A prospective study of frailty in nephrology-referred patients with CKD

American Journal of Kidney Diseases

Volumn 60, Issue 6, 2012, Pages 912-921

  Roshanravan, Baback ^a   Khatri, Minesh ^b   Robinson Cohen, Cassianne ^a   Levin, Greg ^a   Patel, Kushang V ^c   De Boer, Ian H ^a   Seliger, Stephen ^d   Ruzinski, John ^a   Himmelfarb, Jonathan ^a   Kestenbaum, Bryan ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

chronic kidney disease; Frailty; functional limitation; mortality

Indexed keywords

CREATININE; CYSTATIN C;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; COMMUNITY LIVING; CREATININE BLOOD LEVEL; DAILY LIFE ACTIVITY; DIABETES MELLITUS; EXHAUSTION; FEMALE; FOLLOW UP; FRAILTY; GAIT; GLOMERULUS FILTRATION RATE; GROUPS BY AGE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; MORTALITY; MUSCLE MASS; OBSERVATIONAL STUDY; PHYSICAL ACTIVITY; PREVALENCE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RACE DIFFERENCE; RENAL REPLACEMENT THERAPY; RISK ASSESSMENT; SEX DIFFERENCE; WEAKNESS; WEIGHT REDUCTION;

AGED; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; FRAIL ELDERLY; GLOMERULAR FILTRATION RATE; HUMANS; MALE; MIDDLE AGED; NEPHROLOGY; PROSPECTIVE STUDIES; REFERRAL AND CONSULTATION; RENAL INSUFFICIENCY, CHRONIC;

EID: 84868712372     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2012.05.017     Document Type: Article

References (47)

