Uremic Pruritus, Dialysis Adequacy, and Metabolic Profiles in Hemodialysis Patients: A Prospective 5-Year Cohort Study

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Ko, Mei Ju ^a,c,d   Wu, Hon Yen ^b,c,d   Chen, Hung Yuan ^b,c   Chiu, Yen Ling ^b,c   Hsu, Shih Ping ^b,c   Pai, Mei Fen ^b,c   Ju YehYang, ^b,c   Lai, Chun Fu ^b,c   Lu, Hui Min ^b   Huang, Shu Chen ^b   Yang, Shao Yu ^b,c   Wen, Su Yin ^a   Chiu, Hsien Ching ^c   Hu, Fu Chang ^d   Peng, Yu Sen ^b,c   Jee, Shiou Hwa ^c  

^a TAIPEI CITY HOSPITAL   (Taiwan)

^b FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; C REACTIVE PROTEIN; CALCIUM; CHOLESTEROL; FERRITIN; GLUCOSE; PARATHYROID HORMONE;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; ARTIFICIAL KIDNEY; CALCIUM BLOOD LEVEL; CHANGE SCORE; CLINICAL LABORATORY; COHORT ANALYSIS; DEMOGRAPHY; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME BLOOD LEVEL; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; HEMATOCRIT; HEMODIALYSIS PATIENT; HUMAN; LEUKOCYTE COUNT; LINEAR REGRESSION ANALYSIS; LONGITUDINAL STUDY; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; METABOLISM; PROSPECTIVE STUDY; PRURITUS; RATING SCALE; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SCORING SYSTEM; TREATMENT DURATION; UREMIA; UREMIC PRURITUS; VISUAL ANALOG SCALE;

AGED; COHORT STUDIES; FEMALE; HUMANS; MALE; METABOLOME; MIDDLE AGED; PRURITUS; RENAL DIALYSIS; RESEARCH DESIGN; SEVERITY OF ILLNESS INDEX; UREMIA;

EID: 84881148683     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071404     Document Type: Article

References (39)

