-
1
-
-
42949166212
-
Prostacyclin therapies for the treatment of pulmonary arterial hypertension
-
M. Gomberg-Maitland, and H. Olschewski Prostacyclin therapies for the treatment of pulmonary arterial hypertension Eur Respir J 31 2008 891 901
-
(2008)
Eur Respir J
, vol.31
, pp. 891-901
-
-
Gomberg-Maitland, M.1
Olschewski, H.2
-
3
-
-
79958189216
-
Prostacyclins in pulmonary arterial hypertension: The need for earlier therapy
-
J.L. Vachiery Prostacyclins in pulmonary arterial hypertension: the need for earlier therapy Adv Ther 28 2011 251 269
-
(2011)
Adv Ther
, vol.28
, pp. 251-269
-
-
Vachiery, J.L.1
-
4
-
-
84863528040
-
Selexipag, an oral, selective IP receptor agonist for the treatment of pulmonary arterial hypertension
-
G. Simonneau, A. Torbicki, and M.M. Hoeper Selexipag, an oral, selective IP receptor agonist for the treatment of pulmonary arterial hypertension Eur Respir J 40 2012 874 880
-
(2012)
Eur Respir J
, vol.40
, pp. 874-880
-
-
Simonneau, G.1
Torbicki, A.2
Hoeper, M.M.3
-
5
-
-
0032823306
-
Prostanoid receptors: Structures, properties, and functions
-
S. Narumiya, Y. Sugimoto, and F. Ushikubi Prostanoid receptors: structure, properties, and functions Physiol Rev 79 1999 1193 1226 (Pubitemid 29473315)
-
(1999)
Physiological Reviews
, vol.79
, Issue.4
, pp. 1193-1226
-
-
Narumiya, S.1
Sugimoto, Y.2
Ushikubi, F.3
-
6
-
-
79955575162
-
International union of basic and clinical pharmacology. LXXXIII: Classification of prostanoid receptors, updating 15 years of progress
-
D.F. Woodward, R.L. Jones, and S. Narumiya International union of basic and clinical pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress Pharmacol Rev 63 2011 471 538
-
(2011)
Pharmacol Rev
, vol.63
, pp. 471-538
-
-
Woodward, D.F.1
Jones, R.L.2
Narumiya, S.3
-
8
-
-
80052398222
-
Structural basis for iloprost as a dual peroxisome proliferator-activated receptor α/δ agonist
-
L. Jin, S. Lin, and H. Rong Structural basis for iloprost as a dual peroxisome proliferator-activated receptor α/δ agonist J Biol Chem 286 2011 31473 31479
-
(2011)
J Biol Chem
, vol.286
, pp. 31473-31479
-
-
Jin, L.1
Lin, S.2
Rong, H.3
-
9
-
-
84866742055
-
Vascular effects of prostacyclin: Does activation of PPAR delta play a role
-
Z.S. Katusic, A.V. Santhanam, and T. He Vascular effects of prostacyclin: does activation of PPAR delta play a role Trends Pharmacol Sci 33 2012 559 564
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 559-564
-
-
Katusic, Z.S.1
Santhanam, A.V.2
He, T.3
-
10
-
-
34548101404
-
2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy} -N-(methylsulfonyl) acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug
-
DOI 10.1124/jpet.107.124248
-
K. Kuwano, A. Hashino, and T. Asaki 2-[4-[(5,6-diphenylpyrazin-2-yl) (isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug J Pharmacol Exp Ther 322 2007 1181 1188 (Pubitemid 47295780)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.322
, Issue.3
, pp. 1181-1188
-
-
Kuwano, K.1
Hashino, A.2
Asaki, T.3
Hamamoto, T.4
Yamada, T.5
Okubo, K.6
Kuwabara, K.7
-
11
-
-
77957237185
-
Selexipag: A selective prostacyclin receptor agonist that does not affect rat gastric function
-
K. Morrison, R. Ernst, P. Hess, R. Studer, and M. Clozel Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function J Pharmacol Exp Ther 335 2010 249 255
-
(2010)
J Pharmacol Exp Ther
, vol.335
, pp. 249-255
-
-
Morrison, K.1
Ernst, R.2
Hess, P.3
Studer, R.4
Clozel, M.5
-
12
-
-
84869209570
-
Differential effects of selexipag and prostacyclin analogs in rat pulmonary artery
-
K. Morrison, R. Studer, R. Ernst, F. Haag, K. Kauser, and M. Clozel Differential effects of selexipag and prostacyclin analogs in rat pulmonary artery J Pharmacol Exp Ther 343 2012 547 555
-
(2012)
J Pharmacol Exp Ther
, vol.343
, pp. 547-555
-
-
Morrison, K.1
Studer, R.2
Ernst, R.3
Haag, F.4
