Anal canal cancer: Management of inguinal nodes and benefit of prophylactic inguinal irradiation (CORS-03 study)

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 5, 2012, Pages 1988-1995

  Ortholan, Cécile ^a,b   Resbeut, Michel ^c,d,i   Hannoun Levi, Jean Michel ^a,i   Teissier, Eric ^e,i   Gerard, Jean Pierre ^a   Ronchin, Philippe ^e   Zaccariotto, Audrey ^f   Minsat, Mathieu ^d   Benezery, Karen ^a   François, Eric ^a   Salem, Naji ^d,i   Ellis, Steve ^g,i   Azria, David ^h,i   Champetier, Cédric ^f   Gross, Emmanuel ^f   Cowen, Didier ^f,i  

^a CENTRE ANTOINE LACASSAGNE   (France)

^b CENTRE HOSPITALIER PRINCESSE GRACE   (Monaco)

^c French Red Cross   (France)

^d INSTITUT PAOLI CALMETTES   (France)

^e Azurean Cancer Center   (France)

^f Timone Teaching Hospital   (France)

^g Catalan Oncology Center   (France)

^h CENTRE VAL D AURELLE   (France)

ⁱ Cercle des Oncologues Radiothérapeutes du Sud ^*  (France)

Author keywords

Anal cancer; Inguinal involvement; Prophylactic inguinal irradiation; Radiation therapy

Indexed keywords

ANAL CANAL; ANAL CANCER; DISEASE FREE SURVIVAL; DISEASE-SPECIFIC SURVIVALS; INGUINAL INVOLVEMENT; LOWER EXTREMITY; OVERALL SURVIVAL; SQUAMOUS CELL CARCINOMA; TOTAL DOSE;

DISEASES; HYDRAULIC STRUCTURES; IRRADIATION; RADIOTHERAPY; TUMORS;

PATIENT TREATMENT;

ADULT; AGED; ANAL CANAL SQUAMOUS CELL CARCINOMA; ANUS CANCER; ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SPECIFIC SURVIVAL; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; FRANCE; HUMAN; INGUINAL NODE METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POPULATION RESEARCH; PRIORITY JOURNAL; PROPHYLACTIC INGUINAL IRRADIATION; RADIATION DOSE; RETROSPECTIVE STUDY; RISK BENEFIT ANALYSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; SURVIVAL TIME;

AGE FACTORS; AGED; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; FEMALE; FRANCE; HUMANS; INGUINAL CANAL; LYMPHATIC IRRADIATION; LYMPHATIC METASTASIS; MALE; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RADIATION DOSAGE; RETROSPECTIVE STUDIES; TUMOR BURDEN;

EID: 84858708161     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.02.010     Document Type: Article

