Bioanalytical method validation of rapamycin in ocular matrix by QTRAP LC-MS/MS: Application to rabbit anterior tissue distribution by topical administration of rapamycin nanomicellar formulation

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 908, Issue , 2012, Pages 76-86

  Earla, Ravinder ^a   Cholkar, Kishore ^a   Gunda, Sriram ^a   Earla, Rajya Lakshmi ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

0.2 rapamycin nanomicellar formulation; 3200 QTRAP LC MS MS bioanalytical method validation; Protein precipitation extraction; Rabbit anterior ocular tissue distribution study; Rapamycin (Sirolimus)

Indexed keywords

BIOANALYTICAL METHODS; OCULAR TISSUE; PROTEIN PRECIPITATION; RAPAMYCIN; SIROLIMUS;

ACETONITRILE; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; PRECIPITATION (CHEMICAL); PROTEINS; SODIUM; TISSUE;

SKIN;

ACETONITRILE; ERYTHROMYCIN; RAPAMYCIN;

ANALYZER; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CHEMICAL REACTION; DRUG STRUCTURE; ELECTROSPRAY; EVAPORATION; EXPERIMENTAL RABBIT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTERIOR EYE SEGMENT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; LINEAR MODELS; MICELLES; NANOPARTICLES; RABBITS; REPRODUCIBILITY OF RESULTS; SIROLIMUS; TANDEM MASS SPECTROMETRY;

ORYCTOLAGUS CUNICULUS;

EID: 84867590792     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.09.014     Document Type: Article

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