Elective inguinal node irradiation in early-stage T2N0 anal cancer: Prognostic impact on locoregional control

International Journal of Radiation Oncology Biology Physics

Volumn 87, Issue 1, 2013, Pages 60-66

  Zilli, Thomas ^a   Betz, Michael ^a,b   Bieri, Sabine ^a   Ris, Frederic ^a   Roche, Bruno ^a   Roth, Arnaud D ^a   Allal, Abdelkarim S ^a,c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b Hirslanden Radiation Oncology Institute   (Switzerland)

^c Hopital Cantonal de Fribourg   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; ACUTE TOXICITY; CHEMORADIATION THERAPIES; LOCAL CONTROL; LOCOREGIONAL CONTROL; METHODS AND MATERIALS; OVERALL SURVIVAL; RELAPSE RATES;

DISEASES; PATIENT MONITORING;

PATIENT TREATMENT;

CISPLATIN; FLUOROURACIL; MITOMYCIN;

ABDOMINAL PAIN; ADULT; AGED; ANUS CARCINOMA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL EVALUATION; CONTINUOUS INFUSION; DIARRHEA; EARLY CANCER; ERYTHEMA; FEMALE; FOLLOW UP; FRACTURE; HUMAN; INGUINAL REGION; INTESTINE OBSTRUCTION; IRRADIATION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; OVERALL SURVIVAL; PRIORITY JOURNAL; PUBIC BONE; RECTOVAGINAL FISTULA; RECURRENCE FREE SURVIVAL; RECURRENT CANCER; RETROSPECTIVE STUDY; ULCER;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CARCINOMA, TRANSITIONAL CELL; CHEMORADIOTHERAPY; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; HUMANS; INGUINAL CANAL; LYMPHATIC IRRADIATION; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASM STAGING; RETROSPECTIVE STUDIES;

EID: 84881372846     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.03.008     Document Type: Article

References (25)

1. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UK Co-ordinating Committee on Cancer Research Lancet 348 1996 1049 1054
2. H. Bartelink, F. Roelofsen, and F. Eschwege Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups J Clin Oncol 15 1997 2040 2049
3. J.A. Ajani, K.A. Winter, and L.L. Gunderson Fluorouracil, mitomycin, and radiotherapy vs. fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial JAMA 299 2008 1914 1921
4. E. Deniaud-Alexandre, E. Touboul, and E. Tiret Results of definitive irradiation in a series of 305 epidermoid carcinomas of the anal canal Int J Radiat Oncol Biol Phys 56 2003 1259 1273
5. M. Flam, M. John, and T.F. Pajak Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol 14 1996 2527 2539
6. C. Ortholan, A. Ramaioli, and D. Peiffert Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy Int J Radiat Oncol Biol Phys 62 2005 479 485
7. T. Zilli, U. Schick, and M. Ozsahin Node-negative T1-T2 anal cancer: radiotherapy alone or concomitant chemoradiotherapy? Radiother Oncol 102 2012 62 67
8. J. Papillon, and J.F. Montbarbon Epidermoid carcinoma of the anal canal. A series of 276 cases Dis Colon Rectum 30 1987 324 333
9. R.J. Myerson, E.D. Outlaw, and A. Chang Radiotherapy for epidermoid carcinoma of the anus: thirty years' experience Int J Radiat Oncol Biol Phys 75 2009 428 435
10. E. Touboul, M. Schlienger, and L. Buffat Epidermoid carcinoma of the anal canal. Results of curative-intent radiation therapy in a series of 270 patients Cancer 73 1994 1569 1579
11. J.P. Gerard, O. Chapet, and F. Samiei Management of inguinal lymph node metastases in patients with carcinoma of the anal canal: experience in a series of 270 patients treated in Lyon and review of the literature Cancer 92 2001 77 84
12. C. Ortholan, M. Resbeut, and J.M. Hannoun-Levi Anal canal cancer: management of inguinal nodes and benefit of prophylactic inguinal irradiation (CORS-03 Study) Int J Radiat Oncol Biol Phys 82 2012 1988 1995
13. J.H. Matthews, B.H. Burmeister, and M. Borg T1-2 anal carcinoma requires elective inguinal radiation treatment-the results of Trans Tasman Radiation Oncology Group study TROG 99.02 Radiother Oncol 98 2011 93 98
14. P. Das, S. Bhatia, and C. Eng Predictors and patterns of recurrence after definitive chemoradiation for anal cancer Int J Radiat Oncol Biol Phys 68 2007 794 800
15. R. Ferrigno, R.A. Nakamura, and P.E. Dos Santos Novaes Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness Int J Radiat Oncol Biol Phys 61 2005 1136 1142
16. P. Hatfield, R. Cooper, and D. Sebag-Montefiore Involved-field, low-dose chemoradiotherapy for early-stage anal carcinoma Int J Radiat Oncol Biol Phys 70 2008 419 424
17. C. Crowley, A.Z. Winship, and M.A. Hawkins Size does matter: can we reduce the radiotherapy field size for selected cases of anal canal cancer undergoing chemoradiation? Clin Oncol (R Coll Radiol) 21 2009 376 379
18. Y.J. Chen, A. Liu, and P.T. Tsai Organ sparing by conformal avoidance intensity-modulated radiation therapy for anal cancer: dosimetric evaluation of coverage of pelvis and inguinal/femoral nodes Int J Radiat Oncol Biol Phys 63 2005 274 281
19. A. Clivio, A. Fogliata, and A. Franzetti-Pellanda Volumetric-modulated arc radiotherapy for carcinomas of the anal canal: a treatment planning comparison with fixed field IMRT Radiother Oncol 92 2009 118 124
20. K.J. Joseph, A. Syme, and C. Small A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer Radiother Oncol 94 2010 60 66
21. M.T. Milano, A.B. Jani, and K.J. Farrey Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome Int J Radiat Oncol Biol Phys 63 2005 354 361
22. L.A. Kachnic, H.K. Tsai, and J.J. Coen Dose-painted intensity-modulated radiation therapy for anal cancer: a multi-institutional report of acute toxicity and response to therapy Int J Radiat Oncol Biol Phys 82 2012 153 158
23. J.K. Salama, L.K. Mell, and D.A. Schomas Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience J Clin Oncol 25 2007 4581 4586
24. M. Krengli, M.E. Milia, and L. Turri FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma Radiat Oncol 5 2010 10
25. M. Mistrangelo, E. Pelosi, and M. Bello Comparison of positron emission tomography scanning and sentinel node biopsy in the detection of inguinal node metastases in patients with anal cancer Int J Radiat Oncol Biol Phys 77 2010 73 78