Circadian disruption: Potential implications in inflammatory and metabolic diseases associated with alcohol

Alcohol Research: Current Reviews

Volumn 35, Issue 1, 2013, Pages 87-96

  Voigt, Robin M ^a   Forsyth, Christopher B ^a   Keshavarzian, Ali ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alcohol consumption; Alcohol related disorders; Circadian clock; Circadian disruption; Circadian rhythm; Disease factors; Epigenetic mechanisms; Immune function; Inflammatory diseases; Metabolic diseases; Metabolism; Risk factors

Indexed keywords

EID: 84881485304     PISSN: 21683492     EISSN: 21694796     Source Type: Journal    
DOI: None     Document Type: Review

References (91)

1. Allaman-Pillet, N.; Roduit, R.; Oberson, A. et al. Circadian regulation of islet genes involved in insulin production and secretion. Molecular and Cellular Endocrinology 226:59-66, 2004. PMiD: 15489006
2. ANDO, H.; USHIJIMA, K.; KUMAZAKI, M. et al. Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. Chronobiology International 27:194-203, 2010. PMiD:20205566
3. ANDREASEN, A.S.; KRABBE, K.S.; Krogh-Madsen, R. et al. Human endotoxemia as a model of systemic inflamma- ARJONA, A., AND SARKAR, D.K. The circadian gene mPer2 regulates the daily rhythm of IFN-gamma. Journal of Interferon & Cytokine Research 26:645-649, 2006b. PMiD:16978068
4. BERKEY, C.S.; ROCKETT, H.R.; GILLMAN, M.W. et al. Longitudinal study of skipping breakfast and weight change in adolescents. International Journal of Obesity Related Metabolic Disorders 27:1258-1266, 2003. PMiD:14513075
5. BERSON, D.M.; DUNN, F.A.; and TAKAO, M. Phototransduction by retinal ganglion cells that set the circadian clock. Science 295:1070-1073, 2002. PMiD: 11834835
6. BOIVIN, D.B.; JAMES, F.O.; WU, A. et al. Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood 102:4143-4145, 2003. PMiD: 12893774
7. BOLLATI, V.; BACCARELLI, A.; SARTORI, S. et al. Epigenetic effects of shiftwork on blood DNA methylation. Chronobiology International 27:1093-1104, 2010. PMiD: 20636218
8. BOZEK, K.; RELOGIO, A.; KIELBASA, S.M. et al. Regulation of clock-controlled genes in mammals. PLoS One 4:e4882, 2009. PMID:19287494
9. BRAGER, A.J.; RUBY, C.L.; PROSSER, R.A.; and GLASS, J.D. Chronic ethanol disrupts circadian photic entrainment and daily locomotor activity in the mouse. Alcoholism: Clinical and Experimental Research 34:1266-1273, 2010. PMID: 20477766
10. BROWER, K.J. Alcohol's effects on sleep in alcoholics. Alcohol Research & Health 25:110-125, 2001. PMiD: 11584550
11. BRYANT, P.A.; TRINDER, J.; and CURTIS, N. Sick and tired: Does sleep have a vital role in the immune system? Nature Reviews. Immunology 4:457-467, 2004. PMiD: 15173834
12. BUIJS, R.M.; VAN EDEN, C.G.; GONCHARUK, V.D.; and KALSBEEK, A. The biological clock tunes the organs of the body: Timing by hormones and the autonomic nervous sys-tem. Journal of Endocrinology 177:17-26, 2003. PMiD: 12697033
13. BUNGER, M.K.; WILSBACHER, L.D.; MORAN, S.M. et al. Mop3 is an essential component of the master circadian pace-maker in mammals. Cell 103:1009-1017, 2000. PMiD: 11163176
14. Bureau of Labor Statistics. Workers on Flexible Work Schedules in May 2004. Washington, DC, U.S. Department of Labor, 2005.
