytoma in multiple endocrine neoplasia type 2-a plea to conserve adrenal function. Eur J Surg. 1999;165:843-846.
    • (1999) Eur J Surg. , vol.165 , pp. 843-846
    • De Graaf, J.S.1    Dullaart, R.P.2    Zwierstra, R.P.3
  • 39
    • 77952971977 scopus 로고    scopus 로고
    • Laparoscopic adrenalectomy: Balancing the operative indications with the technical advances
    • Mazzaglia PJ, Vezeridis MP. Laparoscopic adrenalectomy: balancing the operative indications with the technical advances. J Surg Oncol. 2010;101:739-744.
    • (2010) J Surg Oncol. , vol.101 , pp. 739-744
    • Mazzaglia, P.J.1    Vezeridis, M.P.2
  • 40
    • 81855224647 scopus 로고    scopus 로고
    • Unilateral subtotal adrenalectomy for pheochromocytoma in multiple endocrine neoplasia type 2 patients: A feasible surgical strategy
    • Scholten A, Valk GD, Ulfman D, Borel Rinkes IH, Vriens MR. Unilateral subtotal adrenalectomy for pheochromocytoma in multiple endocrine neoplasia type 2 patients: a feasible surgical strategy. Ann Surg. 2011;254:1022-1027.
    • (2011) Ann Surg. , vol.254 , pp. 1022-1027
    • Scholten, A.1    Valk, G.D.2    Ulfman, D.3    Borel Rinkes, I.H.4    Vriens, M.R.5
  • 41
    • 33845626189 scopus 로고    scopus 로고
    • Estimated risk of pheochromocytoma recurrence after adrenal-sparing surgery in patients with multiple endocrine neoplasia type 2A
    • Asari R, Scheuba C, Kaczirek K, Niederle B. Estimated risk of pheochromocytoma recurrence after adrenal-sparing surgery in patients with multiple endocrine neoplasia type 2A. Arch Surg. 2006;141:1199-1205.
    • (2006) Arch Surg. , vol.141 , pp. 1199-1205
    • Asari, R.1    Scheuba, C.2    Kaczirek, K.3    Niederle, B.4
  • 42
    • 0344716605 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2: Evaluation of the genotype-phenotype relationship
    • Yip L, Cote GJ, Shapiro SE, et al. Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship. Arch Surg. 2003;138:409-416.
    • (2003) Arch Surg. , vol.138 , pp. 409-416
    • Yip, L.1    Cote, G.J.2    Shapiro, S.E.3
  • 43
    • 0028865592 scopus 로고
    • Primary hhyperparathyroidism in multiple endocrine neoplasia type 2A
    • Raue F, Kraimps JL, Dralle H, et al. Primary hhyperparathyroidism in multiple endocrine neoplasia type 2A. J Intern Med. 1995;238: 369-373.
    • (1995) J Intern Med. , vol.238 , pp. 369-373
    • Raue, F.1    Kraimps, J.L.2    Dralle, H.3
  • 44
    • 0015606335 scopus 로고
    • Sipple's syndrome: Medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease. Studies in a large family.NIHconference
    • Keiser HR, Beaven MA, Doppman J, Wells S Jr, Buja LM. Sipple's syndrome: medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease. Studies in a large family.NIHconference. Ann Intern Med. 1973;78:561-579.
    • (1973) Ann Intern Med. , vol.78 , pp. 561-579
    • Keiser, H.R.1    Beaven, M.A.2    Doppman, J.3    Wells Jr., S.4    Buja, L.M.5
  • 45
    • 68449084079 scopus 로고    scopus 로고
    • Long term parathyroid function following total parathyroidectomy with autotransplantation in adult patients with MEN2A
    • Yoshida S, Imai T, Kikumori T, et al. Long term parathyroid function following total parathyroidectomy with autotransplantation in adult patients with MEN2A. Endocr J. 2009;56:545-551.
    • (2009) Endocr J. , vol.56 , pp. 545-551
    • Yoshida, S.1    Imai, T.2    Kikumori, T.3
  • 47
    • 0024507252 scopus 로고
    • Hereditary localized pruritus in affected members of a kindred with multiple endocrine neoplasia type 2A (Sipple's syndrome)
    • Nunziata V, Giannattasio R, Di Giovanni G, D'Armiento MR, Mancini M. Hereditary localized pruritus in affected members of a kindred with multiple endocrine neoplasia type 2A (Sipple's syndrome). Clin Endocrinol (Oxf). 1989;30:57-63.
    • (1989) Clin Endocrinol (Oxf). , vol.30 , pp. 57-63
    • Nunziata, V.1    Giannattasio, R.2    Di Giovanni, G.3    D'Armiento, M.R.4    Mancini, M.5
  • 49
    • 38349112858 scopus 로고    scopus 로고
    • Hirschsprung disease, associated syndromes and genetics: A review
    • Amiel J, Sproat-Emison E, Garcia-Barcelo M, et al. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet. 2008;45:1-14.
    • (2008) J Med Genet. , vol.45 , pp. 1-14
    • Amiel, J.1    Sproat-Emison, E.2    Garcia-Barcelo, M.3
  • 50
    • 0034602646 scopus 로고    scopus 로고
    • A human model for multigenic inheritance: Phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus
    • Bolk S, Pelet A, Hofstra RM, et al. A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus. Proc Natl Acad Sci U S A. 2000;97:268-273.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , pp. 268-273
    • Bolk, S.1    Pelet, A.2    Hofstra, R.M.3
  • 51
    • 7344264981 scopus 로고    scopus 로고
    • Oncological implications of RET gene mutations in Hirschsprung's disease
    • Sijmons RH, Hofstra RM, Wijburg FA, et al. Oncological implications of RET gene mutations in Hirschsprung's disease. Gut. 1998;43:542-547.
    • (1998) Gut. , vol.43 , pp. 542-547
    • Sijmons, R.H.1    Hofstra, R.M.2    Wijburg, F.A.3
  • 52
    • 0031915455 scopus 로고    scopus 로고
    • Occurrence of MEN 2a in familial Hirschsprung's disease: A new indication for genetic testing of the RET proto-oncogene
    • Decker RA, Peacock ML. Occurrence of MEN 2a in familial Hirschsprung's disease: a new indication for genetic testing of the RET proto-oncogene. J Pediatr Surg. 1998;33:207-214.