Kauser, K.5
Clozel, M.6
-
13
-
-
0032934180
-
Prostanoid receptors involved in the relaxation of human pulmonary vessels
-
L. Walch, C. Labat, J.P. Gascard, M.V. de, C. Brink, and X. Norel Prostanoid receptors involved in the relaxation of human pulmonary vessels Br J Pharmacol 126 1999 859 866 (Pubitemid 29103701)
-
(1999)
British Journal of Pharmacology
, vol.126
, Issue.4
, pp. 859-866
-
-
Walch, L.1
Labat, C.2
Gascard, J.-P.3
De Montpreville, V.4
Brink, C.5
Norel, X.6
-
15
-
-
34548722249
-
Prostanoid receptors in the human vascular wall
-
DOI 10.1100/tsw.2007.184
-
X. Norel Prostanoid receptors in the human vascular wall Sci World J 7 2007 1359 1374 (Pubitemid 47435435)
-
(2007)
TheScientificWorldJournal
, vol.7
, pp. 1359-1374
-
-
Norel, X.1
-
16
-
-
46849122659
-
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension
-
DOI 10.1164/rccm.200710-1519OC
-
4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension Am J Respir Crit Care Med 178 2008 188 196 (Pubitemid 351957777)
-
(2008)
American Journal of Respiratory and Critical Care Medicine
, vol.178
, Issue.2
, pp. 188-196
-
-
Lai, Y.-J.1
Pullamsetti, S.S.2
Dony, E.3
Weissmann, N.4
Butrous, G.5
Banat, G.-A.6
Ghofrani, H.A.7
Seeger, W.8
Grimminger, F.9
Schermuly, R.T.10
-
17
-
-
53849102602
-
A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl) acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino] butoxy}acetic acid (MRE-269), on rat pulmonary artery
-
K. Kuwano, A. Hashino, K. Noda, K. Kosugi, and K. Kuwabara A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6- diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery J Pharmacol Exp Ther 326 2008 691 699
-
(2008)
J Pharmacol Exp Ther
, vol.326
, pp. 691-699
-
-
Kuwano, K.1
Hashino, A.2
Noda, K.3
Kosugi, K.4
Kuwabara, K.5
-
18
-
-
0033971515
-
The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs
-
DOI 10.1016/S1388-1981(99)00164-X, PII S138819819900164X
-
M. Abramovitz, M. Adam, and Y. Boie The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs Biochim Biophys Acta 1483 2000 285 293 (Pubitemid 30029060)
-
(2000)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, vol.1483
, Issue.2
, pp. 285-293
-
-
Abramovitz, M.1
Adam, M.2
Boie, Y.3
Carriere, M.-C.4
Denis, D.5
Godbout, C.6
Lamontagne, S.7
Rochette, C.8
Sawyer, N.9
Tremblay, N.M.10
Belley, M.11
Gallant, M.12
Dufresne, C.13
Gareau, Y.14
Ruel, R.15
Juteau, H.16
Labelle, M.17
Ouimet, N.18
Metters, K.M.19
-
19
-
-
0031565147
-
2 prostanoid receptor subtypes
-
DOI 10.1016/S0014-2999(97)01383-6, PII S0014299997013836
-
2 prostanoid receptor subtypes Eur J Pharmacol 340 1997 227 241 (Pubitemid 28022647)
-
(1997)
European Journal of Pharmacology
, vol.340
, Issue.2-3
, pp. 227-241
-
-
Boie, Y.1
Stocco, R.2
Sawyer, N.3
Slipetz, D.M.4
Ungrin, M.D.5
Neuschafer-Rube, F.6
Puschel, G.P.7
Metters, K.M.8
Abramovitz, M.9
-
20
-
-
84889089520
-
2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor
-
10.1016/j.prostaglandins.2013.07.001
-
2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor Prostaglandins Other Lipid Mediat 2013 10.1016/j.prostaglandins.2013.07.001
-
(2013)
Prostaglandins Other Lipid Mediat
-
-
Benyahia, C.1
Boukais, K.2
Gomez, I.3
-
21
-
-
32244442817
-
RO1138452 and RO3244794: Characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists
-
DOI 10.1038/sj.bjp.0706554, PII 0706554
-
K.R. Bley, A. Bhattacharya, and D.V. Daniels RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists Br J Pharmacol 147 2006 335 345 (Pubitemid 43214691)
-
(2006)
British Journal of Pharmacology
, vol.147
, Issue.3
, pp. 335-345
-
-
Bley, K.R.1
Bhattacharya, A.2
Daniels, D.V.3
Gever, J.4
Jahangir, A.5
O'Yang, C.6
Smith, S.7
Srinivasan, D.8
Ford, A.P.D.W.9
Jett, M.-F.10
-
22
-
-
29144488034
-
2 receptor agonist cicaprost via a cyclic AMP-independent mechanism
-
DOI 10.1016/j.cardiores.2005.08.004, PII S0008636305004165
