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Volumn 173, Issue 3, 2013, Pages 454-462

The influence of bone marrow- and synovium-derived mesenchymal stromal cells from osteoarthritis patients on regulatory T cells in co-culture

Author keywords

Co culture; IL 6; Inflammation; Mesenchymal stromal cells; Osteoarthritis; Regulatory T cells

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALPHA1 INTEGRIN; CD146 ANTIGEN; CD4 ANTIGEN; ENDOGLIN; HERMES ANTIGEN; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; MICROSOMAL AMINOPEPTIDASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; THY 1 ANTIGEN;

EID: 84881488374     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12122     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 33746507884 scopus 로고    scopus 로고
    • Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac
    • Alvarez-Soria MA, Largo R, Santillana J etal. Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac. Ann Rheum Dis 2006; 65:998-1005.
    • (2006) Ann Rheum Dis , vol.65 , pp. 998-1005
    • Alvarez-Soria, M.A.1    Largo, R.2    Santillana, J.3
  • 2
    • 76249119260 scopus 로고    scopus 로고
    • A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells
    • Benito-Miguel M, Garcia-Carmona Y, Balsa A etal. A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells. J Immunol 2009; 183:8268-8279.
    • (2009) J Immunol , vol.183 , pp. 8268-8279
    • Benito-Miguel, M.1    Garcia-Carmona, Y.2    Balsa, A.3
  • 3
    • 0035092531 scopus 로고    scopus 로고
    • Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study
    • Young L, Katrib A, Cuello C etal. Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study. Arthritis Rheum 2001; 44:343-350.
    • (2001) Arthritis Rheum , vol.44 , pp. 343-350
    • Young, L.1    Katrib, A.2    Cuello, C.3
  • 4
    • 12144266695 scopus 로고    scopus 로고
    • Pathology of osteoarthritis
    • Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Edinburgh: Mosby
    • Bullough P. Pathology of osteoarthritis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. Edinburgh: Mosby, 2003:1835-1845.
    • (2003) Rheumatology , pp. 1835-1845
    • Bullough, P.1
  • 5
    • 0025670144 scopus 로고
    • Synovial inflammation in patients with early osteoarthritis of the knee
    • Myers SL, Brandt KD, Ehlich JW etal. Synovial inflammation in patients with early osteoarthritis of the knee. J Rheumatol 1990; 17:1662-1669.
    • (1990) J Rheumatol , vol.17 , pp. 1662-1669
    • Myers, S.L.1    Brandt, K.D.2    Ehlich, J.W.3
  • 6
    • 0023881194 scopus 로고
    • The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies
    • Revell PA, Mayston V, Lalor P etal. The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann Rheum Dis 1988; 47:300-307.
    • (1988) Ann Rheum Dis , vol.47 , pp. 300-307
    • Revell, P.A.1    Mayston, V.2    Lalor, P.3
  • 7
    • 0031047265 scopus 로고    scopus 로고
    • Synovial membrane inflammation and cytokine production in patients with early osteoarthritis
    • Smith MD, Triantafillou S, Parker A etal. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 1997; 24:365-371.
    • (1997) J Rheumatol , vol.24 , pp. 365-371
    • Smith, M.D.1    Triantafillou, S.2    Parker, A.3
  • 8
    • 33846851538 scopus 로고    scopus 로고
    • Repair of full-thickness articular cartilage defects by cultured mesenchymal stem cells transfected with the transforming growth factor beta1 gene
    • Guo X, Zheng Q, Yang S etal. Repair of full-thickness articular cartilage defects by cultured mesenchymal stem cells transfected with the transforming growth factor beta1 gene. Biomed Mater 2006; 1:206-215.
    • (2006) Biomed Mater , vol.1 , pp. 206-215
    • Guo, X.1    Zheng, Q.2    Yang, S.3
  • 9
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL etal. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418:41-49.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 10
    • 77957943567 scopus 로고    scopus 로고
    • The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs
    • Lyons FG, Al-Munajjed AA, Kieran SM etal. The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs. Biomaterials 2010; 31:9232-9243.
    • (2010) Biomaterials , vol.31 , pp. 9232-9243
    • Lyons, F.G.1    Al-Munajjed, A.A.2    Kieran, S.M.3
  • 11
    • 35448996504 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells and clinical experience
    • Le Blanc K, Ringden O. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 2007; 262:509-525.