    • (1998) J Pediatr Surg. , vol.33 , pp. 207-214
    • Decker, R.A.1    Peacock, M.L.2
  • 53
    • 33645290520 scopus 로고    scopus 로고
    • RET receptor signaling: Dysfunction in thyroid cancer and Hirschsprung's disease
    • Asai N, Jijiwa M, Enomoto A, et al. RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease. Pathol Int. 2006;56:164-172.
    • (2006) Pathol Int. , vol.56 , pp. 164-172
    • Asai, N.1    Jijiwa, M.2    Enomoto, A.3
  • 54
    • 0032967662 scopus 로고    scopus 로고
    • Intestinal ganglioneuromatosis and multiple endocrine neoplasia type 2B: Implications for treatment
    • Smith VV, Eng C, Milla PJ. Intestinal ganglioneuromatosis and multiple endocrine neoplasia type 2B: implications for treatment. Gut. 1999;45:143-146.
    • (1999) Gut. , vol.45 , pp. 143-146
    • Smith, V.V.1    Eng, C.2    Milla, P.J.3
  • 55
    • 0036240262 scopus 로고    scopus 로고
    • Gastrointestinal manifestations of multiple endocrine neoplasia type 2
    • discussion 654-655
    • Cohen MS, Phay JE, Albinson C, et al. Gastrointestinal manifestations of multiple endocrine neoplasia type 2. Ann Surg. 2002; 235:648-654; discussion 654-655.
    • (2002) Ann Surg. , vol.235 , pp. 648-654
    • Cohen, M.S.1    Phay, J.E.2    Albinson, C.3
  • 56
    • 0037080134 scopus 로고    scopus 로고
    • Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: Presence of C-cell malignant disease in asymptomatic carriers
    • Sanso GE, Domene HM, Garcia R, et al. Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers. Cancer. 2002; 94:323-330.
    • (2002) Cancer. , vol.94 , pp. 323-330
    • Sanso, G.E.1    Domene, H.M.2    Garcia, R.3
  • 57
    • 58849130564 scopus 로고    scopus 로고
    • Early diagnosis of multiple endocrine neoplasia type 2B: A challenge for physicians
    • Camacho CP, Hoff AO, Lindsey SC, et al. Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians. Arq Bras Endocrinol Metabol. 2008;52:1393-1398.
    • (2008) Arq Bras Endocrinol Metabol. , vol.52 , pp. 1393-1398
    • Camacho, C.P.1    Hoff, A.O.2    Lindsey, S.C.3
  • 59
    • 77951474913 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia [corrected] syndrome type 2B in early childhood: Long-term benefit of prophylactic thyroidectomy [Erratum appears in Cancer. 2010; 116:2727]
    • Waguespack SG, Rich TA. Multiple endocrine neoplasia [corrected] syndrome type 2B in early childhood: long-term benefit of prophylactic thyroidectomy [Erratum appears in Cancer. 2010; 116:2727]. Cancer. 2010;116:2284.
    • (2010) Cancer. , vol.116 , pp. 2284
    • Waguespack, S.G.1    Rich, T.A.2
  • 60
    • 16644397114 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: Clinical manifestation and course in early and late onset disease
    • Brauckhoff M, Gimm O, Weiss CL, et al. Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease. World J Surg. 2004;28:1305-1311.
    • (2004) World J Surg. , vol.28 , pp. 1305-1311
    • Brauckhoff, M.1    Gimm, O.2    Weiss, C.L.3
  • 61
    • 65549112520 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma identified within the first year of life in children with hereditary multiple endocrine neoplasia type 2A (codon 634) and 2B
    • Zenaty D, Aigrain Y, Peuchmaur M, et al. Medullary thyroid carcinoma identified within the first year of life in children with hereditary multiple endocrine neoplasia type 2A (codon 634) and 2B. Eur J Endocrinol. 2009;160:807-813.
    • (2009) Eur J Endocrinol. , vol.160 , pp. 807-813
    • Zenaty, D.1    Aigrain, Y.2    Peuchmaur, M.3
  • 62
    • 0028019769 scopus 로고
    • Parent-of-origin effects in multiple endocrine neoplasia type 2B
    • Carlson KM, Bracamontes J, Jackson CE, et al. Parent-of-origin effects in multiple endocrine neoplasia type 2B. Am J Hum Genet. 1994;55:1076-1082.
    • (1994) Am J Hum Genet. , vol.55 , pp. 1076-1082
    • Carlson, K.M.1    Bracamontes, J.2    Jackson, C.E.3
  • 63
    • 0031018680 scopus 로고    scopus 로고
    • Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine
    • Schuffenecker I, Ginet N, Goldgar D, et al. Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine. Am J Hum Genet. 1997;60: 233-237.
    • (1997) Am J Hum Genet. , vol.60 , pp. 233-237
    • Schuffenecker, I.1    Ginet, N.2    Goldgar, D.3
  • 64
    • 0022535165 scopus 로고
    • Familial medullary thyroid carcinoma without associated endocrinopathies: A distinct clinical entity
    • Farndon JR, Leight GS, Dilley WG, et al. Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. Br J Surg. 1986;73:278-281.
    • (1986) Br J Surg. , vol.73 , pp. 278-281
    • Farndon, J.R.1    Leight, G.S.2    Dilley, W.G.3
  • 65
    • 4644256817 scopus 로고    scopus 로고
    • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    • Eng C, Clayton D, Schuffenecker I, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. Jama. 1996;276:1575-1579.
    • (1996) Jama. , vol.276 , pp. 1575-1579
    • Eng, C.1    Clayton, D.2    Schuffenecker, I.3
  • 66
    • 36549069135 scopus 로고    scopus 로고
    • Pheochromocytoma penetrance varies by RET mutation in MEN 2A
    • discussion 805.e1
    • Quayle FJ, Fialkowski EA, Benveniste R, Moley JF. Pheochromocytoma penetrance varies by RET mutation in MEN 2A. Surgery 2007;142:800-805; discussion 805.e1.
    • (2007) Surgery , vol.142 , pp. 800-805
    • Quayle, F.J.1    Fialkowski, E.A.2    Benveniste, R.3    Moley, J.F.4
  • 67
    • 68849085592 scopus 로고    scopus 로고
    • Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis
    • Rothberg AE, Raymond VM, Gruber SB, Sisson J. Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. Thyroid. 2009;19:651-655.
