Fractional dose-finding methods with late-onset toxicity in phase i clinical trials

Journal of Biopharmaceutical Statistics

Volumn 23, Issue 4, 2013, Pages 856-870

  Yin, Guosheng ^a,b   Zheng, Shurong ^c   Xu, Jiajing ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF TEXAS   (United States)

^c NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

3 + 3 design; Censored data; Continual reassessment method; Dose finding; Kaplan Meier estimator; Maximum tolerated dose; Phase I trial; Up and down design.

Indexed keywords

ALGORITHM; ARTICLE; COMPARATIVE STUDY; DECISION MAKING; DOSE CALCULATION; FOLLOW UP; FRACTIONAL 3 PLUS 3 DESIGN; FRACTIONAL CONTINUAL REASSESSMENT METHOD; FRACTIONAL DOSE FINDING METHOD; FRACTIONAL UP AND DOWN DESIGN; HUMAN; KAPLAN MEIER METHOD; LATE ONSET TOXICITY; MAXIMUM TOLERATED DOSE; OUTCOME ASSESSMENT; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SIMULATION; TOXICITY;

CLINICAL TRIALS, PHASE I AS TOPIC; COMPUTER SIMULATION; DECISION MAKING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HUMANS; MAXIMUM TOLERATED DOSE; MODELS, STATISTICAL; RESEARCH DESIGN; TIME FACTORS;

EID: 84881294056     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543406.2013.789892     Document Type: Article

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