Protective effects of interleukin-10 on the development of epileptiform activity evoked by transient episodes of hypoxia in rat hippocampal slices

Neuroscience and Behavioral Physiology

Volumn 37, Issue 5, 2007, Pages 467-470

  Levin, S G ^a   Godukhin, O V ^a  

^a INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

Author keywords

Epileptiform activity; Field potentials; Hippocampal slices; Hyperexcitability; Hypoxia; Immunomodulation; Interleukin 10

Indexed keywords

INTERLEUKIN 10;

ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN HYPOXIA; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; IMMUNOMODULATION; IN VITRO STUDY; MALE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; RAT; SPIKE WAVE;

ANIMALS; CELL HYPOXIA; EPILEPSY; EVOKED POTENTIALS; HIPPOCAMPUS; HYPOXIA, BRAIN; INTERLEUKIN-10; MALE; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR;

EID: 34249088983     PISSN: 00970549     EISSN: 1573899X     Source Type: Journal    
DOI: 10.1007/s11055-007-0036-1     Document Type: Article

References (17)

1. S. V. Kalemenev, A. V. Satin, C. G. Levin, and O. V. Godukhin, "Long-term potentiation of glutamatergic transmission and epileptiform activity evoked by transient episodes of anoxia in hippocampal field CA1 in rats," Ros. Fiziol. Zh., 86, No. 12, 1676-1681 (2000).
2. J. A. Aarli, "Epilepsy and the immune system," Arch. Neurol., 57, 1689-1692 (2000).
3. K. E. Abraham, D. McMillen, and K. L. Brewer, "The effects of endogenous interleukin-10 on gray matter damage and the development of pain behaviours following excitotoxic spinal cord injury in the mouse," Neurosci., 124, No. 4, 945-952 (2004).
4. A. Bachis, A. M. Colangelo, S. Vicini, P. P. Doe, M. A. De Bernardi, G. Brooker, and I. Mocchetti, "Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity," J. Neurosci., 21, 3104-3112 (2001).
5. M. G. De Simoni, C. Perego, T. Ravizza, D. Moneta, M. Conti, F. Marchesi, A. De Luigi, S. Garattini, and A. Vezzani, "Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus," Eur. J. Neurosci., 12, No. 7, 2623-2633 (2000).
6. 2+ channels," Neuropharmacology, 42, 459-466 (2002).
7. J. L. Jankowsky and P. H. Patterson, "The role of cytokines and growth factors in seizures and their sequelae," Progr. Neurobiol., 63, 125-149 (2001).
8. A. Kelly, A. Lynch, E. Vereker, Y. Nolan, P. Queenan, E. Whittaker, L. A. J. O'Neill, and M. A. Lynch, "The anti-inflammatory cytokine, interleukin-10, blocks the inhibitory effect of IL-1β on long term potentiation," J. Biol. Chem., 276, No. 49, 45564-45572 (2001).
9. T. Mizuno. M. Sawada, T. Marunouchi, and A. Suzumura, "Production of interleukin-10 by mouse glial cells in culture," Biochem. Biophys. Res. Commun., 205, 1907-1915 (1994).
10. E. Molina-Holgado, J. M. Velda, A. Arevalo-Martin, and C. Guaza, "LPS/IFN-gamma cytotoxicity in oligodendroglial cells: Role of nitric oxide and protection by the anti-inflammatory cytokine IL-10," Eur. J. Neurosci., 13, 493-502 (2001).
11. H. Schneider, F. Pitossi, D. Balschun, A. Wagner, A. del Rey, and H. O. Besedovsky, "A neuromodulatory role of interleukin-lβ in the hippocampus," Proc. Natl. Acad. Sci. USA, 95, 7778-7783 (1998).
12. P. A. Spera, J. A. Ellison, G. Z. Feuerstein, and F. C. Barone, "IL-10 reduces rat brain injury following focal stroke," Neurosci. Lett., 251, No. 3, 189-192 (1998).
13. R. Straussberg, J. Amir, L. Harel, I. Punsky, and H. Bessler, "Pro-and anti-inflammatory cytokines in children with febrile convulsions," Pediatr. Neurol., 24, 49-53 (2001).
14. K. Strle, J.-H. Zhou, W.-H. Shen, S. R. Broussard, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelly, "Interleukin-10 in the brain," Crit. Rev. Immunol., 21, No. 5, 427-449 (2001).
15. K. Strle, J. Zhou, S. R. Broussard, H. D. Venters, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelly, "IL-10 promotes survival of microglia without activating Akt," J. Neuroimmunol., 122, 9-19 (2002).
16. J. Szelenyi, "Cytokines and the central nervous system," Brain Res. Bull., 54, No. 4, 329-338 (2001).
17. A. Vezzani, D. Moneta, C. Richichi, C. Perego, and M. G. De Simoni, "Functional role of pro-inflammatory and anti-inflammatory cytokines in seizures," Adv. Exptl. Med. Biol., 548, 123-133 (2004).