Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model

Molecular Imaging

Volumn 3, Issue 2, 2004, Pages 76-84

  Alauddin, Mian M ^a   Shahinian, Atranik ^a   Gordon, Erlinda M ^a   Conti, Peter S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

FHBG; FMAU; Gene; HSV1 tk; PET

Indexed keywords

FHBG; FMAU; HSV1-TK; HUMAN BREAST CANCER; RADIOLABELED PROBES;

CELLS; ENZYMES; MEDICAL IMAGING; POSITRON EMISSION TOMOGRAPHY; TISSUE; TUMORS;

POLYETHYLENE TEREPHTHALATES;

2'-FLUORO-5-METHYLARABINOSYLURACIL; 9 (3 FLUORO 1 HYDROXY 2 PROPOXY)METHYLGUANINE; 9 (4 FLUORO 3 HYDROXYMETHYLBUTYL)GUANINE; 9-(3-FLUORO-1-HYDROXY-2-PROPOXY)METHYLGUANINE; 9-(4-FLUORO-3-HYDROXYMETHYLBUTYL)GUANINE; CARBON; CLEVUDINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GANCICLOVIR; GUANINE; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; URACIL ARABINOSIDE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BREAST TUMOR; CANCER TRANSPLANTATION; CELL CULTURE; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; EVALUATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HERPES SIMPLEX VIRUS 1; HUMAN; METABOLISM; MOUSE; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; TIME; TISSUE DISTRIBUTION;

ANIMALS; ARABINOFURANOSYLURACIL; BREAST NEOPLASMS; CARBON RADIOISOTOPES; DIAGNOSTIC IMAGING; FEMALE; GANCICLOVIR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; GUANINE; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; THYMIDINE KINASE; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 4644294588     PISSN: 15353508     EISSN: None     Source Type: Journal    
DOI: 10.1162/1535350041464900     Document Type: Article

References (32)

