Mutant mice: Experimental organisms as materialised models in biomedicine

Studies in History and Philosophy of Science Part C :Studies in History and Philosophy of Biological and Biomedical Sciences

Volumn 44, Issue 3, 2013, Pages 385-391

  Huber, Lara ^a   Keuck, Lara K ^b  

^a Independent Scholar   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Alzheimer's disease; Animal model; Materiality; Standardisation; Validation

Indexed keywords

ALZHEIMER DISEASE; ANIMAL; ANIMAL MODEL; ARTICLE; DISEASE MODEL; HUMAN; MATERIALITY; MOUSE; STANDARDISATION; TRANSGENIC MOUSE; VALIDATION;

ALZHEIMER'S DISEASE; ANIMAL MODEL; MATERIALITY; STANDARDISATION; VALIDATION;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, TRANSGENIC;

EID: 84881234885     PISSN: 13698486     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.shpsc.2013.03.001     Document Type: Article

References (57)

1. Ankeny R.A. Model organisms as models: Understanding the 'lingua franca' of the human genome project. Philosophy of Science 2001, 68:S251-S261.
2. Ankeny R.A. Historiographic reflections on model organisms: Or, how the mureaucracy may be limiting our understanding of contemporary genetics and genomics. History and Philosophy of the Life Sciences 2010, 32:91-104.
3. Ankeny R.A., Leonelli S. What's so special about model organisms?. Studies in History and Philosophy of Science Part A 2011, 42:313-323.
4. Buckner R.L., Snyder A.Z., Shannon B.J., LaRossa G., Sachs R., Fotenos A.F., et al. Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory. The Journal of Neuroscience 2005, 25:7709-7717.
5. Burian R.M. How the choice of experimental organism matters: Epistemological reflections on an aspect of biological practice. Journal of the History of Biology 1993, 26:351-367.
6. Carlson G.A., Borchelt D.A., Dake A., Turner S., Danielson V., Coffin J.D., et al. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Human Molecular Genetics 1997, 6:1951-1959.
7. Cartwright N. How the laws of physics lie 1983, Clarendon Press, Oxford.
8. Chang H. Inventing temperature: Measurement and scientific progress 2004, Oxford University Press, Oxford, New York.
9. Codita A., Winblad B., Mohammed A.H. Of mice and men: More neurobiology in dementia. Current Opinion in Psychiatry 2007, 19:555-563.
10. Creager A.N.H., Lunbeck E., Wise M.N. Introduction. Science without laws: Model systems, cases, exemplary narratives 2007, 1-20. Duke University Press, Durham. A.N.H. Creager, E. Lunbeck, M.N. Wise (Eds.).
11. Darden L. Mechanisms and models. The Cambridge companion to the philosophy of biology 2007, 139-159. Cambridge University Press, Cambridge. D.L. Hull, M. Ruse (Eds.).
12. Models: The third dimension of science 2004, Stanford University Press, Stanford. S. De Chadarevian, N. Hopwood (Eds.).
13. Dror O.E. Is the mind a scientific object of study? Lessons from history. The mind as a scientific object between brain and culture 2005, Oxford University Press, Oxford. C.E. Erneling, D.M. Johnson (Eds.).
14. Ewers M., Sperling R.A., Klunk W.E., Weiner M.W., Hampel H. Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia. Trends in Neurosciences 2011, 34:430-442.
15. Feest U. What exactly is stabilized when phenomena are stabilized?. Synthese 2011, 182:57-71.
16. Frigg R., Reiss J. The philosophy of simulation: Hot new issues or same old stew?. Synthese 2009, 169:593-613.
17. Goate A. The future of Alzheimer's disease research: A molecular genetic perspective. Neurobiology of Aging 1994, 15(Suppl. 2):S161-S164.
18. Guala F. Experimental localism and external validity. Philosophy of Science 2003, 70:1195-1205.
19. Hacking I. Representing and intervening. Introductory topics in philosophy of science 1983, Cambridge University Press, Cambridge.
20. Higuchi M., Maeda J., Ji B., Maruyama M., Okauchi T., Tokunaga M., et al. In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models. Biochimica et Biophysica Acta 2010, 1802:373-388.
21. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Response to: Routtenberg, A. (1997). Measuring memory in a mouse model of Alzheimer's disease. Science 1997, 277:840-841.
22. Hsiao K., Shapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Aß elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102.
23. Hubbard E.J.A. Model organisms as powerful tools for biomedical research. Science without laws: Model systems, cases, exemplary narratives 2007, 59-72. Duke University Press, Durham. A.N.H. Creager, E. Lunbeck, M.N. Wise (Eds.).
24. Huber L. LONI & Co: Die epistemischen Spezifität digitaler Wissensräume in der kognitiven Neurowissenschaft. Berichte Zur Wissenschaftsgeschichte 2011, 34:174-190.
25. Jackson Laboratories (n.d.). Mouse Phenome Database. (2010). <. Accessed 21.05.10. http://phenome.jax.org/.