    • (2007) J Intern Med , vol.262 , pp. 509-525
    • Le Blanc, K.1    Ringden, O.2
  • 12
    • 77952923309 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders
    • Zhao S, Wehner R, Bornhauser M etal. Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev 2010; 19:607-614.
    • (2010) Stem Cells Dev , vol.19 , pp. 607-614
    • Zhao, S.1    Wehner, R.2    Bornhauser, M.3
  • 13
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E, Casazza S, Pedemonte E etal. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005; 106:1755-1761.
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3
  • 14
    • 34547402979 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    • Ortiz LA, Dutreil M, Fattman C etal. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 2007; 104:11002-11007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11002-11007
    • Ortiz, L.A.1    Dutreil, M.2    Fattman, C.3
  • 15
    • 20844440562 scopus 로고    scopus 로고
    • Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    • Togel F, Hu Z, Weiss K etal. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005; 289:F31-42.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Togel, F.1    Hu, Z.2    Weiss, K.3
  • 16
    • 34250854637 scopus 로고    scopus 로고
    • Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction
    • Guo J, Lin GS, Bao CY etal. Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction. Inflammation 2007; 30:97-104.
    • (2007) Inflammation , vol.30 , pp. 97-104
    • Guo, J.1    Lin, G.S.2    Bao, C.Y.3
  • 17
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B etal. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 18
    • 75749128260 scopus 로고    scopus 로고
    • Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level
    • Jones E, Churchman SM, English A etal. Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level. Ann Rheum Dis 2010; 69:450-457.
    • (2010) Ann Rheum Dis , vol.69 , pp. 450-457
    • Jones, E.1    Churchman, S.M.2    English, A.3
  • 19
    • 34247231682 scopus 로고    scopus 로고
    • Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis
    • Augello A, Tasso R, Negrini SM etal. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum 2007; 56:1175-1186.
    • (2007) Arthritis Rheum , vol.56 , pp. 1175-1186
    • Augello, A.1    Tasso, R.2    Negrini, S.M.3
  • 20
    • 33750933744 scopus 로고    scopus 로고
    • Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves
    • Batten P, Sarathchandra P, Antoniw JW etal. Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves. Tissue Eng 2006; 12:2263-2273.
    • (2006) Tissue Eng , vol.12 , pp. 2263-2273
    • Batten, P.1    Sarathchandra, P.2    Antoniw, J.W.3
  • 21
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    • Krampera M, Glennie S, Dyson J etal. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003; 101:3722-3729.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3
  • 22
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M etal. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30:42-48.
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3
  • 23
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M etal. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99:3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 24
    • 38949175025 scopus 로고    scopus 로고
    • Mesenchymal cells recruit and regulate T regulatory cells
    • Di Ianni M, Del Papa B, De Ioanni M etal. Mesenchymal cells recruit and regulate T regulatory cells. Exp Hematol 2008; 36:309-318.
    • (2008) Exp Hematol , vol.36 , pp. 309-318
    • Di Ianni, M.1    Del Papa, B.2    De Ioanni, M.3
  • 25
    • 17844391825 scopus 로고    scopus 로고
    • Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype
    • Maccario R, Podesta M, Moretta A etal. Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 2005; 90:516-525.
    • (2005) Haematologica , vol.90 , pp. 516-525
    • Maccario, R.1    Podesta, M.2    Moretta, A.3
  • 26
    • 34548739534 scopus 로고    scopus 로고
    • Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction
    • Prevosto C, Zancolli M, Canevali P etal. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 2007; 92:881-888.
    • (2007) Haematologica , vol.92 , pp. 881-888
    • Prevosto, C.1    Zancolli, M.2    Canevali, P.3
  • 27
    • 34548148643 scopus 로고    scopus 로고
    • Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis
    • Behrens F, Himsel A, Rehart S etal. Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Ann Rheum Dis 2007; 66:1151-1156.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1151-1156
    • Behrens, F.1    Himsel, A.2    Rehart, S.3
  • 28
    • 84887019178 scopus 로고    scopus 로고
    • Interaction of human mesenchymal stromal cells and regulatory T-cells in osteoarthritis [Abstract]
    • Hagmann S, Moradi B, Müller T etal. Interaction of human mesenchymal stromal cells and regulatory T-cells in osteoarthritis [Abstract]. Osteoarthritis Cartilage 2011; 19:S30-31.
