ELIXYS-a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers

EJNMMI Research

Volumn 3, Issue 1, 2013, Pages 1-13

  Lazari, Mark ^a,b   Quinn, Kevin M ^b   Claggett, Shane B ^b   Collins, Jeffrey ^b   Shah, Gaurav J ^b,c   Herman, Henry E ^b   Maraglia, Brandon ^b,c   Phelps, Michael E ^b   Moore, Melissa D ^b,c   van Dam, R Michael ^a,b  

^a Engineering IV   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Sofie Biosciences Inc   (United States)

Author keywords

Automated radiosynthesis; Disposable cassette; FAC; Fluorine 18; High pressure synthesis; Multipot synthesis

Indexed keywords

2 DEOXY 2 FLUORO 5 METHYL BETA LEVO ARABINOFURANOSYLURACIL F 18; 2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYLCYTOSINE F 18; FLUORINE 18; TRACER; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IMAGE ANALYSIS; INFORMATION PROCESSING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRESSURE; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIATION EQUIPMENT; RADIOACTIVITY; REACTOR; REACTOR DESIGN; TEMPERATURE;

EID: 84881256661     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/2191-219X-3-52     Document Type: Article

References (26)

1. Phelps ME: Positron emission tomography provides molecular imaging of biological processes. PNAS 2000, 97:9226-9233.
2. +-emitting compounds based on fluorine-18. In Edited by Krause W. Edited by Contrast Agents II. Berlin: Springer; 2002:201-258.
3. Weber WA, Figlin R: Monitoring cancer treatment with PET/CT: does it make a difference? J Nucl Med 2007, 48(Suppl 1):36S-44S.
4. Sachinidis JI, Poniger S, Tochon-Danguy HJ: Automation for optimised production of fluorine-18-labelled radiopharmaceuticals. Curr Radiopharm 2010, 3:248-253.
5. Keng PY, Esterby M, van Dam RM: Emerging technologies for decentralized production of PET tracers. In Positron Emission Tomography-Current Clinical and Research Aspects. Edited by Hsieh CH. Rijeka: InTech; 2012:153-182.
6. Coenen HH, Elsinga PH, Iwata R, Kilbourn MR, Pillai MRA, Rajan MGR, Wagner HN Jr, Zaknun JJ: Fluorine-18 radiopharmaceuticals beyond [18F] FDG for use in oncology and neurosciences. Nucl Med Biol 2010, 37:727-740.
7. Alauddin MM, Shahinian A, Gordon EM, Conti PS: Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model. Mol Imaging 2004, 3:76-84.
8. Chin FT, Namavari M, Levi J, Subbarayan M, Ray P, Chen X, Gambhir SS: Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression. Mol Imaging Biol 2007, 10:82-91.
9. Radu CG, Witte ON, Nair-Gill ED, Satyamurthy N, Shu CJ, Czernin J: Positron emission tomography probes for imaging immune activation and selected cancers. 2012. US Patent 8101740.
10. Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG: Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proc Natl Acad Sci 2009, 106:2847-2852.
11. Alauddin MM, Conti PS, Fissekis JD: Synthesis of [18F]-labeled 2'-deoxy-2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil ([18F]-FMAU). J Label Cpd Radiopharm 2002, 45:583-590.
12. Cai H, Li Z, Conti PS: The improved syntheses of 5-substituted 2'-[18F] fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep onepot strategy. Nucl Med Biol 2011, 38:659-666.
13. Alauddin MM, Fissekis JD, Conti PS: Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents. J Label Compd Radiopharm 2003, 46:805-814.
14. Anderson H, Pillarsetty N, Cantorias M, Lewis JS: Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-[beta]-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU). Nucl Med Biol 2010, 37:439-442.
15. Paolillo V, Riese S, Gelovani JG, Alauddin MM: A fully automated synthesis of [18F]-FEAU and [18F]-FMAU using a novel dual reactor radiosynthesis module. J Label Compd Radiopharm 2009, 52:553-558.
16. Li Z, Cai H, Conti PS: Automated synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module. Nucl Med Biol 2011, 38:201-206.
17. Amarasekera B, Marchis PD, Bobinski KP, Radu CG, Czernin J, Barrio JR, van Dam RM: High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers. Appl Radiat Isot 2013, 78:88-101.
18. Herman H, Flores G, Quinn K, Eddings M, Olma S, Moore MD, Ding H, Bobinski KP, Wang M, Williams D, Williams D, Shen CK, Phelps ME, van Dam RM: Plug-and-play modules for flexible radiosynthesis. Appl Radiat Isot 2013, 78:113-124.
19. Herman H, Quinn K, Esterby M, Shah GJ, Flores G, Phelps ME, Satyamurthy N, van Dam RM: Flexible radiosynthesizer capable of multi-pot high temperature and pressure reactions [abstract]. J Label Compd Radiopharm 2011, 54:s50.
20. Claggett SB, Quinn KM, Lazari M, Moore MD, van Dam RM: Simplified programming and control of automated radiosynthesizers through unit operations. EJNMMI Research 2013, 3:53.
21. Moore MD, Quinn K, Claggett S, Lazari M, Shah GJ, Satyamurthy N, Phelps ME, van Dam RM: ARC-P HS+: a versatile radiosynthesizer for the production of PET tracers [abstract], American Association for Cancer Research Annual Meeting: 31 March-4 April 2012; Chicago. Philadelphia: American Association for Cancer Research; 2012.
22. Iwata R, Yamazaki S, Ido T: Automated injection of a radioactive sample for preparative HPLC with feedback control. Int J Radiat Appl Instrum Appl Radiat Isot 1990, 41:1225-1227.
23. Berridge MS, Apana SM, Hersh JM: Teflon radiolysis as the major source of carrier in fluorine-18. J Label Compd Radiopharm 2009, 52:543-548.
24. Mangner TJ, Klecker RW, Anderson L, Shields AF: Synthesis of 2'-deoxy-2'-[18F]fluoro-[beta]-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation: synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU. Nuc Med Biol 2003, 30:215-224.
25. Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON: Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2'-deoxycytidine analog. Nat Med 2008, 14:783-788.
26. Shen B, Lazari M, Maraglia B, Collier L, Hammond K, Moore M, van Dam RM, Chin FT: Improved [18F]FEAU radiosynthesis on different automated radiochemistry platforms [abstract]. J Label Compd Radiopharm 2013, 56:s471.