26. Jordanova L. Material models as visual culture. Models: The third dimension of science 2004, 443-451. Stanford University Press, Stanford. S. de Chadarevian, N. Hopwood (Eds.).
27. Biofakte. Versuch über den Menschen zwischen Artefakt und Lebewesen 2003, Mentis, Paderborn. N.C. Karafyllis (Ed.).
28. Keller E.F. Models of and models for: Theory and practice in contemporary biology. Philosophy of Science 2000, 67:S72-S86.
29. Khurana V. Modeling tauopathy in the fruit fly Drosophila melanogaster. Journal of Alzheimer's Disease 2008, 15:541-553.
30. Kohler R.E. Lords of the fly. Drosophila genetics and the experimental life 1994, The University of Chicago Press, Chicaco.
31. LaFollette H., Shanks N. Two models of models in biomedical research. The Philosophical Quarterly 1995, 45:141-160.
32. Lederman M., Burian R.M. Introduction: The right organism for the job. Journal of the History of Biology 1993, 26:235-237.
33. Leonelli S. Performing abstraction: Two ways of modelling Arabidopsis thaliana. Biology and Philosophy 2008, 23:509-528.
34. Leonelli S. Special section: Data-driven research in the biological and biomedical sciences. Studies in the History and Philosophy of Biological and Biomedical Sciences 2012, 43:1-87.
35. Löwy I., Gaudillière J.-P. Disciplining cancer: Mice and the practice of genetic purity. The invisible industrialist: Manufactures and the production of scientific knowledge 1998, 209-249. Palgrave Macmillan, London. J.-P. Gaudillière, I. Löwy (Eds.).
36. Macbeth A.H., Luine V.N. Changes in anxiety and cognition due to reproductive experience: A review of data from rodent and human mothers. Neuroscience and Biobehavioral Reviews 2010, 34:452-467.
37. Mitchell S.D. Unsimple truths. Science, complexity and policy 2009, The University of Chicago Press, Chicago.
38. Morgan M.S. Experiments versus models: New phenomena, inference and surprise. Journal of Economic Methodology 2005, 12:317-329.
39. Parker W. Does matter really matter? Computer simulations, experiments, and materiality. Synthese 2009, 169:483-496.
40. Peleg S., Sananbenesi F., Zovoilis A., Burkhardt S., Bahari-Javan S., Agis-Balboa R.C., et al. Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 2010, 328:753-756.
41. Radde R., Duma C., Goedert M., Jucker M. The value of incomplete mouse models of Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging 2008, 35:S70-S74.
42. Rader K. Making mice. Standardizing animals for American biomedical research, 1900-1955 2004, Princeton University Press, Princeton.
43. Rheinberger H.J. Vers la fin des organismes modèles?. Les organismes modèles dans la recherche médicale 2006, 275-277. Presses Universitaires de France, Paris. G. Gachelin (Ed.).
44. Rodriguiz R.M., Wetzel W.C. Assessment of cognitive deficits in mutant mice. Animal models of cognitive impairment 2006, 223-282. Taylor & Francis, Boca Raton. E.D. Levin, J.J. Buccafusco (Eds.).
45. Routtenberg A. Measuring memory in a mouse model of Alzheimer's disease. Science 1997, 277:839-840.
46. Schaffner K.F. Exemplar reasoning about biological models and diseases: A relation between the philosophy of medicine and philosophy of science. Journal of Medicine and Philosophy 1986, 11:63-80.
47. Schaffner K.F. Genes, behavior, and developmental emergentism: One process, indivisible?. Philosophy of Science 1998, 65:209-252.
48. Steel D.P. Across the boundaries. Extrapolation in biology and the social science 2008, Oxford University Press, Oxford.
49. Steel D. A new approach to argument by analogy: Extrapolation and chain graphs. Philosophy of Science 2010, 77:1069-1085.
50. Sullivan J.A. The multiplicity of experimental protocols: A challenge to reductionist and non-reductionist models of the unity of neuroscience. Synthese 2009, 167:511-539.
51. Sullivan J.A. Reconsidering 'spatial memory' and the Morris water maze. Synthese 2010, 177:261-283.
52. Takeda S., Sato N., Niisato K., Takeuchi D., Kurinami H., Shinohara M., et al. Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease. Brain Research 2009, 1280:137-147.
53. van Dam D., de Deyn P.P. Drug discovery in dementia: The role of rodent models. Nature Reviews Drug Discovery 2006, 5:956-970.
54. Weber M. Philosophy of experimental biology 2005, Cambridge University Press, Cambridge.
55. Wimsatt W. Robustness, reliability, and overdetermination. Scientific inquiry and the social sciences 1981, 124-163. Jossey-Bass, San Francisco. R. Brewer, B. Collins (Eds.).
56. Winsberg E. A tale of two methods. Science in the age of computer simulation 2010, 49-71. The University of Chicago Press, Chicago. E. Winsberg (Ed.).
57. Woodruff-Pak D.S. Animal models of Alzheimer's disease: Therapeutic implications. Journal of Alzheimer's Disease 2008, 15:507-521.