Blood levels of cytokines in children with idiopathic partial and generalized epilepsy

Seizure

Volumn 22, Issue 7, 2013, Pages 517-521

  Sonmez, Fatma Mujgan ^a   Serin, Hepsen Mine ^b   Alver, Ahmet ^c   Aliyazicioglu, Rezzan ^c   Cansu, Ali ^c   Can, Gamze ^c   Zaman, Dilek ^d  

^a TURGUT OZAL UNIVERSITY   (Turkey)

^b FIRAT UNIVERSITY   (Turkey)

^c KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^d VakfIkebir Hospital   (Turkey)

Author keywords

Child; Epilepsy; ILs; TNF ; Topiramate; Valproic acid

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOPIRAMATE; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

ARTICLE; CHILD; CLINICAL ARTICLE; COMPLEX PARTIAL SEIZURE; DRUG DOSE INCREASE; ELECTROENCEPHALOGRAM; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HUMAN; IDIOPATHIC DISEASE; MALE; OUTPATIENT DEPARTMENT; PREPUBERTY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SIMPLE PARTIAL SEIZURE; TREATMENT DURATION;

EID: 84881143317     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2013.03.014     Document Type: Article

References (35)

1. J. Mlodzikowska-Albrecht, B. Steinborn, and M. Zarowski Cytokines, epilepsy and antiepileptic drugs - is there a mutual influence? Pharmacological Reports 59 2007 129 138
2. R. Pacifici, L. Paris, S. Di Carlo, A. Bacosi, S. Pichini, and P. Zuccaro Cytokine production in blood mononuclear cells from epileptic patients Epilepsia 36 1995 384 387
3. P. Anderson, and L. Moseklide Immunoglobulin levels and autoantibodies in epileptics on long term anticonvulsant therapy Acta Medica Scandinavica 201 1977 69 74
4. P. Garson, S. Gonzales-Cornejo, S. Roman-Maldonado, and A. Navorro-Ruiz Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients General Pharmacology 16 1985 411 413
5. F. De Ponti, S. Lecchini, M. Cosentino, C.M. Castelletti, A. Malesci, and G.M. Frigo Immunological adverse effects of anticonvulsants. What is their clinical relevance? Drug Safety 8 1993 235 250
6. M.A. Munoz Fernandez, and M. Fresno The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system Progress in Neurobiology 56 1998 307 340
7. A. Vezzani, D. Moneta, C. Richichi, M. Aliprandi, and S.J. Burrows Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis Epilepsia 43 2002 30 35
8. E. Beghi, and S. Shorvon Antiepileptic drugs and the immune system Epilepsia 52 2011 40 44
9. A. Vezzani, and T. Granata Brain inflammation in epilepsy: experimental and clinical evidence Epilepsia 46 2005 1724 1743
10. A. Vezzani, M. Conti, A. De Luigi, T. Ravizza, D. Moneta, and F. Marchesi Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainite application: functional evidence for enhancement of electrographic seizures Journal of Neuroscience 19 1999 5054 5065
11. M. Penkowa, A. Molinero, J. Carraso, and J. Hidalgo Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures Neuroscience 102 2001 805 818
12. K.A. Lehtimaki, T. Keranen, J. Palmio, R. Makinen, M. Hurme, and J. Honkaniemi Increased plasma levels of cytokines after seizures in localization-related epilepsy Acta Neurologica Scandinavica 116 2007 226 230
13. S. Sinha, S.A. Patil, V. Jayalekshmy, and P. Satishchandra Do cytokines have any role in epilepsy? Epilepsy Research 82 2008 171 176
14. A. Verrotti, F. Basciani, D. Trotta, R. Greco, G. Morgese, and F. Chiarelli Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte-chemoattractant protein1 Clinical and Experimental Medicine 1 2001 133 136
15. I.S. Shiah, L.N. Yatham, C.B. Yeh, and A.V. Ravindran Effect of valproate on plasma levels of interleukin-6 in healthy male humans International Clinical Psychopharmacology 20 2005 295 298
