Quantification, mechanism, and mitigation of active ingredient phase transformation in tablets

Molecular Pharmaceutics

Volumn 10, Issue 8, 2013, Pages 3128-3136

  Thakral, Naveen K ^a   Ragoonanan, Vishard ^a   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

colloidal silica; depth profiling; dicalcium phosphate dihydrate; tablet; thiamine hydrochloride; two dimensional X ray diffractometry

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; DRUG ADDITIVE; ETHYL CELLULOSE; SILICON DIOXIDE; THIAMINE; THIAMINE HYDROCHLORIDE HEMIHYDRATE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STABILITY; DRUG STORAGE; FILM COATING; HYDROPHILICITY; HYDROPHOBICITY; MOISTURE; PHASE TRANSITION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; TABLET FORMULATION; TABLET MATRIX; TABLET SURFACE; X RAY DIFFRACTION; X RAY PHOTOELECTRON SPECTROSCOPY;

CALCIUM PHOSPHATES; PHASE TRANSITION; TABLETS; THIAMINE; X-RAY DIFFRACTION;

EID: 84881328759     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400180n     Document Type: Article

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