15. CARUSO, C.C.; LUSK, S.L.; and GILLESPIE, B.W. Relationship of work schedules to gastrointestinal diagnoses, symp-toms, and medication use in auto factory workers. American Journal of Industrial Medicine 46:586-598, 2004. PMiD: 15551368
16. Castanon-Cervantes, O.; WU, M.; EHLEN, J.C. et al. Dysregulation of inflammatory responses by chronic circadian disruption. Journal of Immunology 185:5796-5805, 2010. PMiD: 20944004
17. CAVADINI, G.; PETRZILKA, S.; KOHLER, P. et al. TNF-alpha sup-presses the expression of clock genes by interfering with E-box-mediated transcription. Proceedings of the National Academy of Sciences of the United States of America 104:12843-12848, 2007. PMiD: 17646651
18. CHEN, C.P.; KUHN, P.; ADVIS, J.P.; and SARKAR, D.K. Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expres-sion in the hypothalamus of the male rat. Journal of Neurochemistry 88:1547-1554, 2004. PMiD: 15009656
19. CHEN, C.P.; KUHN, P.; ADVIS, J.P.; and SARKAR, D.K. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neu-rons in the hypothalamus. Journal of Neurochemisty 97:1026-1033, 2006. PMiD: 16686691
20. CONROY, D.A.; HAIRSTON, I.S.; ARNEDT, J.T. et al. Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls. Chronobiology International 29:35-42, 2012. PMiD: 22217099
21. COOGAN, A.N., AND WYSE, C.A. Neuroimmunology of the circadian clock. Brain Research 1232:104-112, 2008. PMiD:18703032
22. CRAWSHAW, L.I.; WALLACE, H.; and CRABBE, J. Ethanol, body temperature and thermoregulation. Clinical and Experimental Pharmacology & Physiology 25:150-154, 1998 PMID: 9493506
23. DAMIOLA, F.; LE MINH, N.; PREITNER, N. et al. Restricted feed-ing uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes & Development 14:2950-2961, 2000. PMiD:11114885
24. DIMITROV, S.; LANGE, T.; FEHM, H.L.; and BORN, J. A regulato-ry role of prolactin, growth hormone, and corticosteroids for human T-cell production of cytokines. Brain, Behavior, and Immunity 18:368-374, 2004. PMiD: 15157954
25. EVERSON, C.A. Sustained sleep deprivation impairs host defense. American Journal of Physiology 265(5 Pt. 2):R1148-R1154, 1993. PMiD: 8238617
26. FARNELL, Y.Z.; ALLEN, G.C.; NAHM, S.S. et al. Neonatal alco-hol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats. Alcoholism: Clinical and Experimental Research 32:544-552, 2008. PMiD: 18215209
27. FORTIER, E.E.; ROONEY, J.; DARDENTE, H. et al. Circadian variation of the response of T-cells to antigen. Journal of Immunology 187:6291-6300, 2011. PMiD: 22075697
28. FU, L.; PATEL, M.S.; BRADLEY, A. et al. The molecular clock mediates leptin-regulated bone formation. Cell 122: 803-815, 2005. PMiD: 16143109
29. GIOVANNUCCI, E.; RIMM, E.B.; ASCHERIO, A. et al. Alcohol, low-methionine-low-folate diets, and risk of colon can-cer in men. Journal of the National Cancer Institute 87:265-273, 1995. PMiD: 7707417
30. GRIMALDI, B.; NAKAHATA, Y.; KALUZOVA, M. et al. Chromatin remodeling, metabolism and circadian clocks: The inter-play of CLOCK and SIRT1. International Journal of Biochemistry & Cell Biology 41:81-86, 2009. PMiD: 18817890
31. HAIMOVICH, B.; CALVANO, J.; HAIMOVICH, A.D. et al. In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes. Critical Care Medicine 38:751-758, 2010. PMiD: 20081528
32. HOFFMAN, A.E.; YI, C.H.; ZHENG, T. et al. CLOCK in breast tumorigenesis: Genetic, epigenetic, and transcriptional profiling analyses. Cancer Research 70:1459-1468, 2010a. PMiD: 20124474
33. HOFFMAN, A.E.; ZHENG, T.; YI, C.H. et al. The core circadi an gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling. Cancer Prevention Research (Philadelphia) 3:539-548, 2010b. PMiD:20233903