1. L. Fried, C. Tangen, J. Walston Frailty in older adults: evidence for a phenotype J Gerontol 56A 3 2001 M146 M156
2. L.P. Fried, Q.L. Xue, A.R. Cappola Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment J Gerontol A Biol Sci Med Sci 64 10 2009 1049 1057
3. P. Cawthon, L. Marshall, Y. Michael Frailty in older men: prevalence, progression, and relationship with mortality J Am Geriatr Soc 55 8 2007 1216 1223
4. N. Woods, A. LaCroix, S. Gray Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study J Am Geriatr Soc 53 8 2005 1321 1330
5. M.D. Rothman, L. Leo-Summers, T.M. Gill Prognostic significance of potential frailty criteria J Am Geriatr Soc 56 12 2008 2211 2216
6. M.A. Fiatarone, E.F. O'Neill, N.D. Ryan Exercise training and nutritional supplementation for physical frailty in very elderly people N Engl J Med 330 25 1994 1769 1775
7. M. Landau, M. Kurella-Tamura, M.G. Shlipak Correlates of insulin resistance in older individuals with and without kidney disease Nephrol Dial Transplant 26 9 2011 2814 2819
8. M. El-Abbadi, C.M. Giachelli Mechanisms of vascular calcification Adv Chronic Kidney Dis 14 1 2007 54 66
9. E. Linden, W. Cai, J.C. He Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation Clin J Am Soc Nephrol 3 3 2008 691 698
10. K.E. Ensrud, L.Y. Lui, B.C. Taylor Renal function and risk of hip and vertebral fractures in older women Arch Intern Med 167 2 2007 133 139
11. M. Jhamb, C. Argyropoulos, J.L. Steel Correlates and outcomes of fatigue among incident dialysis patients Clin J Am Soc Nephrol 4 11 2009 1779 1786
12. M.C. Cruz, C. Andrade, M. Urrutia, S. Draibe, L.A. Nogueira-Martins, C. Sesso Rde Quality of life in patients with chronic kidney disease Clinics (Sao Paulo) 66 6 2011 991 995
13. G. Gyamlani, A. Basu, S. Geraci Depression, screening and quality of life in chronic kidney disease Am J Med Sci 342 3 2011 186 191
14. M. Shlipak, C. Stehman-Breen, L. Fried The presence of frailty in elderly persons with chronic renal insufficiency Am J Kidney Dis 43 5 2004 861 867
15. K. Johansen, G. Chertow, C. Jin, N. Kutner Significance of frailty among dialysis patients J Am Soc Nephrol 18 11 2007 2960 2967
16. E.R. Wilhelm-Leen, Y.N. Hall, M. Kurella-Tamura, G.M. Chertow Frailty and chronic kidney disease: the Third National Health and Nutrition Evaluation Survey Am J Med 122 7 2009 664 671 e662
17. A.J. Cruz-Jentoft, J.P. Baeyens, J.M. Bauer Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People Age Ageing 39 4 2010 412 423
18. E.J. Erlandsen, E. Randers, J.H. Kristensen Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System Scand J Clin Lab Invest 59 1 1999 1 8
19. L.A. Stevens, J. Coresh, C.H. Schmid Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD Am J Kidney Dis 51 3 2008 395 406
20. Y.T. Kwong, L.A. Stevens, E. Selvin Imprecision of urinary iothalamate clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equations Am J Kidney Dis 56 1 2010 39 49
21. A.S. Levey, L.A. Stevens, C.H. Schmid A new equation to estimate glomerular filtration rate Ann Intern Med 150 9 2009 604 612
22. J.E. Fitti, M.G. Kovar The Supplement on Aging to the 1984 National Health Interview Survey Vital Health Stat 1 21 1987 1 115
23. P. Royston Multiple imputation of missing values Stata J 4 3 2004 227 241
24. D. Fouque, K. Kalantar-Zadeh, J. Kopple A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease Kidney Int 73 4 2008 391 398
25. R.H. Mak, A.T. Ikizler, C.P. Kovesdy, D.S. Raj, P. Stenvinkel, K. Kalantar-Zadeh Wasting in chronic kidney disease J Cachex Sarcopenia Muscle 2 1 2011 9 25
26. D. Adey, R. Kumar, J.T. McCarthy, K.S. Nair Reduced synthesis of muscle proteins in chronic renal failure Am J Physiol Endocrinol Metab 278 2 2000 E219 E225
27. E.D. Siew, T.A. Ikizler Insulin resistance and protein energy metabolism in patients with advanced chronic kidney disease Semin Dial 23 4 2010 378 382
28. J. Walston, M.A. McBurnie, A. Newman Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study Arch Intern Med 162 20 2002 2333 2341
29. T.B. Vanitallie Frailty in the elderly: contributions of sarcopenia and visceral protein depletion Metabolism 52 suppl 2 2003 22 26 (10)
30. H. Tilg, A.R. Moschen Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nat Rev Immunol 6 10 2006 772 783
31. T. Stompor, W. Sulowicz, A. Dembinska-Kiec, K. Janda, K. Wojcik, A. Zdzienicka An association between body mass index and markers of inflammation: is obesity the proinflammatory state in patients on peritoneal dialysis? Perit Dial Int 23 1 2003 79 83
32. C.Y. Hsu, C.E. McCulloch, C. Iribarren, J. Darbinian, A.S. Go Body mass index and risk for end-stage renal disease Ann Intern Med 144 1 2006 21 28
33. M. Tesauro, M.P. Canale, G. Rodia Metabolic syndrome, chronic kidney, and cardiovascular diseases: role of adipokines Cardiol Res Pract 2011 2011 653182
34. M.A. Schrager, E.J. Metter, E. Simonsick Sarcopenic obesity and inflammation in the InCHIANTI Study J Appl Physiol 102 3 2007 919 925
35. D. Villareal, M. Banks, C. Seiner, D. Sinacore, S. Klein Physical frailty and body composition in obese elderly men and women Obes Res 12 6 2004 913 920
36. C. Blaum, L.X. Qian, M. Elisabete, D. Richard, P. Linda The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies J Am Geriatr Soc 53 6 2005 927 934
37. M.V. Narici, N. Maffulli Sarcopenia: characteristics, mechanisms and functional significance Br Med Bull 95 2010 139 159
38. H. Honda, A.R. Qureshi, J. Axelsson Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality Am J Clin Nutr 86 3 2007 633 638
39. Garre-Olmo J, Calvo-Perxas L, Lopez-Pousa S, de Gracia Blanco M, Vilalta-Franch J. Prevalence of frailty phenotypes and risk of mortality in a community-dwelling elderly cohort [published online ahead of print March 27, 2012]. Age Ageing. doi:10.1093/ageing/afs047.
40. L.A. Stevens, C.H. Schmid, T. Greene Factors other than glomerular filtration rate affect serum cystatin C levels Kidney Int 75 6 2009 652 660
41. P. Muntner, J. Winston, J. Uribarri, D. Mann, C.S. Fox Overweight, obesity, and elevated serum cystatin C levels in adults in the United States Am J Med 121 4 2008 341 348
42. M. Odden, G. Chertow, L. Fried Cystatin C and measures of physical function in elderly adults The Health, Aging, and Body Composition (HABC) Study Am J Epidemiol 164 2006 1180 1189
43. C. Castaneda, P.L. Gordon, R.C. Parker, K.L. Uhlin, R. Roubenoff, A.S. Levey Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease Am J Kidney Dis 43 4 2004 607 616
44. C. Castaneda, P.L. Gordon, K.L. Uhlin Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency A randomized, controlled trial Ann Intern Med 135 11 2001 965 976
45. V.S. Balakrishnan, M. Rao, V. Menon Resistance training increases muscle mitochondrial biogenesis in patients with chronic kidney disease Clin J Am Soc Nephrol 5 6 2010 996 1002
46. E. Phielix, R. Meex, E. Moonen-Kornips Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals Diabetologia 53 2010 1714 1721
47. C. He, M.C. Bassik, V. Moresi Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis Nature 481 7382 2012 511 515