    • (2009) Thyroid. , vol.19 , pp. 651-655
    • Rothberg, A.E.1    Raymond, V.M.2    Gruber, S.B.3    Sisson, J.4
  • 68
    • 0028566385 scopus 로고
    • Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene
    • Mulligan LM, Eng C, Attié T, et al. Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene. Hum Mol Genet. 1994;3:2163-2167.
    • (1994) Hum Mol Genet. , vol.3 , pp. 2163-2167
    • Mulligan, L.M.1    Eng, C.2    Attié, T.3
  • 69
    • 0028916234 scopus 로고
    • Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease
    • Borst MJ, VanCamp JM, Peacock ML, Decker RA. Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease. Surgery. 1995;117:386-391.
    • (1995) Surgery. , vol.117 , pp. 386-391
    • Borst, M.J.1    Vancamp, J.M.2    Peacock, M.L.3    Decker, R.A.4
  • 70
    • 79953237136 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation
    • Jasim S, Ying AK, Waguespack SG, et al. Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation. Thyroid. 2011;21:189-192.
    • (2011) Thyroid. , vol.21 , pp. 189-192
    • Jasim, S.1    Ying, A.K.2    Waguespack, S.G.3
  • 71
    • 85020449762 scopus 로고    scopus 로고
    • MEN2B patients with a RET A883F mutation have less aggressive MTC than those with the common RET M918T mutation
    • March 15-18 Manchester, UK
    • Worth G, Palazzo F, Tolley N, et al. MEN2B patients with a RET A883F mutation have less aggressive MTC than those with the common RET M918T mutation. In: Society for Endocrinology; March 15-18, 2010; Manchester, UK; p 219.
    • (2010) Society for Endocrinology , pp. 219
    • Worth, G.1    Palazzo, F.2    Tolley, N.3
  • 72
    • 0033045514 scopus 로고    scopus 로고
    • Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation
    • Miyauchi A, Futami H, Hai N, et al. Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation. Jpn J Cancer Res. 1999;90:1-5.
    • (1999) Jpn J Cancer Res. , vol.90 , pp. 1-5
    • Miyauchi, A.1    Futami, H.2    Hai, N.3
  • 73
    • 0036148536 scopus 로고    scopus 로고
    • AtypicalMENtype 2B associated with two germline RET mutations on the same allele not involving codon 918
    • Menko FH, van der Luijt RB, de Valk IA, et al. AtypicalMENtype 2B associated with two germline RET mutations on the same allele not involving codon 918. J Clin Endocrinol Metab. 2002;87:393-397.
    • (2002) J Clin Endocrinol Metab. , vol.87 , pp. 393-397
    • Menko, F.H.1    Van Der Luijt, R.B.2    De Valk, I.A.3
  • 74
    • 33750551726 scopus 로고    scopus 로고
    • RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B
    • Cranston AN, Carniti C, Oakhill K, et al. RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Res. 2006; 66:10179-10187.
    • (2006) Cancer Res. , vol.66 , pp. 10179-10187
    • Cranston, A.N.1    Carniti, C.2    Oakhill, K.3
  • 75
    • 9344234978 scopus 로고    scopus 로고
    • Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group
    • Frank-Raue K, Höppner W, Frilling A, et al. Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group. J Clin Endocrinol Metab. 1996; 81:1780-1783.
    • (1996) J Clin Endocrinol Metab. , vol.81 , pp. 1780-1783
    • Frank-Raue, K.1    Höppner, W.2    Frilling, A.3
  • 76
    • 0028027543 scopus 로고
    • RETproto-oncogene mutations in French MEN 2A and FMTC families
    • Schuffenecker I, Billaud M, Calender A, et al.RETproto-oncogene mutations in French MEN 2A and FMTC families. Hum Mol Genet. 1994;3:1939-1943.
    • (1994) Hum Mol Genet. , vol.3 , pp. 1939-1943
    • Schuffenecker, I.1    Billaud, M.2    Calender, A.3
  • 78
    • 80052486093 scopus 로고    scopus 로고
    • The RET p.G533C mutation confers predisposition to multiple endocrine neoplasia type 2A in a Brazilian kindred and is able to induce a malignant phenotype in vitro and in vivo
    • Oliveira MN, Hemerly JP, Bastos AU, et al. The RET p.G533C mutation confers predisposition to multiple endocrine neoplasia type 2A in a Brazilian kindred and is able to induce a malignant phenotype in vitro and in vivo. Thyroid. 2011;21:975-985.
    • (2011) Thyroid. , vol.21 , pp. 975-985
    • Oliveira, M.N.1    Hemerly, J.P.2    Bastos, A.U.3
  • 79
    • 34548653042 scopus 로고    scopus 로고
    • A newly detected mutation of theRETprotooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2A
    • Bethanis S, Koutsodontis G, Palouka T, et al. A newly detected mutation of theRETprotooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2A. Hormones (Athens). 2007;6:152-156.
    • (2007) Hormones (Athens). , vol.6 , pp. 152-156
    • Bethanis, S.1    Koutsodontis, G.2    Palouka, T.3
  • 80
    • 58149335397 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene
    • Peppa M, Boutati E, Kamakari S, et al. Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene. Eur J Endocrinol. 2008;159:767-771.
    • (2008) Eur J Endocrinol. , vol.159 , pp. 767-771
    • Peppa, M.1    Boutati, E.2    Kamakari, S.3
  • 81
    • 0031765304 scopus 로고    scopus 로고
    • A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A
    • Berndt I, Reuter M, Saller B, et al. A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A. J Clin Endocrinol Metab. 1998;83:770-774.
    • (1998) J Clin Endocrinol Metab. , vol.83 , pp. 770-774
    • Berndt, I.1    Reuter, M.2    Saller, B.3
  • 82
    • 77952877804 scopus 로고    scopus 로고
    • Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC
    • Frank-Raue K, Rondot S, Raue F. Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC. Mol Cell Endocrinol. 2010;322:2-7.
    • (2010) Mol Cell Endocrinol. , vol.322 , pp. 2-7
    • Frank-Raue, K.1    Rondot, S.2    Raue, F.3
  • 83
    • 77955364851 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2 syndromes (MEN 2): Results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes
    • Romei C, Mariotti S, Fugazzola L, et al. Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes. Eur J Endocrinol. 2010;163:301-308.