-
2 receptor agonist cicaprost via a cyclic AMP-independent mechanism Cardiovasc Res 69 2006 107 115 (Pubitemid 41814816)
-
(2006)
Cardiovascular Research
, vol.69
, Issue.1
, pp. 107-115
-
-
Orie, N.N.1
Fry, C.H.2
Clapp, L.H.3
-
23
-
-
0029911551
-
5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats
-
M.R. Maclean, G. Sweeney, M. Baird, K.M. Mcculloch, M. Houslay, and I. Morecroft 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats Br J Pharmacol 119 1996 917 930 (Pubitemid 26366487)
-
(1996)
British Journal of Pharmacology
, vol.119
, Issue.5
, pp. 917-930
-
-
MacLean, M.R.1
Sweeney, G.2
Baird, M.3
McCulloch, K.M.4
Houslay, M.5
Morecroft, I.6
-
24
-
-
0026628265
-
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
-
B.W. Christman, C.D. McPherson, and J.H. Newman An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension N Engl J Med 327 1992 70 75
-
(1992)
N Engl J Med
, vol.327
, pp. 70-75
-
-
Christman, B.W.1
McPherson, C.D.2
Newman, J.H.3
-
25
-
-
84863298193
-
Peroxisome proliferator-activated receptor-beta/delta, the acute signaling factor in prostacyclin-induced pulmonary vasodilation
-
Y. Li, M. Connolly, and C. Nagaraj Peroxisome proliferator-activated receptor-beta/delta, the acute signaling factor in prostacyclin-induced pulmonary vasodilation Am J Respir Cell Mol Biol 46 2012 372 379
-
(2012)
Am J Respir Cell Mol Biol
, vol.46
, pp. 372-379
-
-
Li, Y.1
Connolly, M.2
Nagaraj, C.3
-
27
-
-
79951992176
-
Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release
-
S.M. Wilson, N.A. Sheddan, R. Newton, and M.A. Giembycz Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release Mol Pharmacol 79 2011 586 595
-
(2011)
Mol Pharmacol
, vol.79
, pp. 586-595
-
-
Wilson, S.M.1
Sheddan, N.A.2
Newton, R.3
Giembycz, M.A.4
-
28
-
-
0025853556
-
Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor
-
J.E. Merritt, T.J. Hallam, and A.M. Brown Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor Br J Pharmacol 102 1991 251 259
-
(1991)
Br J Pharmacol
, vol.102
, pp. 251-259
-
-
Merritt, J.E.1
Hallam, T.J.2
Brown, A.M.3
-
29
-
-
0030816051
-
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
-
DOI 10.1038/41780
-
T. Murata, F. Ushikubi, and T. Matsuoka Altered pain perception and inflammatory response in mice lacking prostacyclin receptor Nature (London) 388 1997 678 682 (Pubitemid 27366439)
-
(1997)
Nature
, vol.388
, Issue.6643
, pp. 678-682
-
-
Murata, T.1
Ushikubi, F.2
Matsuoka, T.3
Hirata, M.4
Yamasaki, A.5
Sugimoto, Y.6
Ichikawa, A.7
Aze, Y.8
Tanaka, T.9
Yoshida, N.10
Ueno, A.11
Oh-ishi, S.12
Narumiya, S.13
-
30
-
-
78349278479
-
Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension
-
E. Falcetti, S.M. Hall, and P.G. Phillips Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 182 2010 1161 1170
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 1161-1170
-
-
Falcetti, E.1
Hall, S.M.2
Phillips, P.G.3
-
31
-
-
33748065641
-
Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations
-
DOI 10.1038/sj.bjp.0706841, PII 0706841
-
R.L. Jones, H. Wise, R. Clark, R.L. Whiting, and K.R. Bley Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations Br J Pharmacol 149 2006 110 120 (Pubitemid 44299074)
-
(2006)
British Journal of Pharmacology
, vol.149
, Issue.1
, pp. 110-120
-
-
Jones, R.L.1
Wise, H.2
Clark, R.3
Whiting, R.L.4
Bley, K.R.5
-
32
-
-
38749104227
-
4,5-Dihydro-1H-imidazol-2-yl-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release
-
DOI 10.1124/jpet.107.129312
-
L.M. Ayer, S.M. Wilson, S.L. Traves, D. Proud, and M.A. Giembycz 4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release J Pharmacol Exp Ther 324 2008 815 826 (Pubitemid 351185859)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.324
, Issue.2
, pp. 815-826
-
-
Ayer, L.M.1
Wilson, S.M.2
Traves, S.L.3
Proud, D.4
Giembycz, M.A.5
|