-
1
-
-
79952486262
-
Amyotrophic lateral sclerosis
-
Kiernan MC, Vucic 1. S, Cheah BC, Turner MR, Eisen A, Hardiman O, et al. Amyotrophic lateral sclerosis. Lancet. 2011 ; 377: 942-55
-
(2011)
Lancet
, vol.377
, pp. 942-955
-
-
Kiernan, M.C.1
Vucic, S.2
Cheah, B.C.3
Turner, M.R.4
Eisen, A.5
Hardiman, O.6
-
2
-
-
0028998398
-
Amyotrophic lateral sclerosis is a multifactorial disease
-
Eisen A. Amyotrophic lateral sclerosis is a multifactorial disease. Muscle Nerve. 1995 ; 18: 74-52
-
(1995)
Muscle Nerve
, vol.18
, pp. 74-52
-
-
Eisen, A.1
-
3
-
-
77954344953
-
Clinical trials for neuroprotection in ALS
-
Siciliano G, Carlesi C, Pasquali L, Piazza S, Pietracupa S, Fornai L, et al. Clinical trials for neuroprotection in ALS. CNS & Neurol Disord Drug Targets. 2010 ; 9: 305-13
-
(2010)
CNS & Neurol Disord Drug Targets
, vol.9
, pp. 305-313
-
-
Siciliano, G.1
Carlesi, C.2
Pasquali, L.3
Piazza, S.4
Pietracupa, S.5
Fornai, L.6
-
5
-
-
80755128213
-
Clinical diagnosis and management of amyotrophic lateral sclerosis
-
Hardiman O, van den Berg LH, Kiernan MC. C linical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol. 2011 ; 7: 639-49
-
(2011)
Nat Rev Neurol
, vol.7
, pp. 639-649
-
-
Hardiman, O.1
Van Den Berg, L.H.2
Kiernan, M.C.3
-
6
-
-
60849093466
-
Current hypothesis for the underlying biology of amyotrophic lateral sclerosis
-
Rothstein JD. Current hypothesis for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol. 2009 ; 65: S3-9
-
(2009)
Ann Neurol
, vol.65
-
-
Rothstein, J.D.1
-
7
-
-
1542710385
-
Extracellular ATP and neurodegeneration
-
Volontè C, Amadio S, Cavaliere F, D 'A mbrosi N, Vacca F, Bernardi G. Extracellular ATP and neurodegeneration. Curr Drug Targets CNS Neural Disord. 2003 ; 2: 403-12
-
(2003)
Curr Drug Targets CNS Neural Disord
, vol.2
, pp. 403-412
-
-
Volontè, C.1
Amadio, S.2
Cavaliere, F.3
D'Ambrosi, N.4
Vacca, F.5
Bernardi, G.6
-
8
-
-
46449134214
-
Purinergic signalling and disorders of the central nervous system
-
Burnstock G. P urinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov. 2008 ; 7: 575-90
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 575-590
-
-
Burnstock, G.1
-
9
-
-
76149098862
-
A 2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease
-
Varani K, Vincenzi F, Tosi A, Gessi S, Casetta I, Granieri G, et al. A 2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease. FASEB J. 2010 ; 24: 587-98
-
(2010)
FASEB J.
, vol.24
, pp. 587-598
-
-
Varani, K.1
Vincenzi, F.2
Tosi, A.3
Gessi, S.4
Casetta, I.5
Granieri, G.6
-
11
-
-
51049101334
-
Adenosine receptors: Therapeutic aspects for infl ammatory and immune diseases
-
Hask ò G, Linden J, Cronstein B N, Pacher P. A denosine receptors: Therapeutic aspects for infl ammatory and immune diseases. Nat Rev Drug Discover. 2008 ; 7: 759-70
-
(2008)
Nat Rev Drug Discover
, vol.7
, pp. 759-770
-
-
Haskò, G.1
Linden, J.2
Cronstein, B.N.3
Pacher, P.4
-
13
-
-
80052037502
-
Modulation of innate immunity by adenosine receptor stimulation
-
Ramekers B P, Riksen N P, van der Hoeven J G, Smits P, Pickkers P. Modulation of innate immunity by adenosine receptor stimulation. Shock. 2011; 36: 208-15
-
(2011)
Shock
, vol.36
, pp. 208-215
-
-
Ramekers, B.P.1
Riksen, N.P.2
Van Der Hoeven, J.G.3
Smits, P.4
Pickkers, P.5
-
14
-
-
0037313639
-
Changes of peripheral A 2A adenosine receptors in chronic heart failure and cardiac transplantation
-
Varani K, Laghi-Pasini F, Camurri A, Capecchi PL, Maccherini M, Diciolla F, et al. Changes of peripheral A 2A adenosine receptors in chronic heart failure and cardiac transplantation. FASEB J. 2003 ; 17: 280-2
-
(2003)
FASEB J.