34. HOOGERWERF, W.A.; HELLMICH, H.L.; CORNELISSEN, G. et al. Clock gene expression in the murine gastrointestinal tract: Endogenous rhythmicity and effects of a feeding regimen. Gastroenterology 133:1250-1260, 2007. PMiD: 17919497
35. HUANG, M.C.; HO, C.W.; CHEN, C.H. et al. Reduced expres-sion of circadian clock genes in male alcoholic patients. Alcoholism: Clinical and Experimental Research 34:1899-1904, 2010. PMiD: 20735373
36. IMATOH, N.; NAKAZAWA, Y.; OHSHIMA, H. et al. Circadian rhythm of REM sleep of chronic alcoholics during alco-hol withdrawal. Drug and Alcohol Dependence 18:77-85, 1986. PMiD: 3780412
37. KAKIHANA, R., AND MOORE, J.A. Circadian rhythm of corti-costerone in mice: The effect of chronic consumption of alcohol. Psychopharmacologia 46:301-305, 1976. PMiD: 986057
38. KARLSSON, B.; KNUTSSON, A.; and LINDAHL, B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occupational and Environmental Medicine 58:747-752, 2001. PMiD: 11600731
39. KAWANO, Y.; PONTES, C.S.; ABE, H. et al. Effects of alcohol consumption and restriction on home blood pressure in hypertensive patients: Serial changes in the morning and evening records. Clinical and Experimental Hypertension 24:33-39, 2002. PMiD: 11848167
40. KESHAVARZIAN, A.; FARHADI, A.; FORSYTH, C.B. et al. Evidence that chronic alcohol exposure promotes intestinal oxida-tive stress, intestinal hyperpermeability and endotox- emia prior to development of alcoholic steatohepatitis in rats. Journal of Hepatology50:538-547, 2009. PMiD: 19155080
41. KESHAVARZIAN, A.; FIELDS, J.Z.; VAETH, J.; and HOLMES, E.W. The differing effects of acute and chronic alcohol on gastric and intestinal permeability. American Journal of Gastroenterology 89:2205-2211, 1994. PMiD: 7977243
42. KESHAVARZIAN, A.; HOLMES, E.W.; PATEL, M. et al. Leaky gut in alcoholic cirrhosis: A possible mechanism for alcohol- induced liver damage. American Journal of Gastroenterology 94:200-207, 1999. PMiD: 9934756
43. KIM, J.S., AND SHUKLA, S.D. Histone h3 modifications in rat hepatic stellate cells by ethanol. Alcohol and Alcoholism 40:367-372, 2005. PMiD: 15939707
44. Kim, J.S., and Shukla, S.D. Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissues. Alcohol and Alcoholism 41:126-132, 2006. PMiD:16314425
45. LAMIA, K.A.; STORCH, K.F.; and WEITZ, C.J. Physiological significance of a peripheral tissue circadian clock. Proceedings of the National Academy of Sciences of the United States of America 105:15172-15177, 2008. PMiD:18779586
46. LEVI, F.; CANON, C.; DIPALMA, M. et al. When should the immune clock be reset? From circadian pharmacody-namics to temporally optimized drug delivery. Annals of the New York Academy of Sciences 618:312-329, 1991. PMiD: 2006792
47. LIU, J.; MALKANI, G.; SHI, X. et al. The circadian clock Period 2 gene regulates gamma interferon production of Nk cells in host response to lipopolysaccharide-induced endotoxic shock. Infections and Immunity 74:4750-4756, 2006. PMiD: 16861663
48. Lu, Y., AND CEDERBAUM, A.I. CYP2E1 and oxidative liver injury by alcohol. Free Radical Biology & Medicine 44:723-738, 2008. PMiD: 18078827
49. MA, Y.; BERTONE, E.R.; STANEK, E.J., IIIrd et al. Association between eating patterns and obesity in a free-living US adult population. American Journal of Epidemiology 158:85-92, 2003. PMiD: 12835290
50. MARCHEVA, B.; RAMSEY, K.M.; BUHR, E.D. et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466:627-631, 2010. PMiD: 20562852
51. MOHREN, D.C.; JANSEN, N.W.; KANT, I.J. et al. Prevalence of common infections among employees in different work schedules. Journal of Occupational Environmental Medicine 44:1003-1011, 2002. PMiD: 12449906