    • (2011) Osteoarthritis Cartilage , vol.19
    • Hagmann, S.1    Moradi, B.2    Müller, T.3
  • 29
    • 84887024346 scopus 로고    scopus 로고
    • Osteoarthritis progression is accompanied by inflammatory CD4+ T-cell polarisation [Abstract]
    • Moradi B, Rosshirt N, Hagmann S etal. Osteoarthritis progression is accompanied by inflammatory CD4+ T-cell polarisation [Abstract]. Osteoarthritis Cartilage 2012; 20:S232-233.
    • (2012) Osteoarthritis Cartilage , vol.20
    • Moradi, B.1    Rosshirt, N.2    Hagmann, S.3
  • 30
    • 84881535330 scopus 로고    scopus 로고
    • National Library of Medicine (NLM) at the National Institutes of Health (NIH). ClinicalTrials.gov., homepage. Available at: (accessed 10 December 2012)
    • National Library of Medicine (NLM) at the National Institutes of Health (NIH). ClinicalTrials.gov., homepage. Available at: http://clinicaltrials.gov (accessed 10 December 2012).
  • 31
    • 79955137985 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients
    • Davatchi F, Abdollahi BS, Mohyeddin M etal. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 2010; 14:211-215.
    • (2010) Int J Rheum Dis , vol.14 , pp. 211-215
    • Davatchi, F.1    Abdollahi, B.S.2    Mohyeddin, M.3
  • 32
    • 79961149910 scopus 로고    scopus 로고
    • Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age
    • Dexheimer V, Mueller S, Braatz F etal. Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age. PLoS ONE 2011; 6:e22980.
    • (2011) PLoS ONE , vol.6
    • Dexheimer, V.1    Mueller, S.2    Braatz, F.3
  • 33
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I etal. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8:315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 34
    • 25444503061 scopus 로고    scopus 로고
    • Mesenchymal stem cells avoid allogeneic rejection
    • Ryan JM, Barry FP, Murphy JM etal. Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond) 2005; 2:8.
    • (2005) J Inflamm (Lond) , vol.2 , pp. 8
    • Ryan, J.M.1    Barry, F.P.2    Murphy, J.M.3
  • 35
    • 84873022590 scopus 로고    scopus 로고
    • Interaction between adipose-tissue derived mesenchymal stem cells and regulatory T cells
    • Engela AU, Baan CC, Peeters AM etal. Interaction between adipose-tissue derived mesenchymal stem cells and regulatory T cells. Cell Transplant 2013; 22:41-54.
    • (2013) Cell Transplant , vol.22 , pp. 41-54
    • Engela, A.U.1    Baan, C.C.2    Peeters, A.M.3
  • 36
    • 80054773283 scopus 로고    scopus 로고
    • The time is crucial for ex vivo expansion of T regulatory cells for therapy
    • Marek N, Bieniaszewska M, Krzystyniak A etal. The time is crucial for ex vivo expansion of T regulatory cells for therapy. Cell Transplant 2011; 20:1747-1758.
    • (2011) Cell Transplant , vol.20 , pp. 1747-1758
    • Marek, N.1    Bieniaszewska, M.2    Krzystyniak, A.3
  • 37
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J etal. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-1700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 38
    • 0036125407 scopus 로고    scopus 로고
    • Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis
    • Murphy JM, Dixon K, Beck S etal. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 2002; 46:704-713.
    • (2002) Arthritis Rheum , vol.46 , pp. 704-713
    • Murphy, J.M.1    Dixon, K.2    Beck, S.3
  • 39
    • 64349116001 scopus 로고    scopus 로고
    • Chondrogenic potential of mesenchymal stem cells from patients with rheumatoid arthritis and osteoarthritis: measurements in a microculture system
    • Dudics V, Kunstar A, Kovacs J etal. Chondrogenic potential of mesenchymal stem cells from patients with rheumatoid arthritis and osteoarthritis: measurements in a microculture system. Cells Tissues Organs 2009; 189:307-316.