    • (2010) Eur J Endocrinol. , vol.163 , pp. 301-308
    • Romei, C.1    Mariotti, S.2    Fugazzola, L.3
  • 85
    • 0034997254 scopus 로고    scopus 로고
    • Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of theRETproto-oncogene demonstrating low grade malignancy
    • Siggelkow H, Melzer A, Nolte W, Karsten K, Hoppner W, Hufner M. Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of theRETproto-oncogene demonstrating low grade malignancy. Eur J Endocrinol. 2001;144: 467-473.
    • (2001) Eur J Endocrinol. , vol.144 , pp. 467-473
    • Siggelkow, H.1    Melzer, A.2    Nolte, W.3    Karsten, K.4    Hoppner, W.5    Hufner, M.6
  • 86
    • 3242729164 scopus 로고    scopus 로고
    • A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma
    • Jimenez C, Dang GT, Schultz PN, et al. A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma. J Clin Endocrinol Metab. 2004;89:3521-3526.
    • (2004) J Clin Endocrinol Metab. , vol.89 , pp. 3521-3526
    • Jimenez, C.1    Dang, G.T.2    Schultz, P.N.3
  • 87
    • 0030437796 scopus 로고    scopus 로고
    • Familial medullary thyroid carcinoma: Not a distinct entity? Genotype-phenotype correlation in a large family
    • Moers AM, Landsvater RM, Schaap C, et al. Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family. Am J Med. 1996;101:635-641.
    • (1996) Am J Med. , vol.101 , pp. 635-641
    • Moers, A.M.1    Landsvater, R.M.2    Schaap, C.3
  • 89
    • 4644312198 scopus 로고    scopus 로고
    • Reference intervals for serum calcitonin in men, women, and children
    • Basuyau JP, Mallet E, Leroy M, Brunelle P. Reference intervals for serum calcitonin in men, women, and children. Clin Chem. 2004; 50:1828-1830.
    • (2004) Clin Chem. , vol.50 , pp. 1828-1830
    • Basuyau, J.P.1    Mallet, E.2    Leroy, M.3    Brunelle, P.4
  • 90
    • 33745445205 scopus 로고    scopus 로고
    • Normal range of calcitonin in children measured by a chemiluminescent two-site immunometric assay
    • Verga U, Morpurgo PS, Vaghi I, Radetti G, Beck-Peccoz P. Normal range of calcitonin in children measured by a chemiluminescent two-site immunometric assay. Horm Res. 2006;66:17-20.
    • (2006) Horm Res. , vol.66 , pp. 17-20
    • Verga, U.1    Morpurgo, P.S.2    Vaghi, I.3    Radetti, G.4    Beck-Peccoz, P.5
  • 91
    • 32544440758 scopus 로고    scopus 로고
    • Hook effect" in calcitonin immunoradiometric assay in patients with metastatic medullary thyroid carcinoma: Case report and review of the literature
    • Leboeuf R, Langlois MF, Martin M, Ahnadi CE, Fink GD. "Hook effect" in calcitonin immunoradiometric assay in patients with metastatic medullary thyroid carcinoma: case report and review of the literature. J Clin Endocrinol Metab. 2006;91:361-364.
    • (2006) J Clin Endocrinol Metab. , vol.91 , pp. 361-364
    • Leboeuf, R.1    Langlois, M.F.2    Martin, M.3    Ahnadi, C.E.4    Fink, G.D.5
  • 92
    • 10744223544 scopus 로고    scopus 로고
    • Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: Experience in 10, 864 patients with nodular thyroid disorders
    • Elisei R, Bottici V, Luchetti F, et al. Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10, 864 patients with nodular thyroid disorders. J Clin Endocrinol Metab. 2004;89:163-168.
    • (2004) J Clin Endocrinol Metab. , vol.89 , pp. 163-168
    • Elisei, R.1    Bottici, V.2    Luchetti, F.3
  • 93
    • 33846964878 scopus 로고    scopus 로고
    • Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules
    • Costante G, Meringolo D, Durante C, et al. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab. 2007;92:450-455.
    • (2007) J Clin Endocrinol Metab. , vol.92 , pp. 450-455
    • Costante, G.1    Meringolo, D.2    Durante, C.3
  • 94
    • 1242272712 scopus 로고    scopus 로고
    • Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation
    • Karges W, Dralle H, Raue F, et al. Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation. Exp Clin Endocrinol Diabetes. 2004;112:52-58.
    • (2004) Exp Clin Endocrinol Diabetes. , vol.112 , pp. 52-58
    • Karges, W.1    Dralle, H.2    Raue, F.3
  • 95
    • 33645465719 scopus 로고    scopus 로고
    • Management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    • Cooper DS, Doherty GM, Haugen BR, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006;16:109-142.
    • (2006) Thyroid. , vol.16 , pp. 109-142
    • Cooper, D.S.1    Doherty, G.M.2    Haugen, B.R.3
  • 96
    • 17944370976 scopus 로고    scopus 로고
    • Familial medullary thyroid carcinoma with noncysteine ret mutations: Phenotype-genotype relationship in a large series of patients
    • Niccoli-Sire P, Murat A, Rohmer V, et al. Familial medullary thyroid carcinoma with noncysteine ret mutations: phenotype-genotype relationship in a large series of patients. J Clin Endocrinol Metab. 2001;86:3746-3753.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 3746-3753
    • Niccoli-Sire, P.1    Murat, A.2    Rohmer, V.3
  • 97
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N, Iwashita T, Matsuyama M, Takahashi M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol. 1995;15:1613-1619.
    • (1995) Mol Cell Biol. , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 98
    • 0028914683 scopus 로고
    • Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
    • Santoro M, Carlomagno F, Romano A, et al. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science. 1995;267:381-383.
    • (1995) Science. , vol.267 , pp. 381-383
    • Santoro, M.1    Carlomagno, F.2    Romano, A.3
  • 99
    • 13344286328 scopus 로고
    • RET activation by germline MEN2A and MEN2B mutations
    • BorrelloMG, Smith DP, Pasini B, et al. RET activation by germline MEN2A and MEN2B mutations. Oncogene. 1995;11:2419-2427.
