Considerations in starting a patient with advanced frailty on dialysis: Complex biology meets challenging ethics

Clinical Journal of the American Society of Nephrology

Volumn 8, Issue 8, 2013, Pages 1421-1428

  Swidler, Mark ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMORBIDITY; DIALYSIS; DISEASE ASSOCIATION; HAZARD RATIO; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; INTERPERSONAL COMMUNICATION; KIDNEY DISEASE; KIDNEY FAILURE; LIFE EXPECTANCY; NEPHROLOGIST; PATIENT DECISION MAKING; PATIENT SAFETY; PHENOTYPE; PREVALENCE; QUALITY OF LIFE; RENAL REPLACEMENT THERAPY; RISK FACTOR; SEPTICEMIA; UREMIA;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; FRAIL ELDERLY; HUMANS; KIDNEY FAILURE, CHRONIC; RENAL DIALYSIS;

EID: 84881252708     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.12121112     Document Type: Article

References (73)

1. Kaufman SR, Shim JK, Russ AJ: Revisiting the biomedicalization of aging: Clinical trends and ethical challenges. Gerontologist 44: 731-738, 2004.
2. Renal Physicians Association: Shared Decision-Making in the Appropriate Initiation of and Withdrawal from Dialysis, 2nd Ed., Rockville, M D, Renal Physicians Association, 2010.
3. Kaufman SR: Making longevity in an aging society: Linking ethical sensibility and Medicare spending. Med Anthropol 28: 317-325, 2009.
4. Wong SP, Kreuter W, O'Hare AM: Treatment intensity at the end of life in older adults receiving long-termdialysis. Arch Intern Med 172: 661-663, 2012.
5. Kurella M, Covinsky KE, Collins AJ, Chertow GM: Octogenarians and nonagenarians starting dialysis in the United States. Ann Intern Med 146: 177-183, 2007.
6. Kurella Tamura M, Covinsky KE, Chertow GM, Yaffe K, Landefeld CS, McCulloch CE: Functional status of elderly adults before and after initiation of dialysis. N Engl J Med 361: 1539-1547, 2009.
7. US Renal Data System (USRDS): Atlas of End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases, 2008, p 113.
8. Johansen KL, Chertow GM, Jin C, Kutner NG: Significance of frailty among dialysis patients. J AmSoc Nephrol 18: 2960-2967, 2007.
9. Shlipak MG, Stehman-Breen C, Fried LF, Song X, Siscovick D, Fried LP, Psaty BM, Newman AB: The presence of frailty in elderly persons with chronic renal insufficiency. Am J Kidney Dis 43: 861-867, 2004.
10. Roshanravan B, Khatri M, Robinson-Cohen C, Levin G, Patel KV, de Boer IH, Seliger S, Ruzinski J, Himmelfarb J, Kestenbaum B: A prospective study of frailty in nephrology-referred patients with CKD. Am J Kidney Dis 60: 912-921, 2012.
11. O'Hare AM, Choi AI, Bertenthal D, Bacchetti P, Garg AX, Kaufman JS, Walter LC, Mehta KM, Steinman MA, Allon M, McClellan WM, Landefeld CS: Age affects outcomes in chronic kidney disease. J Am Soc Nephrol 18: 2758-2765, 2007.
12. Bao Y, Dalrymple L, Chertow GM, Kaysen GA, Johansen KL: Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med 172: 1071-1077, 2012.
13. Weisbord SD, Carmody SS, Bruns FJ, Rotondi AJ, Cohen LM, Zeidel ML, Arnold RM: Symptomburden, quality of life, advance care planning and the potential value of palliative care in severely ill haemodialysis patients. Nephrol Dial Transplant 18: 1345-1352, 2003.
14. Ko FC: The clinical care of frail, older adults. Clin Geriatr Med 27: 89-100, 2011.
15. Moss AH: Revised dialysis clinical practice guideline promotes more informed decision-making. Clin J AmSoc Nephrol 5: 2380-2383, 2010.
