Analysis of human ITPase nucleobase specificity by site-directed mutagenesis

Biochimie

Volumn 95, Issue 9, 2013, Pages 1711-1721

  Gall, Amanda D ^a   Gall, Anthony ^a   Moore, Ashley C ^a   Aune, Martin K ^a   Heid, Steven ^a   Mori, Ayaka ^a   Burgis, Nicholas E ^a  

^a EASTERN WASHINGTON UNIVERSITY   (United States)

Author keywords

Hepatitis C; Hypoxanthine; ITPA; Purine metabolism; Thiopurine toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGININE; ASPARAGINE; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATE; HISTIDINE; INORGANIC PYROPHOSPHATASE; INOSINE TRIPHOSPHATE PYROPHOSPHOHYDROLASE; LYSINE; MUTANT PROTEIN; NUCLEIC ACID BASE; PHENYLALANINE; PURINE; SERINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GAIN OF FUNCTION MUTATION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IN VITRO STUDY; NONHUMAN; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; WILD TYPE;

ESCHERICHIA COLI; HEPATITIS C VIRUS; MAMMALIA; MUS;

EID: 84881157109     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.05.016     Document Type: Article

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