, vol.17
, pp. 280-282
-
-
Varani, K.1
Laghi-Pasini, F.2
Camurri, A.3
Capecchi, P.L.4
Maccherini, M.5
Diciolla, F.6
-
15
-
-
4444247043
-
Elevated expression of A 3 adenosine receptors in human colorectal cancer is refl ected in peripheral blood cells
-
Gessi S, Cattabriga E, Avitabile A, Gafa' R, Lanza G, Cavazzini L, et al. Elevated expression of A 3 adenosine receptors in human colorectal cancer is refl ected in peripheral blood cells. Clin Cancer Res. 2004 ; 10: 5895-901
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5895-5901
-
-
Gessi, S.1
Cattabriga, E.2
Avitabile, A.3
Gafa, R.4
Lanza, G.5
Cavazzini, L.6
-
17
-
-
0032692481
-
The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function
-
BDNF ALS Study Group (Phase III)
-
Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al. The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). Neurol Sci. 1999 ; 169: 13-21
-
(1999)
Neurol Sci
, vol.169
, pp. 13-21
-
-
Cedarbaum, J.M.1
Stambler, N.2
Malta, E.3
Fuller, C.4
Hilt, D.5
Thurmond, B.6
-
18
-
-
0031579649
-
Guidelines for the use and performance of quantitative outcome measures in ALS clinical trials
-
Brinkmann JR, Andres P, Mendoza M, Sanjak M. G uidelines for the use and performance of quantitative outcome measures in ALS clinical trials. J Neurol Sci. 1997 ; 147: 97-111
-
(1997)
JNeurol Sci
, vol.147
, pp. 97-111
-
-
Brinkmann, J.R.1
Andres, P.2
Mendoza, M.3
Sanjak, M.4
-
19
-
-
70349773147
-
Normalization of A 2A and A 3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumour necrosis factor alpha but not methotrexate
-
Varani K, Massara A, Vincenzi F, Tosi A, Padovan M, Trotta F, et al. Normalization of A 2A and A 3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumour necrosis factor alpha but not methotrexate. Arthritis Rheum. 2009 ; 60: 2880-91
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2880-2891
-
-
Varani, K.1
Massara, A.2
Vincenzi, F.3
Tosi, A.4
Padovan, M.5
Trotta, F.6
-
20
-
-
82655177570
-
A 2A and A 3 adenosine receptor expression in rheumatoid arthritis: Up-regulation, inverse correlation with disease activity score and suppression of infl ammatory cytokine and metalloproteinase release
-
Varani K, Padovan M, Vincenzi F, Targa M, Trotta F, Govoni M, et al. A 2A and A 3 adenosine receptor expression in rheumatoid arthritis: Up-regulation, inverse correlation with disease activity score and suppression of infl ammatory cytokine and metalloproteinase release. Arthritis Res Ther. 2011; 13: R197
-
(2011)
Arthritis Res Ther
, vol.13
-
-
Varani, K.1
Padovan, M.2
Vincenzi, F.3
Targa, M.4
Trotta, F.5
Govoni, M.6
-
21
-
-
77950933196
-
Expression and functional role of adenosine receptors in regulating infl ammatory responses in human synoviocytes
-
Varani K, Vincenzi F, Tosi A, Targa M, Masieri F F, Ongaro A, et al. Expression and functional role of adenosine receptors in regulating infl ammatory responses in human synoviocytes. Br J Pharmacol. 2010 ; 160: 101-15
-
(2010)
Br J Pharmacol
, vol.160
, pp. 101-115
-
-
Varani, K.1
Vincenzi, F.2
Tosi, A.3
Targa, M.4
Masieri, F.F.5
Ongaro, A.6
-
22
