Radiochemotherapy in the conservative treatment of anal canal carcinoma: Retrospective analysis of results and radiation dose effectiveness

International Journal of Radiation Oncology Biology Physics

Volumn 61, Issue 4, 2005, Pages 1136-1142

  Ferrigno, Robson ^a,b   Nakamura, Ricardo Akiyoshi ^a   Dos Santos Novaes, Paulo Eduardo Ribeiro ^a   Assis Pellizzon, Antonio Cássio ^a   Conte Maia, Maria Aparecida ^a   Fogarolli, Ricardo César ^a   Salvajoli, João Victor ^a   Filho, Waldec Jorge David ^a   Lopes, Ademar ^a  

^a A C CAMARGO CANCER CENTER   (Brazil)

^b NONE   (Brazil)

Author keywords

Anal canal; Chemotherapy; Radiotherapy

Indexed keywords

CHEMOTHERAPY; DOSIMETRY; PATIENT TREATMENT; RADIOTHERAPY; TOXICITY;

CANAL CARCINOMA; COLOSTOMY-FREE SURVIVAL; PROGNOSTIC FACTORS; RADIOCHEMOTHERAPY;

TUMORS;

FLUOROURACIL; MITOMYCIN C;

ACUTE TOXICITY; ADULT; AGE DISTRIBUTION; AGED; ANUS CARCINOMA; ANUS SPHINCTER; ARTICLE; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER INCIDENCE; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; COLOSTOMY; CONSERVATIVE TREATMENT; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DYSURIA; FEMALE; FOLLOW UP; HAND FOOT SYNDROME; HUMAN; INGUINAL REGION; LEUKOPENIA; MALE; METASTASIS; PELVIS; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE; RADIATION INDUCED EMESIS; RETROSPECTIVE STUDY; SKIN MANIFESTATION; SKIN TOXICITY; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY DOSAGE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 14844309350     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.07.687     Document Type: Article

References (40)

