Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 32, 2013, Pages 13026-13031

  Choudhary, Alka ^a,b   Lera, Robert F ^a,b   Martowicz, Melissa L ^a,b,e   Oxendine, Kim ^c   Laffin, Jennifer J ^c   Weaver, Beth A ^a,d   Burkard, Mark E ^a,b  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c WISCONSIN STATE LABORATORY OF HYGIENE   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e Lytic Solutions   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL CYCLE G1 PHASE; CELL FATE; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINESIS; DICTYOSTELIUM; GROWTH CURVE; HUMAN; HUMAN CELL; INTERPHASE; KARYOTYPE; MICROTUBULE; MITOSIS; PRIORITY JOURNAL;

ANEUPLOIDY; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL DIVISION; CELL LINE; CELL NUCLEUS; CYTOKINESIS; EPITHELIAL CELLS; GENOME, HUMAN; GREEN FLUORESCENT PROTEINS; HCT116 CELLS; HISTONES; HUMANS; INTERPHASE; KARYOTYPE; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; MICROTUBULES;

EID: 84881429581     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308203110     Document Type: Article

References (39)

1. Boveri T (1914) Zur Frage der Entstehung maligner Tumoren [Concerning the Origin of Malignant Tumors] (Fischer Verlag, Jena); trans Harris H (2008). J Cell Sci 121(Suppl 1): 1-84.
2. Hanks S, et al. (2004) Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36(11):1159-1161.
3. Michel LS, et al. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409(6818):355-359.
4. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW (2007) Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11(1):25-36.
5. Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM (2007) Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol 179(2):255-267.
6. Brito DA, Rieder CL (2006) Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol 16(12):1194-1200.
7. Lanni JS, Jacks T (1998) Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18(2):1055-1064.
8. Straight AF, Field CM (2000) Microtubules, membranes and cytokinesis. Curr Biol 10(20):R760-R770.
9. Krajcovic M, et al. (2011) A non-genetic route to aneuploidy in human cancers. Nat Cell Biol 13(3):324-330.
10. Mullins JM, Biesele JJ (1977) Terminal phase of cytokinesis in D-98s cells. J Cell Biol 73(3):672-684.
11. Weaver BA, Silk AD, Cleveland DW (2006) Cell biology: Nondisjunction, aneuploidy and tetraploidy. Nature 449(7104):E9-E10.
12. Fujiwara T, et al. (2005) Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437(7061):1043-1047.
13. Ganem NJ, Godinho SA, Pellman D (2009) A mechanism linking extra centrosomes to chromosomal instability. Nature 460(7252):278-282.
14. Dalton WB, Nandan MO, Moore RT, Yang VW (2007) Human cancer cells commonly acquire DNA damage during mitotic arrest. Cancer Res 67(24):11487-11492.
15. Orth JD, Loewer A, Lahav G, Mitchison TJ (2012) Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell 23(4):567-576.
16. Straight AF, et al. (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299(5613):1743-1747.
17. Ganem NJ, Storchova Z, Pellman D (2007) Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 17(2):157-162.
18. Stukenberg PT (2004) Triggering p53 after cytokinesis failure. J Cell Biol 165(5): 607-608.
19. Uetake Y, Sluder G (2004) Cell cycle progression after cleavage failure: Mammalian somatic cells do not possess a "tetraploidy checkpoint" J Cell Biol 165(5):609-615.
20. Brown SS, Spudich JA (1981) Mechanism of action of cytochalasin: Evidence that it binds to actin filament ends. J Cell Biol 88(3):487-491.
21. Maciejowski J, et al. (2010) Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol 190(1):89-100.
22. Sakaue-Sawano A, et al. (2008) Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132(3):487-498.
23. Wist E, Prydz H (1979) The effect of aphidicolin on DNA synthesis in isolated HeLa cell nuclei. Nucleic Acids Res 6(4):1583-1590.
24. Glotzer M (2005) The molecular requirements for cytokinesis. Science 307(5716): 1735-1739.
25. Burkard ME, et al. (2007) Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci USA 104(11):4383-4388.
26. Petronczki M, Glotzer M, Kraut N, Peters JM (2007) Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell 12(5):713-725.
27. Ditchfield C, et al. (2003) Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 161(2):267-280.
28. Lénárt P, et al. (2007) The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol 17(4):304-315.
29. Duncan AW, et al. (2010) The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature 467(7316):707-710.
30. Wong C, Stearns T (2005) Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure. BMC Cell Biol 6(1):6.
31. De Lozanne A, Spudich JA (1987) Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination. Science 236(4805):1086-1091.
32. O'Connell CB, Wheatley SP, Ahmed S, Wang YL (1999) The small GTP-binding protein rho regulates cortical activities in cultured cells during division. J Cell Biol 144(2): 305-313.
33. Uyeda TQ, Nagasaki A (2004) Variations on a theme: The many modes of cytokinesis. Curr Opin Cell Biol 16(1):55-60.
34. Burton K, Taylor DL (1997) Traction forces of cytokinesis measured with optically modified elastic substrata. Nature 385(6615):450-454.
35. Kanada M, Nagasaki A, Uyeda TQ (2005) Adhesion-dependent and contractile ringindependent equatorial furrowing during cytokinesis in mammalian cells. Mol Biol Cell 16(8):3865-3872.
36. Poirier CC, Ng WP, Robinson DN, Iglesias PA (2012) Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLOS Comput Biol 8(4):e1002467.
37. Ng MR, Besser A, Danuser G, Brugge JS (2012) Substrate stiffness regulates cadherindependent collective migration through myosin-II contractility. J Cell Biol 199(3): 545-563.
38. Debnath J, Muthuswamy SK, Brugge JS (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30(3):256-268.
39. Brown KD, Wood KW, Cleveland DW (1996) The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A. J Cell Sci 109(Pt 5):961-969.