1. Urbain JC (2001). Reporter genes and imagene. J Nucl Med. 42:106-109.
2. Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamurthy N, Wo L, Green LA, Bauer L, Maclaren DC, Nguyen K, Berk AJ, Cherry SR, Herschman HR (1999). Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci, USA. 96:2333-2338.
3. Gambhir SS, Barrio JR, Herschman HR, Phelps ME (1999). Assays for non-invasive imaging of reporter gene expression. Nucl Med Biol. 26:481-490.
4. Tjuvajev JG, Avril N, Oku T, Sasajima T, Miyagawa T, Joshi R, Safer M, Beattie B, Diresta G, Dashigian F, Augensen F, Koutcher J, Sweit J, Human J, Larson SM, Finn R, Blasberg RG (1998). Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 58:4333-4341.
5. Tjuvajev JG, Chen SH, Joshi A, Joshi R, Guo ZS, Balatoni J, Ballon D, Koutcher J, Finn R, Woo SL, Blasberg RG (1999). Imaging Adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res. 59:5186-5193.
6. Culver KW, Ram Z, Wallbridge S, Ishi H, Oldfield EH, Blaese RM (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 256:1550-1552.
7. Moolten FL, Wells JM, Heyman RA, Evans RM (1990). Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. Hum Gene Ther. 1:125-134.
8. Oldfield EH, Ram Z, Culver K, Blease RM, DeVroom HL, Anderson WF (1993). Clinical protocols: Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther. 4:39-69.
9. Ram Z, Culver KW, Oshireo EM, Viola JJ, DeVroom HL, Otto E, Chiang Y, McGarrity GJ, Muul LM, Kartz D, Blease RM, Oldfield EH (1997). Therapy of malignant brain tumors by intratumoral implantation of retroviral vector producing cells. Nat Med. 3:1353-1361.
10. Haberkorn U, Altmann A, Morr I, Knopf K, Germann C, Haeckel R, Oberdorfer F, Kaick G (1997). Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: Uptake of specific substrates. J Nucl Med 38:287-294.3.
11. Jacobs A, Tjuvajev JG, Dubrovin M, Akhurst T, Balatoni J, Beattie B, Joshi R, Finn R, Larson SM, Herrlinger U, Pechan PA, Chiocca EA, Breakefield XO, Blasberg RG (2001). Positron emission tomography-based imaging of transgene expression mediated by replication conditional, Oncolytic herpes simplex virus type-1 mutant vectors of cancer. Cancer Res. 61:2983-2995.
12. Yu Y, Annala AJ, Barrio JR, Toyokuni T, Satyamurthy N, Namavari M, Cherry SR, Phelps ME, Herschman HR, Gambhir SS (2000). Quantification of gene expression by imaging reporter gene expression in living animals. Nat Med. 6:933-937.
13. Tjuvajev JG, Stockhammar G, Desai R, Uehera H, Watanabe K, Gansbacher B, Blasberg RG (1995). Imaging the expression of transfected genes in vivo. Cancer Res. 55:6126-6132.
14. 18F]-FHBG) as a probe for PET imaging of gene expression in tumor-bearing nude mice. Anticancer Res. 18:4992-4993.
15. 18F]-FHPG) in vitro and in vivo as a probe for PET imaging of gene incorporation and expression in tumors. Nucl Med Biol. 26:371-376.
16. 14C]-FIAU for imaging of HSV1-tk) reporter gene expression: Adenoviral infection vs. stable transfection. Eur J Nucl Med Mol Imaging. 30:1547-1560.
17. 18F]- fluoropenciclovir: An improved reporter probe for imaging HSV-tk reporter gene expression in vivo using PET. J Nucl Med. 42:96-105.
18. Spadari S, Maga G, Focher F, Ciarrocchi G, Manservigi R, Arcamone F, Capobianco M, Carcuro A, Colonna F, Iotti S, Garbesi A (1992). L-Thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem. 35:4214-4220.
19. 18F]FHPG): A potential imaging agent of viral infection and gene therapy using PET. Nucl Med Biol. 23:787-792.
20. 18F]-FHBG): A new potential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol. 25:175-180.
21. 18F]-FHBG) for in vivo measurement of suicide gene expression with PET. J Nucl Med. 42:1682-1690.
22. Barrio JR, Namavari M, Phelps ME, Satyamurthy N (1996). Regioselective fluorination of substituted guanines with F2: A facile entry for 8-fluorguanine derivatives. J. Org Chem. 61:6084-6085.
23. 18F]-fluoroguanine derivatives: In vivo probes for imaging gene expression with PET. Nucl Med Biol. 27:157-162.
24. Alauddln MM, Shahinian A, Gordon EM, Conti PS (2002). Evaluation of 2′-deoxy-2′-fluoro-5-methyl-1-ß-D-arabinofuranosyluracil (FMAU) as a potential gene imaging agent for HSV-tk expression in vivo. Mol Imaging. 1:74-81.
25. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Beatle B, Larson SM, Conti PS, Blasberg RG (2002). Direct comparison of HSV-tk PET imaging probes: FIAU, FHPG, FHBG. J Nucl Med. 43:1072-1083.
26. Watenabe KA, Richmond W, Hirota K, Lopez C, Fox JJ (1979). Nucleosides 110. Synthesis and herpes virus activity of some 2′-fluoro-2′- deoxyarabinofuranosyl pyrimidine nucleosides. J. Med Chem. 22:21-24.
27. 18F]-FMAU). J Labelled Comp Radiopharm, 45:583-590.
28. 18F]fluoro-5-methyl-1-ß-D- arabinofuranosyluracil and its 5-substituted nucleosides. J Labelled Comp Radiopharm. 46:285-289.
29. Lyons RM, Forry-Schaudies S, Otto E, Wey C, Patilkoota V, Kaloss M, McGarrity GJ, Chiang YL (1995). An improved retroviral vector encoding the herpes simplex virus thymidine kinas gene increasing antitumor efficacy in vivo. Cancer Gene Ther. 2:273-280.
30. Yang L, Hwang R, Chiang Y, Gordon EM, Anderson WF, Parekh D (1998). Mechanism for ganciclovir resistance in gastrointestinal tumor cells transduced with retroviral vector containing the herpes simplex virus thymidine kinas gene. Clin Cancer Res. 4:731-741.
31. 14C]-FMAU) in rat prostate tumor cells. Nucl Med Biol. 27:361-368.
32. Zubay G (1983). Biochemistry. Addison-Wesley Publishing, Reading, MA. pp. 712-733.