Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: Its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 27, Issue 9, 2013, Pages 1123-1128

  Zou, Quanfei ^a   Gu, Yuan ^b   Lu, Rong ^b   Zhang, Tiejun ^b   Zhao, Guang Rong ^a   Liu, Changxiao ^b   Si, Duanyun ^b  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Arctigenin; LC MS MS; Pharmacokinetics; Rat plasma

Indexed keywords

BODY FLUIDS; PHARMACOKINETICS;

ARCTIGENIN; INTERNAL STANDARDS; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; MS DETECTION; MULTIPLE REACTION MONITORING; PHARMACOKINETIC STUDIES; RAT PLASMA; SIMPLE++;

RATS;

ARCTIGENIN; METHANOL; PSORALEN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STORAGE; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; ROOM TEMPERATURE; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84881371668     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2916     Document Type: Article

References (22)

1. Boldizsar I, Fuzfai Z, Toth F, Sedlak E, Borsodi L and Molnar-Perl I. Mass fragmentation study of the trimethylsilyl derivatives of arctiin, matairesinoside, arctigenin, phylligenin, matairesinol, pinoresinol and methylarctigenin: their gas and liquid chromatographic analysis in plant extracts. Journal of Chromtography A 2010; 1217: 1674-1682.
2. Earla R, Cholkar K, Gunda S, Earla RL and Mitra AK. Bioanalytical method validation of rapamycin in ocular matrix by QTRAP LC-MS/MS: application to rabbit anterior tissue distribution by topical administration of rapamycin nanomicellar formulation. Journal of Chromtography B: Analytical Technology in Biomedicine and Life Sciences 2012; 908: 76-86.
3. Fan T, Jiang WL, Zhu J and Zhang YF. Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation. Biological and Pharmaceutical Bulletin 2012; 35: 2004-2009.
4. Ferracane R, Graziani G, Gallo M, Fogliano V and Ritieni A. Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. Journal of Pharmaceutical and Biomedical Analysis 2010; 51: 399-404.
5. Gu Y, Qi C, Sun X, Ma X, Zhang H, Hu L, Yuan J and Yu Q. Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochemical Pharmacology 2012; 84: 468-476.
6. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T and Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biological and Pharmaceutical Bulletin 2010; 33: 1199-1205.
7. He F, Dou DQ, Hou Q, Sun Y and Kang TG. Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method. Natural Product Research 2012a; doi:10.1080/14786419.2012.666745
8. He F, Dou DQ, Sun Y, Zhu L, Xiao HB and Kang TG. Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. Planta Medica 2012b; 78: 800-806.
9. Hirose M, Yamaguchi T, Lin C, Kimoto N, Futakuchi M, Kono T, Nishibe S and Shirai T. Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Letters 2000, 155: 79-88.
10. Hirose M, Nishikawa A, Shibutani M, Imai T and Shirai T. Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats. Environmental and Molecular Mutagens 2002; 39: 271-278.
11. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD and Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia 2012; 55:1469-1481.
12. Kim AR, Kim HS, Lee JM, Choi JH, Kim SN, Kim do K, Kim JH, Mun SH, Kim JW, Jeon HS, Kim YM and Choi WS. Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages. European Journal of Pharmacology 2012; 682: 29-36.
13. Lee JY and Kim CJ. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes. Archives of Pharmaceutical Research 2010; 33: 947-957.
14. Liu H, Zhang Y, Sun Y, Wang X, Zhai Y, Sun Y, Sun S, Yu A, Zhang H and Wang Y. Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection. Journal of Chromtography B: Analytical Technology in Biomedicine and Life Sciences 2010; 878: 2707-2711.
15. Liu S, Chen K, Schliemann W and Strack D. Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS. Phytochemical Analysis 2005; 16: 86-89.
16. Nose M, Fujimoto T, Takeda T, Nishibe S and Ogihara Y. Structural transformation of lignan compounds in rat gastrointestinal tract. Planta Medica 1992; 58: 520-523.
17. Peters FT and Remane D. Aspects of matrix effects in applications of liquid chromatography-mass spectrometry to forensic and clinical toxicology - a review. Analytical and Bioanalytical Chemistry 2012; 403: 2155-2172.
18. Sun WJ, Sha ZF and Gao H. Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC. Yao Xue Xue Bao 1992; 27: 549-551.
19. Susanti S, Iwasaki H, Itokazu Y, Nago M, Taira N, Saitoh S and Oku H. Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L. Journal of Natural Medicine 2012; 66: 614-621.
20. Takasaki M, Konoshima T, Komatsu K, Tokuda H and Nishino H. Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Letters 2000; 158: 53-59.
21. Wang X, Bowman P, Kerwin S and Stavchansky S. Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma. Biomedical Chromatography 2007; 21: 343-350.
22. Zhao F, Wang L and Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. Journal of Ethnopharmacology 2009; 122: 457-462.