Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5054-5063

  Roman, Bart I ^a   De Coen, Laurens M ^a   Mortier, Séverine Thérèse F C ^a   De Ryck, Tine ^b   Vanhoecke, Barbara W A ^b   Katritzky, Alan R ^c,d   Bracke, Marc E ^b   Stevens, Christian V ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c University of Florida   (United States)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Cancer; Chalcone; Invasion; SAR; Stilbene

Indexed keywords

1,2,3 TRIMETHOXY 5 (4' FLUOROPHENYLETHYNYL)BENZENE; 1,2,3 TRIMETHOXY 5 (PHENYLETHYNYL)BENZENE; 3 FLUOROSTILBENE; 3,4' DIFLUOROSTILBENE; 3,4',5 TRIMETHOXY 3' AMINOSTILBENE; 3,4,5 TRIMETHOXYSTILBENE; 4' CHLORO 3 METHOXYSTILBENE; 4' FLUORO 3,4,5 TRIMETHOXYSTILBENE; 4,4' DIFLUOROSTILBENE; COMBRETASTATIN A4 PHOSPHATE; PICEATANNOL; RESVERATROL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHICK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART; HUMAN; HYDROGENATION; HYDROSILYLATION; IN VITRO STUDY; MOUSE; NONHUMAN; PROTODESILYLATION; RAT; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; WITTIG REACTION;

CANCER; CHALCONE; INVASION; SAR; STILBENE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL MOVEMENT; CHALCONES; CHICKENS; DRUG DESIGN; FEMALE; HEART; HUMANS; MCF-7 CELLS; ORGAN CULTURE TECHNIQUES; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881378091     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.048     Document Type: Article

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