Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments

Nature Methods

Volumn 10, Issue 8, 2013, Pages 788-794

  Prewitz, Marina C ^a   Seib, F Philipp ^a,d   Von Bonin, Malte ^b   Friedrichs, Jens ^a   Stißel, Aline ^a   Niehage, Christian ^c   Müller, Katrin ^b   Anastassiadis, Konstantinos ^c   Waskow, Claudia ^c   Hoflack, Bernard ^c   Bornhäuser, Martin ^b,c   Werner, Carsten ^a,c  

^a LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; COLLAGEN; CYTOKINE; GLYCOSAMINOGLYCAN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 8; POLY(OCTADECENE ALT MALEIC ANHYDRIDE); POLYMER; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; METHODOLOGY; MICROENVIRONMENT; MOUSE; NEWBORN; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEOMICS; SCANNING ELECTRON MICROSCOPY; SCID MOUSE; SIGNAL TRANSDUCTION; STEM CELL; XENOTRANSPLANTATION;

ANIMALS; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELLS; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED NOD; MICE, SCID; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; SPECIFIC PATHOGEN-FREE ORGANISMS; STEM CELL NICHE;

EID: 84881476256     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.2523     Document Type: Article

References (54)

1. Schofeld, R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4, 7-25 (1978).
2. Wang, L.D. & Wagers, A.J. Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nat. Rev. Mol. Cell Biol. 12, 643-655 (2011).
3. Discher, D.E., Mooney, D.J. & Zandstra, P.W. Growth factors, matrices, and forces combine and control stem cells. Science 324, 1673-1677 (2009).
4. Engler, A.J., Sen, S., Sweeney, H.L. & Discher, D.E. Matrix elasticity directs stem cell lineage specifcation. Cell 126, 677-689 (2006). (Pubitemid 44233625)
5. Holst, J. et al. Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nat. Biotechnol. 28, 1123-1128 (2010).
6. Gupta, P. et al. Structurally specifc heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche. Blood 92, 4641-4651 (1998). (Pubitemid 29005866)
7. Coulombel, L., Vuillet, M.H., Leroy, C. & Tchernia, G. Lineage-and stage-specifc adhesion of human hematopoietic progenitor cells to extracellular matrices from marrow fbroblasts. Blood 71, 329-334 (1988). (Pubitemid 18089518)
8. Seib, F.P. et al. Engineered extracellular matrices modulate the expression profle and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells. Tissue Eng. Part A 15, 3161-3171 (2009).
9. Chen, X.-D., Dusevich, V., Feng, J.Q., Manolagas, S.C. & Jilka, R.L. Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J. Bone Miner. Res. 22, 1943-1956 (2007). (Pubitemid 351229311)
10. Klimanskaya, I. et al. Human embryonic stem cells derived without feeder cells. Lancet 365, 1636-1641 (2005). (Pubitemid 40693413)
11. Cukierman, E., Pankov, R., Stevens, D.R. & Yamada, K.M. Taking cell-matrix adhesions to the third dimension. Science 294, 1708-1712 (2001). (Pubitemid 33104840)
12. Vlodavsky, I. Preparation of extracellular matrices produced by cultured corneal endothelial and PF-HR9 endodermal cells. Curr. Protoc. Cell Biol. 1, 10.4 (2001).
13. Beacham, D.A., Amatangelo, M.D. & Cukierman, E. Preparation of extracellular matrices produced by cultured and primary fbroblasts. Curr. Protoc. Cell Biol. 33, 10.9 (2007).
14. Calvi, L.M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846 (2003). (Pubitemid 37351468)
15. Méndez-Ferrer, S. et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829-834 (2010).
16. Pompe, T. et al. Maleic anhydride copolymers-a versatile platform for molecular biosurface engineering. Biomacromolecules 4, 1072-1079 (2003). (Pubitemid 36939479)
17. Gordon, M.Y. Extracellular matrix of the marrow microenvironment. Br. J. Haematol. 70, 1-4 (1988).
18. Ren, J. et al. Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency. Cytotherapy 13, 661-674 (2011).
19. Lanfer, B. et al. The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices. Biomaterials 30, 5950-5958 (2009).
20. Shultz, L.D., Ishikawa, F. & Greiner, D.L. Humanized mice in translational biomedical research. Nat. Rev. Immunol. 7, 118-130 (2007). (Pubitemid 46174859)
21. Eppert, K. et al. Stem cell gene expression programs infuence clinical outcome in human leukemia. Nat. Med. 17, 1086-1093 (2011).
22. Flaim, C.J., Chien, S. & Bhatia, S.N. An extracellular matrix microarray for probing cellular differentiation. Nat. Methods 2, 119-125 (2005). (Pubitemid 41131033)
23. Ehninger, A. & Trumpp, A. The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J. Exp. Med. 208, 421-428 (2011).
24. Bianco, P., Robey, P.G. & Simmons, P.J. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2, 313-319 (2008). (Pubitemid 351467394)
