Chronic treatment with Δ9-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain

Behavioural Pharmacology

Volumn 20, Issue 1, 2009, Pages 45-55

  Boucher, Aurélie A ^a,b,c   Vivier, Lucie ^a   Metna Laurent, Mathilde ^a   Brayda Bruno, Laurent ^a   Mons, Nicole ^a   Arnold, Jonathon C ^b,c   Micheau, Jacques ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UNIVERSITY OF SYDNEY   (Australia)

^c SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

Author keywords

Cannabinoid; Chronic; Hippocampus; Memory; Mouse; Tolerance; Zif268

Indexed keywords

DRONABINOL; PROTEIN ZIF268; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, MOUSE; TETRAHYDROCANNABINOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOREBRAIN; HIPPOCAMPUS; HISTOPATHOLOGY; LEARNING; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; PREFRONTAL CORTEX; PROTEIN EXPRESSION; SPATIAL MEMORY; ANIMAL; BEHAVIOR; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG TOLERANCE; MEMORY; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EARLY GROWTH RESPONSE PROTEIN 1; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PREFRONTAL CORTEX; REVERSAL LEARNING; SPATIAL BEHAVIOR; TETRAHYDROCANNABINOL;

EID: 61449213974     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e3283242f6a     Document Type: Article

References (43)

