An extension of the continual reassessment method using decision theory

Statistics in Medicine

Volumn 21, Issue 1, 2002, Pages 51-63

  Leung, Denis Heng Yan ^a,c   Wang, You Gan ^b  

^a SINGAPORE MANAGEMENT UNIVERSITY   (Singapore)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Continual reassessment method; Decision theory; Dose finding; Maximum tolerated dose; Phase I trial; Up and down method

Indexed keywords

ARTICLE; DECISION THEORY; DOSE CALCULATION; DRUG MEGADOSE; DRUG TOLERABILITY; DRUG TOXICITY; MATHEMATICAL ANALYSIS; MAXIMUM TOLERATED DOSE; METHODOLOGY; PHASE 1 CLINICAL TRIAL; PROBABILITY; RISK ASSESSMENT;

CLINICAL TRIALS, PHASE I; DECISION THEORY; HUMANS; MAXIMUM TOLERATED DOSE; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; RESEARCH DESIGN;

EID: 0037080851     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.970     Document Type: Article

References (14)

1. Design and analysis of phase I clinical trials
2. Continual reassessment method: A practical design for Phase I clinical studies in cancer
3. Consistency of continual reassessment method under model misspecification
4. Some practical improvements in the continual reassessment method for phase I studies
5. An extension of the continual reassessment methods using a preliminary up-and-down design in a dose finding study in cancer patients, in order to investigate a greater range of doses
6. Adaptive design improvements in the continual reassessment method for phase I studies
7. Cancer phase I clinical trials: Efficient dose escalation with overdose control
8. Optimal Bayesian-feasible dose escalation for cancer phase I trials
9. Methods for dose finding studies in cancer clinical trials: A review and results of a Monte Carlo study
10. Bayesian decision procedures for dose determining experiments (disc: p897-899)
11. Multiobjective Bayesian bandits