    • (2009) Cells Tissues Organs , vol.189 , pp. 307-316
    • Dudics, V.1    Kunstar, A.2    Kovacs, J.3
  • 40
    • 36549054396 scopus 로고    scopus 로고
    • Chondrogenic potential of human adult mesenchymal stem cells is independent of age or osteoarthritis etiology
    • Scharstuhl A, Schewe B, Benz K etal. Chondrogenic potential of human adult mesenchymal stem cells is independent of age or osteoarthritis etiology. Stem Cells 2007; 25:3244-3251.
    • (2007) Stem Cells , vol.25 , pp. 3244-3251
    • Scharstuhl, A.1    Schewe, B.2    Benz, K.3
  • 41
    • 69249105385 scopus 로고    scopus 로고
    • Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation
    • Arufe MC, De la Fuente A, Fuentes-Boquete I etal. Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation. J Cell Biochem 2009; 108:145-155.
    • (2009) J Cell Biochem , vol.108 , pp. 145-155
    • Arufe, M.C.1    De la Fuente, A.2    Fuentes-Boquete, I.3
  • 42
    • 43549123499 scopus 로고    scopus 로고
    • Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing
    • Ju YJ, Muneta T, Yoshimura H etal. Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing. Cell Tissue Res 2008; 332:469-478.
    • (2008) Cell Tissue Res , vol.332 , pp. 469-478
    • Ju, Y.J.1    Muneta, T.2    Yoshimura, H.3
  • 43
    • 23644456193 scopus 로고    scopus 로고
    • Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    • Sakaguchi Y, Sekiya I, Yagishita K etal. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005; 52:2521-2529.
    • (2005) Arthritis Rheum , vol.52 , pp. 2521-2529
    • Sakaguchi, Y.1    Sekiya, I.2    Yagishita, K.3
  • 44
    • 33644666806 scopus 로고    scopus 로고
    • Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells
    • Djouad F, Bony C, Haupl T etal. Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. Arthritis Res Ther 2005; 7:R1304-1315.
    • (2005) Arthritis Res Ther , vol.7
    • Djouad, F.1    Bony, C.2    Haupl, T.3
  • 45
    • 78650668115 scopus 로고    scopus 로고
    • Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6
    • Eikawa S, Ohue Y, Kitaoka K etal. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. J Immunol 2010; 185:6734-6740.
    • (2010) J Immunol , vol.185 , pp. 6734-6740
    • Eikawa, S.1    Ohue, Y.2    Kitaoka, K.3
  • 46
    • 84857371931 scopus 로고    scopus 로고
    • The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications
    • Zeng C, Shi X, Zhang B etal. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl) 2012; 90:175-186.
    • (2012) J Mol Med (Berl) , vol.90 , pp. 175-186
    • Zeng, C.1    Shi, X.2    Zhang, B.3
  • 47
    • 84859406158 scopus 로고    scopus 로고
    • The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-cell 17 population
    • Svobodova E, Krulova M, Zajicova A etal. The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-cell 17 population. Stem Cells Dev 2012; 21:901-910.
    • (2012) Stem Cells Dev , vol.21 , pp. 901-910
    • Svobodova, E.1    Krulova, M.2    Zajicova, A.3
  • 48
    • 79251543298 scopus 로고    scopus 로고
    • The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells
    • Fujimoto M, Nakano M, Terabe F etal. The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells. J Immunol 2011; 186:32-40.
    • (2011) J Immunol , vol.186 , pp. 32-40
    • Fujimoto, M.1    Nakano, M.2    Terabe, F.3
  • 49
    • 79960735971 scopus 로고    scopus 로고
    • The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function
    • Herrath J, Muller M, Amoudruz P etal. The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function. Eur J Immunol 2011; 41:2279-2290.
    • (2011) Eur J Immunol , vol.41 , pp. 2279-2290
    • Herrath, J.1    Muller, M.2    Amoudruz, P.3
  • 50
    • 0942268955 scopus 로고    scopus 로고
    • Articular cartilage lesions in 993 consecutive knee arthroscopies
    • Aroen A, Loken S, Heir S etal. Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med 2004; 32:211-215.
    • (2004) Am J Sports Med , vol.32 , pp. 211-215
    • Aroen, A.1    Loken, S.2    Heir, S.3


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