1. Arnold JC, Hunt GE, McGregor IS (2001a). Effects of the cannabinoid receptor agonist CP 55 940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats. Life Sci 70:97-108.
2. Arnold JC, Topple AN, Mallet PE, Hunt GE, McGregor IS (2001b). The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain. Brain Res 921:240-255.
3. Bhat RV, Cole AJ, Baraban JM (1992). Chronic cocaine treatment suppresses basal expression of zif268 in rat forebrain: in situ hybridization studies. J Pharmacol Exp Ther 263:343-349.
4. Bozon B, Davis S, Laroche S (2002). Regulated transcription of the immediate-early gene zif268: mechanisms and gene dosage-dependent function in synaptic plasticity and memory formation. Hippocampus 12:570-577.
5. 9-THC- induced spatial learning deficit in a Morris-type water maze in mice. Prog Neuropsychopharmacol Biol Psychiatry 26:321-325.
6. 9-THC following 35 days of exposure. Neurosci Res Commun 17:9-18.
7. Derkinderen P, Valjent E, Toutant M, Corvol JC, Enslen H, Ledent C, et al. (2003). Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J Neurosci 23:2371-2382.
8. 9-THC: search for the impairment of spatial memory in the eight-arm radial maze in rats. Brain Res 952:239-245.
9. 9-THC- induced deficits in reversal learning: neural correlates of affective inflexibility. Neuropsychopharmacology 30:1895-1905.
10. Fadda P, Robinson L, Fratta W, Pertwee RG, Riedel G (2004). Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology 47:1170-1179.
11. Ferrari F, Ottani A, Vivoli R, Giuliani D (1999). Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water-maze task. Pharmacol Biochem Behav 64:555-561.
12. Fletcher JM, Page JB, Francis DJ, Copeland K, Naus MJ, Davis CM, et al. (1996). Cognitive correlates of long-term cannabis use in Costa Rican men. Arch Gen Psychiatry 53:1051-1057.
13. Glass M, Dragunow M, (1995). Induction of the krox 24 transcription factor in striosomes by a cannabinoid agonist. Neuroreport 6:241-244.
14. Gonzalez S, Cebeira M, Fernandez-Ruiz J (2005). Cannabinoid tolerance and dependence: a review of studies in laboratory animals. Pharmacol Biochem Behav 81:300-318.
15. Hampson RE, Deadwyler SA (2000). Cannabinoids reveal the necessity of hippocampal neural encoding for short-term memory in rats. J Neurosci 20:8932-8942.
16. Hampson RE, Simeral JD, Kelly EJ, Deadwyler SA (2003). Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons. Hippocampus 13:543-556.
17. Hill MN, Froese LM, Morrish AC, Sun JC, Floresco SB (2006). Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists. Psychopharmacology (Berl) 187:245-259.
18. 9-THC reduces prefrontal cortical dopamine metabolism in the rat. Neurosci Lett 246:169-172.
19. Kanayama G, Rogowska J, Pope HG, Gruber SA, Yurgelun-Todd DA (2004). Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology (Berl) 176:239-247.
20. Laroche S, Davis S, Jay TM (2000). Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation. Hippocampus 10:438-446.
21. 9-THC impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology (Berl) 126:125-131.
22. Lichtman AH, Dimen KR Martin BR (1995). Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology (Berl) 119:282-290.
23. Mailleux P, Verslype M, Preud'homme X, Vanderhaeghen JJ (1994). Activation of multiple transcription factor genes by THC in rat forebrain. Neuroreport 5:1265-1268.
24. McDonald RJ, King AL, Foong N, Rizos Z, Hong NS (2008). Neurotoxic lesions of the medial prefrontal cortex or medial striatum impair multiple-location place learning in the water task: evidence for neural structures with complementary roles in behavioural flexibility. Exp Brain Res 187:419-427.
25. Messinis L, Kyprianidou A Malefaki S, Papathanasopoulos P (2006). Neuropsychological deficits in long-term frequent cannabis users. Neurology 66:737-739.
26. Misner DL, Sullivan JM (1999). Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. J Neurosci 19:6795-6805.
27. 9-THC on memory in the rat. Drug Alcohol Depend 28:167-175.
28. 9-THC treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze. Neuropharmacology 41:392-399.
29. Niyuhire F, Varvel SA, Martin BR, Lichtman AH (2007). Exposure to marijuana smoke impairs memory retrieval in mice. J Pharmacol Exp Ther 322:1067-1075.
30. Oliva JM, Ortiz S, Palomo T, Manzanares J (2003). Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice. J Neurochem 85:94-104.
31. Packard MG, Teather LA (1998). Amygdala modulation of multiple memory systems: hippocampus and caudate-putamen. Neurobiol Learn Mem 69:163-203.
32. Riedel G, Davies SN (2005). Cannabinoid function in learning, memory and plasticity. Handb Exp Pharmacol 168:445-477.
33. Rog DJ, Nurmikko TJ, Friede T, Young CA (2005). Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology 65:812-819.
34. Rossato Jl, Zinn CG, Furini C, Bevilaqua LR, Medina JH, Cammarota M, Izquierdo I (2006). A link between the hippocampal and the striatal memory systems of the brain. An Acad Bras Cienc 78:515-523.
35. 9-THC administered into the medial prefrontal cortex disrupts the spatial working memory. Psychopharmacology (Berl) 183:54-64.
36. Smith PF (2005). The safety of cannabinoids for the treatment of multiple sclerosis. Expert Opin Drug Saf 4:443-456.
37. Solowij N, Michie PT, Fox AM (1995). Differential impairments of selective attention due to frequency and duration of cannabis use. Biol Psychiatry 37:731-739.
38. Solowij N, Stephens RS, Roffman RA, Babor T, Kadden R, Miller M, et al. (2002). Cognitive functioning of long-term heavy cannabis users seeking treatment. JAMA 287:1123-1131.
39. 9-THC on spatial reference and working memory in mice. Psychopharmacology (Bert) 157:142-150.
40. 9-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline. Psychopharmacology (Berl) 178:317-327.
41. Verrico CD, Jentsch JD, Roth RH (2003). Persistent and anatomically selective reduction in prefrontal cortical dopamine metabolism after repeated, intermittent cannabinoid administration to rats. Synapse 49:61-66.
42. 9-THC in the rat. Drug Alcohol Depend 71:169-177.
43. Yucel M, Solowij N, Respondek C, Whittle S, Fornito A, Pantelis C, Lubman Dl (2008). Regional brain abnormalities associated with long-term heavy cannabis use. Arch Gen Psychiatry 65:694-701.