    • (1995) Oncogene. , vol.11 , pp. 2419-2427
    • Borrello, M.G.1    Smith, D.P.2    Pasini, B.3
  • 100
    • 0028938721 scopus 로고
    • Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
    • Songyang Z, Carraway KL 3rd, Eck MJ, et al. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature. 1995;373:536-539.
    • (1995) Nature. , vol.373 , pp. 536-539
    • Songyang, Z.1    Carraway III, K.L.2    Eck, M.J.3
  • 101
    • 33845963343 scopus 로고    scopus 로고
    • Structure and chemical inhibition of the RET tyrosine kinase domain
    • Knowles PP, Murray-Rust J, Kjaer S, et al. Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem. 2006; 281:33577-33587.
    • (2006) J Biol Chem. , vol.281 , pp. 33577-33587
    • Knowles, P.P.1    Murray-Rust, J.2    Kjaer, S.3
  • 102
    • 84881516498 scopus 로고    scopus 로고
    • GTR:Genetic Testing Registry. National Center for Biotechnology Information, U.S. National Library of Medicine Accessed June 22, 2013
    • GTR:Genetic Testing Registry. National Center for Biotechnology Information, U.S. National Library of Medicine. http:// www.ncbi.nlm.nih.gov/ gtr/. Accessed June 22, 2013.
  • 103
    • 0029028664 scopus 로고
    • Low frequency of germline mutations in the RET proto-oncogene in patients with apparently sporadic medullary thyroid carcinoma
    • Eng C, Mulligan LM, Smith DP, et al. Low frequency of germline mutations in the RET proto-oncogene in patients with apparently sporadic medullary thyroid carcinoma. Clin Endocrinol (Oxf). 1995;43:123-127.
    • (1995) Clin Endocrinol (Oxf). , vol.43 , pp. 123-127
    • Eng, C.1    Mulligan, L.M.2    Smith, D.P.3
  • 104
    • 36849056630 scopus 로고    scopus 로고
    • RET genetic screening in patients with medullary thyroid cancer and their relatives: Experience with 807 individuals at one center
    • Elisei R, Romei C, Cosci B, et al. RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. J Clin Endocrinol Metab. 2007;92: 4725-4729.
    • (2007) J Clin Endocrinol Metab. , vol.92 , pp. 4725-4729
    • Elisei, R.1    Romei, C.2    Cosci, B.3
  • 105
    • 84865148926 scopus 로고    scopus 로고
    • Pediatric ethics guidelines for hereditary medullary thyroid cancer
    • Rosenthal MS, Diekema DS. Pediatric ethics guidelines for hereditary medullary thyroid cancer. Int J Pediatr Endocrinol. 2011; 2011:847603.
    • (2011) Int J Pediatr Endocrinol. , vol.2011 , pp. 847603
    • Rosenthal, M.S.1    Diekema, D.S.2
  • 107
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma: Demographic, clinical, and pathologic predictors of survival in 1252 cases
    • Roman S, Lin R, Sosa JA. Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer. 2006;107:2134-2142.
    • (2006) Cancer. , vol.107 , pp. 2134-2142
    • Roman, S.1    Lin, R.2    Sosa, J.A.3
  • 108
    • 17844400055 scopus 로고    scopus 로고
    • Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level
    • Machens A, Schneyer U, Holzhausen HJ, Dralle H. Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level. J Clin Endocrinol Metab. 2005;90:2029-2034.
    • (2005) J Clin Endocrinol Metab. , vol.90 , pp. 2029-2034
    • Machens, A.1    Schneyer, U.2    Holzhausen, H.J.3    Dralle, H.4
  • 109
    • 34547415590 scopus 로고    scopus 로고
    • Locoregional recurrence and death from medullary thyroid carcinoma in a contemporaneous series: 5-year results
    • Machens A, Hofmann C, Hauptmann S, Dralle H. Locoregional recurrence and death from medullary thyroid carcinoma in a contemporaneous series: 5-year results. Eur J Endocrinol. 2007;157: 85-93.
    • (2007) Eur J Endocrinol. , vol.157 , pp. 85-93
    • Machens, A.1    Hofmann, C.2    Hauptmann, S.3    Dralle, H.4
  • 110
    • 34248158281 scopus 로고    scopus 로고
    • Evidence-based approach to the management of sporadic medullary thyroid carcinoma
    • Moley JF, Fialkowski EA. Evidence-based approach to the management of sporadic medullary thyroid carcinoma. World J Surg. 2007;31:946-956.
    • (2007) World J Surg. , vol.31 , pp. 946-956
    • Moley, J.F.1    Fialkowski, E.A.2
  • 111
    • 14444272505 scopus 로고    scopus 로고
    • Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: Results in 899 patients. The GETC Study Group. Groupe d'etude des tumeurs a calcitonine
    • Modigliani E, Cohen R, Campos JM, et al. Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: results in 899 patients. The GETC Study Group. Groupe d'etude des tumeurs a calcitonine. Clin Endocrinol (Oxf). 1998;48:265-273.
    • (1998) Clin Endocrinol (Oxf). , vol.48 , pp. 265-273
    • Modigliani, E.1    Cohen, R.2    Campos, J.M.3
  • 113
    • 28844469325 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma
    • Kinlaw WB, Scott SM, Maue RA, et al. Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma. Clin Endocrinol (Oxf). 2005;63:676-682.
    • (2005) Clin Endocrinol (Oxf). , vol.63 , pp. 676-682
    • Kinlaw, W.B.1    Scott, S.M.2    Maue, R.A.3
  • 114
    • 70449526559 scopus 로고    scopus 로고
    • Characterization of the largest kindred with MEN2A due to a Cys609Ser RET mutation
    • Mian C, Barollo S, Zambonin L, et al. Characterization of the largest kindred with MEN2A due to a Cys609Ser RET mutation. Fam Cancer. 2009;8:379-382.
    • (2009) Fam Cancer. , vol.8 , pp. 379-382
    • Mian, C.1    Barollo, S.2    Zambonin, L.3
  • 115
    • 18444398955 scopus 로고    scopus 로고
    • Occurrence of pheochromocytoma in aMEN2Afamily with codon 609 mutation of the RET proto-oncogene
    • Igaz P, Patocs A, Racz K, Klein I, Varadi A, Esik O. Occurrence of pheochromocytoma in aMEN2Afamily with codon 609 mutation of the RET proto-oncogene. J Clin Endocrinol Metab. 2002;87: 2994.