25. Dexter, T.M., Spooncer, E., Simmons, P. & Allen, T.D. Long-term marrow culture: an overview of techniques and experience. Kroc Found. Ser. 18, 57-96 (1984).
26. Baxter, M.A. et al. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22, 675-682 (2004). (Pubitemid 39172200)
27. Wagner, W. et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS ONE 3, e2213 (2008).
28. Matsubara, T. et al. A new technique to expand human mesenchymal stem cells using basement membrane extracellular matrix. Biochem. Biophys. Res. Commun. 313, 503-508 (2004). (Pubitemid 38021856)
29. Mauney, J.R., Volloch, V. & Kaplan, D.L. Matrix-mediated retention of adipogenic differentiation potential by human adult bone marrow-derived mesenchymal stem cells during ex vivo expansion. Biomaterials 26, 6167-6175 (2005). (Pubitemid 40826985)
30. Chen, X.-D. Extracellular matrix provides an optimal niche for the maintenance and propagation of mesenchymal stem cells. Birth Defects Res. C Embryo Today 90, 45-54 (2010).
31. Sun, Y. et al. Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. FASEB J. 25, 1474-1485 (2011).
32. Bruckner, P. Suprastructures of extracellular matrices: paradigms of functions controlled by aggregates rather than molecules. Cell Tissue Res. 339, 7-18 (2010).
33. Hines, M., Nielsen, L. & Cooper-White, J. The hematopoietic stem cell niche: what are we trying to replicate? J. Chem. Technol. Biotechnol. 83, 421-443 (2008). (Pubitemid 351460908)
34. Lapidot, T. & Kollet, O. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-defcient NOD/SCID and NOD/SCID/B2mnull mice. Leukemia 16, 1992-2003 (2002). (Pubitemid 35203441)
35. Fleming, H.E. et al. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2, 274-283 (2008). (Pubitemid 351298592)
36. Janowska-Wieczorek, A., Majka, M., Ratajczak, J. & Ratajczak, M.Z. Autocrine/paracrine mechanisms in human hematopoiesis. Stem Cells 19, 99-107 (2001). (Pubitemid 32222234)
37. Tsuji, K., Ueda, T. & Ebihara, Y. Cytokine-mediated expansion of human NOD-SCID-repopulating cells. Methods Mol. Biol. 215, 387-395 (2003).
38. Alakel, N. et al. Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profle of CD133+ hematopoietic stem cells during ex vivo expansion. Exp. Hematol. 37, 504-513 (2009).
39. Kurth, I., Franke, K., Pompe, T., Bornhäuser, M. & Werner, C. Hematopoietic stem and progenitor cells in adhesive microcavities. Integr. Biol. (Camb.) 1, 427-434 (2009).
40. Franke, K., Pompe, T., Bornhäuser, M. & Werner, C. Engineered matrix coatings to modulate the adhesion of CD133+ human hematopoietic progenitor cells. Biomaterials 28, 836-843 (2007). (Pubitemid 44667018)
41. Melkoumian, Z. et al. Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells. Nat. Biotechnol. 28, 606-610 (2010).
42. Rodin, S. et al. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat. Biotechnol. 28, 611-615 (2010).
43. Lanfer, B. et al. Aligned fbrillar collagen matrices obtained by shear fow deposition. Biomaterials 29, 3888-3895 (2008).
44. Oswald, J. et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22, 377-384 (2004). (Pubitemid 38736621)
45. Gilbert, T.W., Sellaro, T.L. & Badylak, S.F. Decellularization of tissues and organs. Biomaterials 27, 3675-3683 (2006).
46. Pittenger, M.F., Mbalaviele, G., Black, M., Mosca, J.D. & Marshak, D.R. Mesenchymal stem cells. in Human Cell Culture Vol. 5 (eds. Koller, M.R., Palsson, B.O. & Masters, J.R.W.) Ch. 9, 189-207 (Kluwer, 2001).
47. Sen, A. et al. Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J. Cell. Biochem. 81, 312-319 (2001). (Pubitemid 32298263)
48. Waskow, C. et al. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 9, 676-683 (2008). (Pubitemid 351712638)
49. Wight, T.N., Kinsella, M.G., Keating, A. & Singer, J.W. Proteoglycans in human long-term bone marrow cultures: biochemical and ultrastructural analyses. Blood 67, 1333-1343 (1986). (Pubitemid 16080603)
50. Hutter, J.L. & Bechhoefer, J. Calibration of atomic-force microscope tips. Rev. Sci. Instrum. 64, 1868-1873 (1993).
51. Krieg, M. et al. Tensile forces govern germ-layer organization in zebrafsh. Nat. Cell Biol. 10, 429-436 (2008).
52. Shevchenko, A., Tomas, H., Havlis, J., Olsen, J.V. & Mann, M. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat. Protoc. 1, 2856-2860 (2006).
53. Cox, J. & Mann, M. MaxQuant enables high peptide identifcation rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantifcation. Nat. Biotechnol. 26, 1367-1372 (2008).
54. Hubner, N.C. & Mann, M. Extracting gene function from protein-protein interactions using Quantitative BAC InteraCtomics (QUBIC). Methods 53, 453-459 (2011).