1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 4951-4957

  Papastavrou, Nikolaos ^a   Chatzopoulou, Maria ^a   Pegklidou, Kyriaki ^a   Nicolaou, Ioannis ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Aldose reductase inhibitors; Bioisosterism; Inflammatory pathologies; Long term diabetic complications; Molecular obesity

Indexed keywords

(1,1' BIPHENYL) 4 YL(1H PYRROL 2 YL)METHANONE; (1,1' BIPHENYL) 4 YL[1 (1 HYDROXY 1H PYRAZOL 4 YL) 1H PYRROL 2 YL]METHANONE; (1,1' BIPHENYL) 4 YL[1 (1 HYDROXY 1H PYRAZOL 4 YL) 1H PYRROL 3 YL]METHANONE; (1,1' BIPHENYL) 4 YL[1 [1 (BENZYLOXY) 1H PYRAZOL 4 YL] 1H PYRROL 2 YL]METHANONE; 1 (BENZYLOXY) 4 (1H PYRROL 1 YL) 1H PYRAZOLE; 1 (BENZYLOXY) 4 IODO 1H PYRAZOLE; 1 HYDROXYPYRAZOLE; 2 [2 (4 METHOXYBENZOYL) 1H PYRROL 1 YL]ACETIC ACID; 2 [2 [(1,1' BIPHENYL) 4 CARBONYL] 1H PYRROL 1 YL]ACETIC ACID; [1 (1 HYDROXY 1H PYRAZOL 4 YL) 1H PYRROL 2 YL](4 METHOXYPHENYL)METHANONE; [1 (1 HYDROXY 1H PYRAZOL 4 YL) 1H PYRROL 2 YL](PHENYL)METHANONE; [1 (1 HYDROXY 1H PYRAZOL 4 YL) 1H PYRROL 3 YL](4 METHOXYPHENYL)METHANONE; [1 (1 HYDROXY 1H PYRAZOL 4 YL) 1H PYRROL 3 YL](PHENYL)METHANONE; [1 [1 (BENZYLOXY) 1H PYRAZOL 4 YL] 1H PYRROL 2 YL](4 METHOXYPHENYL)METHANONE; [1 [1 (BENZYLOXY) 1H PYRAZOL 4 YL] 1H PYRROL 2 YL](PHENYL)METHANONE; [1 [1 (BENZYLOXY) 1H PYRAZOL 4 YL] 1H PYRROL 3 YL](4 METHOXYPHENYL)METHANONE; [1 [1 (BENZYLOXY) 1H PYRAZOL 4 YL] 1H PYRROL 3 YL](PHENYL)METHANONE; [1,1' BIPHENYL] 4 YL[1 [1 (BENZYLOXY) 1H PYRAZOL 4 YL] 1H PYRROL 3 YL]METHANONE; ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; ETHYL 2 [2 (4 METHOXYBENZOYL) 1H PYRROL 1 YL]ACETATE; ETHYL 2 [2 [(1,1' BIPHENYL) 4 CARBONYL] 1H PYRROL 1 YL]ACETATE; PYRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOISOSTERE; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FRIEDEL CRAFTS REACTION; HYDROGENOLYSIS; MALE; NONHUMAN; OBESITY; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION;

1,4-DIHYDROXYNONENE; 4-HYDROXYNONENAL; ADVANCED GLYCATION END-PRODUCTS; AGES; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ALDOSE REDUCTASE INHIBITORS; ALR1; ALR2; ARI; BEI; BINDING EFFICIENCY INDEX; BIOISOSTERISM; DHN; GLUTATHIONE; GSH; HNE; INFLAMMATORY PATHOLOGIES; LE; LELP; LIGAND EFFICIENCY; LIGAND EFFICIENCY-DEPENDENT LIPOPHILICITY; LIPOPHILIC LIGAND EFFICIENCY; LLE; LONG-TERM DIABETIC COMPLICATIONS; MOLECULAR OBESITY; REACTIVE OXYGEN SPECIES; ROS; SDH; SORBITOL DEHYDROGENASE;

ACETIC ACID; ALDEHYDE REDUCTASE; ANIMALS; ENZYME INHIBITORS; KIDNEY; KINETICS; LENS CORTEX, CRYSTALLINE; PROTEIN BINDING; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881369164     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.062     Document Type: Article

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