16. M. Ashrafi, S.A. Hosseini, S. Abolmaali, M. Biglari, R. Azizi, and M. Farghadan Effect of antiepileptic drugs on serum immunoglobulin levels in children Acta Neurologica Belgica 110 2010 65 70
17. T. Ichiyama, K. Okada, J.M. Lipton, T. Matsubara, T. Hayashi, and S. Furukawa Sodium valproate inhibits production of TNF-a and IL-6 and activation of NF-kB Brain Research 857 2000 246 251
18. G. Li, S. Bauer, M. Nowak, B. Norwood, B. Tackenberg, and F. Rosenow Cytokines and epilepsy Seizure 20 2011 249 256
19. T. Ravizza, and A. Vezzani Status epilepticus induces time dependent neuronal and astrocytic expression of IL-1 receptor type-1 in the rat limbic system Neuroscience 138 2006 301 308
20. C. Ozkara, and R. Vigevano Immuno and inflammatory therapies in epileptic disorders Epilepsia 52 2011 45 51
21. N. Marchi, T. Granata, E. Freri, E. Ciusani, F. Ragona, and V. Puvenna Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics PLoS ONE 6 3 2011 e18200 10.1371/journal.pone.0018200
22. M.L. Oueiroz, and P.W. Mullen Effects of sodium valproate on the immune response International Journal of Immunopharmacology 14 1992 1133
23. Y. Okamoto, K. Shimizu, K. Tamura, M. Yamada, Y. Matsui, and T. Hayakawa Effects of anticonvulsants on cellular immunity No to Shinkei: Brain and Nerve 41 3 1989 299 [abstract]
24. N. Başaran, E. Kansu, and F. Hical Serum immunoglobulins, complement levels and lymphocyte subpopulations in phenytoin-treated epileptic patients Immunopharmacology and Immunotoxicology 11 1989 335 346
25. A. Schreiber, K. Frei, W. Lichtensteiger, and M. Schlumpf The effect of prenatal diazepam exposure on TNF-α production by rat splenocytes Agents and Actions 38 1993 265 272
26. E. Aronica, and P.B. Crino Inflammation in epilepsy: clinical observation Epilepsia 52 Suppl. 3 2011 26 32
27. M. Kubera, B. Budziszewska, L. Jaworska-Feil, A. Basta-Kaim, M. Leśkiewicz, and M. Tetich Effects of topiramate on the kainite-induced status epilepticus, lipid peroxidation and immunoreactivity of rats Polish Journal of Pharmacology 56 2004 553 561
28. Y. Kim, H. Jung, A. Myint, H. Kim, and S. Park Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder Journal of Affective Disorders 104 2007 91 95
29. M. Maes, H.Y. Meltzer, E. Bosmans, R. Bergmans, E. Vandoolaeghe, and R. Ranjan Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression Journal of Affective Disorders 34 1995 301 309
30. T. Ichiyama, K. Okada, J.M. Lipton, T. Matsubara, T. Hayashi, and S. Furukawa Sodium valproate inhibits production of TNF-a and IL-6 and activation of NF-κB Brain Research 857 2000 246 251
31. C.R. Plata-Salaman, S.E. Ilyin, N.P. Turrin, D. Gayle, M.C. Flynn, and A.E. Romano witch Kindling modulates the IL-1beta system, TNF-alpha, TGF-beta1, and neuropeptide mRNAs in specific brain regions Brain Research. Molecular Brain Research 75 2000 248 258
32. S.G. Levin, and O.V. Godukhin Protective effects of interleukin-10 on the development of epileptiform activity evoked by transient episodes of hypoxia in rat hippocampal Neuroscience and Behavioral Physiology 37 2007 467 470
33. M.R. Opp, E.M. Smith, and T.K. Hughes Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep Journal of Neuroimmunology 60 1995 165 168
34. J. Hulkkonen, E. Koskikallio, S. Rainesalo, T. Keranen, M. Hurme, and J. Peltola The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients Epilepsy Research 59 2004 199 205
35. H.Y. Tormoum, N.M. Badawy, A.A. Mostafa, and M.Y. Harb Plasma interleukin-1beta levels in children with febrile seizures Journal of Child Neurology 22 2007 689 692