The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage

Anesthesia and Analgesia

Volumn 117, Issue 2, 2013, Pages 514-522

  Breu, Anita ^a   Rosenmeier, Katharina ^a   Kujat, Richard ^a   Angele, Peter ^a   Zink, Wolfgang ^b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b KLINIKUM LUDWIGSHAFEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CASPASE; MEPIVACAINE; ROPIVACAINE;

ANALGESIC ACTIVITY; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PRIORITY JOURNAL;

ADULT; AMIDES; ANESTHETICS, LOCAL; APOPTOSIS; BUPIVACAINE; CARTILAGE; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; MEPIVACAINE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NECROSIS; OSTEOARTHRITIS; TIME FACTORS;

EID: 84881375629     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31829481ed     Document Type: Article

References (32)

1. Koyonos L, Yanke AB, McNickle AG, Kirk SS, Kang RW, Lewis PB, Cole BJ. A randomized, prospective, double-blind study to investigate the effectiveness of adding DepoMedrol to a local anesthetic injection in postmeniscectomy patients with osteoar-thritis of the knee. Am J Sports Med 2009;37:1077-82
2. Karpie JC, Chu CR. Lidocaine exhibits dose-and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. Am J Sports Med 2007;35:1621-7
3. Chu CR, Izzo NJ, Coyle CH, Papas NE, Logar A. The in vitro effects of bupivacaine on articular chondrocytes. J Bone Joint Surg Br 2008;90:814-20
4. Chu CR, Coyle CH, Chu CT, Szczodry M, Seshadri V, Karpie JC, Cieslak KM, Pringle EK. In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. J Bone Joint Surg Am 2010;92:599-608
5. Grishko V, Xu M, Wilson G, Pearsall AW 4th. Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine. J Bone Joint Surg Am 2010;92:609-18
6. Syed HM, Green L, Bianski B, Jobe CM, Wongworawat MD. Bupivacaine and triamcinolone may be toxic to human chon-drocytes: a pilot study. Clin Orthop Relat Res 2011;469:2941-7
7. Goldring MB. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 2000;43:1916-26
8. Slabaugh MA, Friel NA, Cole BJ. Rapid chondrolysis of the knee after anterior cruciate ligament reconstruction: a case report. J Bone Joint Surg Am 2010;92:186-9
9. Saltzman M, Mercer D, Bertelsen A, Warme W, Matsen F. Postsurgical chondrolysis of the shoulder. Orthopedics 2009;32:215
10. Bailie DS, Ellenbecker TS. Severe chondrolysis after shoulder arthroscopy: a case series. J Shoulder Elbow Surg 2009;18:742-7
11. Berde CB, Strichartz GR. Local anesthetics. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL, eds. Miller's Anesthesia. 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier, 2010:913-40
12. Zink W, Seif C, Bohl JR, Hacke N, Braun PM, Sinner B, Martin E, Fink RH, Graf BM. The acute myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blockades. Anesth Analg 2003;97:1173-9
13. Zink W, Graf BM. Beneft-risk assessment of ropivacaine in the management of postoperative pain. Drug Saf 2004;27:1093-114
14. Zink W, Graf BM. Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms. Anaesthesist 2003;52:1102-23
15. Graf BM, Zausig Y, Zink W. Current status and clinical relevance of studies of minimum local-anaesthetic concentration (MLAC). Curr Opin Anaesthesiol 2005;18:241-5
16. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specifc recognition and removal by macrophages. J Immunol 1992;148:2207-16
17. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phos-phatidylserine expression on early apoptotic cells using fuo-rescein labelled Annexin V. J Immunol Methods 1995;184:39-51
18. Braun JS, Novak R, Herzog KH, Bodner SM, Cleveland JL, Tuomanen EI. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat Med 1999;5:298-302
19. Braun JS, Tuomanen EI, Cleveland JL. Neuroprotection by cas-pase inhibitors. Expert Opin Investig Drugs 1999;8:1599-610
20. D'Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, Lotz MK. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 2001;9:712-9
21. Hashimoto S, Ochs RL, Komiya S, Lotz M. Linkage of chondro-cyte apoptosis and cartilage degradation in human osteoarthri-tis. Arthritis Rheum 1998;41:1632-8
22. Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, Lotz M. Chondrocyte-derived apoptotic bodies and calcifcation of articular cartilage. Proc Natl Acad Sci USA 1998;95:3094-9
23. Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am 2008;90:986-91
24. Farkas B, Kvell K, Czömpöly T, Illés T, Bárdos T. Increased chondrocyte death after steroid and local anesthetic combination. Clin Orthop Relat Res 2010;468:3112-20
25. Park J, Sutradhar BC, Hong G, Choi SH, Kim G. Comparison of the cytotoxic effects of bupivacaine, lidocaine, and mepivacaine in equine articular chondrocytes. Vet Anaesth Analg 2011;38:127-33
26. Lo IK, Sciore P, Chung M, Liang S, Boorman RB, Thornton GM, Rattner JB, Muldrew K. Local anesthetics induce chondrocyte death in bovine articular cartilage disks in a dose-and duration-dependent manner. Arthroscopy 2009;25: 707-15
27. Debruyne D, Moulin MA, Carmes C, Beguin JA, Locker B. Monitoring serum bupivacaïne levels during arthroscopy. Eur J Clin Pharmacol 1985;27:733-5
28. Kaeding CC, Hill JA, Katz J, Benson L. Bupivacaine use after knee arthroscopy: pharmacokinetics and pain control study. Arthroscopy 1990;6:33-9
29. Dye SF. The knee as a biologic transmission with an envelope of function: a theory. Clin Orthop Relat Res 1996:10-8
30. Suh JK, Youn I, Fu FH. An in situ calibration of an ultrasound transducer: a potential application for an ultrasonic indentation test of articular cartilage. J Biomech 2001;34:1347-53
31. Lee JI, Sato M, Ushida K, Mochida J. Measurement of diffusion in articular cartilage using fuorescence correlation spectros-copy. BMC Biotechnol 2011;11:19
32. Brandl A, Hartmann A, Bechmann V, Graf B, Nerlich M, Angele P. Oxidative stress induces senescence in chondrocytes. J Orthop Res 2011;29:1114-20