1. Mathur VS, Lindberg J, Germain M, Block G, Tumlin J, et al. (2010) A longitudinal study of uremic pruritus in hemodialysis patients. Clin J Am Soc Nephrol 5: 1410-1419.
2. Pisoni RL, Wikstrom B, Elder SJ, Akizawa T, Asano Y, et al. (2006) Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 21: 3495-3505.
3. Duque MI, Thevarajah S, Chan YH, Tuttle AB, Freedman BI, et al. (2006) Uremic pruritus is associated with higher kt/V and serum calcium concentration. Clin Nephrol 66: 184-191.
4. Hiroshige K, Kabashima N, Takasugi M, Kuroiwa A, (1995) Optimal dialysis improves uremic pruritus. Am J Kidney Dis 25: 413-419.
5. Morton CA, Lafferty M, Hau C, Henderson I, Jones M, et al. (1996) Pruritus and skin hydration during dialysis. Nephrol Dial Transplant 11: 2031-2036.
6. Massry SG, Popovtzer MM, Coburn JW, Makoff DL, Maxwell MH, et al. (1968) Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia. Disappearance of itching after subtotal parathyroidectomy. N Engl J Med 279: 697-700.
7. Graf H, Kovarik J, Stummvoll HK, Wolf A, (1979) Disappearance of uraemic pruritus after lowering dialysate magnesium concentration. Br Med J 2: 1478-1479.
8. Narita I, Alchi B, Omori K, Sato F, Ajiro J, et al. (2006) Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. Kidney Int 69: 1626-1632.
9. Chiu YL, Chen HY, Chuang YF, Hsu SP, Lai CF, et al. (2008) Association of uraemic pruritus with inflammation and hepatitis infection in haemodialysis patients. Nephrol Dial Transplant 23: 3685-3689.
10. Kaysen GA, (2001) The microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol 12: 1549-1557.
11. Wikstrom B, Gellert R, Ladefoged SD, Danda Y, Akai M, et al. (2005) Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 16: 3742-3747.
12. Peer G, Kivity S, Agami O, Fireman E, Silverberg D, et al. (1996) Randomised crossover trial of naltrexone in uraemic pruritus. Lancet 348: 1552-1554.
13. Chen HY, Chiu YL, Hsu SP, Pai MF, Lai CF, et al. (2010) Elevated C-reactive protein level in hemodialysis patients with moderate/severe uremic pruritus: a potential mediator of high overall mortality. QJM 103: 837-846.
14. Ko MJ, Yang JY, Wu HY, Hu FC, Chen SI, et al. (2011) Narrowband ultraviolet B phototherapy for patients with refractory uraemic pruritus: a randomized controlled trial. Br J Dermatol 165: 633-639.
15. Pauli-Magnus C, Mikus G, Alscher DM, Kirschner T, Nagel W, et al. (2000) Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. J Am Soc Nephrol 11: 514-519.
16. Yosipovitch G, Zucker I, Boner G, Gafter U, Shapira Y, et al. (2001) A questionnaire for the assessment of pruritus: validation in uremic patients. Acta Derm Venereol 81: 108-111.
17. Hemodialysis Adequacy 2006 Work Group (2006) Clinical practice guidelines for hemodialysis adequacy, update 2006. Am J Kidney Dis 48Suppl 1: S2-90.
18. Daugirdas JT, (1995) Simplified equations for monitoring Kt/V, PCRn, eKt/V, and ePCRn. Adv Ren Replace Ther 2: 295-304.
19. Clarke PS, (2004) Causal Analysis of Individual Change Using the Difference Score. Epidemiology 15: 414-421.
20. Ware JH, (1985) Linear models for the analysis of longitudinal studies. The American Statistician 39(2): 95-101.
21. Benedetti A, Abrahamowicz M, Leffondré K, Goldberg MS, Tamblyn R (2009) Using Generalized Additive Models to Detect and Estimate Threshold Associations. The International Journal of Biostatistics 5.
22. Yee TW (2012) VGAM: Vector generalized linear and additive models. R package, version 0.9-0.
23. Yee TW, Wild CJ, (1996) Vector generalized additive models. Journal of the Royal Statistical Society Series B-Methodological 58: 481-493.
24. Hastie T, Tibshirani R (1990) The gam Package. London: Chapman and Hall.
25. Hastie TJ, Tibshirani R (1991) Generalized additive models. Chapter 7 of Statistical Models in S eds J M Chambers and T J Hastie, Pacific Grove, CA: Wadsworth & Brooks/Cole.
26. Youden WJ, (1950) Index for rating diagnostic tests. Cancer 3: 32-35.
27. Dyachenko P, Shustak A, Rozenman D, (2006) Hemodialysis-related pruritus and associated cutaneous manifestations. Int J Dermatol 45: 664-667.
28. Zucker I, Yosipovitch G, David M, Gafter U, Boner G, (2003) Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. J Am Acad Dermatol 49: 842-846.
29. Eknoyan G, Beck GJ, Cheung AK, Daugirdas JT, Greene T, et al. (2002) Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 347: 2010-2019.
30. Chertow GM, Levin NW, Beck GJ, Depner TA, Eggers PW, et al. (2010) In-center hemodialysis six times per week versus three times per week. N Engl J Med 363: 2287-2300.
31. Owen WF Jr, Chertow GM, Lazarus JM, Lowrie EG, (1998) Dose of hemodialysis and survival: differences by race and sex. JAMA 280: 1764-1768.
32. Port FK, Ashby VB, Dhingra RK, Roys EC, Wolfe RA, (2002) Dialysis dose and body mass index are strongly associated with survival in hemodialysis patients. J Am Soc Nephrol 13: 1061-1066.
33. Wolfe RA, Ashby VB, Daugirdas JT, Agodoa LY, Jones CA, et al. (2000) Body size, dose of hemodialysis, and mortality. Am J Kidney Dis 35: 80-88.
34. Narita I, Iguchi S, Omori K, Gejyo F, (2008) Uremic pruritus in chronic hemodialysis patients. J Nephrol 21: 161-165.
35. Masi CM, Cohen EP, (1992) Dialysis efficacy and itching in renal failure. Nephron 62: 257-261.
36. Seres DS, Strain GW, Hashim SA, Goldberg IJ, Levin NW, (1993) Improvement of plasma lipoprotein profiles during high-flux dialysis. J Am Soc Nephrol 3: 1409-1415.
37. van Ypersele de Strihou C, Jadoul M, Malghem J, Maldague B, Jamart J, (1991) Effect of dialysis membrane and patient's age on signs of dialysis-related amyloidosis. The Working Party on Dialysis Amyloidosis. Kidney Int 39: 1012-1019.
38. Koda Y, Nishi S, Miyazaki S, Haginoshita S, Sakurabayashi T, et al. (1997) Switch from conventional to high-flux membrane reduces the risk of carpal tunnel syndrome and mortality of hemodialysis patients. Kidney Int 52: 1096-1101.
39. Mistik S, Utas S, Ferahbas A, Tokgoz B, Unsal G, et al. (2006) An epidemiology study of patients with uremic pruritus. J Eur Acad Dermatol Venereol 20: 672-678.