References (32)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-249.
2. Fleshner PR, Chalasani S, Chang GJ, et al. Standards Practice Task Force, American Society of Colon and Rectal Surgeons. Practice parameters for anal squamous neoplasms. Dis Colon Rectum 2008;51:2-9.
3. Recio PM. Radical surgery in the treatment of epidermoid carcinoma of the anal canal. Philipp J Surg 1955;10:1-8.
4. Harrison EG Jr., Beahrs OH, Hill JR. Anal and perianal malignant neoplasms: Pathology and treatment. Dis Colon Rectum 1966;9:255-267.
5. Papillon J, Dargent M, Pinet A, et al. Irradiation with curative aim in cancer of the rectum and anus. J Radiol Electrol Med Nucl 1961;42:818-820.
6. Papillon J, Montbarbon JF, Chassard JL, et al. Radiotherapy of malpighian cancers of the anus. Role of interstitial curietherapy, alone or combined with cobalt therapy, in the treatment of epidermoid cancers of the anus. J Radiol Electrol Med Nucl 1973;54:627-633.
7. Nigro ND, Vaitkevicius VK, Considine B Jr. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 1974;17:354-356.
8. Cummings BJ, Keane TJ, OSullivan B, et al. Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Rad Oncol Biol Phys 1991;21:1115-1125.
9. Arnott SJ, Cunningham JD, Gallagher J, et al., UKCCCR Anal Cancer Trial Working Party. Epidermoid anal cancer: Results from the UKCCCR randomized trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 1996;348:1049-1054. (Pubitemid 26343598)
10. Flam M, John M, Pajak TF, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: Results of a phase 3 randomized intergroup study. J Clin Oncol 1996;14:2527-2539. (Pubitemid 26300120)
11. The UKCCCR Anal Cancer Trial Working Party. Epidermoid anal cancer: Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil and mitomycin C. Lancet 1996;348:1049-1054.
12. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of Phase 3 randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997;15:2040-2049. (Pubitemid 27209535)
13. Schlienger M, Krzisch C, Pene F, et al. Epidermoid carcinoma of the anal canal treatment results and prognostic variables in a series of 242 cases. Int J Radiat Oncol Biol Phys 1989;17:1141-1151. (Pubitemid 20028629)
14. Touboul E, Schlienger M, Buffat L, et al. Epidermoid carcinoma of the anal canal. Results of curative-intent radiation therapy in a series of 270 patients. Cancer 1994;73:1569-1579. (Pubitemid 24085255)
15. Myerson RJ, Outlaw ED, Chang A, et al. Radiotherapy for epidermoid carcinoma of the anus: thirty years' experience. Int J Radiat Oncol Biol Phys 2009;75:428-435.
16. Ajani JA, Winter KA, Gunderson LL, et al. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: A randomized controlled trial. JAMA 2008;299:1914-21. (Pubitemid 351574921)
17. James R, Wan S, Glynne-Jones R, Sebag-Montefiore D, et al. A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/5FU in squamous cell carcinoma of the anus (ACT II). J Clin Oncol 2009;18s. abstr LBA4009. 2.3.
18. Conroy T, Ducreux M, Lemanski C, et al. Treatment intensification by induction chemotherapy (ICT) and radiation dose escalation in locally advanced squamous cell anal canal carcinoma (LAAC): Definitive analysis of the intergroup ACCORD 03 trial. J Clin Oncol 2009;27:15s (suppl; abstr 4033).
19. American Joint Committee on Cancer. Anal canal. In: AJCC Cancer Staging Manual. 6th ed. New York: Springer; 2002. p. 125-130.
20. International Commission on Radiation Units Measurements. Icru 58, Dose and Volume Specification for Reporting Interstitial Therapy. 1998.
21. Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials 1996;17:343-346. (Pubitemid 26342716)
22. Das P, Bhatia S, Eng C, et al. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys 2007;68:794-800. (Pubitemid 46818735)
23. Gerard JP, Chapet O, Samiei F, et al. Management of inguinal lymph node metastases in patients with carcinoma of the anal canal: experience in a series of 270 patients treated in Lyon and review of the literature. Cancer 2001;92:77-84. (Pubitemid 32623043)
24. Papillon J, Mayer M, Montbarbon JF, et al. A new approach to the management of epidermoid carcinoma of the anal canal. Cancer 1983;51:1830-1837. (Pubitemid 13093951)
25. Crowley C, Winship AZ, Hawkins MA, et al. Size does matter: Can we reduce the radiotherapy field size for selected cases of anal canal cancer undergoing chemoradiation? Clin Oncol 2009;21:376-379.
26. Ferrigno R, Nakamura RA, Dos Santos Novaes PE, et al. Radiochemotherapy in the conservative treatment of anal canal carcinoma: Retrospective analysis of results and radiation dose effectiveness. Int J Radiat Oncol Biol Phys 2005;61:1136-1142. (Pubitemid 40340908)
27. Gretschel S, Warnick P, Bembenek A, et al. Lymphatic mapping and sentinel lymph node biopsy in epidermoid carcinoma of the anal canal. Eur J Surg Oncol 2008;34:890-894.
28. Cotter SE, Grigsby PW, Siegel BA, et al. FDG-PET/CT in the evaluation of anal carcinoma. Int J Radiat Oncol Biol Phys 2006;65:720-725. (Pubitemid 43795859)
29. Krengli M, Milia ME, Turri L, et al. FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma. Radiat Oncol 2010;5:10.
30. Salama JK, Mell LK, Schomas DA, et al. Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. J Clin Oncol 2007;25:4581-4586. (Pubitemid 350035316)
31. Gerard JP, Ayzac L, Hun D, et al. Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. Long-term results in 95 patients. Radiother Oncol 1998;46:249-256. (Pubitemid 28157274)
32. Peiffert D, Bey P, Pernot M, et al. Conservative treatment by irradiation of epidermoid carcinomas of the anal margin. Int J Radiat Oncol Biol Phys 1997;39:57-66. (Pubitemid 27396282)