16. Davison SN, Jhangri GS, Holley JL, Moss AH: Nephrologists' reported preparedness for end-of-life decision-making. Clin J Am Soc Nephrol 1: 1256-1262, 2006.
17. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group: Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: M146-M156, 2001.
18. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP; Cardiovascular Health Study: Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study. Arch Intern Med 162: 2333-2341, 2002.
19. Leng S, Chaves P, Koenig K, Walston J: Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study. J Am Geriatr Soc 50: 1268-1271, 2002.
20. Walston J, Fedarko N, Yang H, Leng S, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K: The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci 63: 391-398, 2008.
21. Ko F, Yu Q, Xue QL, Yao W, Brayton C, Yang H, Fedarko N, Walston J: Inflammation and mortality in a frail mouse model. Age (Dordr) 34: 705-715, 2012.
22. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM: The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 62: 1524-1538, 2002.
23. Stenvinkel P: Interactions between inflammation, oxidative stress, and endothelial dysfunction in end-stage renal disease. J Ren Nutr 13: 144-148, 2003.
24. Fried LP, Hadley EC, Walston JD, Newman AB, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L: From bedside to bench: Research agenda for frailty. Sci SAGE KE 2005: pe24, 2005.
25. US Renal Data System (USRDS): Atlas of End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases, 2004, p 128.
26. Painter P, Kuskowski M: A closer look at frailty in ESRD: Getting the measure right. Hemodial Int 17: 41-49, 2013.
27. Lorenz KA, Lynn J, Dy SM, Shugarman LR, Wilkinson A, Mularski RA, Morton SC, Hughes RG, Hilton LK, Maglione M, Rhodes SL, Rolon C, Sun VC, Shekelle PG: Evidence for improving palliative care at the end of life: A systematic review. Ann Intern Med 148: 147-159, 2008.
28. Swidler MA: Palliative Care and Geriatric Treatment of Patients with Advanced Chronic Kidney Disease. NephSAP Geriatric Nephrology, Washington, DC, American Society ofNephrology, 2011.
29. Martocchia A, Frugoni P, Indiano I, Tafaro L, Comite F, Amici A, Cacciafesta M, Marigliano V, Falaschi P: Screening of frailty in elderly patients with disability by the means of Marigliano- Cacciafesta polypathology scale (MCPS) and Canadian Study of Health and Aging (CSHA) scales. Arch Gerontol Geriatr 56: 339-342, 2013.
30. Daniels R, van Rossum E, deWitte L, Kempen GI, van den Heuvel W: Interventions to prevent disability in frail community-dwelling elderly: A systematic review. BMC Health Serv Res 8: 278, 2008.
31. Jassal SV, Chiu E, Li M: Geriatric hemodialysis rehabilitation care. Adv Chronic Kidney Dis 15: 115-122, 2008.
32. Jassal SV, Chiu E, Hladunewich M: Loss of independence in patients starting dialysis at 80 years of age or older. N Engl J Med 361: 1612-1613, 2009.
33. Tamura MK, Tan JC, O'Hare AM: Optimizing renal replacement therapy in older adults: A framework for making individualized decisions. Kidney Int 82: 261-269, 2012.
34. Swidler MA: Geriatric renal palliative care. J Gerontol A Biol Sci Med Sci 67: 1400-1409, 2012.
35. HD Mortality Predictor. Available at: http://touchcalc.com/calculators/sq. Accessed November 29, 2012.
36. Beddhu S, Bruns FJ, Saul M, Seddon P, Zeidel ML: A simple comorbidity scale predicts clinical outcomes and costs in dialysis patients. Am J Med 108: 609-613, 2000.
37. Couchoud C, Labeeuw M, Moranne O, Allot V, Esnault V, Frimat L, Stengel B; French Renal Epidemiology and Information Network (REIN) registry: A clinical score to predict 6-month prognosis in elderly patients starting dialysis for end-stage renal disease. Nephrol Dial Transplant 24: 1553-1561, 2009.