    • (2002) J Clin Endocrinol Metab. , vol.87 , pp. 2994
    • Igaz, P.1    Patocs, A.2    Racz, K.3    Klein, I.4    Varadi, A.5    Esik, O.6
  • 116
    • 67650999685 scopus 로고    scopus 로고
    • When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation?
    • Calva D, O'Dorisio TM, Sue O'Dorisio M, et al. When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation? Ann Surg Oncol. 2009;16:2237-2244.
    • (2009) Ann Surg Oncol. , vol.16 , pp. 2237-2244
    • Calva, D.1    O'Dorisio, T.M.2    Sue O'Dorisio, M.3
  • 117
    • 0036255690 scopus 로고    scopus 로고
    • V804M RET mutation and familial medullary thyroid carcinoma: Report of a large family with expression of the disease only in the homozygous gene carriers
    • Lecube A, Hernandez C, Oriola J, et al. V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers. Surgery. 2002;131:509-514.
    • (2002) Surgery. , vol.131 , pp. 509-514
    • Lecube, A.1    Hernandez, C.2    Oriola, J.3
  • 118
    • 0033670409 scopus 로고    scopus 로고
    • Update on the MEN 2A c804 RET mutation: Is prophylactic thyroidectomy indicated?
    • discussion 1057-1058
    • Frohnauer MK, Decker RA. Update on the MEN 2A c804 RET mutation: is prophylactic thyroidectomy indicated? Surgery. 2000; 128:1052-1057; discussion 1057-1058.
    • (2000) Surgery. , vol.128 , pp. 1052-1057
    • Frohnauer, M.K.1    Decker, R.A.2
  • 119
    • 0033917197 scopus 로고    scopus 로고
    • Variable expressivityof familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-ATG) mutation
    • Feldman GL, Edmonds MW, Ainsworth PJ, et al. Variable expressivityof familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-ATG) mutation. Surgery. 2000;128:93-98.
    • (2000) Surgery. , vol.128 , pp. 93-98
    • Feldman, G.L.1    Edmonds, M.W.2    Ainsworth, P.J.3
  • 120
    • 84856950356 scopus 로고    scopus 로고
    • The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center
    • Elisei R, Romei C, Renzini G, et al. The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center. J Clin Endocrinol Metab. 2012;97:426-435.
    • (2012) J Clin Endocrinol Metab. , vol.97 , pp. 426-435
    • Elisei, R.1    Romei, C.2    Renzini, G.3
  • 121
    • 9044232867 scopus 로고    scopus 로고
    • The identification of false positive responses to the pentagastrin stimulation test in RET mutation negative members of MEN 2A families
    • Marsh DJ, McDowall D, Hyland VJ, et al. The identification of false positive responses to the pentagastrin stimulation test in RET mutation negative members of MEN 2A families. Clin Endocrinol (Oxf). 1996;44:213-220.
    • (1996) Clin Endocrinol (Oxf). , vol.44 , pp. 213-220
    • Marsh, D.J.1    McDowall, D.2    Hyland, V.J.3
  • 122
    • 0027480815 scopus 로고
    • The clinical implications of a positive calcitonin test for C-cell hyperplasia in genetically unaffected members of an MEN2Akindred
    • Landsvater RM, Rombouts AG, te Meerman GJ, et al. The clinical implications of a positive calcitonin test for C-cell hyperplasia in genetically unaffected members of anMEN2Akindred.AmJHum Genet. 1993;52:335-342.
    • (1993) AmJHum Genet. , vol.52 , pp. 335-342
    • Landsvater, R.M.1    Rombouts, A.G.2    Te Meerman, G.J.3
  • 123
    • 0030945124 scopus 로고    scopus 로고
    • False-positive results of basal and pentagastrin-stimulated calcitonin in non-gene carriers of multiple endocrine neoplasia type 2A
    • Hernández G, Simó R, Oriola J, Mesa J. False-positive results of basal and pentagastrin-stimulated calcitonin in non-gene carriers of multiple endocrine neoplasia type 2A. Thyroid. 1997;7:51-54.
    • (1997) Thyroid. , vol.7 , pp. 51-54
    • Hernández, G.1    Simó, R.2    Oriola, J.3    Mesa, J.4
  • 124
    • 28844445630 scopus 로고    scopus 로고
    • Experience of prophylactic thyroidectomy in multiple endocrine neoplasia type 2A kindreds with RET codon 804 mutations
    • Learoyd DL, Gosnell J, ElstonMS, et al. Experience of prophylactic thyroidectomy in multiple endocrine neoplasia type 2A kindreds with RET codon 804 mutations. Clin Endocrinol (Oxf). 2005;63: 636-641.
    • (2005) Clin Endocrinol (Oxf). , vol.63 , pp. 636-641
    • Learoyd, D.L.1    Elstonms, G.J.2
  • 125
    • 0021368579 scopus 로고
    • Relation of doubling time of plasma calcitonin levels to prognosis and recurrence of medullary thyroid carcinoma
    • Miyauchi A, Onishi T, MorimotoS, et al. Relation of doubling time of plasma calcitonin levels to prognosis and recurrence of medullary thyroid carcinoma. Ann Surg. 1984;199:461-466.
    • (1984) Ann Surg. , vol.199 , pp. 461-466
    • Miyauchi, A.1    Morimotos, O.T.2
  • 126
    • 27744485886 scopus 로고    scopus 로고
    • Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    • GTE Study Group.
    • Barbet J, Campion L, Kraeber-Bodéré F, Chatal JF; GTE Study Group. Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma. J Clin Endocrinol Metab. 2005;90:6077-6084.
    • (2005) J Clin Endocrinol Metab. , vol.90 , pp. 6077-6084
    • Barbet, J.1    Campion, L.2    Kraeber-Bodéré, F.3    Chatal, J.F.4
  • 127
    • 0021325077 scopus 로고
    • Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma
    • Busnardo B, Girelli ME, Simioni N, Nacamulli D, Busetto E. Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma. Cancer. 1984; 53:278-285.
