Chronic critical illness

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 4, 2010, Pages 446-454

  Nelson, Judith E ^a   Cox, Christopher E ^b   Hope, Aluko A ^a   Carson, Shannon S ^c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Artificial; Chronic disease; Critical illness; Respirator; Respiratory care units

Indexed keywords

ARTIFICIAL VENTILATION; CAREGIVER BURDEN; CHRONIC DISEASE; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; COST EFFECTIVENESS ANALYSIS; CRITICAL ILLNESS; DECISION MAKING; DOCTOR PATIENT RELATION; FUNCTIONAL DISEASE; HEALTH CARE COST; HEALTH CARE SYSTEM; HEALTH CARE UTILIZATION; HUMAN; INTENSIVE CARE; MORTALITY; NUTRITIONAL SUPPORT; OUTCOME ASSESSMENT; PALLIATIVE THERAPY; PRIORITY JOURNAL; REVIEW; SURVIVAL; TRACHEOTOMY; COST OF ILLNESS; ECONOMICS; METHODOLOGY; UNITED STATES;

CHRONIC DISEASE; COST OF ILLNESS; CRITICAL CARE; CRITICAL ILLNESS; HUMANS; NUTRITIONAL SUPPORT; UNITED STATES; VENTILATOR WEANING;

EID: 77957058329     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201002-0210CI     Document Type: Review

References (77)