38. Moss AH, Ganjoo J, Sharma S, Gansor J, Senft S, Weaner B, Dalton C, MacKay K, Pellegrino B, Anantharaman P, Schmidt R: Utility of the "surprise" question to identify dialysis patients with high mortality. Clin J Am Soc Nephrol 3: 1379-1384, 2008.
39. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G: Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59: 255-263, 2004.
40. Rakowski DA, Caillard S, Agodoa LY, Abbott KC: Dementia as a predictor of mortality in dialysis patients. Clin J Am Soc Nephrol 1: 1000-1005, 2006.
41. Jonsen AR, Siegler M, Winslade WJ: Clinical Ethics, New York, McGraw-Hill Medical, 2010.
42. Lo B: Resolving Ethical Dilemmas: A Guide for Clinicians, Philadelphia, Wolters Kluwer Health/Lippincott Williams & Wilkins, 2005.
43. Kaufman SR, Shim JK, Russ AJ: Old age, life extension, and the character of medical choice. J Gerontol B Psychol Sci Soc Sci 61: S175-S184, 2006.
44. Fried TR, O'Leary J, Van Ness P, Fraenkel L: Inconsistency over time in the preferences of older persons with advanced illness for life-sustaining treatment. J Am Geriatr Soc 55: 1007-1014, 2007.
45. Miura Y, Asai A, Matsushima M, Nagata S, Onishi M, Shimbo T, Hosoya T, Fukuhara S: Families' and physicians' predictions of dialysis patients' preferences regarding life-sustaining treatments in Japan. Am J Kidney Dis 47: 122-130, 2006.
46. Shalowitz DI, Garrett-Mayer E, Wendler D: The accuracy of surrogate decision makers: A systematic review. Arch Intern Med 166: 493-497, 2006.
47. Murtagh FE, Marsh JE, Donohoe P, Ekbal NJ, Sheerin NS, Harris FE: Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrol Dial Transplant 22: 1955-1962, 2007.
48. Nelson JE, Cox CE, Hope AA, Carson SS: Chronic critical illness. Am J Respir Crit Care Med 182: 446-454, 2010.
49. Cohen LM, Germain M, Poppel DM, Woods A, Kjellstrand CM: Dialysis discontinuation and palliative care. Am J Kidney Dis 36: 140-144, 2000.
50. Murtagh F, Cohen LM, Germain MJ: Dialysis discontinuation: Quo vadis? Adv Chronic Kidney Dis 14: 379-401, 2007.
51. Murtagh FE, Addington-Hall JM, Edmonds PM, Donohoe P, Carey I, Jenkins K, Higginson IJ: Symptoms in advanced renal disease: A cross-sectional survey of symptom prevalence in stage 5 chronic kidney disease-managed without dialysis. J Palliat Med 10: 1266-1276, 2007.
52. Gabbay E, Meyer KB, Griffith JL, Richardson MM, Miskulin DC: Temporal trends in health-related quality of life among hemodialysis patients in the United States. Clin J Am Soc Nephrol 5: 261-267, 2010.
53. Mujais SK, Story K, Brouillette J, Takano T, Soroka S, Franek C, Mendelssohn D, Finkelstein FO: Health-related quality of life in CKD Patients: Correlates and evolution over time. Clin J Am Soc Nephrol 4: 1293-1301, 2009.
54. Abdel-Kader K, Unruh ML, Weisbord SD: Symptom burden, depression, and quality of life in chronic and end-stage kidney disease. Clin J Am Soc Nephrol 4: 1057-1064, 2009.
55. Murtagh FE, Sheerin NS, Addington-Hall J, Higginson IJ: Trajectories of illness in stage 5 chronic kidney disease: A longitudinal study of patient symptoms and concerns in the last year of life. Clin J Am Soc Nephrol 6: 1580-1590, 2011.