52. MORIKAWA, Y.; NAKAGAWA, H.; MIURA, K. et al. Shift work and the risk of diabetes mellitus among Japanese male fac-tory workers. Scandinavian Journal of Work, Environment & Health 31:179-183, 2005. PMiD: 15999569
53. NOSHIRO, M.; USUI, E.; KAWAMOTO, T. et al. Multiple mecha-nisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis. Journal of Biological Rhythms 22:299-311, 2007. PMiD: 17660447
54. OISHI, K.; MIYAZAKI, K.; KADOTA, K. et al. Genome-wide expression analysis of mouse liver reveals CLOCk-regu-lated circadian output genes. Journal of Biological Chemistry 278:41519-41527, 2003. PMiD: 12865428
55. OISHI, K.; OHKURA, N.; KADOTA, K. et al. Clock mutation affects circadian regulation of circulating blood cells. Journal of Circadian Rhythms 4:13, 2006. PMiD: 17014730
56. OKADA, K.; YANO, M.; DOKI, Y. et al. injection of LPS caus-es transient suppression of biological clock genes in rats. Journal of Surgical Research 145:5-12, 2008. PMiD: 18279697
57. OKANO, S.; AKASHI, M.; HAYASAKA, K.; and NAKAJIMA, O. Unusual circadian locomotor activity and pathophysiolo-gy in mutant CRY1 transgenic mice. Neuroscience Letters 451:246-251, 2009. PMiD: 19159659
58. PANDA, S.; ANTOCH, M.P.; MILLER, B.H. et al. Coordinated transcription of key pathways in the mouse by the circa-dian clock. Cell 109:307-320, 2002. PMiD: 12015981
59. PARK, P.H.; MILLER, R.; and SHUKLA, S.D. Acetylation of his-tone H3 at lysine 9 by ethanol in rat hepatocytes. Biochemical and Biophysical Research Communications 306:501-504, 2003. PMiD: 12804592
60. PENEV, P.D.; KOLKER, D.E.; ZEE, P.C.; and TUREK, F.W. Chronic circadian desynchronization decreases the sur-vival of animals with cardiomyopathic heart disease. American Journal of Physiology 275(6 Pt 2):H2334-H2337, 1998. PMiD: 9843836
61. PERES, R.; DO AMARAL, F.G.; MADRIGRANO, T.C. et al. Ethanol consumption and pineal melatonin daily profile in rats. Addiction Biology 16:580-590, 2011. PMiD: 21635669
62. PURI, S.K.; Si, L.; FAN, C.Y.; and HANNA, E. Aberrant promot-er hypermethylation of multiple genes in head and neck squamous cell carcinoma. American Journal of Otolaryngology 26:12-17, 2005. PMiD: 15635575
63. RAJAKRISHNAN, V.; SUBRAMANIAN, P.; VISWANATHAN, P.; and MENON, V.P. Effect of chronic ethanol ingestion on bio-chemical circadian rhythms in Wistar rats. Alcohol 18:147-152, 1999. PMiD: 10456565
64. REPPERT, S.M., AND WEAVER, D.R. Coordination of circadian timing in mammals. Nature 418:935-941, 2002. PMiD: 12198538
65. ROSENWASSER, A.M.; LOGAN, R.W.; and FECTEAU, M.E. Chronic ethanol intake alters circadian period-responses to brief light pulses in rats. Chronobiology International 22:227-236, 2005. PMiD: 16021840
66. RUDIC, R.D.; MCNAMARA, P.; CURTIS, A.M. et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biology 2:e377, 2004. PMiD: 15523558
67. Salgado-Delgado, R.; Angeles-Castellanos, M.; Saderi, N. et al. Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work. Endocrinology 151:1019-1029, 2010. PMiD:20080873
68. SCHERNHAMMER, E.S.; LADEN, F.; SPEIZER, F.E. et al. Night- shift work and risk of colorectal cancer in the Nurses' Health Study. Journal of the National Cancer Institute 95:825-828, 2003. PMiD: 12783938
69. SCHEVING, L.A. Biological clocks and the digestive system. Gastroenterology 119:536-549, 2000. PMiD:10930389
70. SCOTT, E.M.; CARTER, A.M.; and GRANT, P.J. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. International Journal of Obesity (London) 32:658-662, 2008. PMiD: 18071340
71. SHIMBA, S.; ISHII, N.; OHTA, Y. et al. Brain and muscle Arnt- like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 102:12071-12076, 2005. PMiD: 16093318
