Radiotherapy for Epidermoid Carcinoma of the Anus: Thirty Years' Experience

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 2, 2009, Pages 428-435

  Myerson, Robert J ^a   Outlaw, Elesyia D ^a   Chang, Albert ^a   Birnbaum, Elisa H ^a   Fleshman, James W ^a   Grigsby, Perry W ^a   Kodner, Ira J ^a   Malayapa, Robert S ^a   Mutch, Matthew G ^a   Parikh, Parag ^a   Picus, Joel ^a   Tan, Benjamin R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anal cancer; Chemoradiotherapy; Normal tissue complications

Indexed keywords

ANAL CANCER; ANTEROPOSTERIOR; BONE INJURY; CHEMORADIOTHERAPY; FEMORAL HEADS; HUMAN IMMUNODEFICIENCY VIRUS; NORMAL TISSUE COMPLICATIONS; RADIATION FIELD; SMALL BOWEL; TREATMENT PLANNING; TUMOR DOSE; UNIVARIATE ANALYSIS;

DISEASE CONTROL; FLUORESCENT SCREENS; TELEVISION PICTURE TUBES; TUMORS;

RADIOTHERAPY;

FLUOROURACIL; MITOMYCIN C;

ADULT; AGED; ANUS CARCINOMA; ARTICLE; BONE INJURY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE CONTROL; FEMALE; FOLLOW UP; GROUPS BY AGE; HISTOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NEUTROPENIA; PAIN; PALPATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RADIATION DOSE; SEX DIFFERENCE; SMALL INTESTINE OBSTRUCTION; SQUAMOUS CELL CARCINOMA; UNIVARIATE ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HIV SEROPOSITIVITY; HOSPITALS, UNIVERSITY; HUMANS; MALE; MIDDLE AGED; MISSOURI; MITOMYCIN; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS, MULTIPLE PRIMARY; NEOPLASMS, RADIATION-INDUCED; RADIATION INJURIES; RADIOTHERAPY DOSAGE; SALVAGE THERAPY;

EID: 69549103259     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.11.047     Document Type: Article

References (29)

1. Myerson R.J., Karnell L.H., and Menck H.R. The National Cancer Data Base report on carcinoma of the anus. Cancer 80 (1997) 805-815
2. Cummings B.J., Keane T.J., O'Sullivan B., et al. Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys 21 (1991) 1115-1125
3. Cummings B.J., Rider W.D., Harwood A.R., et al. Combined radical radiation therapy and chemotherapy for primary squamous cell carcinoma of the anal canal. Cancer Treat Rep 66 (1982) 489-492
4. Flam M.S., John M.J., Mowry P.A., et al. Definitive combined modality therapy of carcinoma of the anus: A report of 30 cases including results of salvage therapy in patients with residual disease. Dis Colon Rectum 30 (1987) 495-502
5. Myerson R.J., Shapiro S.J., Lacey D., et al. Carcinoma of the anal canal. Am J Clin Oncol 18 (1995) 32-39
6. Nigro N.D. An evaluation of combined therapy for squamous cell cancer of the anal canal. Dis Colon Rectum 27 (1984) 763-766
7. Nigro N.D., Seydel H.G., Considine B., et al. Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. Cancer 51 (1983) 1826-1829
8. Nigro N.D., Vaitkevicius V.K., Buroker T., et al. Combined therapy for cancer of the anal canal. Dis Colon Rectum 24 (1981) 73-75
9. Sischy B., Doggett R., and Krall J. Definitive irradiation and chemotherapy for radiosensitization in management of anal carcinoma: Interim report on Radiation Therapy Oncology Group Study No. 8314. J Natl Cancer Inst 54 (1984) 850-856
10. Bartelink H., Roelofsen F., Eschwege F., et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 15 (1997) 2040-2049
11. UKCCCR Anal Cancer Trial Working Party and UK Co-ordinating Committee on Cancer Research. Epidermoid anal cancer: Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 348 (1996) 1049-1054
12. Flam M., John M., Pajak T.F., et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: Results of a phase III randomized intergroup study. J Clin Oncol 14 (1996) 2527-2539
13. Ajani J.A., Winter K.A., Gunderson L.L., et al. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: A randomized controlled trial. JAMA 299 (2008) 1914-1921
14. Myerson R.J., Kong F., Birnbaum E.H., et al. Radiation therapy for epidermoid carcinoma of the anal canal, clinical and treatment factors associated with outcome. Radiother Oncol 61 (2001) 15-22
15. Das P., Bhatia S., Eng C., et al. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys 68 (2007) 794-800
16. John M., Pajak T., Flam M., et al. Dose escalation in chemoradiation for anal cancer: Preliminary results of RTOG 92-08. Cancer J Sci Am 2 (1996) 205-211
17. American Joint Committee on Cancer. AJCC cancer staging manual. 6th ed (2002), Lippincott Raven, Philadelphia
18. Cotter S.E., Grigsby P.W., Siegel B.A., et al. FDG-PET/CT in the evaluation of anal carcinoma. Int J Radiat Oncol Biol Phys 65 (2006) 720-725
19. Schwarz J.K., Siegel B.A., Dehdashti F., et al. Tumor response and survival predicted by post-therapy FDG-PET/CT in anal cancer. Int J Radiat Oncol Biol Phys 71 (2008) 180-186
20. Myerson R.J., Michalski J.M., King M.L., et al. Adjuvant radiation therapy for rectal carcinoma: Predictors of outcome. Int J Radiat Oncol Biol Phys 32 (1995) 41-50
21. Mould R.F. Introductory medical statistics. 3rd ed (1998), Institute of Physics Publishing, Philadelphia
22. Cox D.R. Regression models and life tables. J Royal Stat Soc 34 Series B (1972) 187-220
23. Myerson R., Picus J., and Read T.E. Combining chemotherapy with radiation in the adjuvant care of rectal cancer: Morbidity of treatment and its impact on management decisions. Perspect Colon Rectal Surg 12 (2000) 113-129
24. Schiller D.E., Cummings B.J., Rai S., et al. Outcomes of salvage surgery for squamous cell carcinoma of the anal canal. Ann Surg Oncol 14 (2007) 2780-2789
25. Chiao E.Y., Giordano T.P., Richardson P., et al. Human immunodeficiency virus-associated squamous cell cancer of the anus: Epidemiology and outcomes in the highly active antiretroviral therapy era. J Clin Oncol 26 (2008) 474-479
26. Salama J.K., Mell L.K., Schomas D.A., et al. Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: A multicenter experience. J Clin Oncol 25 (2007) 4581-4586
27. Milano M.T., Jani A.B., Farrey K.J., et al. Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: Toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 63 (2005) 354-361
28. Lin A., and Ben-Josef E. Intensity-modulated radiation therapy for the treatment of anal cancer. Clin Colorectal Cancer 6 (2007) 716-719
29. Chen Y.J., Liu A., Tsai P.T., et al. Organ sparing by conformal avoidance intensity-modulated radiation therapy for anal cancer: Dosimetric evaluation of coverage of pelvis and inguinal/femoral nodes. Int J Radiat Oncol Biol Phys 63 (2005) 274-281