Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance

Journal of Pharmaceutical Sciences

Volumn 101, Issue 4, 2012, Pages 1410-1422

  Chakravarty, Paroma ^a,c   Suryanarayanan, Raj ^a   Govindarajan, Ramprakash ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b GLAXOSMITHKLINE   (United States)

^c GENENTECH INC   (United States)

Author keywords

Crushing strength; Crystals; Hydrate; Microscopy; Microstructure; Phase transition; Porosity; Preformulation; Raman spectroscopy; Solid state; Tablet

Indexed keywords

MERCURY; MICROCRYSTALLINE CELLULOSE; NONSTOICHIOMETRIC COMPOUND; THIAMINE;

ARTICLE; CRYSTALLIZATION; DRUG FORMULATION; DRUG GRANULATION; DRUG STORAGE; DRUG STRUCTURE; DRUG TRANSFORMATION; HUMIDITY; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; TABLET; TABLET COMPRESSION; TABLET DISINTEGRATION TIME;

EID: 84857507260     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23020     Document Type: Article

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