Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation

American Journal of Sports Medicine

Volumn 41, Issue 8, 2013, Pages 1819-1826

  Mendias, Christopher L ^a   Lynch, Evan B ^a   Davis, Max E ^a   Sibilsky Enselman, Elizabeth R ^a   Harning, Julie A ^a   Dewolf, Paul D ^a   Makki, Tarek A ^a   Bedi, Asheesh ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

ACL reconstruction; C reactive protein; cartilage oligomeric matrix protein; muscle atrophy; myostatin; transforming growth factor

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CARTILAGE MATRIX PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CYTOKINE; GLYCOPROTEIN; MSTN PROTEIN, HUMAN; MYOSTATIN; SCLEROPROTEIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ADULT; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; ARTICLE; BLOOD; CHONDROGENESIS; CLINICAL TRIAL; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; INJURY; KNEE INJURY; MALE; METABOLISM; MIDDLE AGED; MUSCLE ATROPHY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; TRANSFORMING GROWTH FACTOR-Β; TREATMENT OUTCOME;

ACL RECONSTRUCTION; C-REACTIVE PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; MUSCLE ATROPHY; MYOSTATIN; TRANSFORMING GROWTH FACTOR-Β;

ADOLESCENT; ADULT; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHONDROGENESIS; CYTOKINES; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FOLLOW-UP STUDIES; GLYCOPROTEINS; HUMANS; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; KNEE INJURIES; MALE; MIDDLE AGED; MUSCULAR ATROPHY; MYOSTATIN; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84881431808     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513490651     Document Type: Article

References (46)