72. SPANAGEL, R.; PENDYALA, G.; ABARCA, C. et al. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nature Medicine 11:35-42, 2005. PMiD: 15608650
73. SRINIVASAN, V.; MAESTRONI, G.J.; CARDINALI, D.P. et al. Melatonin, immune function and aging. Immunity & Ageing 2:17, 2005. PMiD: 16316470
74. STORCH, K.F.; LIPAN, O.; LEYKIN, I. et al. Extensive and diver-gent circadian gene expression in liver and heart. Nature 417:78-83, 2002. PMiD: 11967526
75. STRAIF, K.; BAAN, R.; GROSSE, Y. et al. Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncology 8:1065-1066, 2007. PMiD: 19271347
76. SWANSON, G.; FORSYTH, C.B.; TANG, Y. et al. Role of intesti-nal circadian genes in alcohol-induced gut leakiness. Alcoholism: Clinical and Experimental Research 35:1305-1314, 2011. PMiD: 21463335
77. TRINKOFF, A.M., AND STORR, C.L. Work schedule characteris-tics and substance use in nurses. American Journal of Industrial Medicine 34:266-271, 1998. PMiD: 9698996
78. TUREK, F.W. Are the suprachiasmatic nuclei the location of the biological clock in mammals? Nature 292:289-290, 1981. PMiD: 7254326
79. TUREK, F.W.; JOSHU, C.; KOHSAKA, A. et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308:1043-1045, 2005. PMiD: 15845877
80. VAN DER HORST, G.T.; MUIJTJENS, M.; KOBAYASHI, K. et al. Mammalian Cry1 and Cry2 are essential for mainte-nance of circadian rhythms. Nature 398:627-630, 1999. PMiD: 10217146
81. VAN ENGELAND, M.; WEIJENBERG, M.P.; ROEMEN, G.M. et al. Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: The Netherlands Cohort Study on Diet and Cancer. Cancer Research 63:3133-3137, 2003. PMiD: 12810640
82. VGONTZAS, A.N.; ZOUMAKIS, E.; BIXLER, E.O. et al. Adverse effects of modest sleep restriction on sleepiness, perfor-mance, and inflammatory cytokines. Journal of Clinical Endocrinology and Metabolism 89:2119-2126, 2004. PMiD:15126529
83. VITATERNA, M.H.; KING, D.P.; CHANG, A.M. et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264:719-725, 1994. PMiD: 8171325
84. WOON, P.Y.; KAISAKI, P.J.; BRAGANCA, J. et al. Aryl hydrocar-bon receptor nuclear translocator-like (BMAL1) is associ-ated with susceptibility to hypertension and type 2 dia-betes. Proceedings of the National Academy of Sciences of the United States of America 104:14412-14417, 2007. PMiD: 17728404
85. YAMAMURA, Y.; YANO, I.; KUDO, T.; and SHIBATA, S. Time- dependent inhibitory effect of lipopolysaccharide injec-tion on Per1 and Per2 gene expression in the mouse heart and liver. Chronobiology International 27:213-232, 2010. PMiD: 20370466
86. YAMATO, M.; ITO, T.; IWATANI, H. et al. E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney. Journal of Nephrology 23:102-110, 2010. PMID: 20091493
87. YANG, S.; LIU, A.; WEIDENHAMMER, A. et al. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology 150:2153-2160, 2009. PMiD: 19179447
88. Yoo, S.H.; YAMAZAKI, S.; LOWREY, P.L. et al. PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proceedings of the National Academy of Sciences of the United States of America 101:5339-5346, 2004. PMiD: 14963227
89. ZHENG, B.; ALBRECHT, U.; KAASIK, K. et al. Nonredundant roles of the mPerl and mPer2 genes in the mammalian circadian clock. Cell 105:683-694, 2001. PMiD: 11389837
90. ZHU, Y.; STEVENS, R.G.; HOFFMAN, A.E. et al. Epigenetic impact of long-term shiftwork: Pilot evidence from circa-dian genes and whole-genome methylation analysis. Chronobiology International 28:852-861, 2011. PMiD: 22080730
91. ZVONIC, S.; PTITSYN, A.A.; CONRAD, S.A. et al. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55:962-970, 2006. PMiD: 16567517