Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 3, 2008, Pages 544-552

  Farnell, Yuhua Z ^a,b   Allen, Gregg C ^a,b   Nahm, Sang Soep ^a,b   Neuendorff, Nichole ^a,b   West, James R ^a   Chen, Wei Jung A ^a   Earnest, David J ^a,b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Bmal1; Circadian Rhythms; Clock; Cry1; Oscillation; Per1; Per2; Rev erb

Indexed keywords

ALCOHOL; CRYPTOCHROME 1; MESSENGER RNA; PER1 PROTEIN; PER2 PROTEIN; PROTEIN BMAL1; REV ERB ALPHA PROTEIN; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MATURATION; CEREBELLUM; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENE EXPRESSION; LIVER; MALE; NONHUMAN; OSCILLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; REARING; RUNNING; SUPRACHIASMATIC NUCLEUS;

ANIMALIA; RATTUS;

EID: 39749097419     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2007.00598.x     Document Type: Article

References (48)

1. Albers HE (1981) Gonadal hormones organize and modulate the circadian system of the rat. Am J Physiol 241: R62–R66.
2. Albers HE, Gerall AA, Axelson JF (1981) Effect of reproductive state on circadian periodicity in the rat. Physiol Behav 26: 21–25.
3. Allen GC, Farnell Y, Bell‐Pedersen D, Cassone VM, Earnest DJ (2004a) Effects of altered Clock gene expression on the pacemaker properties of SCN2.2 cells and oscillatory properties of NIH/3T3 cells. Neuroscience 127: 989–999.
4. Allen GC, Farnell YZ, Maeng J‐U, West JR, Chen W‐JA, Earnest DJ (2005b) Long‐term effects of neonatal alcohol exposure on photic re‐entrainment and phase–shifting responses of the activity rhythm in adult rats. Alcohol 37: 79–88.
5. Allen GC, West JR, Chen W‐JA, Earnest DJ (2004b) Developmental alcohol exposure disrupts circadian regulation of BDNF in the rat suprachiasmatic nucleus. Neurotoxicol Teratol 26: 353–358.
6. Allen GC, West JR, Chen W‐JA, Earnest DJ (2005a) Neonatal alcohol exposure permanently disrupts the circadian properties and photic entrainment of the activity rhythm in adult rats. Alcohol Clin Exp Res 29: 1845–1852.
7. Arjona A, Boyadjieva N, Kuhn P, Sarkar DK (2006) Fetal ethanol exposure disrupts the daily rhythms of splenic granzyme B, IFN‐gamma, and NK cell cytotoxicity in adulthood. Alcohol Clin Exp Res 30: 1039–1044.
8. Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR (2001) Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30: 525–536.
9. Bonthius DJ, Bonthius NE, Napper RM, West JR (1992) Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: a stereological study. J Comp Neurol 324: 557–566.
10. Bonthius DJ, West JR (1988) Blood alcohol concentration and microencephaly: a dose‐response study in the neonatal rat. Teratology 37: 223–231.
11. Bonthius DJ, West JR (1990) Alcohol‐induced neuronal loss in developing rats: increased brain damage with binge exposure. Alcohol Clin Exp Res 14: 107–118.
12. Chen CP, Kuhn P, Advis JP, Sarkar DK (2004) Chronic ethanol consumption impairs the circadian rhythm of pro‐opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. J Neurochem 88: 1547–1554.
13. Chen CP, Kuhn P, Advis JP, Sarkar DK (2006) Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta‐endorphin neurons in the hypothalamus. J Neurochem 97: 1026–1033.
14. Chen W‐JA, Parnell SE, West JR (1998) Neonatal alcohol and nicotine exposure limits brain growth and depletes cerebellar Purkinje cells. Alcohol 15: 33–41.
15. Chen W‐JA, Parnell SE, West JR (1999) The effects of alcohol and nicotine on the developing olfactory bulb: loss of mitral cells and changes in neurotransmitter levels. Alcohol Clin Exp Res 23: 18–25.
16. Chudley AE, Conry J, Cook JL, Loock C, Rosales T, LeBlanc N (2005) Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. CMAJ 172 (Suppl. 5): S1–S21.
17. Diaz J (1991) Experimental rearing of rat pups using chronic gastric fistulas, in Developmental Psychobiology: New Methods and Changing Concepts ( Shair HN, Barr GA, Hofer MA eds), pp 272–284. Oxford Univ Press, New York.
18. Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3: 79–83.
19. Earnest DJ, Sladek CD (1986) Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro. Brain Res 382: 129–133.
20. Farnell YZ, West JR, Chen W‐JA, Allen GC, Earnest DJ (2004) Developmental alcohol exposure alters light‐induced phase shifts of the circadian activity rhythm in rats. Alcohol Clin Exp Res 28: 1020–1027.
21. Goodlett CR, Kelly SJ, West JR (1987) Early postnatal alcohol exposure that produces high blood alcohol levels impairs development of spatial navigation learning. Psychobiology 15: 64–74.
22. Goodlett CR, Nonneman AJ, Valentino ML, West JR (1988) Constraints on water maze spatial learning in rats: implications for behavioral studies of brain damage and recovery of function. Behav Brain Res 28: 275–286.
