Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model

Journal of Neuro-Oncology

Volumn 114, Issue 1, 2013, Pages 33-42

  Jacobs, Valerie L ^a,b   De Leo, Joyce A ^a,b,c  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Neuroscience Center at Dartmouth   (United States)

^c EMMANUEL COLLEGE   (United States)

Author keywords

Glioma; GLT 1; Methylxanthine; U 251

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; LIPOCORTIN 5; PROPENTOFYLLINE; VESICULAR GLUTAMATE TRANSPORTER 1;

AMINO ACID TRANSPORT; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN EXPRESSION; RAT; TUMOR MICROENVIRONMENT;

ANIMALS; ANIMALS, NEWBORN; ANNEXIN A5; APOPTOSIS; ASTROCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; CEREBRAL CORTEX; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMIC ACID; HUMANS; NEUROPROTECTIVE AGENTS; RATS; RATS, INBRED LEW; RNA, SMALL INTERFERING; XANTHINES;

EID: 84881133011     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-013-1158-7     Document Type: Article

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