1. M.W. Stearns Jr, C. Urmacher, S.S. Sternberg Cancer of the anal canal Curr Probl Cancer 4 1980 1 44
2. S.H. Landis, T. Murray, S. Bolden Cancer statistics, 1999 CA Cancer J Clin 49 1999 8 31
3. N.D. Nigro, V.K. Vaitkevicius, B. Considine Jr Combined therapy for cancer of the anal canal: A preliminary report Dis Colon Rectum 17 1974 354 356
4. American Joint Committee on Cancer. Anal cancer. In: Greene FL, Page DL, Fleming ID, editors. AJCC cancer staging manual. New York: Springer-Verlag; 2001. p. 139.
5. A.M. Kalend, T.L. Park, A. Wu Transmission blocks: Clinical and biologic rationales Int J Radiat Oncol Biol Phys 19 1990 153 158
6. J.F. Cox, J. Stetz, T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
7. E.L. Kaplan, P. Meier Nonparametric estimation from incomplete observation J Am Stat Assoc 53 1958 457 481
8. B.D. Minsky, J.P. Hoffman, D.P. Kelsen Cancer of the anal region V.T. DeVita Jr S. Hellman S.A. Rosenberg Cancer: Principles and practice of oncology Sixth edition 2002 Lippincott-Williams & Wilkins Philadelphia 1319 1342
9. B.D. Minsky Anal canal cancer S. Leibel T.L. Phillips Textbook of radiation oncology 1998 WB Saunders Philadelphia 703 709
10. J.V. Klas, D.A. Rothenberg, W.D. Wong Malignant tumors of the anal canal: The spectrum of disease, treatment and outcomes Cancer 85 1999 1686 1693
11. A. Habr-Gama, A.H.S. Souza Jr, W. Nadalin Epidermoid carcinoma of the anal canal: Results of treatment by combined chemotherapy and radiation therapy Dis Colon Rectum 32 1989 773 777
12. N.D. Nigro An evaluation of combined therapy for squamous cell cancer of the anal cancer Dis Colon Rectum 27 1984 763 766
13. E. Touboul, M. Schlinger, L. Buffat Epidermoid carcinoma of the anal canal: Results of curative-intent radiotherapy in a series of 270 patients Cancer 73 1994 1569 1579
14. MS Flam, M. John, T.F. Pajak Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: Results of a phase III randomized intergroup study J Clin Oncol 14 1996 2527 2539
15. M.S. Flam, M.J. John, T. Peters Radiation and 5-fluorouracil (5 FU) vs. radiation, 5 FU, mitomycin-C (MMC) in the treatment of anal canal carcinoma: Preliminary results of a phase III randomized RTOG/ECOG intergroup trial J Clin Oncol 14 1995 191
16. B.J. Cummings, T.J. Keane, B. O'Sullivan Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C Int J Radiat Oncol Biol Phys 21 1991 1115 1125
17. S.S. Nigh, S.R. Smalley, A.T. Elman Conservative therapy for anal carcinoma: An analysis of prognostic factors Proceedings of the annual ASTRO meeting Int J Radiat Oncol Biol Phys 21 1991 224
18. E.C. Constantinou, W. Daly, C.Y. Fung Time-dose considerations in the treatment of anal cancer Int J Radiat Oncol Biol Phys 39 1997 651 662
19. L.L. Hughes, T.A. Rich, L. Delclos Radiotherapy for anal cancer: Experience from 1979-1987 Int J Radiat Oncol Biol Phys 17 1989 1153 1161
20. M. John, T. Pajak, M.S. Flam Dose escalation in chemoradiation for anal cancer: Preliminary results of RTOG 92-08 Cancer J Sci Am 2 1996 205 211
21. J.A. Marterson, S.R. Lipsitz, H. Wagner Initial results of a phase II trial of high dose radiation therapy, 5-fluorouracil, and cisplatin for patients with anal cancer (E4292): An Eastern Cooperative Oncology Group Study Int J Radiat Oncol Biol Phys 35 1996 745 757
22. Minsky BD. Cancer of the colon, rectum and anus. In: Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO). Salt Lake City 2003 Educational Session 202.
23. H. Bartelink, F. Roelofsen, F. Eschwge Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer radiotherapy and gastrointestinal cooperative groups J Clin Oncol 15 1997 2040 2049
24. UKCCCR Anal Cancer Trial Working Party Epidermoid anal cancer: Results from the UKCCCR randomized trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin Lancet 348 1996 1049 1054
25. A.P. Sandhu, R.P. Symonds, A.G. Robertson Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: Ten years experience Int J Radiat Oncol Biol Phys 40 1998 575 581
26. D. Peiffert, P. Bey, M. Pernot Conservative treatment by irradiation of epidermoid cancers of the anal canal: Prognostic factors of tumor control and complications Int J Radiat Oncol Biol Phys 37 1997 313 324
27. G. Newman, D. Calverley, B. Alker The management of carcinoma of the anal canal by external beam radiotherapy, experience in Vancouver 1971-1988 Radiother Oncol 25 1992 196 202
28. A. De La Rochefordiere, D. Pntvert, B. Asselain Radiothérapie des cancers du canal anal Expérience de I'Institut Curie dans le traitement des aires ganglionnaires Bull Cancer Radiother 80 1993 391 398
29. J.P. Gerard, L. Ayzac, D. Hun Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum Long-term results in 95 patients Radiother Oncol 46 1998 249 256
30. J. Papillon, M. Mayer, J.F. Montbarbon A new approach to the management of epidermoid carcinoma of the anal canal Cancer 51 1983 1830 1837
31. A. Allal, F.M. Laurencet, A. Reymond Effectiveness of surgical salvage therapy for patients with locally uncontrolled anal carcinoma after sphincter conserving treatment Cancer 86 1999 405 409
32. Schlienger M, Krzisch C, Pene F, et al. Epidermoid carcinoma of the anal canal. Treatment results and prognostic variables in a series of 242 cases. Int J Radiat Oncol Biol Phys 1989;17:1141-1151.
33. J.P. Gerard, O. Chapet, F. Samiei Management of inguinal lymph node metastasis in patients with carcinoma of the anal canal: Experience in a series of 270 patients treated in Lyon and review of the literature Cancer 92 2001 77 84
34. G. Tanum, K. Tveit, M.D. Karlsen Chemotherapy and radiation therapy for anal carcinoma Cancer 67 1991 2462 2466
35. G. Grabenbaur, K. Matzel, I. Schneider Sphincter preservation with chemoradiation in anal canal carcinoma Abdominoperineal resection in selected cases Dis Colon Rectum 41 1998 441 450
36. G. Tanum, K.M. Tveit, K.O. Karlsen Chemoradiotherapy of anal carcinoma: Tumor response and acute toxicity Oncology 50 1993 14 17
37. S.E. Mitchell, W.M. Mendenhal, R.A. Zlotecki Squamous cell carcinoma of the anal canal Int J Radiat Oncol Biol Phys 45 2001 1007 1013
38. A.S. Allal, M.A. Sprangers, F.M. Laurencet Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy Br J Cancer 80 1999 1588 1594
39. R. Graf, P. Wust, B. Hildebrandt Impact of overall treatment time on local control of anal cancer treated with radiochemotherapy Oncology 65 2003 14 22
40. D.C. Weber, J.M. Kurtz, A.S. Allal The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy Int J Radiat Oncol Biol Phys 50 2001 675 680