1. Girard K, Raffin TA. The chronically critically ill: to save or let die? Respir Care 1985;30:339-347.
2. MacIntyre NR, Epstein SK, Carson S, Scheinhorn D, Christopher K, Muldoon S. Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference. Chest 2005; 128:3937-3954. (Pubitemid 43062657)
3. Daly BJ, Douglas SL, Kelley CG, O'Toole E, Montenegro H. Trial of a disease management program to reduce hospital readmissions of the chronically critically ill. Chest 2005;128:507-517. (Pubitemid 41140474)
4. Chelluri L, Im KA, Belle SH, Schulz R, Rotondi AJ, Donahoe MP, Sirio CA, Mendelsohn AB, Pinsky MR. Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 2004;32: 61-69.
5. Gracey DR, Naessens JM, Krishan I, Marsh HM. Hospital and post-hospital survival in patients mechanically ventilated for more than 29 days. Chest 1992;101:211-214.
6. Hollander JM, Mechanick JI. Nutrition support and the chronic critical illness syndrome. Nutr Clin Pract 2006;21:587-604.
7. Van den Berghe G, de Zegher F, Veldhuis JD, Wouters P, Awouters M, Verbruggen W, Schetz M, Verwaest C, Lauwers P, Bouillon R, et al. The somatotropic axis in critical illness: effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion. J Clin Endocrinol Metab 1997;82:590-599.
8. Van den Berghe G, de Zegher F, Veldhuis JD, Wouters P, Gouwy S, Stockman W, Weekers F, Schetz M, Lauwers P, Bouillon R, et al. Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormonesecretagogues. Clin Endocrinol (Oxf) 1997;47:599-612.
9. Kalb TH, Lorin S. Infection in the chronically critically ill: unique risk profile in a newly defined population. Crit Care Clin 2002;18:529-552.
10. Scheinhorn DJ, Hassenpflug MS, Votto JJ, Chao DC, Epstein SK, Doig GS, Knight EB, Petrak RA. Post-ICU mechanical ventilation at 23 long-term care hospitals: a multicenter outcomes study. Chest 2007; 131:85-93.
11. Nelson JE, Tandon N, Mercado AF, Camhi SL, Ely EW, Morrison RS. Brain dysfunction: another burden for the chronically critically ill. Arch Intern Med 2006;166:1993-1999.
12. Carasa M, Polycarpe M. Caring for the chronically critically ill patient: establishing a wound-healing program in a respiratory care unit. Am J Surg 2004;188:18-21.
13. Nelson JE, Meier DE, Litke A, Natale DA, Siegel RE, Morrison RS. The symptom burden of chronic critical illness. Crit Care Med 2004; 32:1527-1534.
14. Engoren M, Arslanian-Engoren C, Fenn-Buderer N. Hospital and long-term outcome after tracheostomy for respiratory failure. Chest 2004; 125:220-227.
15. Seneff MG, Zimmerman JE, Knaus WA, Wagner DP, Draper EA. Predicting the duration of mechanical ventilation: the importance of disease and patient characteristics. Chest 1996;110:469-479.
16. Wagner DP. Economics of prolonged mechanical ventilation. Am Rev Respir Dis 1989;140:S14-S18.
17. Kahn JM, Carson SS, Angus DC, Linde-Zwirble WT, Iwashyna TJ. Development and validation of an algorithm for identifying prolonged mechanical ventilation in administrative data. Health Serv Outcomes Res Methodol 2009;9:117-132.
18. Cox CE, Carson SS, Holmes GM, Howard A, Carey TS. Increase in tracheostomy for prolonged mechanical ventilation in North Carolina, 1993-2002. Crit Care Med 2004;32:2219-2226.
19. Scheinhorn DJ, Hassenpflug MS, Votto JJ, Chao DC, Epstein SK, Doig GS, Knight EB, Petrak RA. Ventilator-dependent survivors of catastrophic illness transferred to 23 long-term care hospitals for weaning from prolonged mechanical ventilation. Chest 2007;131:76-84.
20. Nelson JE, Mercado AF, Camhi SL, Tandon N, Wallenstein S, August GI, Morrison RS. Communication about chronic critical illness. Arch Intern Med 2007;167:2509-2515.
21. Engoren M, Arslanian-Engoren C. Hospital and long-term outcome of trauma patients with tracheostomy for respiratory failure. Am Surg 2005;71:123-127.
22. Nierman DM, Mechanick JI. Biochemical response to treatment of bone hyperresorption in chronically critically ill patients. Chest 2000;118: 761-766.
23. Estenssoro E, Reina R, Canales HS, Saenz MG, Gonzalez FE, Aprea MM, Laffaire E, Gola V, Dubin A. The distinct clinical profile of chronically critically ill patients: a cohort study. Crit Care 2006;10: R89.
24. Cox CE, Carson SS, Lindquist JH, Olsen MK, Govert JA, Chelluri L. Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study. Crit Care 2007;11:R9.
25. Carson SS, Garrett J, Hanson LC, Lanier J, Govert J, Brake MC, Landucci DL, Cox CE, Carey TS. A prognostic model for one-year mortality in patients requiring prolonged mechanical ventilation. Crit Care Med 2008;36:2061-2069.
26. Bigatello LM, Stelfox HT, Berra L, Schmidt U, Gettings EM. Outcome of patients undergoing prolonged mechanical ventilation after critical illness. Crit Care Med 2007;35:2491-2497.