1. Anderson AF, Irrgang JJ, Kocher MS, Mann BJ, Harrast JJ. The International Knee Documentation Committee Subjective Knee Evaluation Form: normative data. Am J Sports Med. 2006 ; 34 (1). 128-135
2. Attie KM, Borgstein NG, Yang Y, et al. A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013 ; 47 (3). 416-423
3. Bergin PF, Doppelt JD, Kephart CJ, et al. Comparison of minimally invasive direct anterior versus posterior total hip arthroplasty based on inflammation and muscle damage markers. J Bone Joint Surg Am. 2011 ; 93 (15). 1392-1398
4. Beynnon BD, Johnson RJ, Abate JA, Fleming BC, Nichols CE. Treatment of anterior cruciate ligament injuries: part 2. Am J Sports Med. 2005 ; 33 (11). 1751-1767
5. Beynnon BD, Uh BS, Johnson RJ, et al. Rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind comparison of programs administered over 2 different time intervals. Am J Sports Med. 2005 ; 33 (3). 347-359
6. Bigoni M, Sacerdote P, Turati M, et al. Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury. J Orthop Res. 2013 ; 31 (2). 315-321
7. Black S, Kushner I, Samols D. C-reactive protein. J Biol Chem. 2004 ; 279 (47). 48487-48490
8. Brown TN, Palmieri-Smith RM, McLean SG. Sex and limb differences in hip and knee kinematics and kinetics during anticipated and unanticipated jump landings: implications for anterior cruciate ligament injury. Br J Sports Med. 2009 ; 43 (13). 1049-1056
9. Brunelli S, Rovere-Querini P. The immune system and the repair of skeletal muscle. Pharmacol Res. 2008 ; 58 (2). 117-121
10. Cameron M, Buchgraber A, Passler H, et al. The natural history of the anterior cruciate ligament-deficient knee: changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med. 1997 ; 25 (6). 751-754
11. Carlson CJ, Booth FW, Gordon SE. Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. Am J Physiol. 1999 ; 277 (2 Pt 2). R601 - R606
12. Chen S, Murphy J, Toth R, Campbell DG, Morrice NA, Mackintosh C. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 ; 409 (2). 449-459
13. Cuellar VG, Cuellar JM, Golish SR, Yeomans DC, Scuderi GJ. Cytokine profiling in acute anterior cruciate ligament injury. Arthroscopy. 2010 ; 26 (10). 1296-1301
14. Delfino GB, Peviani SM, Durigan JLQ, et al. Quadriceps muscle atrophy after anterior cruciate ligament transection involves increased mRNA levels of atrogin-1, muscle ring finger 1, and myostatin. Am J Phys Med Rehabil. 2013 ; 92 (5). 411-419
15. Dumont N, Lepage K, Côté CH, Frenette J. Mast cells can modulate leukocyte accumulation and skeletal muscle function following hindlimb unloading. J Appl Physiol. 2007 ; 103 (1). 97-104
16. Fulzele S, Arounleut P, Cain M, et al. Role of myostatin (GDF-8) signaling in the human anterior cruciate ligament. J Orthop Res. 2010 ; 28 (8). 1113-1118
17. Garvican ER, Vaughan-Thomas A, Clegg PD, Innes JF. Biomarkers of cartilage turnover, part 2: non-collagenous markers. Vet J. 2010 ; 185 (1). 43-49
18. Golightly YM, Marshall SW, Kraus VB, et al. Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms?. Arthritis Rheum. 2011 ; 63 (8). 2276-2283
19. Griffin LY, Albohm MJ, Arendt EA, et al. Understanding and preventing noncontact anterior cruciate ligament injuries: a review of the Hunt Valley II meeting, January 2005. Am J Sports Med. 2006 ; 34: 1512-1532
20. Haddad F, Zaldivar F, Cooper DM, Adams GR. IL-6-induced skeletal muscle atrophy. J Appl Physiol. 2005 ; 98 (3). 911-917
21. Hasegawa S, Kobayashi M, Arai R, Tamaki A, Nakamura T, Moritani T. Effect of early implementation of electrical muscle stimulation to prevent muscle atrophy and weakness in patients after anterior cruciate ligament reconstruction. J Electromyogr Kinesiol. 2011 ; 21 (4). 622-630
22. Hawke TJ, Garry DJ. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol. 2001 ; 91 (2). 534-551
23. Hayward AL, Deehan DJ, Aspden RM, Sutherland AG. Analysis of sequential cytokine release after ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2011 ; 19 (10). 1709-1715
24. Ingersoll CD, Grindstaff TL, Pietrosimone BG, Hart JM. Neuromuscular consequences of anterior cruciate ligament injury. Clin Sports Med. 2008 ; 27 (3). 383 vii - 404
25. Koh TJ, Pizza FX. Do inflammatory cells influence skeletal muscle hypertrophy?. Front Biosci (Elite Ed). 2009 ; 1: 60-71
26. Li W, Moylan JS, Chambers MA, Smith J, Reid MB. Interleukin-1 stimulates catabolism in C2C12 myotubes. Am J Physiol Cell Physiol. 2009 ; 297 (3). C706 - C714
27. Li Y-P, Chen Y, John J, et al. TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J. 2005 ; 19 (3). 362-370
28. Lohmander LS, Ostenberg A, Englund M, Roos H. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum. 2004 ; 50 (10). 3145-3152
29. Mendias CL, Gumucio JP, Davis ME, Bromley CW, Davis CS, Brooks SV. Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis. Muscle Nerve. 2012 ; 45 (1). 55-59
30. Mendias CL, Kayupov E, Bradley JR, Brooks SV, Claflin DR. Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation. J Appl Physiol. 2011 ; 111 (1). 185-191
31. Murton AJ, Greenhaff PL. Physiological control of muscle mass in humans during resistance exercise, disuse and rehabilitation. Curr Opin Clin Nutr Metab Care. 2010 ; 13 (3). 249-254
32. Palmieri-Smith RM, Thomas AC, Wojtys EM. Maximizing quadriceps strength after ACL reconstruction. Clin Sports Med. 2008 ; 27 (3). 405 vii - 424 ix
33. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003 ; 107: 499-511
34. Punzi L, Oliviero F, Plebani M. New biochemical insights into the pathogenesis of osteoarthritis and the role of laboratory investigations in clinical assessment. Crit Rev Clin Lab Sci. 2005 ; 42 (4). 279-309
35. Roos EM. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol. 2005 ; 17 (2). 195-200
36. Sandri M. Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda, Md). 2008 ; 23: 160-170
37. Shen H, Zhang N, Zhang X, Ji W. C-reactive protein levels after 4 types of arthroplasty. Acta Orthop. 2009 ; 80 (3). 330-333
38. Smith C, Kruger MJ, Smith RM, Myburgh KH. The inflammatory response to skeletal muscle injury: illuminating complexities. Sports Med. 2008 ; 38 (11). 947-969
39. Stinckens A, Georges M, Buys N. Mutations in the myostatin gene leading to hypermuscularity in mammals: indications for a similar mechanism in fish?. Anim Genet. 2011 ; 42 (3). 229-234
40. Vassallo JD, Janovitz EB, Wescott DM, Chadwick C, Lowe-Krentz LJ, Lehman-McKeeman LD. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 ; 111 (2). 402-412
41. Villalta SA, Rinaldi C, Deng B, Liu G, Fedor B, Tidball JG. Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype. Hum Mol Genet. 2011 ; 20 (4). 790-805
42. von Porat A, Roos EM, Roos H. High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis. 2004 ; 63 (3). 269-273
43. Ware JE SF-12v2 Health Survey: Administration Guide for Clinical Trial Investigators. Lincoln, Rhode Island: QualityMetric Incorporated ; 2010 :
44. Williams GN, Snyder-Mackler L, Barrance PJ, Buchanan TS. Quadriceps femoris muscle morphology and function after ACL injury: a differential response in copers versus non-copers. J Biomech. 2005 ; 38 (4). 685-693
45. Yamada S, Buffinger N, DiMario J, Strohman RC. Fibroblast growth factor is stored in fiber extracellular matrix and plays a role in regulating muscle hypertrophy. Med Sci Sports Exerc. 1989 ; 21: S173 - S180
46. Zimmers TA, Davies MV, Koniaris LG, et al. Induction of cachexia in mice by systemically administered myostatin. Science. 2002 ; 296 (5572). 1486-1488 Skin Diseases