    • (1984) Cancer. , vol.53 , pp. 278-285
    • Busnardo, B.1    Girelli, M.E.2    Simioni, N.3    Nacamulli, D.4    Busetto, E.5
  • 128
    • 0023204936 scopus 로고
    • Gastric carcinoid tumors, endocrine cell hyperplasia, and associated intestinal metaplasia. Histologic, histochemical, and immunohistochemical findings
    • Mendelsohn G, de la Monte S, Dunn JL, Yardley JH. Gastric carcinoid tumors, endocrine cell hyperplasia, and associated intestinal metaplasia. Histologic, histochemical, and immunohistochemical findings. Cancer. 1987;60:1022-1031.
    • (1987) Cancer. , vol.60 , pp. 1022-1031
    • Mendelsohn, G.1    De La Monte, S.2    Dunn, J.L.3    Yardley, J.H.4
  • 129
    • 0022626440 scopus 로고
    • Reoperation in the treatment of asymptomatic metastasizing medullary thyroid carcinoma
    • Tisell LE, Hansson G, Jansson S, Salander H. Reoperation in the treatment of asymptomatic metastasizing medullary thyroid carcinoma. Surgery. 1986;99:60-66.
    • (1986) Surgery. , vol.99 , pp. 60-66
    • Tisell, L.E.1    Hansson, G.2    Jansson, S.3    Salander, H.4
  • 130
    • 0036359652 scopus 로고    scopus 로고
    • Lymph node dissection and medullary thyroid carcinoma
    • Dralle H. Lymph node dissection and medullary thyroid carcinoma. Br J Surg. 2002;89:1073-1075.
    • (2002) Br J Surg. , vol.89 , pp. 1073-1075
    • Dralle, H.1
  • 131
    • 42449107686 scopus 로고    scopus 로고
    • Long-term outcome of reoperations for medullary thyroid carcinoma
    • Fialkowski E, DeBenedetti M, Moley J. Long-term outcome of reoperations for medullary thyroid carcinoma. World J Surg. 2008;32:754-765.
    • (2008) World J Surg. , vol.32 , pp. 754-765
    • Fialkowski, E.1    Debenedetti, M.2    Moley, J.3
  • 132
    • 47549104319 scopus 로고    scopus 로고
    • Postoperative radiotherapy for advanced medullary thyroid cancer-local disease control in the modern era
    • Schwartz DL, Rana V, ShawS, et al. Postoperative radiotherapy for advanced medullary thyroid cancer-local disease control in the modern era. Head Neck. 2008;30:883-888.
    • (2008) Head Neck. , vol.30 , pp. 883-888
    • Schwartz, D.L.1    Shaws, R.V.2
  • 133
    • 0035679630 scopus 로고    scopus 로고
    • The role of radiotherapy in the management of elevated calcitonin after surgery for medullary thyroid cancer
    • Fersht N, Vini L, A'Hern R, Harmer C. The role of radiotherapy in the management of elevated calcitonin after surgery for medullary thyroid cancer. Thyroid. 2001;11:1161-1168.
    • (2001) Thyroid. , vol.11 , pp. 1161-1168
    • Fersht, N.1    Vini, L.2    A'Hern, R.3    Harmer, C.4
  • 134
    • 0013930214 scopus 로고
    • Diarrhoea and thyroid carcinoma
    • Williams ED. Diarrhoea and thyroid carcinoma. Proc R Soc Med. 1966;59:602-603.
    • (1966) Proc R Soc Med. , vol.59 , pp. 602-603
    • Williams, E.D.1
  • 135
    • 29144439756 scopus 로고    scopus 로고
    • Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma
    • discussion 993
    • Lorenz K, Brauckhoff M, Behrmann C, et al. Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma. Surgery. 2005;138:986-993; discussion 993.
    • (2005) Surgery. , vol.138 , pp. 986-993
    • Lorenz, K.1    Brauckhoff, M.2    Behrmann, C.3
  • 137
    • 22244486665 scopus 로고    scopus 로고
    • Ectopic adrenocorticotropic hormone-syndrome in medullary carcinoma of the thyroid: A retrospective analysis and review of the literature
    • Barbosa SL, Rodien P, Leboulleux S, et al. Ectopic adrenocorticotropic hormone-syndrome in medullary carcinoma of the thyroid: a retrospective analysis and review of the literature. Thyroid. 2005; 15:618-623.
    • (2005) Thyroid. , vol.15 , pp. 618-623
    • Barbosa, S.L.1    Rodien, P.2    Leboulleux, S.3
  • 138
    • 84866244957 scopus 로고    scopus 로고
    • Management strategies for aggressive Cushing's syndrome: From macroadenomas to ectopics
    • Pozza C, Graziadio C, Giannetta E, Lenzi A, Isidori AM. Management strategies for aggressive Cushing's syndrome: from macroadenomas to ectopics. J Oncol. 2012;2012:685213.
    • (2012) J Oncol. , vol.2012 , pp. 685213
    • Pozza, C.1    Graziadio, C.2    Giannetta, E.3    Lenzi, A.4    Isidori, A.M.5
  • 139
    • 0029916917 scopus 로고    scopus 로고
    • Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables
    • Dottorini ME, Assi A, Sironi M, Sangalli G, Spreafico G, Colombo L. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables. Cancer. 1996;77:1556-1565.
    • (1996) Cancer. , vol.77 , pp. 1556-1565
    • Dottorini, M.E.1    Assi, A.2    Sironi, M.3    Sangalli, G.4    Spreafico, G.5    Colombo, L.6
  • 140
    • 0025322092 scopus 로고
    • Combination chemotherapy of advanced medullary and differentiated thyroid cancer. Phase II study
    • Scherübl H, Raue F, Ziegler R. Combination chemotherapy of advanced medullary and differentiated thyroid cancer. Phase II study. J Cancer Res Clin Oncol. 1990;116:21-23.
    • (1990) J Cancer Res Clin Oncol. , vol.116 , pp. 21-23
    • Scherübl, H.1    Raue, F.2    Ziegler, R.3
  • 141
    • 0028876778 scopus 로고
    • Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. The Groupe d'Etude des Tumeurs a Calcitonine (GETC)
    • Schlumberger M, Abdelmoumene N, Delisle MJ, Couette JE. Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. The Groupe d'Etude des Tumeurs a Calcitonine (GETC). Br J Cancer. 1995;71:363-365.