27. MacIntyre NR, Cook DJ, Ely EW Jr, Epstein SK, Fink JB, Heffner JE, Hess D, Hubmayer RD, Scheinhorn DJ. Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest 2001;120:375S-395S.
28. Stoller JK, Xu M, Mascha E, Rice R. Long-term outcomes for patients discharged from a long-term hospital-based weaning unit. Chest 2003; 124:1892-1899.
29. Cox CE, Carson SS, Govert JA, Chelluri L, Sanders GD. An economic evaluation of prolonged mechanical ventilation. Crit Care Med 2007; 35:1918-1927.
30. Douglas SL, Daly BJ, Gordon N, Brennan PF. Survival and quality of life: short-term versus long-term ventilator patients. Crit Care Med 2002;30:2655-2662.
31. Carson SS, Bach PB, Brzozowski L, Leff A. Outcomes after long-term acute care. An analysis of 133 mechanically ventilated patients. Am J Respir Crit Care Med 1999;159:1568-1573.
32. Douglas SL, Daly BJ, Brennan PF, Gordon NH, Uthis P. Hospital readmission among long-term ventilator patients. Chest 2001;120: 1278-1286.
33. Nasraway SA, Button GJ, Rand WM, Hudson-Jinks T, Gustafson M. Survivors of catastrophic illness: outcome after direct transfer from intensive care to extended care facilities. Crit Care Med 2000;28: 19-25.
34. Combes A, Costa M-A, Trouillet J-L, Baudot J, Mokhtari M, Gibert C, Chastre J. Morbidity, mortality, and quality-of-life outcomes of patients requiring ≥14 days of mechanical ventilation. Crit Care Med 2003;31:1373-1381.
35. Hofhuis JGM, van Stel HF, Schrijvers AJP, Rommes JH, Bakker J, Spronk PE. Conceptual issues specifically related to health-related quality of life in critically ill patients. Crit Care 2009;13:118.
36. Van Pelt DC, Milbrandt EB, Qin L, Weissfeld LA, Rotondi AJ, Schulz R, Chelluri L, Angus DC, Pinsky MR. Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med 2007;175:167-173.
37. Douglas SL, Daly BJ. Caregivers of long-term ventilator patients: physical and psychological outcomes. Chest 2003;123:1073-1081.
38. Van Pelt DC, Schulz R, Chelluri L, Pinsky MR. Patient-specific, time-varying predictors of post-ICU informal caregiver burden: the caregiver outcomes after ICU discharge project. Chest 2010;137:88-94.
39. Cox CE, Martinu T, Sathy SJ, Clay AS, Chia J, Gray AL, Olsen MK, Govert JA, Carson SS, Tulsky JA. Expectations and outcomes of prolonged mechanical ventilation. Crit Care Med 2009;37:2888-2894.
40. Swoboda SM, Lipsett PA. Impact of a prolonged surgical critical illness on patients' families. Am J Crit Care 2002;11:459-466.
41. Dematte D'Amico JE, Donnelly HK, Mutlu GM, Feinglass J, Jovanovic BD, Ndukwu IM. Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness. Chest 2003;124: 1039-1045.
42. Carson SS, Bach PB. Predicting mortality in patients suffering from prolonged critical illness: an assessment of four severity-of-illness measures. Chest 2001;120:928-933.
43. Schonhofer B, Euteneuer S, Nava S, Suchi S, Kohler D. Survival of mechanically ventilated patients admitted to a specialised weaning centre. Intensive Care Med 2002;28:908-916. (Pubitemid 34762226)
44. Zilberberg MD, de Wit M, Pirone JR, Shorr AF. Growth in adult prolonged acute mechanical ventilation: implications for healthcare delivery. Crit Care Med 2008;36:1451-1455.
45. Carson SS, Cox CE, Holmes GM, Howard A, Carey TS. The changing epidemiology of mechanical ventilation: a population-based study. J Intensive Care Med 2006;21:173-182.
46. Behrendt CE. Acute respiratory failure in the United States: incidence and 31-day survival. Chest 2000;118:1100-1105.
47. Halpern NA, Pastores SM, Greenstein RJ. Critical care medicine in the United States 1985-2000: an analysis of bed numbers, use, and costs. Crit Care Med 2004;32:1254-1259.
48. Medicare Payment Advisory Commission (MEDPAC). Report to the Congress: new approaches in Medicare, Chapter 5: Defining long-term care hospitals. Washington DC: MEDPAC; 2004. Accessed June 1, 2010. Available at www.medpac.gov/publications%5Ccongressional-reports%5CJune04-ch5.pdf
49. Scheinhorn DJ, Chao DC, Stearn-Hassenpflug M, LaBree LD, Heltsley DJ. Post-ICU mechanical ventilation: treatment of 1,123 patients at a regional weaning center. Chest 1997;111:1654-1659.
50. RTI International. Medicare post-acute care payment reform demonstration. Accessed June 1, 2010. Available at: http://www.pacdemo.rti.org
51. Scheinhorn DJ, Chao DC, Stearn-Hassenpflug M, Wallace WA. Outcomes in post-ICU mechanical ventilation: a therapist-implemented weaning protocol. Chest 2001;119:236-242.
52. Chao DC, Scheinhorn DJ. Determining the best threshold of rapid shallow breathing index in a therapist-implemented patient-specific weaning protocol. Respir Care 2007;52:159-165.