23. Heid CA, Stevens J, Livak KJ, Williams PM (1996) Real time quantitative PCR. Genome Res 6: 986–994.
24. Van Der Horst GTJ, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, De Wit J, Verkerk A, Eker APM, Van Leenen D, Buijs R, Bootsma D, Hoeijmakers JHJ, Yasui A (1999) Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 398: 627–630.
25. Hoyme HE, May PA, Kalberg WO, Kodituwakku P, Gossage JP, Trujillo PM, Buckley DG, Miller JH, Aragon AS, Khaole N, Viljoen DL, Jones KL, Robinson LK (2005) A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine criteria. Pediatrics 115: 39–47.
26. Kelly SJ, Goodlett CR, Hulsether SA, West JR (1988) Impaired spatial navigation in adult female but not adult male rats exposed to alcohol during the brain growth spurt. Behav Brain Res 27: 247–257.
27. Liang F‐Q, Walline R, Earnest DJ (1998) Circadian rhythm of brain‐derived neurotrophic factor in the rat suprachiasmatic nucleus. Neurosci Lett 242: 89–92.
28. Lund TD, McGivern RF, Handa RJ (2004) Prenatal exposure to ethanol alters biological rhythms of adult male rats (abstract). Alcohol Clin Exp Res 28 (Suppl. 5): 136A.
29. Menger GJ, Allen GC, Neuendorff N, Nahm S‐S, Thomas T, Cassone VM, Earnest DJ (2007) Circadian profiling of the transcriptome in NIH/3T3 fibroblasts: comparison with rhythmic gene expression in SCN2.2 cells and the rat SCN. Physiol Genomics 29: 280–289.
30. Menger GJ, Lu K, Thomas T, Cassone VM, Earnest DJ (2005) Circadian profiling of the transcriptome in immortalized rat SCN cells. Physiol Genomics 21: 370–381.
31. Moore RY (1991) Disorders of circadian function and the human circadian timing system, in Suprachiasmatic Nucleus: The Mind’s Clock ( Klein DC, Moore RY, Reppert SM eds), pp 429–441. Oxford Univ Press, New York.
32. Morin LP, Fitzgerald KM, Zucker I (1977) Estradiol shortens the period of hamster circadian rhythms. Science 196: 305–307.
33. Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N (1998) Antiphase circadian expression between Bmal1 and period homologue RNA in the suprachiasmatic nucleus and peripheral tissues of rats. Biochem Biophys Res Commun 253: 199–203.
34. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935–941.
35. Roebuck TM, Mattson SN, Riley EP (1999) Prenatal exposure to alcohol: effects on brain structure and neuropsychological functioning, in Alcohol and Alcoholism: Effects on Brain and Development ( Hannigan JH, Spear LP, Spear NE, Goodlett CR eds), pp 1–16. Lawrence Erlbaum Assoc, Mahwah.
36. Schwartz WJ (1993) A clinician’s primer on the circadian clock: its localization, function and resetting. Adv Intern Med 38: 81–106.
37. Sei H, Sakata‐Haga H, Ohta K, Sawada K, Morita Y, Fukui Y (2003) Prenatal exposure to alcohol alters the light response in postnatal circadian rhythm. Brain Res 987: 131–134.
38. Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr, Reppert SM (1997) Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron 19: 1261–1269.
39. Sher L (2004) Etiology, pathogenesis, and treatment of seasonal and non‐seasonal mood disorders: possible role of circadian rhythm abnormalities related to developmental alcohol exposure. Med Hypotheses 62: 797–801.
40. Thomas JD, Goodlett CR, West JR (1998) Alcohol‐induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performance. Brain Res Dev Brain Res 105: 159–166.
41. Thomas JD, Wasserman EA, West JR, Goodlett CR (1996) Behavioral deficits induced by bingelike exposure to alcohol in neonatal rats: importance of developmental timing and number of episodes. Dev Psychobiol 29: 433–452.
42. Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptacek LJ, Fu YH (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291: 1040–1043.
43. Vitaterna MH, Selby CP, Todo T, Niwa H, Thompson C, Fruechte EM, Hitomi K, Thresher RJ, Ishikawa T, Miyazaki J, Takahashi JS, Sancar A (1999) Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A 96: 12114–12119.
44. West JR (1993) Use of pup in a cup model to study brain development. J Nutr 123: 382–385.
45. West JR, Hamre KM, Pierce DR (1984) Delay in brain growth induced by alcohol in artificially reared rat pups. Alcohol 1: 213–222.
46. Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H (2000) Resetting central and peripheral circadian oscillators in transgenic rats. Science 288: 682–685.
47. Zheng BH, Albrecht U, Kaasik K, Sage M, Lu WQ, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105: 683–694.
48. Zylka MJ, Shearman LP, Weaver DR, Reppert SM (1998) Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron 20: 1103–1110.