-
-
17544384891
-
3h]-mre 3008f20: A novel antagonist radioligand for the pharmacological and biochemical characterization of human a3 adenosine receptors
-
Varani K, Merighi S, Gessi S, Klotz KN, Leung E, Baraldi PG, et al. [3H]-MRE 3008F20: A novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors. Mol Pharmacol. 2000 ; 57: 968-75
-
(2000)
Mol Pharmacol
, vol.57
, pp. 968-975
-
-
Varani, K.1
Merighi, S.2
Gessi, S.3
Klotz, K.N.4
Leung, E.5
Baraldi, P.G.6
-
23
-
-
27544446871
-
Pharmacological characterization of novel adenosine ligands in recombinant and native human A 2B receptors
-
Varani K, Gessi S, Merighi S, Vincenzi F, Cattabriga E, Benini A, et al. Pharmacological characterization of novel adenosine ligands in recombinant and native human A 2B receptors. Biochem Pharmacol. 2005 ; 70: 1601-12
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 1601-1612
-
-
Varani, K.1
Gessi, S.2
Merighi, S.3
Vincenzi, F.4
Cattabriga, E.5
Benini, A.6
-
24
-
-
47349112609
-
Adenosine A 2A receptor antagonists and Parkinson's disease: State of the art and future directions
-
Simola N, Morelli M, Pinna A. A denosine A 2A receptor antagonists and Parkinson's disease: State of the art and future directions. Curr Pharm Des. 2008 ; 14: 1475-89
-
(2008)
Curr Pharm Des
, vol.14
, pp. 1475-1489
-
-
Simola, N.1
Morelli, M.2
Pinna, A.3
-
25
-
-
77954994281
-
Clinical Efficacy of istradefylline (KW 6002) in Parkinson's disease: A randomized, controlled study
-
Japanese Istradefylline Study Group
-
Mizuno Y, Haegawa K, Kondo T, Kuno S, Yamamoto Y. Japanese Istradefylline Study Group. Clinical Efficacy of istradefylline (KW 6002) in Parkinson's disease: A randomized, controlled study. Mov Disord. 2010; 25: 1437-43
-
(2010)
Mov Disord
, vol.25
, pp. 1437-1443
-
-
Mizuno, Y.1
Haegawa, K.2
Kondo, T.3
Kuno, S.4
Yamamoto, Y.5
-
26
-
-
0034987784
-
Involvement of astrocytes in purine-mediated separative processes in the brain
-
Ciccarelli R, Ballerini P, Sabatino G, Rathbone MP, D'Onofrio M, Caciagli F, et al. Involvement of astrocytes in purine-mediated separative processes in the brain. Int J Dev Neurosci. 2001 ; 19: 395-414
-
(2001)
Int J Dev Neurosci
, vol.19
, pp. 395-414
-
-
Ciccarelli, R.1
Ballerini, P.2
Sabatino, G.3
Rathbone, M.P.4
D'Onofrio, M.5
Caciagli, F.6
-
27
-
-
77951929051
-
Integrated brain circuits: Astrocytic networks modulate neuronal activity and behavior
-
Halassa MM, Haydon PG. I ntegrated brain circuits: Astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol. 2010 ; 72: 335-55
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 335-355
-
-
Halassa, M.M.1
Haydon, P.G.2
-
28
-
-
33748497107
-
Protecting motor neurons from toxic insult by antagonism of adenosine A 2A and Trk receptors
-
Mojsilovic-Petrovic J, Jeong G B, Crocker A, Arneja A, David S, Russel DS, et al. Protecting motor neurons from toxic insult by antagonism of adenosine A 2A and Trk receptors. J Neurosci. 2006 ; 26: 9250-63
-
(2006)
JNeurosci
, vol.26
, pp. 9250-9263
-
-
Mojsilovic-Petrovic, J.1
Jeong, G.B.2
Crocker, A.3
Arneja, A.4
David, S.5
Russel, D.S.6
-
29
-