53. Carasa M, Nespoli G. Nursing the chronically critically ill patient. Crit Care Clin 2002;18:493-507.
54. Ceriana P, Carlucci A, Navalesi P, Rampulla C, Delmastro M, Piaggi G, De Mattia E, Nava S. Weaning from tracheotomy in long-term mechanically ventilated patients: feasibility of a decisional flowchart and clinical outcome. Intensive Care Med 2003;29:845-848.
55. Dwolatzky T, Berezovski S, Friedmann R, Paz J, Clarfield AM, Stessman J, Hamburger R, Jaul E, Friedlander Y, Rosin A, et al. A prospective comparison of the use of nasogastric and percutaneous endoscopic gastrostomy tubes for long-term enteral feeding in older people. Clin Nutr 2001;20:535-540.
56. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373:1874-1882.
57. Nieszkowska A, Combes A, Luyt C-E, Ksibi H, Trouillet J-L, Gibert C, Chastre J. Impact of tracheotomy on sedative administration, sedation level, and comfort of mechanically ventilated intensive care unit patients. Crit Care Med 2005;33:2527-2533.
58. Pisani MA, Murphy TE, Araujo KLB, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med 2009;37:177-183.
59. Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006;104:21-26.
60. Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, Pun BT, Thompson JL, Shintani AK, Meltzer HY, et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 2010;38:428-437.
61. Gracey DR. Ventilator care beyond the intensive-care unit. Mayo Clin Proc 1995;70:595-597.
62. Rudy EB, Daly BJ, Douglas S, Montenegro HD, Song R, Dyer MA. Patient outcomes for the chronically critically ill: special care unit versus intensive care unit. Nurs Res 1995;44:324-331.
63. Burns SM, Earven S, Fisher C, Lewis R, Merrell P, Schubart JR, Truwit JD, Bleck TP. Implementation of an institutional program to improve clinical and financial outcomes of mechanically ventilated patients: one-year outcomes and lessons learned. Crit Care Med 2003;31:2752-2763.
64. Griffiths J, Barber VS, Morgan L, Young JD. Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilation. BMJ 2005;330:1243.
65. Freeman BD, Borecki IB, Coopersmith CM, Buchman TG, Freeman BD, Borecki IB, Coopersmith CM, Buchman TG. Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients. Crit Care Med 2005;33:2513-2520.
66. Pronovost PJ, Angus DC, Dorman T, Robinson KA, Dremsizov TT, Young TL. Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA 2002;288:2151-2162.
67. Carson SS, Stocking C, Podsadecki T, Christenson J, Pohlman A, MacRae S, Jordan J, Humphrey H, Siegler M, Hall J. Effects of organizational change in the medical intensive care unit of a teaching hospital: a comparison of "open" and "closed" formats. JAMA 1996; 276:322-328.
68. Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, Johnson MM, Browder RW, Bowton DL, Haponik EF. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996;335:1864-1869.
69. Kress JP, Vinayak AG, Levitt J, Schweickert WD, Gehlbach BK, Zimmerman F, Pohlman AS, Hall JB, Kress JP, Vinayak AG, et al. Daily sedative interruption in mechanically ventilated patients at risk for coronary artery disease. Crit Care Med 2007; 35:365-371.
70. Carson SS, Kress JP, Rodgers JE, Vinayak A, Campbell-Bright S, Levitt J, Bourdet S, Ivanova A, Henderson AG, Pohlman A, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med 2006; 34:1326-1332.
71. Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006;355:2725-2732. (Pubitemid 46021509)
72. Camhi SL, Mercado AF, Morrison RS, Du Q, Platt DM, August GI, Nelson JE. Deciding in the dark: advance directives and continuation of treatment in chronic critical illness. Crit Care Med 2009;37: 919-925.
73. SUPPORT Principal Investigators. A controlled trial to improve care for seriously ill hospitalized patients. JAMA 1995;274:1591-1598.
74. Society of Critical Care Medicine. Chronic critical illness in adults requiring prolonged mechanical ventilation [support brochure]. Accessed June 1, 2010. Available at http://www.myicucare.org/Support-Brochures/Pages/ ChronicCriticalIllness.aspx
75. Lautrette A, Darmon M, Megarbane B, Joly LM, Chevret S, Adrie C, Barnoud D, Bleichner G, Bruel C, Choukroun G, et al. A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med 2007;356:469-478.
76. Azoulay E, Pochard F, Chevret S, Jourdain M, Bornstain C, Wernet A, Cattaneo I, Annane D, Brun F, Bollaert P-E, et al. Impact of a family information leaflet on effectiveness of information provided to family members of intensive care unit patients: a multicenter, prospective, randomized, controlled trial. Am J Respir Crit Care Med 2002;165: 438-442.
77. Kahn JM. The evolving role of dedicated weaning facilities in critical care. Intensive Care Med 2010;36:8-10.