Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality

Nature Structural and Molecular Biology

Volumn 20, Issue 8, 2013, Pages 923-928

  Ntini, Evgenia ^a   Järvelin, Aino I ^b   Bornholdt, Jette ^c   Chen, Yun ^c   Boyd, Mette ^c   Jørgensen, Mette ^c   Andersson, Robin ^c   Hoof, Ilka ^c   Schein, Aleks ^a,d   Andersen, Peter R ^a   Andersen, Pia K ^a   Preker, Pascal ^a   Valen, Eivind ^c,e   Zhao, Xiaobei ^c   Pelechano, Vicent ^b   Steinmetz, Lars M ^b   Sandelin, Albin ^c   Jensen, Torben Heick ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d RIKEN YOKOHAMA INSTITUTE   (Japan)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROMOTER UPSTREAM TRANSCRIPT; RNA POLYMERASE II; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; DOWNSTREAM PROCESSING; GENETIC ASSOCIATION; HIGH THROUGHPUT SEQUENCING; HUMAN; MUTAGENESIS; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; RNA DEGRADATION; RNA TRANSCRIPTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

BASE SEQUENCE; BLOTTING, NORTHERN; HELA CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; POLYADENYLATION; PROMOTER REGIONS, GENETIC; RNA POLYMERASE II; RNA STABILITY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 84881474625     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2640     Document Type: Article

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