-
36249032646
-
Adenosine A 2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and 'fine tuning' modulation
-
Chen JF, Sonsalla PK, Pedata F, Melani A, Domenici MR, Popoli P, et al. Adenosine A 2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and 'fine tuning' modulation. Prog Neurobiol. 2007 ; 83: 310-31
-
(2007)
Prog Neurobiol
, vol.83
, pp. 310-331
-
-
Chen, J.F.1
Sonsalla, P.K.2
Pedata, F.3
Melani, A.4
Domenici, M.R.5
Popoli, P.6
-
30
-
-
34047161070
-
Functions, dysfunctions and possible therapeutic relevance of adenosine A 2A receptors in Huntington's disease
-
Popoli P, Blum D, Martire A, Ledent C, Ceruti S, Abbracchio MP. Functions, dysfunctions and possible therapeutic relevance of adenosine A 2A receptors in Huntington's disease. Prog Neurobiol. 2007 ; 81: 331-48
-
(2007)
Prog Neurobiol
, vol.81
, pp. 331-348
-
-
Popoli, P.1
Blum, D.2
Martire, A.3
Ledent, C.4
Ceruti, S.5
Abbracchio, M.P.6
-
31
-
-
84863781432
-
Trk and cAMP-dependent survival activity of adenosine (A 2A) agonist CGS21680 on rat motor neurons in culture
-
Komaki S, Ishikawa K, Arakawa Y. T rk and cAMP-dependent survival activity of adenosine (A 2A) agonist CGS21680 on rat motor neurons in culture. Neurosci Lett. 2012 ; 522: 21-4
-
(2012)
Neurosci Lett
, vol.522
, pp. 21-24
-
-
Komaki, S.1
Ishikawa, K.2
Arakawa, Y.3
-
32
-
-
84862992874
-
Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis
-
Yanpallewar S U, Barrick C A, Buckley H, Becker J, Tessarollo L. Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis. PLoS One. 2012; 7: E39946
-
(2012)
PLoS One
, vol.7
-
-
Yanpallewar, S.U.1
Barrick, C.A.2
Buckley, H.3
Becker, J.4
Tessarollo, L.5
-
33
-
-
80052057252
-
CGS 21680, an agonist of the adenosine (A 2A) receptor, decreases acute lung infl ammation
-
Impellizzeri D, Di Paola R, Esposito E, Mazzon E, Paterniti I, Melani A, et al. CGS 21680, an agonist of the adenosine (A 2A) receptor, decreases acute lung infl ammation. Eur J Pharmacol. 2011; 668: 305-16
-
(2011)
Eur J Pharmacol
, vol.668
, pp. 305-316
-
-
Impellizzeri, D.1
Di Paola, R.2
Esposito, E.3
Mazzon, E.4
Paterniti, I.5
Melani, A.6
-
34
-
-
85027927189
-
Adenosine (A 2A) receptor activation prevents progressive kidney fi brosis in a model of immune-associated chronic infl ammation
-
Garcia G E, Truong L D, Chen J F, Johnson R J, Feng L. Adenosine (A 2A) receptor activation prevents progressive kidney fi brosis in a model of immune-associated chronic infl ammation. Kidney Int. 2011 ; 80: 378-88
-
(2011)
Kidney Int
, vol.80
, pp. 378-388
-
-
Garcia, G.E.1
Truong, L.D.2
Chen, J.F.3
Johnson, R.J.4
Feng, L.5
-
35
-
-
0037207972
-
Adenosine A 2A or A 3 receptors are required for inhibition of infl ammation by methotrexate and its analog MX-68
-
Montesinos MC, Desai A, Delano D, Chen JF, Fink JS, Jacobson MA, et al. Adenosine A 2A or A 3 receptors are required for inhibition of infl ammation by methotrexate and its analog MX-68. Arthritis Rheum. 2003 ; 48: 240-7
-
(2003)
Arthritis Rheum
, vol.48
, pp. 240-247
-
-
Montesinos, M.C.1
Desai, A.2
Delano, D.3
Chen, J.F.4
Fink, J.S.5
Jacobson, M.A.6
|