Effects of polymers on the crystallinity of nanonized meloxicam during a co-grinding process

European Polymer Journal

Volumn 49, Issue 9, 2013, Pages 2426-2432

  Mártha, Csaba ^a   Kürti, Levente ^a   Farkas, Gabriella ^a   Jójárt Laczkovich, Orsolya ^a   Szalontai, Balázs ^b   Glässer, Erik ^b   Deli, Mária A ^b   Szabó Révész, Piroska ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Co grinding; Crystallinity; Meloxicam; Polyethylene glycol; Polyvinylpyrrolidone

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; CO-GRINDING; CRYSTALLINITIES; HIGH-ENERGY INPUT; MELOXICAM; NANOPARTICLE SIZES; PARTICLE SIZE REDUCTION; POLY VINYL PYRROLIDONE;

DRUG PRODUCTS; GRINDING (MACHINING); POLYETHYLENE GLYCOLS;

POLYMERS;

EID: 84881367655     PISSN: 00143057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpolymj.2013.03.006     Document Type: Article

References (16)

1. H. Chen, C. Khemtong, X. Yang, X. Chang, and J. Gao Nanoization strategies for poorly-water soluble drugs Drug Discov Today 16 2011 354 360
2. H. Chen, C. Khemtong, X. Yang, X. Chang, and J. Gao Nanonization strategies for poorly water-soluble drugs Drug Discov Today 16 7-8 2011 1 7
3. H. Choi, W. Lee, and S. Kim Effect of grinding aids on the kinetics of fine grinding energy consumed of calcite powders by a stirred ball mill Adv Powder Technol 20 4 2009 350 354
4. E.M. Merisko-Liversidge, and G.G. Liversidge Drug nanoparticles: formulating poorly water-soluble compounds Toxicol Pathol 36 1 2008 43 48
5. N. Yam, X. Li, and B.R. Jasti Interactions of topiramate with polyethylene glycol 8000 in solid state with formation of new polymorph Int J Pharm 411 1-2 2011 86 91
6. F.E. Bailey, and J.V. Koleske Poly(ehtylene oxide) 1976 Academic New York
7. C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur J Pharm Biopharm 50 1 2000 47 60
8. M. Sugimoto, T. Okagi, S. Narisawa, Y. Koida, and K. Nakjima Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water soluble-polymer Int J Pharm 160 1 1998 11 19
9. A. Martini, C. Torricelli, and R. De Ponti Physico-pharmaceutical characteristics of steroid-crosslinked polyvinylpyrrolidone coground systems Int J Pharm 75 2-3 1991 141 146
10. J.Z. Wu, and P.C. Ho Evaluation of the in vitro activity and in vivo bioavailability of realgar nanoparticles prepared by cryo-grinding Eur J Pharm Sci 29 1 2006 35 44
11. P. Mura, M. Cirri, M.T. Faucci, J.M. Ginès-Dorado, and G.P. Bettinetti Investigation of the effects of grinding and co-grinding on physicochemical properties of glisentide J Pharm Biomed Anal 30 2 2002 227 237
12. L.S. Taylor, and G. Zografi Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions Pharm Res 14 12 1997 1691 1698
13. T. Watanabe, S. Hasegawa, N. Wakiyama, A. Kusai, and M. Senna Comparison between polyvinylpyrrolidone and silica nanoparticles as carriers for indomethacin in a solid state dispersion Int J Pharm 250 1 2003 283 286
14. L. Kurti, A. Kukovecz, G. Kozma, R. Ambrus, M. Deli, and P. Szabó-Révész Study of the parameters influencing the co-grinding process for the production of meloxicam nanoparticles Powder Technol 212 1 2011 210 217
15. G. Hanft, D. Türck, S. Scheuerer, and R. Sigmund Meloxicam oral suspension: a treatment alternative to solid meloxicam formulations Inflamm Res 50 Suppl 1 2001 S35 S37
16. R. Ambrus, P. Kocbek, J. Kristl, R. Sibanc, R. Rajkó, and P. Szabó-Révész Investigation of preparation parameters to improve the dissolution of poorly water-soluble meloxicam Int J Pharm 381 2 2009 153 159