    • (1995) Br J Cancer. , vol.71 , pp. 363-365
    • Schlumberger, M.1    Abdelmoumene, N.2    Delisle, M.J.3    Couette, J.E.4
  • 142
    • 34548189195 scopus 로고    scopus 로고
    • Phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid carcinomas
    • Ain KB, Lee C, Williams KD. Phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid carcinomas. Thyroid. 2007;17:663-670.
    • (2007) Thyroid. , vol.17 , pp. 663-670
    • Ain, K.B.1    Lee, C.2    Williams, K.D.3
  • 143
    • 58149387609 scopus 로고    scopus 로고
    • Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma
    • Woyach JA, Kloos RT, Ringel MD, et al. Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma. J Clin Endocrinol Metab. 2009;94:164-170.
    • (2009) J Clin Endocrinol Metab. , vol.94 , pp. 164-170
    • Woyach, J.A.1    Kloos, R.T.2    Ringel, M.D.3
  • 144
    • 33744961755 scopus 로고    scopus 로고
    • Phase II study of celecoxib in metastatic differentiated thyroid carcinoma
    • Mrozek E, Kloos RT, Ringel MD, et al. Phase II study of celecoxib in metastatic differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2006;91:2201-2204.
    • (2006) J Clin Endocrinol Metab. , vol.91 , pp. 2201-2204
    • Mrozek, E.1    Kloos, R.T.2    Ringel, M.D.3
  • 146
    • 2442474103 scopus 로고    scopus 로고
    • Dendritic cell vaccination in medullary thyroid carcinoma
    • Stift A, Sachet M, Yagubian R, et al. Dendritic cell vaccination in medullary thyroid carcinoma. Clin Cancer Res. 2004;10:2944-2953.
    • (2004) Clin Cancer Res. , vol.10 , pp. 2944-2953
    • Stift, A.1    Sachet, M.2    Yagubian, R.3
  • 147
    • 33645834287 scopus 로고    scopus 로고
    • Survival improvement in patients with medullary thyroid carcinoma who undergo pretargeted anti-carcinoembryonic-antigen radioimmunotherapy: A collaborative study with the French Endocrine Tumor Group
    • Chatal JF, Campion L, Kraeber-Bodéré F, et al. Survival improvement in patients with medullary thyroid carcinoma who undergo pretargeted anti-carcinoembryonic-antigen radioimmunotherapy: a collaborative study with the French Endocrine Tumor Group. J Clin Oncol. 2006;24:1705-1711.
    • (2006) J Clin Oncol. , vol.24 , pp. 1705-1711
    • Chatal, J.F.1    Campion, L.2    Kraeber-Bodéré, F.3
  • 148
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355:2408-2417.
    • (2006) N Engl J Med. , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 149
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009; 361:947-957.
    • (2009) N Engl J Med. , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 150
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • ChapmanPB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507-2516.
    • (2011) N Engl J Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 151
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol. 2008;26:4708-4713.
    • (2008) J Clin Oncol. , vol.26 , pp. 4708-4713
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 152
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • Schlumberger MJ, Elisei R, Bastholt L, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol. 2009;27:3794-3801.
    • (2009) J Clin Oncol. , vol.27 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3
  • 153
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • Lam ET, Ringel MD, Kloos RT, et al. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol. 2010;28:2323-2330.
    • (2010) J Clin Oncol. , vol.28 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 154
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab. 2010;95:2664-2671.
    • (2010) J Clin Endocrinol Metab. , vol.95 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 155
    • 79959936054 scopus 로고    scopus 로고
    • Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
    • Kurzrock R, Sherman SI, Ball DW, et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol. 2011;29:2660-2666.
    • (2011) J Clin Oncol. , vol.29 , pp. 2660-2666
    • Kurzrock, R.1    Sherman, S.I.2    Ball, D.W.3
  • 158
    • 79953904634 scopus 로고    scopus 로고
    • Inhibition of the Ras/ Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies
    • Hong DS, Cabanillas ME, Wheler J, et al. Inhibition of the Ras/ Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies. J Clin Endocrinol Metab. 2011;96:997-1005.
    • (2011) J Clin Endocrinol Metab. , vol.96 , pp. 997-1005
    • Hong, D.S.1    Cabanillas, M.E.2    Wheler, J.3
  • 159
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • Wells SA Jr, Robinson BG, Gagel RF, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol. 2012;30: 134-141.
    • (2012) J Clin Oncol. , vol.30 , pp. 134-141
    • Wells Jr., S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 160
    • 84867754481 scopus 로고    scopus 로고
    • An international doubleblind randomized placebo-controlled phase III trial (EXAM) of cabozantinib (XL184) in medullary thyroid carcinoma (MTC) patients (pts) with documented RECIST progression at baseline
    • (abstract)
    • Schoffski P, Elisei R, Mueller M, et al. An international, doubleblind, randomized, placebo-controlled phase III trial (EXAM) of cabozantinib (XL184) in medullary thyroid carcinoma (MTC) patients (pts) with documented RECIST progression at baseline. J Clin Oncol. 2012;30(suppl):5508 (abstract).
    • (2012) J Clin Oncol. , vol.30 , Issue.SUPPL. , pp. 5508
    • Schoffski, P.1    Elisei, R.2    Mueller, M.3
  • 161
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA Jr, Gosnell JE, Gagel RF, et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol. 2010;28:767-772.
    • (2010) J Clin Oncol. , vol.28 , pp. 767-772
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 162
    • 77649112149 scopus 로고    scopus 로고
    • Efficacy of sunitinib in advanced medullary thyroid carcinoma: Intermediate results of phase II THYSU
    • author reply 214
    • Ravaud A, de la Fouchardiere C, Asselineau J, et al. Efficacy of sunitinib in advanced medullary thyroid carcinoma: intermediate results of phase II THYSU. Oncologist. 2010;15:212-213; author reply 214.
    • (2010) Oncologist. , vol.15 , pp. 212-213
    • Ravaud, A.1    De La Fouchardiere, C.2    Asselineau, J.3
  • 163
    • 33747080744 scopus 로고    scopus 로고
    • RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors
    • de Groot JW, Links TP, Plukker JT, Lips CJ, Hofstra RM. RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors. Endocr Rev. 2006;27:535-560.
    • (2006) Endocr Rev. , vol.27 , pp. 535-560
    • De Groot, J.W.1    Links, T.P.2    Plukker, J.T.3    Lips, C.J.4    Hofstra, R.M.5


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