Exploring the Mode of Action of Bioactive Compounds by Microfluidic Transcriptional Profiling in Mycobacteria

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Murima, Paul ^a   de Sessions, Paola Florez ^b   Lim, Vivian ^a   Naim, Ahmad Nazri Mohamed ^b   Bifani, Pablo ^a   Boshoff, Helena I M ^c   Sambandamurthy, Vasan K ^a   Dick, Thomas ^a,d   Hibberd, Martin L ^b   Schreiber, Mark ^a,e   Rao, Srinivasa P S ^a  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; AMIKACIN; AMINOSALICYLIC ACID; AMPICILLIN; ANTIMYCOBACTERIAL AGENT; BEDAQUILINE; CAPREOMYCIN; CLOFAZIMINE; ETHAMBUTOL; ETHIONAMIDE; GATIFLOXACIN; ISONIAZID; KANAMYCIN; LEVOFLOXACIN; LINEZOLID; MOXIFLOXACIN; NITD 101; OFLOXACIN; PROTIONAMIDE; RIFABUTIN; RIFAMPICIN; RIFAPENTINE; SPARFLOXACIN; STREPTOMYCIN; TETRACYCLINE; THIORIDAZINE; TRANSCRIPTOME; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALNEMULIN; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENETICS; BACTERIAL GENOME; CELL ACTIVITY; DRUG CLASSIFICATION; DRUG DETERMINATION; DRUG DEVELOPMENT; GENE EXPRESSION PROFILING; GENETIC MARKER; MICROFLUIDIC ANALYSIS; MICROFLUIDIC TRANSCRIPTIONAL PROFILING; MYCOBACTERIUM; NONHUMAN; STRUCTURE ACTIVITY RELATION; WHOLE CELL;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CLUSTER ANALYSIS; DRUG DISCOVERY; GENE EXPRESSION REGULATION, BACTERIAL; MICROFLUIDIC ANALYTICAL TECHNIQUES; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTOME;

EID: 84881180487     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069191     Document Type: Article

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