56. Carson RC, Juszczak M, Davenport A, Burns A: Is maximum conservative management an equivalent treatment option to dialysis for elderly patients with significant comorbid disease? Clin J Am Soc Nephrol 4: 1611-1619, 2009.
57. Morton RL, Snelling P, Webster AC, Rose J, Masterson R, Johnson DW, Howard K: Factors influencing patient choice of dialysis versus conservative care to treat end-stage kidney disease. CMAJ 184: E277-E283, 2012.
58. Morton RL, Tong A, Howard K, Snelling P, Webster AC: The views of patients and carers in treatment decision making for chronic kidney disease: Systematic review and thematic synthesis of qualitative studies. BMJ 340: c112, 2010.
59. Murray MA, Brunier G, Chung JO, Craig LA, Mills C, Thomas A, Stacey D: A systematic review of factors influencing decision-making in adults living-with chronic kidney disease. Patient Educ Couns 76: 149-158, 2009.
60. Schell JO, Patel UD, Steinhauser KE, Ammarell N, Tulsky JA: Discussions of the kidney disease trajectory by elderly patients and nephrologists: A qualitative study. Am J Kidney Dis 59: 495-503, 2012.
61. Davison SN: End-of-life care preferences and needs: Perceptions of patients with chronic kidney disease. Clin J AmSoc Nephrol 5: 195-204, 2010.
62. Williams AW, Dwyer AC, Eddy AA, Fink JC, Jaber BL, Linas SL, Michael B, O'Hare AM, Schaefer HM, Shaffer RN, Trachtman H, Weiner DE, Falk AR; American Society of Nephrology Quality, and Patient Safety Task Force: Critical and honest conversations: The evidence behind the "Choosing Wisely" campaign recommendations by the American Society of Nephrology. Clin J Am Soc Nephrol 7: 1664-1672, 2012.
63. Holley JL: Advance care planning in CKD/ESRD: An evolving process. Clin J Am Soc Nephrol 7: 1033-1038, 2012.
64. Detering KM, Hancock AD, Reade MC, Silvester W: The impact of advance care planning on end of life care in elderly patients: Randomised controlled trial. BMJ 340: c1345, 2010.
65. Kirchhoff KT, Hammes BJ, Kehl KA, Briggs LA, Brown RL: Effect of a disease-specific advance care planning intervention on end-of-life care. J Am Geriatr Soc 60: 946-950, 2012.
66. International Patient Decision Aid Standards (IPDAS). Available at: http://ipdas.ohri.ca/. Accessed November 26, 2012.
67. Barry MJ, Edgman-Levitan S: Shared decision making-pinnacle of patient-centered care. N Engl J Med 366: 780-781, 2012.
68. Stacey D, Bennett CL, Barry MJ, Col NF, Eden KB, Holmes-Rovner M, Llewellyn-Thomas H, Lyddiatt A, Légaré F, Thomson R: Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev 10: CD001431, 2011.
69. Murray MA, Thomas A, Wald R, Marticorena R, Donnelly S, Jeffs L: Exploring the impact of a decision support intervention on vascular access decisions in chronic hemodialysis patients: Study protocol. BMC Nephrol 12: 7, 2011.
70. Ottawa Hospital Research Institute: Ottawa Health Research Institutes A to Z Inventory of Decision Aids. Available at: http://decisionaid.ohri.ca/index.html
71. Murtagh FE, Murphy E, Shepherd KA, Donohoe P, Edmonds PM: End-of-life care in end-stage renal disease: Renal and palliative care. Br J Nurs 15: 8-11, 2006.
72. Davison SN: Integrating palliative care for patients with advanced chronic kidney disease: Recent advances, remaining challenges. J Palliat Care 27: 53-61, 2011.
73. Swidler M: Geriatric renal palliative care is coming of age. Int Urol Nephrol 42: 851-855, 2010.